Follicular and marginal zone B cells differ in their development and in their role in subverting pathogens with marginal zone B cells bearing more innate-like properties, such as production of proinflammatory cytokines. Here authors show via B-cell specific genomic deletion mouse models that the transcriptional repressor capicua (CIC) and its binding partner, ataxin-1-like (ATXN1L), differentially regulate the development and function of these two main mature B cell populations, while playing a shared role in sepsis mediated by marginal zone B cells.
- Jong Seok Park
- Minjung Kang
- Yoontae Lee
