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Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease group with CAR T cells offering therapeutic success in otherwise hard-to-treat cases. Here, authors study the in vivo expansion and persistence of CAR T cells in the peripheral blood of successfully treated DLBCL patients, demonstrating that two different CD8+ precursor phenotypes in the initial cell product give rise to two independent waves of clonally expanded CAR T cells with distinct phenotypes in peripheral blood.

Plasmonic nanostructures enable the concentration of large electric fields into small spaces. The classical analogue of electromagnetically induced transparency has now been achieved in such devices, leading to a narrow resonance in their absorption spectrum. This combination of high electric-field concentration and sharp resonance offers a pathway to ultracompact sensors with extremely high sensitivity.

Arguably, the most counterintuitive aspects of quantum mechanics are indeterminacy of physical quantities and ambiguity of wave/particle behaviour prior to measurement. Terno et al.propose an experiment to test hidden-variable models that aim to restore objectivity and determinism in quantum theory.

Phase singularities are known to have applications in various branches of optics. Here the authors demonstrate that phase singularities can be created and controlled, all optically, in a simple thin film of organic molecules using cavity-free strong light-matter coupling.

Heat transport across interfaces can be restricted due to interfacial thermal resistance between different materials. Here, authors find experimental evidence of a significant and enduring heat barrier between two high-energy-density materials that is consistent with interfacial thermal resistance.

The ultrafast optical control of resonances in temporally symmetry-broken metasurfaces allows resonances to be created, annihilated or programmably manipulated, which is useful for applications that require active real-time tunability.

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Global commitments to reducing antimicrobial use in agrifood systems underscore the urgent need to address antimicrobial resistance. Here, the authors project changes in antibiotic use in livestock through 2040, exploring various potential pathways

Predictive coding is a popular theory of brain function, but it remains unclear if and how it may be implemented in the brain. The authors present a spiking neural network model that offers a fresh perspective on predictive coding and reproduces many observations from visual cortex.

A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

Electric fields in the solar atmosphere are not studied as widely as the magnetic fields mainly due to small, short living signals. Here, the authors show measurement of an electric field associated with magnetic diffusion triggering an energetic event in the solar atmosphere.

As presented at the 2025 ASCO Annual Meeting: in a randomized controlled phase 3 trial evaluating subcutaneous administration of sasanlimab, an anti-PD-1 inhibitor, with Bacillus Calmette–Guérin induction and maintenance treatment, combination treatment significantly improved event-free survival versus standard-of-care therapy.

A geological climate archive documents the effects of ocean warming on Antarctic marine ice-sheets. Large sediment fluxes from the interior of West Antarctica precede the onset of sustained retreat to a smaller footprint for the ice-sheet.

The authors investigated the mechanisms underlying hippocampal sharp waves. They found that CA3 axo-axonic cells (AACs) stopped firing during sharp waves in vivo. They also identified GABAergic cells in the medial septum that are activated during sharp waves and project to CA3; these cells may inhibit AACs during sharp waves.

Understanding liquid behavior is a challenge due to their disorder nature and rapid molecular rearrangements. Here, the authors show how weak interactions between OH groups and aromatic rings can participate in cooperative mechanisms that give rise to highly structured molecular arrangements in the liquid state.

Lithium-ion intercalation of bilayer graphene is shown to proceed via four distinct stages corresponding to different ordered in-plane arrangements of Li ions, commensurate with the underlying graphene lattices in both AA and AB stacking configurations.

Large-scale genome-wide analyses identify hundreds of genetic loci associated with hypothyroidism and thyroid hormone levels, demonstrating the potential of using polygenic risk scores to predict disease onset and progression.

The interaction between proximal 2D materials can lead to fundamental changes in electronic properties. Here, the authors provide evidence of two distinct types of spin-orbit coupling induced in bilayer graphene through the presence of a proximal MoS₂ layer.

Prions are infectious agents that initiate transmissible spongiform encephalopathies. The study demonstrates that Prion proteins lower cellular oxidative stress via GPX8, remodel membrane lipids, and together with RAC3, sensitize cells to ferroptotic death, highlighting new therapeutic targets in prion diseases.

Parvalbumin-positive interneurons in the hippocampal CA3 substantially reduce firing on approach to and at goal locations while food-deprived mice learn to find food.

An Fe^III/V redox mechanism in Li₄FeSbO₆ on delithiation without Fe^IV or oxygen formation with resistance to aging, high operating potential and low voltage hysteresis is demonstrated, with implications for Fe-based high-voltage applications.

Dendritic cells are supplied antigens by other cells such as lymphatic endothelial cells (LEC) at late time points after immunization. Here the authors show antigen archiving is defined by a transcriptional program that can predict antigen archiving depending on the priming pathogen, and that boosting of immune responses increases the archiving.

The icy surface compositions, as revealed by JWST, of small bodies beyond the orbit of Neptune can be classified into three groups that can be related to the ice retention lines in the early Solar System, possibly before the planets migrated.

The synthesis of crystalline 2D polymers typically relies on reversible dynamic covalent reactions, but achieving 2D polymers through irreversible carbon-carbon coupling reactions remains a formidable challenge. Here, the authors present an on-liquid surface synthesis method for constructing diyne-linked 2D polymers.

Exploratory biomarker analyses of the phase 3 CheckMate 649 trial show that in patients with advanced gastroesophageal cancer, KRAS alterations were associated with greater overall survival (OS) benefit when treated with nivolumab plus chemotherapy vs chemotherapy alone, whereas high regulatory T-cell signatures were associated with greater OS benefit when treated with nivolumab plus ipilimumab.

Myeloid-specific mechanotransduction ablation downregulates pro-fibrotic fibroblast transcriptional profiles to reduce scar formation in human cells

Adjuvants are an important component of modern vaccines. Here, the authors employ a phenotypic screen of ~200k compounds and identify PVP-057, a TLR3 agonist with a simple scalable 3-step synthesis, as an adjuvant that induces durable humoral and cellular immunity to varicella-zoster virus (VZV) gE in mice.

Cytochrome P450 enzymes can be repurposed to catalyse asymmetric metal–hydride hydrogen atom transfer, a new-to-nature reaction.

Five-year follow-up and prespecified exploratory biomarker analysis from the phase 3 KEYNOTE-426 trial show that pembrolizumab plus axitinib compared to sunitinib as first-line therapy continues to show overall and progression-free survival benefits in patients with advanced clear cell renal cell carcinoma and indicate that a T-cell-inflamed gene expression profile is predictive of response.

Stable and robust topological edge modes are observed at finite temperatures in an array of 100 programmable superconducting qubits because of emergent symmetries present in the prethermal regime of this system.

Semipermeable polymeric anion exchange membranes are essential for separation, filtration and energy conversion technologies such as fuel cells. Quasi-elastic neutron scattering is now used to disentangle water, polymer relaxation and OH⁻ diffusional dynamics in a commercially available membrane.

Florfenicol treatment substantially increased the abundance and mobility of antibiotic resistance genes (ARGs) in the common carp gut microbiome. The resistome and mobilome profiles failed to return to baseline after the mandated withdrawal time, indicating that this period is insufficient to mitigate the risk of ARG transmission to consumers.

Optical frequency combs are key tools in spectroscopy and telecom. Here, authors report a stable and broadband comb (>10 THz) from a high-Q fiber Fabry-Perot resonator via Kerr-Brillouin passive mode-locking. This easily integrable platform ensures state-of-the-art photonic performance.

The impact of breakage fusion bridge (BFB) cycles on tumour heterogeneity and clinical outcomes remains poorly understood. Here, the authors develop OM2BFB, an algorithm to detect and reconstruct BFB amplifications using optical genome maps and use it to study BFB events across 2557 primary tumours and cancer cell lines.

Cloaking is a technique for rendering obstacles undetectable, previously applied to waves and now extended to particles. Here using a time-periodic magnetic field, authors report that paramagnetic colloidal particles are guided around cloaked regions in a deformed magnetic lattice, resuming motion as if the distortion were nonexistent.

This study shows that aboveground plant diversity is only weakly related to belowground mycorrhizal fungal diversity, although these relationships can be stronger at regional scales. Therefore, conservation efforts centered only on plant diversity may overlook critical fungal diversity hotspots.

NIPBL perturbation activates long terminal repeat (LTR)-derived alternative promoters due to reorganization of chromatin’s hierarchical structure, leading to LTR co-option and oncogene activation in melanoma cell lines.

While in 3D materials melting is a single, first-order phase transition, in 2D systems, it can also proceed via an intermediate phase. For a skyrmion lattice in Cu₂OSeO₃, magnetic field variations can tune this quasiparticle 2D solid into a skyrmion liquid via an intermediate hexatic phase with short-range translational and quasi-long-range orientational order.

3D printing can be used to manufacture composite materials, but to modify material properties multiple feedstocks are required. Here the authors modify printing temperature or light intensity to modify the material properties and achieve property differentiation from a single feedstock.

Interplay between lattice, orbital, magnetic and nematic degrees of freedom is crucial for the superconductivity in Fe-based materials. Here, the authors demonstrate the subdominant roles of pure lattice distortions and/or orbital ordering in BaFe₂As₂ by characterizing the in-plane magnetic susceptibility anisotropy.