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Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO₂ as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO₂ dissolved in seawater that is subsequently converted to succinate in a bioreactor.

Structural and functional understanding of the afferent inputs to histaminergic neurons remains incomplete and lacks systematic characterization. Herein, the authors establish a comprehensive and precise whole-brain atlas of long-range inputs to mouse histaminergic neurons and investigate the representative upstream histaminergic neural circuits in regulating the sleep-wake cycle.

A single adaptive neuromorphic vision device is reported to emulate four high-order visual neuronal dynamics, enabling a highly efficient and compact artificial general vision intelligence system towards dynamic scenarios.

Efficient and accurate constant potential simulation is essential for electrochemical modeling. Here, authors propose a constant potential framework by combining the machine learning force field with the charge equilibration method to study the dendrites nucleation at the Li metal battery interface.

Cu-based catalysts for the conversion of C₂H₂ to C₂H₄ are plagued by side reactions. Here, Cu nanodots for C₂H₂ semihydrogenation are reported to reach current densities >400 mA cm⁻² and selectively produce polymer-grade ethylene over 130 h.

Here, the authors propose an anion intercalation strategy to mitigate the stability problem of aqueous non-Kolbe electrolysis, which enables the efficient upgrading of carboxylate salts to value-added chemicals.

Raiff, Zhao and colleagues identified the E3 ligase CRL2^FEM1B as a regulator of mitochondrial fusion. CRL2^FEM1B is recruited to mitochondria by TOM20, where it promotes PLD6 ubiquitination and degradation to maintain mitochondrial health.

A complete genome assembly of a crab-eating macaque, revealing 46% fewer segmental duplications and 3.83 times longer centromeres than those of humans, is presented, enhancing understanding of lineage-specific phenotypes, adaptation and primate evolution.

A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered gut microbiome.

Here the authors report the cryo-EM structure of Frizzeled 4 in complex with the DEP domain of Dishevelled 2. The study unveils the key mechanism of WNT signalling activation, the recruitment of dishevelled to Frizzled receptor.

A key question in the ubiquitin-proteasome system is how E3 ligases select their substrates. Here, the authors reveal that CRL2^FEM1B E3 ligase functions as a dimer and employs a bipartite mode of substrate recognition, requiring a C-terminal proline and an upstream aromatic residue in the target.

The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical. Here, authors determined the structures of wildtype and disease-causing I607T mutant of ClC-3 in the apo and adenine nucleotides bounded states, which lays the structural basis of adenine nucleotides regulation in ClC-3.

Lysosomes are best known for their roles in inflammatory responses via autophagy. Here, Xing et al., find that lysosomes regulate macrophage inflammatory responses by finely controlling interleukin-1β production, altering lysosomal Fe2+ release through the TRPML1 channel.

A phase-contrast CT study of obstructive biliary disease suggests that the evolution of bile infarct and the formation of infarct-sinusoidal microchannels promote the disease progression.

Structural characterization of the substrate adapters of the C-degron pathway reveals the selective recognition mode towards substrates with C-terminal arginine by FEM1A/C and FEM1B.

The neural mechanisms responsible for cold defense regulation are still unclear. Here, authors show parallel thermogenic pathways from the brain stem to the hypothalamus work together to enable resilience to cold temperature exposure and hypothermia.

La-substitution in BiFeO₃ enables an electric field-driven conversion of a multi-domain into a single ferroelectric domain accompanied by a single variant spin cycloid. A single domain multiferroic generates 400% larger non-local inverse spin Hall voltage at the output.

Here, the authors probe a magneto-electric coupling in freestanding BiFeO₃ by optical second harmonic generation with varying magnetic field and temperature. They find the coupling to be suppressed by strain releasing whereas it remains robust against thermal fluctuations.

Type 2 diabetes often presents with reproductive disorders, including reduced male and female fertility. Here they show that diabetes disrupts the APLN signaling axis in the testes and that spermatogenesis can be restored through treatment with an APLN antagonist.

Microspherical structures are broadly applicable, but their morphology and function is limited by the molecular building blocks available. Here, the authors describe the selfassembly process of condensed Schiff bases into multifunctional hierarchical organic microspheres.’

Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.

Real-time mid-infrared photothermal imaging of nitrile chameleons enables simultaneous, multiplexed measurement of enzymatic activity in living systems and is poised to reveal the spatiotemporal regulation of enzymes in health and disease.

GPR174 is a lysophosphatidylserine (LysoPS) activated GPCR. Here, the authors report the cryo-EM structure of LysoPS-bound human GPR174 in complex with G_s protein. The study reveals how GPR174 recognizes the lipid ligand and engages G_s in a distinct binding mode.

Cryo-EM structures of the mouse TRPV2 channel, combined with electrophysiology and simulations, reveal that endogenous cholesterol binds to the vanilloid binding pocket to inhibit this channel, while exogenous 2-APB binds to same pocket to open TRPV2.

aGPCRs play key roles in multiple physiological processes. Here the authors report cryo-EM structures of GPR110 in complexes with G_q, G_s, G_i, G₁₂ and G₁₃ protein to reveal a detailed mechanism of aGPCR activation via the tethered stalk peptide and principles of G-protein coupling and selectivity on GPR110.

Directly linked porphyrin dimers show intriguing electronic features but emphasis has been placed on planar monomeric units. Here, the authors report a Twisted-Planar-Twisted framework which can undergo a cis-trans transformation accompanied by a colour change in presence of methanol, making this framework applicable as a methanol sensor.

Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.

Here the authors show enhancers in the Igh locus play a major role in configuring locus architecture and in V(D)J recombination, and identify a link between enhancer hub formation, locus contraction and cohesin-mediated loop extrusion.

A tomato super-pangenome constructed using chromosome-scale genomes of nine wild species and two cultivated accessions highlights genomic diversity and structural variation across wild and cultivated tomatoes.

This study shows that excitatory neurons in the ventral hippocampus that express the serotonin receptor 2c gene control attention through direct innervation of the mouse equivalent of the Edinger–Westphal nucleus.

A combined structural and biochemical analysis reveals that TRIM7 E3 ligase targets viral proteins for degradation by recognizing their C-terminal glutamine (C-Gln) via its PRY-SPRY domain, providing mechanistic insight into the C-degron pathway.

Schistosoma mansoni and Schistosoma japonicum are the pathogenic agents that cause the tropical disease schistosomiasis. Here, and in an accompanying paper, the genomes of these two flatworms are sequenced and analysed. The results provide insights into the molecular architecture and host interactions of the flatworms, as well as avenues for future development of targeted interventions for schistosomiasis.

The history of halogen-containing solid electrolytes is presented, and the advantages of halogen-chemistry for solid electrolytes related to crystal structures, migration pathways and ion transport mechanisms are summarized. Finally, the main challenges and future developments of halogen-containing solid electrolytes are discussed.