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Olfactory perception of food-derived odors influences feeding behavior, but the underlying neural pathways remain unclear. Here, the authors show that prolonged exposure to food odor suppresses food intake and body weight gain by activating an olfactory bulb–hypothalamus circuit.

This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake.

Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Glutamatergic neurons in the parvocellular part of the medial vestibular nucleus mediate motion-induced hypothermia and can be targeted to prevent diet-induced obesity.

S-chirogenic pharmacophores play an essential role in drug discovery within bioscience and medicinal chemistry. Here, the authors report a methodology for synthesizing diverse classes of S-chirogenic sulfinamides through asymmetric reductive addition of aryl and alkenyl halides to sulfinylamines via common-Earth-metal catalysis.

ERα^vlVMH neurons mediate the inhibitory role of 17β-oestradiol on prolactin production, and this inhibition is lifted in lactating mice to promote lactation-associated metabolic adaptations.

Twisted photonic crystals enable a strong light-matter interaction due to the flatband and high Q factor. Here, authors demonstrate Purcell enhancement between single quantum dots and Moiré nanocavities, with a PL intensity enhancement of about 8.4 times and a Purcell factor around 3.0.

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

Full polarization control of photons is achieved using coupled nanobeam cavities, in which the ultra-subwavelength gap results in the evanescent wave coupling and introduces non-Hermitian effects.

The authors identify a neural population in the basal forebrain of mice that is key for maintaining energy balance by facilitating homoeostatic feeding while suppressing hedonic overeating.

In-depth mechanistic insights inform the fabrication of an all-solid-state, Co-free lithium battery with good performance and cyclability.

While liquid-liquid interface offers better contact and charge transfer potential than solid-based counterparts, fluidity still poses challenges for their application. Here, authors show that charge transfer exists in aqueous two-phase systems and propose a nanogenerator design based on the immiscible aqueous-aqueous interface.

Chinese agricultural production is key to achieve the country’s 2060 carbon neutrality target. Combining meta-analysis and life-cycle assessment, this study estimates the climate change mitigation potential of straw, biochar, and an integrated biomass pyrolysis and electricity generation system.

Grb10, an adaptor protein known to regulate insulin signalling, can interact with the leptin receptor for enhancement of leptin signalling in hypothalamic AgRP and POMC neurons in mice.

Microspherical structures are broadly applicable, but their morphology and function is limited by the molecular building blocks available. Here, the authors describe the selfassembly process of condensed Schiff bases into multifunctional hierarchical organic microspheres.’

Diverse cellular E3 ubiquitin ligase–degron pairs are used to generate live attenuated influenza vaccines. Attenuation and humoral, mucosal and cellular immune responses were characterized in mouse and ferret models.

Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown. Here, the authors show in a murine model of ischemic stroke that inhibition of phagocytosis by MEGF10 and MERTK deletion in microglia and astrocytes attenuated damage and improved neurological outcomes by preventing synapse loss.

It is challenging to produce biomass FG continuously due to the lack of an integrated device. Here, we create an integrated automatic system with energy requirement-oriented allocation to achieve continuous biomass FG production with a much lower carbon footprint.

An abnormal stress memory effect is discovered in different types of glassy materials when they are subjected to a low strain after a high strain. This strategy can be used to depress the stress relaxation and increase the stability under loading.

The biological and clinical implications of high genome instability in esophageal squamous cell carcinoma (ESCC) remain to be explored. Here, the authors analyse 528 whole genomes and investigate the landscape and molecular mechanisms underlying structural variations in ESCC patients.

Identification and characterization of variants in HTR2C in people with severe obesity, reveals a role for serotonin 2C receptor in regulation of appetite, weight and behavior.

The authors show that stimulus strength-dependent effects of DA on 5-HT^DRN neurons bidirectionally regulate feeding in mice. DRD1-mediated activation of 5-HT^DRN neurons contributes to activity-based anorexia, and this can be prevented by blocking DRD1.

Layered Ni-rich oxide cathodes are susceptible to challenges with surface reconstruction and strain propagation, limiting their cyclability. The authors propose a solution involving oriented attachment-driven reactions, utilizing Wadsley–Roth nanocrystals and layered oxide to induce an epitaxial entropy-assisted coating, effectively addressing these issues.

The microscopic origin and valley physics of quantum emitters (QEs) in 2D semiconductors are still not fully understood. Here, the authors report an anomalous magneto-optical behaviour of QEs in WSe₂ monolayers coupled to chiral plasmonic nanocavities, suggesting the absence of intrinsic valley symmetry of the emitters.

Food production systems need to balance yield and sustainability. Here, the authors conduct 6 years long crop diversification field experiments in the North China Plain, showing that diversifying cereal monocultures with cash crops and legumes cand improve yield and reduce GHG emissions.

Nanosized ceria has conventionally been thought to have a cubic fluorite structure. Here, the authors use a combination of experiments and simulations to show that oxygen vacancies in ceria promote a charge-transfer induced phase transition from tetragonal to cubic.

Lipoic acid is a food supplement and approved neuropathy drug but lacks known molecular targets. Here, Lechner et al. employ chemoproteomic target deconvolution to demonstrate that (R)- but not (S)-lipoic acid stereoselectively inhibits histone deacetylases at physiologically achievable doses.

The transition from normal esophageal tissue to squamous carcinoma is characterized by an altered SOX2 cistrome. This transcriptional reprogramming activates endogenous retroviruses and double-stranded RNA expression, creating a dependency on the RNA editing enzyme ADAR1.

The combination of systemic immune checkpoint inhibition with local administration of a hydrogel containing the enzyme catalase, a radioisotope and an immunostimulatory agent promotes effective antitumour immune responses in mice models.

Almost half of globally leached nitrate from nitrogen-fertilized soil is released in China, India, and the United States, according to a meta-analysis covering 2500 field observations worldwide.

The Automatic Emesis Detection (AED) tool uses deep learning to quantify emesis in Suncus murinus with high accuracy, reducing human error and enhancing efficiency, offering potential for preclinical research and drug development.