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An online tailored coaching intervention, delivered over 3 years, improved global cognition, dementia risk, physical activity, nutrition and depression in older dementia-free community-dwelling individuals.

Cooperative institutional networks are essential to achieve SDG targets. Combining SDG interaction analysis with a transition management framework, this study finds that in Aruba prioritizing benefits from sustainable marine development leads to the greatest amount of direct co-benefits to other SDGs.

Protein/protein interaction (PPI) interfaces have emerged as drug targets to develop medications with less side effects. Here, Dvorak et al. show that small molecule targeting of PPIs in the brain is an approach for psychiatric drug discovery.

This Resource presents the genetic subset of the 136,000 chemical and genetic perturbations tested by the Joint Undertaking for Morphological Profiling (JUMP) Cell Painting Consortium and associated analysis of phenotypic profiles.

Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

The mechanical properties of structural ceramics are characterized by a high degree of fragility and brittleness. This study demonstrates that, contrary to expectation, their brittleness can be reduced substantially by introducing nanopores together with weak grain boundary phases.

Rettkowski, Romero-Mulero et al. show that myocardial infarction impacts bone marrow haematopoietic stem cells and leads to inflammatory myelopoiesis, which can be dampened by treatment with 4-oxo-retinoic acid, promoting cardiac recovery.

The triple-alpha process plays a role in nucleosynthesis, in the formation of ¹²C. Here, the authors discuss the rate and role of the neutron upscattering phenomenon on the triple-alpha process in a multi-step process.

The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice.

Singh and colleagues present an integrative genotypic approach using large-scale GWAS data for depression and coronary artery disease to identify genes associated with both conditions.

The magnetoresistance suggests an exotic topological phase in LaBi, but the evidence is still missing. Here, Nayaket al. report the existence of surface states of LaBi through the observation of three Dirac cones, confirming it a topological semimetal.

Shocked compression experiments support the melt line of nickel above that of iron, as recently theorised, which helps to constrain the behavior of nickel at conditions relevant to Earth’s core where it makes up 5-20 wt %

Chiral metamaterials present interesting ways to manipulate and distinguish between different circular polarizations of light. Zhanget al. realize chiral metamaterials that exhibit photoinduced switching between left- and right-handed circular polarization interactions at terahertz frequencies.

Understanding oscillation phenomena in catalysis is a long-standing challenge. Here the authors report a temporally and spatially resolved operando analysis of CO oxidation over Rh/Al₂O₃, revealing the interplay of Boudouard reaction and carbon combustion in generating the oscillations.

The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (dys)function and create a pathogenicity-severity variant classifier.

The Mass Spectrometry Query Language (MassQL) is an open-source language that enables instrument-independent searching across mass spectrometry data for complex patterns of interest via concise and expressive queries without the need for programming skills.

Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in preserving vesicle integrity, K+ homeostasis, and physiological function.

Nonlinear chiral optical activity is difficult to measure because of weak signal amidst strong achiral background. Here, the authors perform a nonlinear chiral two-dimensional spectroscopic mapping of light-harvesting complex 2 during photoexcitation and observe exciton delocalization.

Cotton plants are protected from the sap-sucking whitefly and a viral disease it transmits by transgenic expression of an insecticidal fern protein.

The mechanisms underlying the interplay between tumour cells and the microenvironment remain to be explored. Here, the authors report that the transcription factor FOXM1 epigenetically silences the DNA sensing pathway suppressing anti-tumour immunity and immune memory.

As presented at the 2025 ASCO Annual Meeting, intracerebroventricular infusion of bivalent CAR T cells targeting EGFR and IL-13Rα2 in patients with multifocal, recurrent glioblastoma was feasible and well tolerated, with the maximum tolerated dose identified, one patient with a partial response and one patient with durable stable disease.

An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of inflammatory bowel disease, and models stage 4 progression.

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Luo et al. identify schizophrenia risk loci in East Asians and uncover potential causal genes and therapeutic targets through cross-ancestry GWAS, fine mapping and functional genomics, offering insights into the genetic basis of schizophrenia.

Designing energy-efficient and scalable hardware capable of accelerating Monte Carlo algorithms is highly desirable for probabilistic computing. Here, Singh et al. combine stochastic magnetic tunnel junction-based probabilistic bits with versatile field programmable gate arrays to achieve this goa

In this work, the authors report Cryo-EM imaging revealing diversity in amyloid fibril structures among ATTR patients with the same genetic mutation I84S. Further study is warranted to grasp the implications in ATTR amyloidosis pathology.

The connection between plasma proteomic and brain structure remains unclear. Here, the authors establish a comprehensive atlas of the patterns of associations between microscale proteome and brain structure, and demonstrate their potential value for studying brain disorders.

Isolation of antigen-reactive T cell receptors (TCRs) to cancer epitopes is important for engineered T cell immunotherapies. Here the authors show an aptamer-based microfluidic single-cell method to isolate antigen-reactive TCRs and show proof of principle isolations for cytomegalovirus and prostate specific antigen.

Systemic barriers to sustained academic participation in the activities of international science–policy organizations undermine equitable knowledge co-production — a collaborative multi-actor creation of knowledge. We outline institutional reforms to tackle such barriers to the benefit of researchers, organizations and society at large.

Changes in terrestrial runoff into the Bay of Bengal during both extremely weak and strong Indian summer monsoon phases since the Last Glacial Maximum caused a collapse in marine primary production linked to increased stratification, according to proxy records from a marine sediment core.

Implant-associated infections with Staphylococcus aureus pose serious clinical challenges. Here, the authors develop a biosensor based on toxin-responsive liposomes encapsulating gold nanoclusters, providing a non-invasive, colourimetric diagnostic tool for bacterial infection detection with urinary readout.