Nature Search

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh
Igor Klyubin
Dennis J. Selkoe

Research04 Apr 2002

Nature

Volume: 416, P: 535-539

Association of nucleos(t)ide analogue therapy with Parkinson disease in chronic hepatitis B patients

Jihye Lim
Hyo Young Lee
Ha Il Kim

ResearchOpen Access30 Apr 2025

Scientific Reports

Volume: 15, P: 1-8

Portable 3D-printed electrochemiluminescence sensor for simultaneous glucose and lactate monitoring

Amol S. Kulkarni
Sarika Khandelwal
Manish Bhaiyya

ResearchOpen Access03 Oct 2025

Scientific Reports

Volume: 15, P: 1-14

Production of an antigenic peptide by insulin-degrading enzyme

Most antigenic peptides presented by MHC class I are produced by the proteasome. Van den Eynde and co-workers show that a MAGE-A3–derived peptide is produced directly by the cytosolic metallopeptidase IDE.

Nicolas Parmentier
Vincent Stroobant
Benoît J Van den Eynde

Research04 Apr 2010

Nature Immunology

Volume: 11, P: 449-454

Real-world experience of patients with multiple myeloma receiving ide-cel after a prior BCMA-targeted therapy

Christopher J. Ferreri
Michelle A. T. Hildebrandt
Omar Alexis Castaneda Puglianini

ResearchOpen Access09 Aug 2023

Blood Cancer Journal

Volume: 13, P: 1-9

NOVAsort for error-free droplet microfluidics

Droplet microfluidic tools with single-cell resolution and high-throughput screening capacities remain scarce. Here, the authors propose NOVAsort, a next-generation droplet sorter that can discern droplets based on both size and fluorescence, which can overcome common problems with conventional sorters.

Han Zhang
Rohit Gupte
Arum Han

ResearchOpen Access01 Nov 2024

Nature Communications

Volume: 15, P: 1-13

Idecabtagene vicleucel for relapsed and refractory multiple myeloma: post hoc 18-month follow-up of a phase 1 trial

This is a post hoc 18-month follow-up analysis of the CRB-401 trial, testing idecabtagene vicleucel (ide-cel, bb2121) in relapsed and refractory multiple myeloma, and reports sustained safety and clinical efficacy, which correlates with T cell phenotypes.

Yi Lin
Noopur S. Raje
James N. Kochenderfer

ResearchOpen Access17 Aug 2023

Nature Medicine

Volume: 29, P: 2286-2294

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Nelson H. Knudsen
Giulia Escobar
Marcela V. Maus

Research24 Sept 2025

Nature

P: 1-10

Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection

Xiaoman Zhang
Xianli Chen
Zhengju Xu

ResearchOpen Access30 May 2019

Scientific Reports

Volume: 9, P: 1-9

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Alzheimer's disease is linked to metabolic syndrome and Type-2 diabetes, but the mechanism behind this association is unclear. Here, the authors show that elevated glucose and amyloid ß work together to increase nitrosative stress, leading to aberrant mitochondrial activity and synaptic dysfunction.

Mohd Waseem Akhtar
Sara Sanz-Blasco
Stuart A. Lipton

ResearchOpen Access08 Jan 2016

Nature Communications

Volume: 7, P: 1-11

Nature of the Causative Agent of the Rous Fowl Sarcoma

E. M. FRAENKEL
C. A. MAWSON

Research13 Feb 1937

Nature

Volume: 139, P: 282-283

Model-based rational design of an oncolytic virus with improved therapeutic potential

Oncolytic viruses can serve as self-replicating anticancer agents. Le Bœuf et al. combine synthetic modelling and molecular biology approaches to create a virus with enhanced oncolytic activity in vitro and in vivodue to its expression of an interferon antagonist.

Fabrice Le Bœuf
Cory Batenchuk
John C. Bell

Research14 Jun 2013

Nature Communications

Volume: 4, P: 1-8

Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics

Light can control neural activity but often requires genetic modification. Here, the authors present a graphene-based platform for non-genetic light controlled neuronal stimulation, enabling all-optical network analysis, stem cell derived neuron maturation, and closed-loop robotics.

Elena Molokanova
Teng Zhou
Alex Savchenko

ResearchOpen Access20 Aug 2025

Nature Communications

Volume: 16, P: 1-20

Clinical vs. chronological skin age: exploring determinants and stratum corneum protein markers of differential skin ageing in 351 healthy women

A. Foucher
S. Nouveau
N. Cavusoglu

ResearchOpen Access09 Oct 2024

Scientific Reports

Volume: 14, P: 1-9

Deciphering response dynamics and treatment resistance from circulating tumor DNA after CAR T-cells in multiple myeloma

Circulating tumor DNA (ctDNA) allows genotyping of the tumor in multiple myeloma. Here, the authors show that minimal residual disease (MRD) by ctDNA can be detected after CAR-T therapy correlates with bone marrow-based MRD to track clonal evolution and inform treatment resistance mechanisms.

Hitomi Hosoya
Mia Carleton
David M. Kurtz

ResearchOpen Access20 Feb 2025

Nature Communications

Volume: 16, P: 1-13

Real-world impact of bridging therapy on outcomes of ide-cel for myeloma in the U.S. Myeloma Immunotherapy Consortium

Aimaz Afrough
Hamza Hashmi
Yi Lin

CorrespondenceOpen Access12 Apr 2024

Blood Cancer Journal

Volume: 14, P: 1-5

Aspiration-assisted bioprinting of spheroids

Aspiration-assisted bioprinting is a versatile biofabrication technique that enables the precise and selective patterning of biologics, such as tissue spheroids and organoids, addressing the limitations of conventional bioprinting techniques.

Myoung Hwan Kim
Ibrahim T. Ozbolat

Protocols19 Sept 2025

Nature Protocols

P: 1-49

Activity of CAR-T cells and bispecific antibodies in multiple myeloma with extramedullary involvement

Maximilian J. Steinhardt
Christoph Schaefers
Leo Rasche

ResearchOpen Access30 Jul 2025

Blood Cancer Journal

Volume: 15, P: 1-7

Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition

Presequence protease (PreP) is essential to mitochondrial proteostasis. This study leverages advanced vitrification techniques to solve cryoEM structures of apo- and substrate-bound PreP and integrates these data with other analysis to reveal key stages and mechanistic insights of the PreP catalytic cycle.

Wenguang G. Liang
Juwina Wijaya
Wei-Jen Tang

ResearchOpen Access05 Apr 2022

Nature Communications

Volume: 13, P: 1-14

LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer’s disease model by reprogramming microglia

Qiuyang Zhang
Hsuan Lo
Xiaodong Pan

ResearchOpen Access06 Oct 2025

Translational Psychiatry

Volume: 15, P: 1-14

Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry

Liwen Li
Qinghuang Tang
Han-Sung Jung

ResearchOpen Access28 Nov 2016

Scientific Reports

Volume: 6, P: 1-12

Investigating the potential of 6-substituted 3-formyl chromone derivatives as anti-diabetic agents using in silico methods

Minhaz Zabin Saif
Nusrat Jahan Ikbal Esha
Kabir M. Uddin

ResearchOpen Access08 Jun 2024

Scientific Reports

Volume: 14, P: 1-20

A genome-wide association study identifies novel risk loci for type 2 diabetes

A survey of the entire human genome has found that five genetic loci contribute a large fraction of disease risk in type 2 diabetes.

Robert Sladek
Ghislain Rocheleau
Philippe Froguel

Research11 Feb 2007

Nature

Volume: 445, P: 881-885

Amygdala–liver signalling orchestrates glycaemic responses to stress

Studies in mice show that acute stress activates hyperglycaemia via activation of a medial amygdala–ventral hypothalamic circuit that controls glucose metabolic responses in the liver, independently of adrenal and pancreatic hormones.

J. R. E. Carty
K. Devarakonda
S. A. Stanley

ResearchOpen Access03 Sept 2025

Nature

Volume: 646, P: 697-706

A reconfigurable piezo-ionotropic polymer membrane for sustainable multi-resonance acoustic sensing

Sensorineureal hearing loss is a form of deafness when sensory cells cannot sense vibrations. Here the authors design a piezo-ionotropic polymer for multi-resonance acoustic sensing, driven by ion hitching-in cage effect.

Wu Bin Ying
Joo Sung Kim
Do Hwan Kim

ResearchOpen Access02 Sept 2025

Nature Communications

Volume: 16, P: 1-13

Hepatitis B therapy

Substantial progress had been made in the treatment of hepatitis B in the past decade; many safe and effective drugs are now available. However, these drugs suppress but do not eradicate HBV. In addition, these agents may be associated with drug resistance and adverse effects. Hellan Kwon and Anna Lok address important questions regarding the optimization of treatment in patients with hepatitis B.

Hellan Kwon
Anna S. Lok

Reviews22 Mar 2011

Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 275-284

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Deposition and spreading of amyloid-β pathology in mice requires binding to microglia-released ASC specks.

Carmen Venegas
Sathish Kumar
Michael T. Heneka

Research21 Dec 2017

Nature

Volume: 552, P: 355-361

Real-world analysis of teclistamab in 123 RRMM patients from Germany

C. Riedhammer
F. Bassermann
L. Rasche

ResearchOpen Access20 Jan 2024

Leukemia

Volume: 38, P: 365-371

EHA–EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myeloma

In these Evidence-Based Guidelines, a multidisciplinary panel of experts from the European Hematology Association and the European Myeloma Network provide key treatment recommendations for patients with smouldering multiple myeloma, and newly diagnosed or relapsed and/or refractory multiple myeloma, addressing the use of established drugs and novel immunotherapies as well as the management of disease-specific and treatment-related complications and adverse events.

Meletios A. Dimopoulos
Evangelos Terpos
Pieter Sonneveld

Reviews07 Jul 2025

Nature Reviews Clinical Oncology

Volume: 22, P: 680-700

Enzyme target to latch on to

Insulin-degrading enzyme is implicated in diabetes and Alzheimer's disease, but few molecular tools exist that can probe its function. A study now reveals its unusual structure and may lead to an expanded toolbox.

Malcolm A. Leissring
Dennis J. Selkoe

News & Views11 Oct 2006

Nature

Volume: 443, P: 761-762

Capturing nematic order on tissue surfaces of arbitrary geometry

Multicellular tissues behave akin to nematic liquid crystals, which are fluid as well as ordered. Here, the authors develop an image analysis method to capture the nematic ordering of tissues with the complex geometries typical of morphogenesis.

Julia Eckert
Toby G. R. Andrews
Richard G. Morris

ResearchOpen Access15 Aug 2025

Nature Communications

Volume: 16, P: 1-13

Elranatamab in relapsed or refractory multiple myeloma: the MagnetisMM-1 phase 1 trial

In the first-in-human trial of elranatamab, patients with refractory or relapsed multiple myeloma who received the bispecific antibody against BCMA and CD3 experienced no dose-limiting toxicities during dose escalation, and the agent showed promising clinical efficacy.

Nizar J. Bahlis
Caitlin L. Costello
Alexander M. Lesokhin

ResearchOpen Access02 Oct 2023

Nature Medicine

Volume: 29, P: 2570-2576

Modelling sex differences of neurological disorders in vitro

This Review discusses sex-related differences in brain disorders and surveys in vitro models, including 2D and 3D organ-on-a-chip technologies. It emphasizes the need to address sex-related differences in brain research, which remain under researched in 2025.

Laura Castro-Aldrete
Melanie Einsiedler
Antonella Santuccione Chadha

Reviews13 Oct 2025

Nature Reviews Bioengineering

P: 1-22

Microfabricated polymer-metal biosensors for multifarious data collection from electrogenic cellular models

Charles M. Didier
Julia F. Orrico
Swaminathan Rajaraman

ResearchOpen Access01 Mar 2023

Microsystems & Nanoengineering

Volume: 9, P: 1-14

A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy

In a systematic review and meta-analysis of nonrelapse mortality (NRM) following CAR T cell treatment in 7,604 patients with lymphoma and myeloma, almost half of cases were atrributable to infections and NRM estimates varied across both tumor types and CAR T cell products

David M. Cordas dos Santos
Tobias Tix
Kai Rejeski

Research08 Jul 2024

Nature Medicine

Volume: 30, P: 2667-2678

Allogeneic BCMA-targeting CAR T cells in relapsed/refractory multiple myeloma: phase 1 UNIVERSAL trial interim results

In an interim phase 1 trial analysis, escalating doses of off-the-shelf allogeneic anti-BCMA CAR T cells, in combination with an anti-CD52 antibody-containing lymphodepletion regimen, were feasible to administer and exhibited an encouraging safety profile in patients with relapsed or refractory multiple myeloma

Sham Mailankody
Jeffrey V. Matous
Shaji K. Kumar

Research23 Jan 2023

Nature Medicine

Volume: 29, P: 422-429

3-year follow-up of a prospective, multicenter study of the Amplatzer Piccolo™ Occluder for transcatheter patent ductus arteriosus closure in children ≥ 700 grams

Brian H. Morray
Shyam K. Sathanandam
Evan M. Zahn

ResearchOpen Access16 Aug 2023

Journal of Perinatology

Volume: 43, P: 1238-1244

An instantaneous voice-synthesis neuroprosthesis

A brain-to-voice neuroprosthesis enables a man with amyotrophic lateral sclerosis to synthesize his voice in real time by decoding neural activity, demonstrating the potential of brain–computer interfaces to enable people with paralysis to speak intelligibly and expressively.

Maitreyee Wairagkar
Nicholas S. Card
Sergey D. Stavisky

Research12 Jun 2025

Nature

Volume: 644, P: 145-152

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Late-life cognitive dysfunction is common, but the biological substrates are largely unknown. Here, the authors examined a panel of 90 neurology-related protein biomarkers and show that plasma levels of 22 of these proteins are associated with general fluid cognitive ability in later life.

Sarah E. Harris
Simon R. Cox
Ian J. Deary

ResearchOpen Access10 Feb 2020

Nature Communications

Volume: 11, P: 1-12

Highly reversible extrinsic electrocaloric effects over a wide temperature range in epitaxially strained SrTiO₃ films

Electrocaloric effects are large in a limited set of materials that display hysteretic first-order phase transitions. Here epitaxial SrTiO₃ thin films are strain engineered to achieve anhysteretic second-order phase transitions, with electrocaloric effects enhanced by one order of magnitude over bulk.

S. Zhang
J. Deliyore-Ramírez
N. D. Mathur

ResearchOpen Access21 Mar 2024

Nature Materials

Volume: 23, P: 639-647

Grid-like entorhinal representation of an abstract value space during prospective decision making

Values of choice options often change over time. Here, the authors show that during prospective decision making the entorhinal cortex encodes changing values using a grid-like representation, suggesting the formation of a cognitive value map.

Alexander Nitsch
Mona M. Garvert
Christian F. Doeller

ResearchOpen Access09 Feb 2024

Nature Communications

Volume: 15, P: 1-20

Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease

Paul Armstrong
Hüseyin Güngör
Steven J. Clapcote

ResearchOpen Access23 Mar 2024

Neuropsychopharmacology

Volume: 49, P: 1559-1568

The endogenous T cell landscape is reshaped by CAR-T cell therapy and predicts treatment response in multiple myeloma

Julia Frede
Julia C. Poller
Jens G. Lohr

ResearchOpen Access19 Sept 2025

Leukemia

P: 1-11

Impact of vitamin A on aged people’s cognition and Alzheimer’s disease progression in an animal model

Pengfei Li
Jingjing Xu
Linhong Yuan

ResearchOpen Access08 May 2025

npj Science of Food

Volume: 9, P: 1-15

A mathematical model of H5N1 influenza transmission in US dairy cattle

Influenza A H5N1 is an increasing concern in cattle herds in the United States. Here, the authors use mathematical modelling to estimate the size of the current epidemic, predict states at risk in the future, and highlight gaps in data collection.

Thomas Rawson
Christian Morgenstern
Neil Ferguson

ResearchOpen Access08 May 2025

Nature Communications

Volume: 16, P: 1-12

Diabetes in China: epidemiology, pathophysiology and multi-omics

In this Review, the authors summarize epidemiological trends of type 2 diabetes in China, discuss unique risk factors contributing to diabetes risk in the Chinese population and highlight how recent advances from multi-omics studies can affect treatment of diabetes in China.