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Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

OrganoidTracker 2.0 enables fast and accurate cell tracking in complex systems such as developing organoids. A key aspect of the work is determining cell tracks with error probabilities for any tracking feature, from cell cycles to lineage trees.

Perturbations to strongly lensed galaxy light in very long baseline interferometric imaging reveal a dark and unusually low-mass object at redshift z ≈ 0.9.

Animals are often thought to follow simple alignment rules, but this study explores how collective behavior could instead emerge from neural ring-attractor networks encoding allocentric and egocentric bearings. The results show that group motion arises spontaneously when allocentric bearings are used, with rapid switching between the two representations further boosting coordination.

Metadata annotation is crucial for data analysis, however it is often overlooked when depositing proteomics data. Here, the authors introduce Sample and Data Relationship Format (SDRF)-compliant metadata integration feature in MaxQuant, a widely used software for proteomics data analysis.

Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.

Membrane-free complex coacervate microdroplets are compelling models for primitive compartmentalization, but it is unclear how molecular co-operativity influences physicochemical properties and activity of membrane-free compartments. Here, the authors use RNA/peptide coacervates as a model to reveal the relationship between coacervate properties and ribozyme activity.

National parochialism is the tendency to cooperate more with people of the same nation. In a 42-nations study, the authors show that national parochialism is a pervasive phenomenon, present to a similar degree across all the studied nations, and occurs both when decisions are private or public.

Separating how sub- and surface species affect catalyst function is a challenge. Here, the authors follow sub- and surface carbon time-resolved in a Pd catalyst while oxidizing CH₄ and show that subsurface carbon traffic jam changes the catalyst function.

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

To what degree do the laws of thermodynamics constrain biological function? This work shows that the amount of free energy dissipated by microbes during growth imposes tight constraints on the versatility of their metabolism.

Previous work on periodically driven many-body systems has demonstrated the formation of time crystals that break time-translation symmetry. Now, more general phases with partial temporal ordering have been realized.

Arterial development is critical for proper blood flow, but the mechanisms mediating this process at the organ level remain unclear. Here, they show that a subpopulation of endothelial cells is important for formation of arterial endothelium in the intestine.

Children’s ability to generalize from episodic memories varies by both age and the level of abstraction. Here, the authors show that lower level generalization increasingly depends on episodic memory with age, whereas higher level generalization shows no such relationship.

Nuclear architecture depends on proper regulation of lamin A/C modifications. Here, the authors show that TAF4A and NF-Y control Kansl2 expression in muscle stem cells, preserving genome stability and supporting muscle regeneration.

Late Bronze Age and Early Iron Age dairy pastoralists in Mongolia are associated with diverse mortuary practices. Here, the authors analyze aDNA from 30 individuals and identify two genetic groups associated with distinct mortuary traditions that seem to have mixed rarely, pointing to complexities in these pastoralist societies.

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

Current photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofactor has now been developed as a biocompatible alternative for diazirine activation inside living cells, offering accurate mapping of protein interactors and dynamics with excellent spatio-temporal control.

NaHCO₃ production is energy- and cost-intensive. Here the authors report an operando electrosynthesis system by embedding nitrate reduction reaction into Solvay system, achieving high NaHCO₃ productivity even up to 4.58 times of benchmark industrial route.

By combining left- and right-handed DNA-PAINT probes, Unterauer et al. achieve simple, robust, and highly multiplexed super-resolution. They show 13-plex neuronal maps, revealing nanoscale organization of cytoskeleton, organelles, and synapses.

A general stereospecific glycosylation is developed that is applicable across a range of monosaccharides. A directing-group-on-leaving-group strategy allows mild donor activation and enables the complete inversion of anomeric configuration with excellent yields. This method can be applied in multistep oligosaccharide syntheses and automated glycan assembly.

Here, the authors present archaeological excavations from two sites paired with life-size rock engravings from 12,800 to 11,400 years ago in the Nefud desert of northern Arabia. These engravings, depicting camels, ibex and more, combined with stone tools from associated archaeological deposits and sediment analyses of playa deposits, provide evidence of human populations exploiting seasonal waterbodies.

Fu et al. uncover the features that allow the HIV capsid to cross the permeability barrier of nuclear pores in an importin-independent manner, explaining how the viral genome can reach the nuclear compartment when infecting nondividing cells.

Analyses of ancient human DNA show that cultural and political transformations in Central Europe during the second half of the first millennium ce were associated with movements of Slavic populations into Germany, Poland and Croatia.

This work introduces the kinetic selectivity achievable in nanoporous crystals into the field of chemical sensors, opening the door for selective VOC detection in health, safety, and environmental monitoring

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Multiple freezing–melting pathways of ice VI are found at room temperature, occurring via the ice XXI and ice VII phases. Supercompressed water structurally evolves from high-density water to very-high-density water.

How the brain combines sensory with non-sensory information is unknown. Here, the authors find that sensory input from the thalamus to the apical dendrites of the main cortical output neurons enables the first stage of this combination process.

Augmin is essential for microtubule nucleation during cell division. This study reveals how the conserved calponin homology domain of the augmin subunit HAUS6 binds to microtubules to orient augmin for microtubule branching.

This study of 89 multinational firms finds no significant link between voluntarily offsetting emissions and decarbonization speed. Firms spend little funds on carbon credits, and emission offsetting is not a central part of their climate strategies.

Systematic characterization of Arabidopsis aminotransferase family enzymes uncovered many previously unrecognized activities and revealed their multi-substrate specificity, aspects that probably contribute to the robustness of the nitrogen metabolic network.

Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.

This study introduces a deep active optimization pipeline that effectively tackles high-dimensional, complex problems with limited data. The approach minimizes sample size and surpasses existing methods, achieving optimal solutions in up to 2,000 dimensions.

Tau aggregation, a hallmark of Alzheimer’s disease, disrupts neuron structure. Aging weakens chaperone defenses like Hsp90. This study designs β-Hsp90, a small peptide mimicking Hsp90, to prevent Tau aggregation, offering promise for new amyloid disease drugs.

Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

Genomes of nine brown algal species with different sex determination systems show that U/V sex chromosomes evolved 450–224 Ma and show remarkable conservation of genes within the sex-determining region despite independent expansions of the sex locus in each lineage.

The authors combine tracking and body mass data from five migratory waterfowl species to understand their capacity to accelerate migration in response to earlier spring. They show considerable scope for faster migration by reducing the fuelling time before departure and subsequently on stopovers

Gallium is used as a sacrificial agent and mixing medium for the isothermal solidification synthesis of high-entropy alloy nanomaterials with diverse crystallinities and morphologies.

Microglia proliferate in response to ischemic stroke. Here, the authors show the clonal dynamics of this proliferation and how clonality contributes to microglial heterogeneity in a mouse stroke model, revealing distinct interclonal interactions.

Authors show that water trapped between 2D MXene sheets forms amorphous ice clusters at low temperatures, which cause a hysteresis of electrical conductivity. This structural rearrangement of water is affected by the presence of solvated cations, allowing reversible switching of the electronic properties of MXene films.

Mepolizumab (anti-IL-5 therapy) has been shown to reduce type 2 inflammation in asthma. Here the authors use bulk transcriptomics from nasal samples before and after mepolizumab treatment to assess the changes and associations with treatment outcomes.

New concepts for comparing the genomes of 27 naturally inbred Arabidopsis thaliana accessions provide essential insights into obtaining a less biased view of whole-genome polymorphism.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mechanism conserved in vertebrate aging and mammalian cancer.

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.