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Existing biodegradable materials lack long-term therapeutical effect because of their gradual degradation. Here, the authors develop a degradable material with continuous ROS modulation, which rapidly eliminates bacteria and promotes bone regeneration in infected cranial defects.

The surface charging layer in nanomaterials, which determines their pseudocapacitive behavior, is challenging to characterize. Here the authors perform Faradic electrochemical impedance spectroscopy measurements of single cuboid Prussian blue nanoparticles, displaying a hybrid charge storage mechanism, and determine the depth of the surface charging layer.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

KN046 is a bispecific antibody targeting PD-L1 and CTLA4. Here the authors report the results of a phase II trial of KN046 combined with lenvatinib in patients with advanced hepatocellular carcinoma.

Printed stretchable electronics with sustainable elastomers are typically limited by their electro-mechanical performances. Herein, Lv et al. report a sustainable vegetable oil-based polyurethane-enabled printed conductor with high performance enabled by the porous binder and sintering of silver flakes.

Biased medical artificial intelligence systems pose significant potential risks to achieving fair and equitable healthcare. Here, we demonstrate a fairer ophthalmology AI that mitigates sexism and ageism through implicit fairness learning.

IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.

Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.

A large-scale single-cell transcriptomic atlas of the non-human primate Macaca fascicularis encompasses over 1 million cells from 45 adult tissues.

Substituted bicyclo[1.1.1]pentanes (BCPs) are widely used as bioisosteres for para-substituted phenyl rings, providing improved pharmacological profiles for drug candidates, but strategies for the preparation of chiral BCPs remain limited. Now a route to chiral bridge-substituted BCPs has been developed via a nitrogen-atom insertion-and-deletion strategy, enabling a practical avenue towards chiral BCP bioisosteres of lomitapide.

While chemotherapy may initially be effective in patient with nasopharyngeal carcinoma (NPC), resistance often develops. Here, the authors identify PJA1 as a driver of resistance to docetaxel via inhibition of GSDME-mediated proptosis and target this using a PJA1 inhibitor to restore sensitivity in preclinical models of NPC.

Insulating molecular layers on the basal plane of 2D perovskite is a major bottleneck for charge injection that limiting device performance. Here, the authors show that plane-contacted graphene functions as a low barrier and gate-tunable contact to overcome this limitation.

Electrocatalytic CO₂ reduction into multicarbon products offers a means to close the anthropogenic carbon cycle using renewable electricity. Here, the authors report a cascade AgCu single-atom and nanoparticle electrocatalyst with favorable properties to improve the selectivity of multicarbon products.

How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.

A functional interfacial material has been developed for soft integration of bioelectronic devices with biological tissues. This has been applied in battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy as well as wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays.

How the intertropical convergence zone (ITCZ) changes has strong effects on tropical regions. Here the authors show that while the ITCZ moves northwards over the first one to two decades of CO₂ emissions, the long-term migration is southward, linked to delayed surface warming in the Southern Ocean.

By combining non-recurrent encoding with spatial harmonic retrieval, a programmable metasurface antenna can be created that can approach the theoretical upper limit of the information mapping efficiency.

Synthetic cells mimicking the viscoelastic and T-cell-activation properties of antigen-presenting cells provide substantial enhancements in the expansion and potency of engineered human cytotoxic T cells.

Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Researchers demonstrate a single phase Mg₂Ni(Cu) alloy via atomic reconstruction to achieve the ideal integration of photothermal and catalytic effects, leading to a 6.1 wt. % H₂ reversible capacity with 95 % retention under 3.5 W cm⁻².

The authors introduce nanoscale titanium layers to boost the flexibility of flexible thermoelectric device with 162 thin-film legs (p-Bi0.5Sb_1.5Te₃/n-Bi₂Te_2.7Se_0.3), achieving a high normalized power density >4 μW cm⁻² K⁻² and offering good flexibility.

The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.

AQP5 is identified as a marker for pyloric stem cells in humans and mice, and stem cells in the AQP5⁺ compartment are shown to be a source of invasive gastric cancer in mouse models.

A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.

Site-specific and efficient RNA editing is achieved with a CasRx editor.

In the phase 3 EVER-132-002 trial, patients with HR⁺HER2⁻ metastatic breast cancer from Asia were treated with the Trop-2-directed antibody–drug conjugate sacituzumab govitecan or chemotherapy, and those receiving sacituzumab govitecan experienced prolonged progression-free survival compared with patients treated with chemotherapy.

A study presents the results of surveillance for SARS-CoV-2 in animal and environmental samples from a market linked to early human cases of coronavirus disease 2019.

The stabilization of the zinc electrode/electrolyte interface is critical for aqueous zinc battery operation. Here, authors report an electrolyte additive which promotes the formation of a bilayer solid electrolyte interphase, increasing the efficiency and utilization of zinc plating and stripping.

The performance of wide-bandgap perovskite photovoltaics is limited by the undesired phase transition and high density of deep level traps. Here, Tan et al. incorporate dipolar methylammonium cation to make the material defect-tolerant and achieve a high power conversion efficiency of 20.7%.

Here, the authors isolate a SARS-CoV-2 mutant that has developed decreased sensitivity to Paxlovid and remdesivir from an immunocompromised patient, show that drug resistance can be overcome by simultaneous treatment with both drugs in vitro, and demonstrate that the drug resistant virus can efficiently transmit in the hamster model.

Insights into how the linker histone H1 promotes chromatin alterations and allows repair of DNA damage are described.