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Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

Superconductivity was recently reported experimentally in nitrogen-doped lutetium hydride with T_c = 294 K at a pressure of 1 GPa. Here, via theoretical calculations, the authors find no structures capable of supporting conventional superconductivity in the Lu-N-H system at ambient pressure.

Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.

Fungal diseases threaten crops worldwide. By resolving the cryo-EM structure of fungal succinate dehydrogenase, researchers designed an inhibitor with broad antifungal activity, strong field performance, and reduced environmental toxicity.

Metamorphic soles beneath ophiolites record rapid subduction initiation, with high-temperature metamorphism that may be driven by relative motion across the plate interface, according to diffusion speedometry of garnets combined with isotopic data.

Screening of DNA-encoded chemical libraries against prostatic acid phosphatase yielded OncoACP3, a modular small organic ligand with picomolar binding affinity that enabled targeted payload delivery to prostate cancer.

N-acetyltransferase 10 (NAT10) is an N⁴‐acetylcytidine (ac⁴C) writer, which catalyzes RNA acetylation at cytidine N⁴ position on RNAs. Here, the authors show that NAT10 catalyzes ac⁴C addition to a long non-coding RNA encoded by the oncogenic DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV), triggering viral lytic reactivation from latency, which promotes NAT10 recruitment of IFI16 mRNA, resulting in inflammasome activation.

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

In an integrated analysis of transcriptomic data from the SUBSPACE consortium and public datasets of patients with sepsis, acute respiratory distress syndrome, trauma and burns, dysregulation within four consensus molecular clusters related to myeloid and lymphoid cells is associated with mortality and illness severity.

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

High-resolution X-ray imaging requires a high radiation dose. Here, the authors achieve low-dose 3D imaging by increasing the XEPL intensity using a double-shell nanostructure with two heterogeneous interfaces.

A molecular strand can be knotted and unknotted into three different topologies, depending on the complexing metal ion used (copper or lanthanide or none).

Infant KMT2A-rearranged acute lymphoblastic leukemia is associated with poor overall survival rates. Here, the authors use WGS and WES of 36 relapsed KMT2A-rearranged ALL and AML patients and find alterations in drug response genes in ALL, which may correspond with relapse time. Longitudinal analyses of >250 samples could track residual leukemia cells, clonal drug responses, and the upcoming relapse.

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

The triple synergy of oxygen, proton, and electron supply is crucial for hydrogen peroxide photosynthesis. Here, the authors report a squaric-acid zwitterionic covalent organic framework that achieves this synergy, boosting hydrogen peroxide yield and enabling solar-driven continuous-flow production.

Anthropogenic habitat modification is considered a driver of non-native species establishment. Here, the authors quantify the occurrence of non-native species in local assemblages of vascular plants, ants, spiders, birds and mammals, finding generally greater presence and frequency under disturbed land-use types.

In a prospective study enrolling 1,222 patients from 22 emergency departments, a device using a machine-learning-based signature of blood mRNAs demonstrated clinically acceptable performance to diagnose bacterial and viral infections and to predict the all-cause need for critical care interventions within 7 days, with benchmark to established biomarkers and risk scores.

For fertilization, sperm migrate through the utero-tubal junction (UTJ) and bind to the zona pellucida (ZP). Here the authors identify sperm expressed GALNTL5 as a GalNAc binding factor required for migration though the UTJ and attachment to the ZP.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Inspired by class II aldolases found in nature, the authors report a biomimetic copper/squaramide cooperative catalysis strategy for asymmetric Mannich reactions between challenging acyclic ketimines and α-substituted β-keto esters.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Nematicity, the spontaneous breaking of lattice rotational symmetry, plays an important role in kagome metals. Here, the authors report on a nematic phase within seven Kelvin below the charge density wave transition in the bilayer kagome metal ScV₆Sn₆.

The wave equation was first discovered by the French scientist d’Alembert. It has since been intriguing, but so far unsuccessful to answer if ‘one-way’ versions of it might exist. Here, the authors report the discovery of such an equation in three dimensions, showing that it has a topological character.

Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ₁ modify the same host tRNA. PreQ₁-tRNA reduces cell proliferation, slows tumour growth, decreases the translation of ribosomal proteins and is cleaved by IRE1 on the ER ribosome.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Missense mutations in the twelfth codon of KRAS are key drivers of lung cancer. Here, the authors develop a CRISPR-High Fidelity-Cas9-based strategy to target KRAS-G12C and KRAS-G12D mutants, reducing tumourigenicity without wild type KRAS off-targeting and circumventing certain therapy resistance mechanisms in preclinical models.

Short-lived halogens have a substantial indirect cooling effect on climate and this cooling effect has increased since pre-industrial times owing to anthropogenic amplification of natural halogen emissions.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Aqueous zinc batteries possess advantages in safety, cost and environmental friendliness. To address side reaction, limited cycle life and other challenges, the authors formulate a dual-salt electrolyte that decouples the interfacial electrolyte from the bulk, enabling suppressed hydrogen evolution, fast zinc transport and resilience against low temperature.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Coastal risk assessment under future climate change is important for effective adaptation, but multidimensional analyses are still rare. Here the researchers find that inappropriate development policies could have a greater effect on exposure to flooding than sea-level rise up to 2100 in China.

Using polarimetric satellite data, the authors quantify the global impact of cloud droplet distribution changes on aerosol–cloud interactions and introduce a parameterization to enhance climate model performance.

Lowering the levels of coagulation factor XII may prevent thrombosis without increasing the risk of bleeding. Here, Haj et al. use a large human dataset to show that this is the case for people carrying mutations that lower the levels of factor XII.

Zhe Lu et al. reveal that phytoplankton taxa and seasonal changes shape ocean surficial carbon. Machine learning and satellite data show that diatoms dominate surface DOC, with more recalcitrant DOC produced during growth than decline seasons.

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue thermogenesis is identified.

Electrification is a promising way to decarbonize the chemical industry but could also have important effects on power systems. Here the authors assess the impact of electrifying the production of methanol and ammonia on the Chinese power system in terms of emissions and potential security risks.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

WNT–β-catenin activation is common in hepatocellular carcinoma (HCC). In this Review, the authors summarize our understanding of the role of WNT–β-catenin activation in HCC — based on results from in vitro and in vivo models — and implications for precision treatment of HCC via targeting β-catenin.

It is crucial, yet challenging, to develop effective polymeric membranes for removing organic micropollutants from water. Here the authors present a data-mechanism-fused machine learning approach to assist the development of such membranes.

A comprehensive understanding of how urban nature affects mental health at a global scale remains essential. This study addresses that need through a systematic review and meta-analysis, revealing the effects of exposure to various urban nature types on 12 distinct mental health outcomes.

Researchers have been working on radiosensitizers to improve radiotherapy efficacy. Here the authors generate gadolinium nanotexaphyrins (Gd-NTs) that self-assemble and further load it with myoglobulin to relieve hypoxia, improve radiosensitization effects of Gd-coordinated Texaphyrin, and suppress tumor recurrence.

An E. coli–thylakoid hybrid is produced in which the thylakoid can convert solar energy into energy molecules, such as ATP and NADPH. A dual-channel energy pathway, combining energy molecule supply and electron transfer, enables the E. coli–thylakoid hybrid to produce H₂ at a rate of \(15.1\,{\mathrm{mmol}}\,{\mathrm{h}}^{-1}\,{\mathrm{g}}_{\mathrm{dcw}}^{-1}\).

Crystal structures of human CB₁ bound to two cannabinoid agonists reveal key features, including a twin toggle switch and binding pocket reduction, advancing understanding of receptor dynamics and guiding cannabinoid drug design.

In this study, Yang et al. compile a global dataset to uncover the degree to which plants coordinate root and seed traits. They report a global positive correlation between root diameter and seed size, driven by dual roles of arbuscular mycorrhiza in phosphorus uptake and pathogen defence.