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The electroreduction of CO₂ to C₂₊ oxygenates at industrial current density in acidic media is highly significant yet remains a challenge. Here, the authors report an ionic liquid-modified Cu electrode that enables efficient and stable production of C₂₊ oxygenates at ampere-level current densities.

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Noninvasive transcranial photoacoustic computed tomography (PACT) of the human brain remains impeded by the acoustic distortion induced by the skull. Here, using a homogeneous elastic skull model, the authors de-aberrate the PACT images of light-absorbing phantoms acquired through an ex-vivo human skull for different levels of phantom complexity.

Metabolite signatures were identified for subtypes of dietary carbohydrate, including added sugar, whole grain and refined grain, and showed different associations with type 2 diabetes, providing an objective measure of dietary risk.

piR48444 targets METTL7A to inhibit BMP2 mRNA m6A methylation and METTL7A/eIF4E complex-mediated BMP2 mRNA stability and translation, ultimately inhibiting osteogenic differentiation of MSCs and bone regeneration.

A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.

High-temperature, ultrathin, and high-performance microwave absorption is realized in the dual-layer structure with rare earth zirconate ceramics via electron delocalization-mediated thermionic migration and macroscopic interfacial resonance.

Experiments have shown that carbon nanotubes are ideal optical wires, with properties affected by excitonic and other intrinsic properties, as well as by shape.

This study introduces 3D-PanoPACT, a panoramic photoacoustic imaging system enabling high spatiotemporal-resolution visualization of whole-body dynamics and metabolism, overcoming limitations in speed and field of view for advanced 3D tomography.

A combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

Wastewater-based surveillance tends to focus on specific pathogens. Here, the authors mapped the wastewater virome from 62 cities worldwide to identify over 2,500 viruses, revealing city-specific virome fingerprints and showing that wastewater metagenomics enables early detection of emerging viruses.

The extent to which SARS-CoV-2 serum neutralising antibodies are informative as correlates of protection for Omicron strains is uncertain. Here, the authors use data from a household-based prospective cohort study in Nicaragua to investigate correlates of protection against infection and symptomatic infection for Omicron BA.1 and BA.2.

The B.1.1.529/Omicron variant of SARS-CoV-2 is resistant to neutralization by serum not only from patients who recovered from COVID-19, but also from individuals vaccinated with one of the four widely used COVID-19 vaccines.

LncRNAs modulate diverse physiological cellular processes, however, their involvement in heme-dependent processes are not yet clear. Here the authors reveal the role of lncRNA UCA1 in erythroid cell development.

Antimicrobial resistance genes that have been mobilized between bacterial species represent a subset of the naturally occurring resistome. Here, the authors compare the abundance, diversity and geographical patterns of acquired resistance genes with latent resistance genes in global sewage metagenomes.

Pumpkin rootstock delivers CmoKARI1 mRNA to cucumber scion under chilling stress, enhancing tolerance by activating JA-Ile signaling. This mobile mRNA acts as a key chilling-responsive signal, redefining the understanding of rootstock–scion communication.

A class of core–shell nanoparticles self-assembled from amphiphilic peptides can kill a range of bacteria, yeast and fungus. They are more potent than their unassembled peptide counterparts and can suppress bacterial growth in the brains of rabbits infected with meningitis. These particles, which carry a high number of positive charges, are promising antimicrobial agents.

Lipase is one of the most important industrial biocatalysts with wide applications, but its catalytic efficiency is often hindered by a closed lid conformation. Here, the authors present an aggregation-induced conformation locking strategy that enables the facile synthesis of highly activated lipase hybrid biocatalysts.

Forming and steering a tight optical focus noninvasively in scattering media is a pivotal challenge in biomedical optics. The authors present an iterative time-reversal mechanism using nonlinearity to achieve this without a point-like guide star.

The authors present Compressed Ultrafast Planar Polarization Anisotropy Imaging, capturing real-time, wide-field, non-invasive measurements of molecular size in liquids and gases. The method could enable scientists to visualize dynamic processes like drug binding and nanoparticle formation.

Rare earth elements are widely used in agriculture to promote plant growth. Here the authors show that aerial application of a rare earth element to the leaves triggers a graft-transmissible, RbohD- and jasmonic acid-dependent systemic signal that triggers endocytosis and mineral nutrient uptake in roots.

Photoacoustic microscopy allows for label-free 3D in vivo imaging by detecting the acoustic response of a photoexcited material. Here, Yang et. al use a digital-micromirror-device based structured illumination scheme to both improve resolution and greatly increase the depth of field, enabling 3D volumetric imaging.

A clinical study of women with abnormal breast mammograms establishes a workflow to evaluate the capability of breast photoacoustic computed tomography in the classification, monitoring and segmentation of lesions.

POMC and AgRP neurons in hypothalamus were widely known to regulate energy balance. Here, authors show that ARC^CRABP1 neurons are identified as a new player influencing appetite and metabolism.

Spermine is a polyamine dysregulated in different cancers. This group shows that Serpinb9 prevents spermine synthase degradation, raising spermine levels and impairing the tumor immune microenvironment, and identifying Serpinb9 as a potential therapeutic target for pancreatic cancer immunotherapy.

CO₂ reduction (CO₂R) to C₂₊ alcohols has low selectivity and current density due to competing C₂+ pathways that produce ethylene. Defect-rich Pr–Cu oxide heterointerfaces are developed to induce asymmetric carbon–carbon coupling and selective hydrodeoxygenation of CO₂R intermediates, accelerating the production of C₂₊ alcohols.

Patients with sickle cell disease or β-thalassemia are treated with drugs that aim to reactivate production of fetal hemoglobin, but these drugs are not effective in all patients and have side effects. Lihong Shi et al. identify a new therapeutic strategy for these anemias, showing that a drug used to treat depression, tranylcypromine, can raise fetal hemoglobin levels in human erythroid cells and transgenic mice harboring the human β-globin locus, most likely by inhibiting a lysine demethylase that controls fetal globin gene expression.

Diagnosing rare diseases, such as choroid neoplasias, remains a critical challenge. Here, the authors develop a multimodal concept-based interpretable model (MMCBM) to distinguish uveal melanoma from hemangioma and metastatic carcinoma, obtaining performance comparable to senior ophthalmologists in a large cohort of Asian patients with choroid neoplasms.

Antibodies against SARS-CoV-2 provide protection against infection, but the virus has evolved to evade them. Here, the authors characterize a human antibody with incomplete neutralization of SARS-CoV-2 variants and engineer it to enhance potency and expand coverage to all tested variants by increasing conformational flexibility.

Rice taste is a crucial trait that determines consumer preference, but how it is established has been unclear. Here, the authors report that the formation of taste quality is mediated by the OsGATA7-SMOS1 protein content module and identify elite haplotypes for improving rice taste quality.

A mechanical exfoliation method for producing freestanding metal oxide ultrathin flakes is reported. The flakes can be transferred and integrated with 2D materials, providing a platform to investigate the fundamental properties of ultrathin metal oxides.

Rice is a staple crop for much of the world’s population, but its production can be a major source of greenhouse gas emissions. Supplemental nano iron oxides application can halve these emissions while boosting crop yield.

Photoacoustic tomography using a single laser pulse and a single element functioning as thousands of virtual detectors allows for the volumetric capture of fast haemodynamic changes in the feet of human volunteers.

Sea cucumbers are predominant deposit feeders in benthic ecosystems. This study elucidates the mechanisms within the sea cucumber digestive system and their symbiotic microbiome which enable them to efficiently utilize nutrients from seabed sediments.

The quality of the Li–electrolyte interface is key to solid-state battery performance, especially at low pressure. Here, authors use operando electron microscopy to reveal how Li-Mg alloy anodes improve interfacial contact and low-pressure cycling stability by suppressing void formation.

Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease (PD) and providing a mechanistic link between PD and renal dysfunction.