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The fair-sampling loophole is closed in a Bell inequality violation experiment with entangled photons, making the photon the first physical system for which all the main loopholes have been closed.

The authors in this work present a study with multiplexed gene editing that is used to assess all possible mutations at a native drug binding site. The approach yields data that predicts spontaneous resistance, that aligns with in silico predictions, and that promises to facilitate drug discovery.

The treatment of Bell palsy remains a matter of debate. A recent update of the American Academy of Neurology practice parameter concluded that corticosteroids should be offered to increase the probability of facial nerve recovery. The benefits of antiviral treatment, however, have not been established.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

A T colour centre in silicon, hyperfine-coupled to two nuclear spins, enables entanglement between the two nuclear spins with a fidelity of 0.77.

A nondestructive and complete Bell-state measurement is demonstrated between two 60-m-distant atomic qubits in different optical cavities. The main building block is a photon-atom gate, which is executed upon reflection of the photon from the cavity.

Untrustworthy sources or detectors mean that quantum entanglement cannot always be ensured, but quantum steering inequalities can verify its presence. Using a highly efficient system, Smithet al. are able to close the detection loophole and clearly demonstrate steering between two parties.

Spontaneous parametric down-conversion, the standard technique for generating entangled photons, is limited by low pair extraction efficiencies at near-unity fidelity. The authors show quantum dots in nanowires efficiently emit an oscillating state with near-unity entanglement fidelity and propose a time-resolved quantum key distribution protocol.

Quantum key distribution (QKD) for information-theoretic secure distribution of cryptographic keys is one of the best known applications that will be enabled by the Quantum Internet. Here, the authors deploy the protocol of measurement-device-independent quantum key distribution into a realistic network environment, testing its field performances and showing the co-existing of this QKD protocol and the classical network infrastructure.

Stable and robust topological edge modes are observed at finite temperatures in an array of 100 programmable superconducting qubits because of emergent symmetries present in the prethermal regime of this system.

A juvenile iguanodontian from the Lower Cretaceous of China preserves both spikes and scales in its skin that are different from integumentary structures in either non-avian dinosaurs or extant squamates and may have had a defensive function.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

A programmable quantum processor based on encoded logical qubits operating with up to 280 physical qubits is described, in which improvement of algorithmic performance using a variety of error-correction codes is enabled.

Wastewater-based surveillance tends to focus on specific pathogens. Here, the authors mapped the wastewater virome from 62 cities worldwide to identify over 2,500 viruses, revealing city-specific virome fingerprints and showing that wastewater metagenomics enables early detection of emerging viruses.

Here, the authors look at present day and medieval genome samples from Northern France to piece together demographic history and population structure across Brittany and the Loire basin.

Impressive progress has been achieved in isolating quantum systems from the environment and coherently controlling their dynamics. However, engineering the dynamics of many particles by a controlled coupling to an environment (in an 'open' quantum system) remains largely unexplored. Here, an approach is demonstrated based on ion-trap technology for simulating an open quantum system with up to five qubits. By adding controlled dissipation to coherent operations, the work offers novel prospects for open-system quantum simulation and computation.

This Review provides an overview of the biology of amylin and highlights opportunities, as well as challenges, in the development of amylin-based drugs for the treatment of cardiometabolic diseases.

Spontaneous parametric down-conversion in thin films should allow to realise extremely compact entangled photon sources. Here, the authors generate entangled photon pairs from a 3R-MoS2 flake, characterize them via quantum state tomography, and show how to tune between different Bell state outputs by changing the pump polarization.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The unification of the theory of relativity and quantum mechanics is a long-standing challenge in physics. Here the authors investigate the effects of a wide range of accelerations on an entangled photon pair, providing an upper bound for the effects of non-inertial frames on quantum systems.

With ever more experiments involving ever fewer photons, there is increasing need for detectors capable of accurately resolving low numbers of photons. By modulating the electric field on a silicon avalanche diode, Thomaset al. show a high-speed device that can discriminate signals from just a few photons.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

A three-photon entangled Greenberger–Horne–Zeilinger state is directly produced by cascading two entangled down-conversion processes. Experimentally, 11.1 triplets per minute are detected on average. The three-photon entangled state is used for state tomography and as a test of local realism by violating the Mermin and Svetlichny inequalities.

Multiplexed entanglement distribution in a quantum network, with each node comprising multiple solid-state emitters in nanophotonic cavities, enables scalable quantum communication.

Here the authors develop an assay capable of selecting Sec61 inhibitors by exploiting the inactivation of firefly luciferase, once translocated into the endoplasmic reticulum (ER), and the possibility of diverting and “re-lighting” luciferase into the cytosol by a Sec61 inhibitor.

Some patients experience long-lasting symptoms after coronavirus disease (COVID-19). Here the authors report the clinical and laboratory parameters in patients with post-COVID-19 syndrome from a prospective observational cohort study.

Arguably, the most counterintuitive aspects of quantum mechanics are indeterminacy of physical quantities and ambiguity of wave/particle behaviour prior to measurement. Terno et al.propose an experiment to test hidden-variable models that aim to restore objectivity and determinism in quantum theory.

Via spin-exchange interactions with ⁵¹V⁵⁺ ions, an optically addressed ¹⁷¹Yb³⁺ qubit in a nuclear-spin-rich yttrium orthovanadate crystal is used to implement a reproducible nuclear-spin-based quantum memory, and entangled Yb–V Bell states are demonstrated.

Experimentally verifying that quantum states are indeed entangled is not always straightforward. With the recently proposed device-independent entanglement witnesses, genuine multiparticle entanglement of six ions has now been demonstrated.

Surgical sterilization alone cannot control global stray and feral domestic cat populations. Here, Godin et al. show that a single-dose injectable female sterilant administered before puberty safely and completely prevents pregnancy after maturity.

Using an optical resonator containing two individually addressable atoms in a single cavity, fusion of deterministically generated photonic graph states to create ring and tree graph states with up to eight qubits is demonstrated.

An experiment distributing entangled photons over 144 km significantly raises the bar on distance, channel loss and transmission time—encouraging news with regard to future long-distance quantum-communication networks.

Solving a task of optimal route search may be challenging for conventional algorithms. Here, authors use tunable random signals from magnetic tunnel junctions to improve a probabilistic greedy Traveling Salesman Problem solver to better balance exploration and efficiency, and make it applicable for larger problems.

Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experiments across multiple continents suggest that these learned calls provoke an innate response even among allopatric species.

Multiple scattering with wave-like atoms is known to produce non-trivial many-body effects. Here, the authors investigate multiple scattering in the semi-classical limit using deviations in the scattering halos produced by the collision of indistinguishable ultracold fermions.

Being able to perform qubit measurements within a quantum circuit and adapt to their outcome broadens the power of quantum computers. These mid-circuit measurements have now been used to implement a cryptographic proof of non-classical behaviour.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A manufacturable platform for quantum computing with photons is introduced and a set of monolithically integrated silicon-photonics-based modules is benchmarked, demonstrating dual-rail photonic qubits with performance close to thresholds required for operation.

The number of ligand binding sites in the dopamine transporter is enigmatic due to conflicting data from structures and molecular pharmacology. Here, force spectra reveal the position and dynamics of a previously invisible transient site.

Genome-wide data from 400 individuals indicate that the initial spread of the Beaker archaeological complex between Iberia and central Europe was propelled by cultural diffusion, but that its spread into Britain involved a large-scale migration that permanently replaced about ninety per cent of the ancestry in the previously resident population.