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Long-lived entanglement is a key resource for quantum metrology with optical clocks. Rydberg-based entangling gates within arrays of neutral atoms enable the generation of clock-transition Bell states with high fidelity and long coherence times.

Qubit-cavity entanglement can be used for quantum information processing and for investigating the quantum-to-classical transition with high control. Here, the authors characterize the entanglement between an artificial atom and a cat state and its susceptibility to decoherence through Bell test witnesses.

A study demonstrates a public generator of random numbers based on device-independent techniques, with the randomness being fully auditable and traceable.

Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experiments across multiple continents suggest that these learned calls provoke an innate response even among allopatric species.

Beck et al. develop a model where striosomes create a flexible “decision-space” that adapts to environmental context and internal state. It explains how we make choices and why decision-making varies between people, and in neuropsychiatric disorders.

Lange, Ratz, et al. investigate the number and distribution of human prohibitin complexes in the mitochondrial inner membrane, uncovering their bell-shaped structure and assembly of alternating PHB1 and PHB2 molecules.

Spontaneous parametric down-conversion, the standard technique for generating entangled photons, is limited by low pair extraction efficiencies at near-unity fidelity. The authors show quantum dots in nanowires efficiently emit an oscillating state with near-unity entanglement fidelity and propose a time-resolved quantum key distribution protocol.

The extracellular matrix provides a critical scaffold for the epidermal layers of the skin. Here, He and Boraas et al. discover that the foundation for resilient skin healing in embryos lies in the supportive matrix beneath stem cells.

Quantum steering is a form of quantum non-locality that can be verified for arbitrarily low detection efficiencies and high losses at the price of requiring complete trust in one of the parties. Here, Kocsis et al. present measurement-device-independent steering protocols that remove this need for trust.

A programmable quantum processor based on encoded logical qubits operating with up to 280 physical qubits is described, in which improvement of algorithmic performance using a variety of error-correction codes is enabled.

Sperm–egg adhesion is crucial for mammalian reproduction. Here, authors report the human Izumo1:Juno complex, a key regulator of sperm-egg adhesion, forms an unusually strong bond through a secondary binding site, which is impaired in an infertility-associated Juno mutant.

The diversity of ponerine ants varies widely across the globe. This study finds that the origin and early colonization in Gondwana’s tropical regions mainly shaped this distribution, while differences in diversification and dispersal have balanced regional diversity over time.

DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening avenues for the treatment of blood disorders.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

Here, the authors look at present day and medieval genome samples from Northern France to piece together demographic history and population structure across Brittany and the Loire basin.

An interconnect based on a low-loss detachable cable connection between two superconducting qubit devices can be used to create elementary quantum networks of interchangeable superconducting quantum devices.

Impressive progress has been achieved in isolating quantum systems from the environment and coherently controlling their dynamics. However, engineering the dynamics of many particles by a controlled coupling to an environment (in an 'open' quantum system) remains largely unexplored. Here, an approach is demonstrated based on ion-trap technology for simulating an open quantum system with up to five qubits. By adding controlled dissipation to coherent operations, the work offers novel prospects for open-system quantum simulation and computation.

An electrically driven on-chip light source of entangled photon pairs is developed by combining an InP gain section and Si₃N₄ microrings. A pair generation rate of 8,200 counts s⁻¹ and a coincidence-to-accidental ratio of more than 80 are achieved around the wavelength of 1,550 nm.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

The number of ligand binding sites in the dopamine transporter is enigmatic due to conflicting data from structures and molecular pharmacology. Here, force spectra reveal the position and dynamics of a previously invisible transient site.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

This study reports on excavations of hearths and stone artefacts from 20,000-year-old deposits at Dargan Shelter, which at an elevation of 1,073 m is believed to be the oldest occupied high-altitude site in Australia.

A manufacturable platform for quantum computing with photons is introduced and a set of monolithically integrated silicon-photonics-based modules is benchmarked, demonstrating dual-rail photonic qubits with performance close to thresholds required for operation.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Qudits can encode a richer class of topologically ordered states, which are promising for quantum information, but experimental realizations have been limited to qubits. Here, the authors report a study of a qutrit toric code on a trapped-ion quantum computer.

Automated pathotyping of synovial tissue in arthritis is a major unmet need. Here, the authors develop and demonstrate the efficacy of an automated tissue and cellular pathotyping tool for inflammatory arthritis.

DNA rotaxanes can be prepared using a simple interlocking approach in which a DNA rod is threaded through a DNA macrocycle by base pairing.

Deterministic sources of entangled photons are important for photonic quantum networks, but many applications are only possible when their wavelengths are tunable. Here, the authors use on-chip strain engineering to demonstrate such a source with silicon-integrated InAs/GaAs quantum dots.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

By coupling two quantum dots via a superconductor-semiconductor hybrid region in a 2D electron gas, the authors achieve efficient splitting of Cooper pairs. Further, by applying a magnetic field perpendicular to the spin-orbit field, they can induce and measure large triplet correlations in the Cooper pair splitting process.