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Transition metal dichalcogenide nanotubes possess symmetry-breaking properties promising for fundamental physics research. Here, the authors report a direct synthesis of crystalline MoS₂ nanotubes exhibiting strong polarization and bulk photovoltaic effects.

Pancreatic cancer detection can be challenging, and is often diagnosed at a late stage. Here, the authors present a cfDNA-based liquid biopsy model that enables early detection and prognosis prediction of pancreatic cancer.

A core-shell hydride 3CeH₃@BaH₂, which exhibits fast H⁻ conduction at ambient temperature and becomes a superionic conductor above 60 °C, is used to construct an all-solid-state rechargeable H⁻ battery.

Polycystic ovary syndrome is a common cause of female infertility linked to metabolic and hormonal imbalances. Here, the authors show that androgen driven SLC1A5 upregulation increases glutamine uptake, leading to abnormal follicular development in PCOS via histone deacetylation.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

How metabolic signals are sensed by the cell cycle machinery remains unclear. Here, the authors demonstrate that the glycolytic enzyme PFKM acts as a citrate sensor to promote mitosis, coupling metabolic activity to cell cycle regulation.

By utilizing an AI-accelerated silicon photonic slow-light technology, researchers demonstrate a record 400 Gbps/λ PAM-4 transmission based on pure silicon modulators, paving the way for next-generation optical interconnects in computing centers.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

[n]Peri-acenes have attracted interest as promising candidates for nanoelectronics and spintronics but the synthesis of large (n > 4) [n]peri-acenes is extremely challenging due to their intrinsic open-shell radical character and high reactivity. Herein, the authors report the synthesis and isolation of a derivative of peri-hexacene in crystalline form.

Cobalt-free Mn-based lithium metal batteries suffer from serious Mn dissolution and lithium dendrite problems. Here, authors propose ferrocene hexafluorophosphate as an electrolyte additive to achieve dynamic doping of positive electrode and interphase stabilization of electrodes.

Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF₃Et₂O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF₃·Et₂O as the fluorine reagent in the presence of chiral iodine catalyst.

Chang’e-6 mission’s analysis of farside lunar soils reveals stronger magnetic properties than nearside samples and identifies distinct magmatic and impact-formed minerals. This offers insights into the Moon’s magnetic history and crustal anomalies.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

Metallic molybdenum disulfide is a metastable phase of the material. Here, the authors synthesize two-dimensional metallic molybdenum disulfide nanosheets, stabilized by adsorbed aqueous monolayers, and evaluate their catalytic hydrogen evolution activity.

Acoustic graphene plasmons (AGPs) hold promise for nanophotonics and sensing applications. Here, the authors observe enhanced in-plane scattering of mid-infrared AGPs caused by atomic steps on the substrate surface, suggesting potential strategies for controlling their propagation via substrate engineering.

The mechanism of lipoprotein sorting to the bacterial cell surface is still unclear. Here, authors determine the crystal structures of paLptDE-LptM and apo-paLptDE, providing insights into how SLPs are transported to the cell surface via LptDE.

Wu et al. show that versions of IL-2 that preserve CD25 activity expand tumor-specific T cells more effectively than CD25-sparing agonists and find that the efficacy of anti-PD-1 depends on the activation of PD-1⁺CD25⁺ T cells through autocrine IL-2 signaling.

Selectively extracting U(VI) from seawater is challenging. Here, authors propose a dynamically matched spatial coordination strategy to improve the extraction of U(VI). With the size-matching and the spatial coordination, uranium species are precisely captured in confined coordination space.

A large range of inert and non-defective sites in catalysts is a primary factor impeding catalyst activity in acidic CO₂ electroreduction. Here, the authors achieve high HCOOH selectivity and activity in acidic electrolyte by introducing tensile strain to activate inert sites.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Hepatocellular carcinomas (HCC) present spatial intratumour heterogeneity (sITH). Here, the authors perform a genomic and phylogenetic analysis of spatially-sampled HCC tumour sections, observe block-shaped sITH, and find ongoing natural selection where ancestral and derived clones spatially compete in the same tumor.

Current brain-targeted delivery strategies using orthosteric sites of receptors is highly susceptible to cross-reactions limiting efficiency. Here, the authors report on the allosteric targeting of receptors to avoid this and demonstrate application in drug delivery across the blood brain barrier.

The suboptimal performance of perovskite solar cells based on non-fullerene acceptor as the electron-transporting layer underscores the need for their molecular engineering. Here, authors substitute the core of Y6 with phenanthroline and crown ether, achieving a certified efficiency of 25.59%.

Zymomonas mobilis is an ethanolognic microbial chassis cell for non-food feedstocks biorefinery. Here, the authors report an improved genome-scale metabolic model, develop an intermediate-chassis to bypass the dominant ethanol pathway, and demonstrate the application potential of using lignocellulosic waste for D-lactate production.

An efficient molecular nanojunction photocatalyst for hydrogen evolution is identified from a combinatorial molecular library, assisted by a materials acceleration platform, which is then scaled-up to the litre scale using flow synthesis.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

Lu and colleagues show that signaling through the lactate receptor HCAR1 in colorectal tumor cells promotes the recruitment of immunosuppressive CCR2⁺ PMN-MDSCs and that inhibition of HCAR1 by reserpine augments the CD8⁺ T cell-mediated antitumor immune response.

Resistance to ferroptosis in hepatocellular carcinoma remains to be understood. Here, the authors identify S100 calcium binding protein P (S100P) as a ferroptosis suppressor in HCC cells, which promotes lysosomal degradation of acetyl-CoA carboxylase alpha (ACC1) to downregulate lipid biosynthesis.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Most LiDARs have an intrinsic tradeoff between acquisition rate and non-ambiguity range. Researchers demonstrated a LiDAR called RRMFC based on an integrated lithium niobate frequency comb, leading to a 1.79 GHz acquisition rate and infinite non-ambiguity range.

Recent studies have reported the exceptional plasticity of InSe van der Waals crystals, but their deformation-correlated lattice dynamics remains unexplored. Here, the authors investigate the correlations of plastic interlayer slip, lattice anharmonicity and thermal transport in β-InSe crystals via neutron scattering techniques.

Targeting PGC-1α with liposomal nanoparticles disrupts energy metabolism and mitochondrial function, reducing lung metastasis in bladder cancer and offering a promising therapeutic strategy.

Numerous methods for transition metal-catalysed hydrosilylation exist but iridium catalysis offers attractive advantages. Here the authors describe a broadly-applicable method for the Markovnikov hydrosilylation of terminal alkynes using a commercial iridium catalyst.

The current use of elastography ultrasound faces challenges, including vulnerability to subjective manipulation, echo signal attenuation, unknown risks of elastic pressure and high imaging hardware cost. Here, the author shows a virtual elastography to empower low-end ultrasound devices with state-of-art elastography function.

Phase engineering of 2D tellurium could enable potential applications for (opto-)electronic devices. Here, the authors report the phase- and thickness-controlled synthesis of α-Te nanosheets and β-Te nanoribbons, showing their application for the realization of short-channel transistors.

SARS-CoV-2 Omicron variant evolves into multiple sub-variants. Here, authors evaluate the binding capacity of these sub-variants to human and animal ACE2s and reveal molecular bases for their receptor binding and broader interspecies recognition.

Among other exotic properties graphene exhibits the highest thermal conductivity observed so far. This is true at least for graphene composed of only ¹²C atoms. However, it is now shown experimentally that regions of ¹³C atoms can substantially reduce the thermal conductivity. Aside from their fundamental importance, these results suggest that thermal conductivity can be tailored by varying the relative amounts of carbon isotopes used.