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Showing 51–100 of 678 results
Advanced filters: Author: Nicholas Waters Clear advanced filters
  • Hydrographic properties of the North Atlantic Ocean have changed significantly over the past decades. A combination of changes in seawater density, calculated from observed properties of sea water and a numerical ocean model, reveals that the strength of the meridional overturning circulation has changed in different directions in the subpolar and subtropical basins, respectively.

    • M. Susan Lozier
    • Vassil Roussenov
    • Richard G. Williams
    Research
    Nature Geoscience
    Volume: 3, P: 728-734
  • Failing to account for emission differences between day and night will lead to an underestimate of global CO2 emissions from rivers by up to 0.55 PgC yr–1, according to analyses of high-frequency CO2 measurements.

    • Lluís Gómez-Gener
    • Gerard Rocher-Ros
    • Ryan A. Sponseller
    Research
    Nature Geoscience
    Volume: 14, P: 289-294
  • Experiments suggest that magnetite precipitation on early Mars was accompanied by the release of H2 that may have helped to warm the planet and stabilize liquid water at the Martian surface.

    • Nicholas J. Tosca
    • Imad A. M. Ahmed
    • Joel A. Hurowitz
    Research
    Nature Geoscience
    Volume: 11, P: 635-639
    • Alan F. Wright
    • Michel Goedert
    • Nicholas D. Hastie
    News & Views
    Nature
    Volume: 349, P: 653-654
  • The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

    • Benjamin S. Haslund-Gourley
    • Kyra Woloszczuk
    • Mary Ann Comunale
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19
  • Metabolism can influence gene expression through histone modifications. Using a mouse model of the inborn error of metabolism propionic acidaemia, Park et al. show how raised propionate levels produce epigenetic actions that impact cardiac function.

    • Kyung Chan Park
    • Nicholas T. Crump
    • Pawel Swietach
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 1221-1245
  • The analysis of biomolecular frustration yielded insights into several aspects of protein behavior. Here the authors describe a framework to efficiently quantify and localize biomolecular frustration within proteins at atomic resolution, and observe that drug specificity is correlated with a minimally frustrated binding pocket leading to a funneled binding landscape.

    • Mingchen Chen
    • Xun Chen
    • Peter G. Wolynes
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9
  • The rate of warming in many marine ecosystems is faster in winter than in summer. Winter warming will impact fish species’ associations in the Mediterranean more than summer warming, and this has implications for how communities form and for future biodiversity, particularly in heavily fished areas.

    • Nicholas J. Clark
    • James T. Kerry
    • Ceridwen I. Fraser
    Research
    Nature Climate Change
    Volume: 10, P: 862-867
  • Although ubiquitous throughout chemistry and biology, the structure and transport mechanism of the aqueous proton in solution remain elusive. Through advances in ultrafast broadband 2D IR spectroscopy, the structure of the aqueous proton is revealed to have a charge-delocalized H5O2+ Zundel-like core arrangement with surprisingly persistent structural heterogeneity.

    • Joseph A. Fournier
    • William B. Carpenter
    • Andrei Tokmakoff
    Research
    Nature Chemistry
    Volume: 10, P: 932-937
  • Using two different mass spectrometric platforms, authors demonstrate how metabolomic data fusion and multivariate analysis can be used to accurately identify the geographic origin and production method of salmon.

    • Yunhe Hong
    • Nicholas Birse
    • Christopher T. Elliott
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • This study examines the history of North Atlantic deep-water masses, as recorded in marine sediments. Major lithological changes and increased rate of deposition reveal that stronger deep-ocean circulation initiated 3.6 million years ago.

    • Matthias Sinnesael
    • Boris-Theofanis Karatsolis
    • Ross E. Parnell-Turner
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Generative AI has made it trivial to generate fake microscopy images that are indistinguishable from real images, even for experts. As researchers in nanoscience, it is time for us to face this reality and discuss strategies to conserve the integrity of our discipline.

    • Nadiia Davydiuk
    • Elisha Krieg
    • Quinn A. Besford
    Comments & Opinion
    Nature Nanotechnology
    Volume: 20, P: 1174-1177
  • Contributions of iron sources to Southern Ocean CO2sequestration during the last glacial period remain uncertain. Here, based on the biogeochemical analysis of subglacial calcites, the authors propose Antarctic volcanism, via subglacial drainage of Fe-rich waters, as a key contributor.

    • Silvia Frisia
    • Laura S. Weyrich
    • Alan Cooper
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9
  • The sustainability of the majority of multispecies reef fisheries around the globe remains unassessed. This study provides context-specific sustainable reference points for coral reef fish using environmental conditions. Using these reference points, they show that most reef fish stocks have failed at least one fisheries sustainability benchmark.

    • Jessica Zamborain-Mason
    • Joshua E. Cinner
    • Sean R. Connolly
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15
  • IL-33, released by epithelial cells in response to stress, is a potent activator of inflammation. Here Cohenet al. show that secreted IL-33 is rapidly inactivated by disulfide bond formation that prevents binding to its receptor, and that IL-33-related cytokines are susceptible to similar oxidation.

    • E. Suzanne Cohen
    • Ian C. Scott
    • Tomas Mustelin
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10
  • The geographical distribution and controlling factors of marine N2 fixation are understudied. Here the authors find increasing rates of N2 fixation from the Sargasso Sea to the coastal waters of North America, driven primarily by cyanobacterial diazotrophs and best correlated with phosphorus availability and chlorophyll-a concentrations.

    • Weiyi Tang
    • Seaver Wang
    • Nicolas Cassar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • Spectroscopic studies of allosteric activation of Aurora A kinase using a site-specific infrared probe combined with FRET analysis and molecular dynamics simulations reveals a water-mediated hydrogen bond network in the active site that regulates Aurora A activity.

    • Soreen Cyphers
    • Emily F Ruff
    • Nicholas M Levinson
    Research
    Nature Chemical Biology
    Volume: 13, P: 402-408
  • Exploitation of the high seas risks doing irreversible damage to biodiversity, climate stability and ocean equity. A consensus must be built now to save them.

    • Callum M. Roberts
    • Emilia Dyer
    • Mark Lynas
    Comments & Opinion
    Nature
    Volume: 642, P: 34-37
  • Low levels of nitrogen fixation may be occurring in the Southern Ocean, according to in-situ measurements of seawater from the western Antarctic Peninsula and Palmer Station

    • Shuai Gu
    • Hugo Berthelot
    • Nicolas Cassar
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 6, P: 1-9
  • GPCRs include inactive and active states. 19F-NMR and stopped-flow fluorescence kinetic assays reveal that neurotensin activates the prototypical peptide-binding GPCR, neurotensin receptor 1, through an induced-fit mechanism, where ligand binding precedes receptor conformational changes.

    • Kazem Asadollahi
    • Sunnia Rajput
    • Paul R. Gooley
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13
  • Structures of Cdc48 with heterodimeric cofactor Ufd1–Npl4 reveal the location of Npl4's MPN domain above Cdc48’s central pore, thus suggesting how Npl4 engages with polyubiquitinated substrates and promotes their translocation into the ATPase.

    • Nicholas O. Bodnar
    • Kelly H. Kim
    • Tom A. Rapoport
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 616-622
  • Satellite imagery, vessel GPS data and deep-learning models are used to map industrial fishing vessel activities missing from public tracking systems and changes in offshore energy infrastructure in the world’s coastal waters during 2017–2021.

    • Fernando S. Paolo
    • David Kroodsma
    • Patrick Halpin
    ResearchOpen Access
    Nature
    Volume: 625, P: 85-91
  • Oceanic deposition of wildfire aerosols can enhance marine productivity, as supported here by satellite and in situ profiling floats data showing that emissions from the 2019–2020 Australian wildfires fuelled phytoplankton blooms in the Southern Ocean.

    • Weiyi Tang
    • Joan Llort
    • Nicolas Cassar
    Research
    Nature
    Volume: 597, P: 370-375
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • Biocatalytic methods to access thioesters, such as acyl-coenzyme A, from carboxylic acids are underdeveloped. Now, it is shown that the adenylation domain of a carboxylic acid reductase enzyme can be exploited as a promiscuous thioester synthetase and combination with acyltransferases facilitates the synthesis of amides and peptide labelling.

    • Christian Schnepel
    • Laura Rodríguez Pérez
    • Sabine L. Flitsch
    Research
    Nature Catalysis
    Volume: 6, P: 89-99
  • DiNardo et al. perform a phase 1b/2 clinical trial of telaglenastat (CB-839) in combination with azacytidine in persons with advanced myelodysplastic syndromes and report on the treatment safety and efficacy, including a definition of clinical responders.

    • Courtney D. DiNardo
    • Divij Verma
    • Marina Konopleva
    Research
    Nature Cancer
    Volume: 5, P: 1515-1533
  • Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined and the pathophysiology unknown. Here, the authors conduct deep phenotyping of a cohort of PI-ME/CFS patients.

    • Brian Walitt
    • Komudi Singh
    • Avindra Nath
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-29
  • Here, the authors identify a small molecule degrader (XL44) for hRpn13 and solve the XL44-hRpn13 structure. XL44 induces apoptosis in myeloma cells with hRpn13 dependency and also targets KEN box proteins PCLAF and RRM2. Loss of hRpn13 and PCLAF abrogates XL44 restriction of cell viability.

    • Xiuxiu Lu
    • Monika Chandravanshi
    • Kylie J. Walters
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Engineering enzymes capable of performing chemical transformations requires high-throughput assays to screen activity. In this protocol, reactions in cell lysates are analyzed directly by desorption electrospray ionization (DESI) mass spectrometry.

    • Ruth Knox
    • Rachel Smith
    • Perdita E. Barran
    Protocols
    Nature Protocols
    P: 1-19
  • Structural and physiological studies show that the inner membrane protein PbgA is a crucial sensor of lipopolysaccharide (LPS) and regulates the activity of the LPS biosynthesis enzyme LpxC.

    • Thomas Clairfeuille
    • Kerry R. Buchholz
    • Steven T. Rutherford
    Research
    Nature
    Volume: 584, P: 479-483
  • Distributed multi-omic digitization of clinical specimen across multiple sites is a prerequisite for turning molecular precision medicine into reality. Here, the authors show that coordinated proteotype data acquisition is feasible using standardized MS data acquisition and analysis strategies.

    • Yue Xuan
    • Nicholas W. Bateman
    • Thomas P. Conrads
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Early drivers of T2D include ectopic fat accumulation that impairs insulin sensitivity. Here, the authors show that GLP1/GCGR dual agonism provides multimodal benefits in obese male mice by reducing liver fat and improving insulin sensitivity resulting in endogenous β-cell recovery.

    • Rhianna C. Laker
    • Shaun Egolf
    • Christopher J. Rhodes
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • Antarctic coastal polynyas have a critical role in the Earth system, influencing the atmosphere, hydrosphere, cryosphere and biosphere. This Review outlines the importance of Antarctic coastal polynyas and documents their changes over time.

    • Nicholas R. Golledge
    • Elizabeth D. Keller
    • Dirk Notz
    Reviews
    Nature Reviews Earth & Environment
    Volume: 6, P: 126-139
  • Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

    • Bethany L. Clark
    • Ana P. B. Carneiro
    • Maria P. Dias
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14
  • Marine fisheries and aquaculture support global food security. This Review considers how fishery and aquaculture activities influence marine nutrient dynamics and trophic structure, with implications for biogeochemical cycles from local to global scales.

    • Nicholas E. Ray
    • Stefano Bonaglia
    • Junji Yuan
    Reviews
    Nature Reviews Earth & Environment
    Volume: 6, P: 163-177
  • Familial dysautonomia is a rare genetic disease caused in part by neurodegeneration. Here, the authors show that the gut-metabolism axis is altered in both patients and transgenic mice and that disease pathology is ameliorated by controlling microbiome divergence.

    • Alexandra M. Cheney
    • Stephanann M. Costello
    • Seth T. Walk
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12
  • Producing individual cannabinoids by metabolically engineered microbes has proven challenging. Here, the authors develop a cell-free enzymatic prenylating system to generate isoprenyl pyrophosphate substrates directly from glucose and produce both common and rare cannabinoids at >1 g/L.

    • Meaghan A. Valliere
    • Tyler P. Korman
    • James U. Bowie
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9