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Creating and maintaining a superior microenvironment is challenging for electrocatalytic CO₂ reduction reaction. Here the authors report an in situ activation method to deliver silver nanoparticles within the gas diffusion layer, constructing a feasible and stable interfacial microenvironment.

The efficient construction of trifluoromethylated alkanes bearing a CF₃ chiral center is of great importance in organic synthesis. Here, the authors disclose the enantioselective syntheses of α-trifluoromethylated allylic alkanes via reductive trifluoroalkylation.

Compound 8-1-(3-chlorophenethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione was previously reported to be a selective inhibitor of the Ca_V1.3 calcium channel. Now, Huang et al. demonstrate that selectivity towards Ca_V1.3 relative to Ca_V1.2 is dependent on the type of β-subunit and Ca_V1.3 splice variant assayed.

Quantum spin Hall edge states are protected by time-reversal symmetry and are expected to disappear in a strong magnetic field. Here, the authors use microwave impedance microscopy and find, surprisingly, edge conduction in mercury telluride quantum wells that survives up to 9 T with little change.

Optical tweezers can apply 3D forces to trap and move microparticles, but application of 3D optical torques for controlled rotations remains challenging. Here, the authors report a technique for controlling 3D optical torque via a single beam, achieving dynamic 3D rotations around an arbitrary axis.

Ruthenium dioxide exhibits good activity for the oxygen evolution reaction in acidic conditions but fails to maintain stable performance over long periods. Here, the authors report a confinement strategy that suppresses ruthenium dioxide degradation, enhancing its long-term durability.

Climate-intensified supply–demand imbalances may raise hourly costs of wind and solar power systems, but well-designed climate-resilient strategies can provide help.

A Z-type ZnO@COF heterostructure composite with excellent piezoelectric properties was synthesized for the piezocatalytic uranium extraction from seawater, helping to realize efficient uranium extraction by wave energy

Here, Chen et. al. characterize the relationship between the gut microbiota and plasma metabolite changes in the context of ST-elevation myocardial infarction (STEMI), unveiling a role of butyrate-producing bacteria and their ketogenesis in post-STEMI cardiac repair, a finding validated in nonhuman primate and mouse models. They show that butyrate supplementation reduces myocardial infarction severity in mice, underscoring the significance of butyrate-producing bacteria and beta-hydroxybutyrate in improving post-MI outcomes.

Hyperbolic lattices in non-Euclidean space challenge conventional band theory due to the breakdown of Bloch’s theorem. The authors develop a reciprocal-space supercell method to determine non-Hermitian spectra under periodic and open boundaries, revealing higher-dimensional skin effects and topological transitions enabled by non-Abelian translations.

Using single-cell and spatial molecular profiling of infarcted mouse and human hearts, Li, Ni, Wang and colleagues identify a subset of cardiac fibroblasts expressing CD248 that plays a critical role in fibroblast–T cell interaction, and show that disrupting this interaction with monoclonal antibodies or anti-CD248 chimeric antigen receptor T cells results in reduced cardiac fibrosis and improved function.

This work reveals a eukaryotic ribosome elongation cycle in situ, uncovers over 20 structural conformations, highlights the new role of compact eukaryotic elongation factor 2 (eEF2) during peptidyl transfer and discovers new conformations of open-eEF3.

High-resolution in situ protein structure can be solved by cryo-ET, which requires several days of data collection. Here Cheng et al. report GisSPA, a program that may enable determining sub-4 Å resolution structures on cellular lamellae within one day of data collection.

Wafer-scale monolayers of MoS₂ can be used to create flexible transistors and circuits that exhibit on/off ratios of 10¹⁰, current densities of ~35 μA μm⁻¹ and mobilities of ~55 cm² V⁻¹ s⁻¹.

A wearable, ultrasonically-actuated magnetic-dipole rotating resonator (UA-MDRR) enables efficient ELF wave transmission in extreme environments. It outperforms traditional antennas with high emission capacity and low power consumption, ideal for emergency communication in seawater.

The authors introduce the concepts of Robo-Matter and Robot-Matter duality, using magnetic spinner micro-robots. A wide range of functionalities and applications beyond the capability of both traditional inert and active materials is enabled.

In this work, the authors report that citronellal stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. Structural and functional analysis elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. These findings can help move skin healthcare forward.

Sustainable management of soil organic carbon (SOC) in farmland is critical for mitigating climate change and improving soil health. Degradable film mulching is a promising alternative to plastic film mulching, sequestering SOC and reducing C loss in dryland agroecosystems under climate change.

Xue Zhang, Jing Yu Liu and colleagues report SLC20A2 mutations in familial idiopathic basal ganglia calcification (IBGC, also known as Fahr disease). These mutations impair the function of the type III phosphate transporter encoded by SLA20A2 and may disturb phosphate homeostasis in the body.

Inverse electron-demand cycloadditions in palladium catalysis are inherently limited by the linear selectivity in the allylic substitution step. To overcome this issue, the authors report a synergetic iridium (branched-selective) and amine catalysis in [4+2] cycloadditions of vinyl aminoalcohols with carbonyls.

The spin-orbit torque (SOT) induced magnetic switching makes metal/magnetic insulators bilayers preferred in the energy efficient spintronic applications. Here the authors show SOT switching in W/TmIG bilayers and reveal the dimension crossover of SOT as a function of TmIG thickness.

Proteins can serve as means of medical treatment, but their efficient delivery to cells is difficult. Here, the authors present a type of polymers, fluoroamphiphiles, acting as chemical chaperones that can facilitate the import of proteins into the inner compartment, i.e. cytosol, of cells.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

This study developed an electrochemical sensor based on a nitrogen-doped hollow carbon sphere @ZIF-8 composite material (NC@ZIF-8), designed to efficiently detect the natural flavonoid luteolin. The composite material combines the high conductivity of hollow carbon spheres with the large specific surface area of ZIF-8. By optimizing the synthesis process and electrode modification conditions, the sensitivity and selectivity of the sensor were significantly enhanced. Experimental results show that the sensor exhibits excellent detection performance over a wide linear range (0.05–30 μM), with a detection limit as low as 0.011 μM. It also demonstrates good interference resistance and stability. The recovery rates for actual samples (Honeysuckle extract and watermelon juice) ranged from 95.41% to 101.20%, confirming its practical value in food safety and drug analysis.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Drug-induced interstitial lung disease (DIILD) is emerging as a hidden toll of modern oncology. Diagnosis of DIILD is confounded by non-specific symptoms and the absence of validated biomarkers, leaving clinicians to navigate heterogeneous, drug-specific guidelines. Herein, we discuss this predicament and advocate a shift from reactive management towards proactive survivorship.

Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose.

A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

Axions are hypothetical particles that might play an important part in particle physics, astrophysics and cosmology. So far they have eluded observation, but theoretical work now predicts that axion physics might be explored in condensed-matter systems known as topological insulators.

Polymers that are both elastic and self-healing are desirable for a variety of applications, but often rely on hydrogen bonding which makes them moisture-sensitive. Now, by incorporating metal–ligand interactions with different bond strengths into flexible polymer backbones, an elastomer has been devised that combines high stretchability and high dielectric strength with autonomous self-healing and mechanical actuation capabilities.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

A description is given of the ENCODE consortium’s efforts to examine the principles of human transcriptional regulatory networks; the results are integrated with other genomic information to form a hierarchical meta-network where different levels have distinct properties.

Topological photonic structures enable robust light transport but face coupling challenges. The authors demonstrate transverse spin matching governs the coupling between the topological waveguide and waveguide, achieving 96.3% theoretical and 94.2% experimental transmission efficiencies.

Nanoreactors, with biomimetic features and distinct catalytic functions, show promise in catalytic energy conversion. Here the authors propose the utilization of precisely engineered mesoporous carbon spheres with tunable hollow sizes as nanoreactors, leveraging their catalytic functionalities for enhanced diffusion and microenvironment modulation effects to achieve efficient hydrogen peroxide electrosynthesis.

A light-inducible RNA base editor fine-tunes gene expression for therapeutics.