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Li, He, Liu and colleagues characterize the dynamic bivalent chromatin landscape during mouse peri-implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Spiral spin liquids emerge from cooperative fluctuations among degenerate spiral states. Here, Zhao et al uncover itinerant and topological low-energy spin excitations intrinsic to the spiral spin-liquid candidate material GdZnPO.

Here, authors design and test synthetic nano-kirigami structures with Archimedean spirals to achieve large-range, bi-directional deformations. These results in high-performance optical modulation and high-resolution dynamic information displays, addressing limitations in existing nano-kirigami deformability.

HiScanner, a tool for identification of copy number alterations from single cell whole-genome sequencing data, uncovers cell-type-specific somatic mosaicism in human brain and offers a way to track clonal evolution at the single cell resolution.

Na Super Ionic Conductor (NASICON) materials are an important class of solid-state electrolytes. Here, authors combine calculations, experimental synthesis and testing, and text-mined historical data on NASICON ionic conductivity to understand how composition influences the Na-ion conductivity.

There is no noninvasive solution for tPAresistant thrombi as the mechanism remains obscure. Here, the authors show a constructed ultrasound-responsive theranostic platform for real-time monitoring and efficient thrombolysis by breaking the keychain in tPA-resistant thrombi.

Transcription factor regulatory networks underlie major features of cellular identity and complex function such as pluripotency, development and differentiation. Li and colleagues develop a graph neural network to predict transcription factor regulatory networks based on single-cell ATAC-seq data.

Rational design of the morphology of inorganic microstructures is challenging. Now an electrochemical method is reported for designing the morphology of inorganic microarchitectures via programming of the potential waveforms applied during microstructure growth. These microstructures have potential application as SERS sensors.

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Asymmetric histone modifications in parental pronuclei displays epigenetic regulation. Here the authors reveal the role of LSM1-mediated Major Satellite RNA decay in the H3 variant incorporation and modifications in male pronucleus.

Wu et al. optimized the m⁶A mapping method for ultralow-input materials and characterized the transcriptome-wide landscape of m⁶A methylation in mouse oocytes and early embryos.

Templating method holds great promise for fabricating surface nanopatterns. Here authors present a guiding growth mode using metal-organic framework microparticles as templates during metal electrodeposition, where metals exclusively grow underneath the microparticles.

Injecting Cas9 and gRNA into an animal zygote often produces mosaicism and random biallelic targeting. Here, the authors use pronuclear transfer to reduce mosaicism and selectively target parental alleles.

H3K9me3 is an epigenetic barrier to the reprogramming of somatic cells to a totipotent state during somatic cell nuclear transfer. Here, the authors uncover molecular mechanisms regulating H3K9me3 modifications in this process.

The organisation of chromatin in somatic cell nuclear transfer (SCNT) embryos remains poorly understood. Here, the authors examine higher order chromatin structures of mouse SCNT embryos and provide insights into chromatin architecture reorganisation during SCNT embryo development.

Here the authors find that farrerol directly binds to UCHL3 and activates its deubiquitinase activity, and that farrerol promotes development of SCNT embryos by enhancing HR repair and restoring epigenetic networks in a UCHL3-dependent manner.

Mice can be generated from induced pluripotent stem cells (iPSCs) but the impact of accumulated mutations on the developmental potential of the cells remains to be determined. Here the authors show that mice generated from iPSCs tolerate the accumulation of somatic mutations for up to six generations, but their viability decreased with increasing generations.

A modeling study using case and mortality data from the first 8 months of the COVID-19 pandemic in the United States explores five potential future scenarios of social distancing mandates and mask use at the state level, with projections of the course of the epidemic through winter 2021.

Inorganic lithium superionic conductors are central to the development of solid-state batteries, but the availability of practical superionic conductors is still limited. This Review highlights structural and chemical strategies to enhance ionic conductivity and maps a strategic approach to discover, design and optimize fast lithium-ion conductors for safe and high-energy-density all-solid-state batteries.

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

Cell segmentation is crucial in many image analysis pipelines. This analysis compares many tools on a multimodal cell segmentation benchmark. A Transformer-based model performed best in terms of performance and general applicability.

We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our understanding of human biology.

Multi-omics profiling of matched normal colon, primary tumor, and liver metastasis from colorectal carcinoma patients based on Hi-C, ATAC-seq and RNA-seq technologies sheds light on the changes and regulatory mechanisms of 3D genomics during the tumorigenesis and metastasis of colorectal carcinoma.

Gao and colleagues characterize genome-wide H3K9me3 distributions in pre- and post-implantation mouse embryos, providing a resource to further our understanding of epigenomic dynamics during mammalian embryogenesis.