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In this study, authors show that the El Niño–Southern Oscillation (ENSO) drives 63% of dengue case variation via rising local temperatures. They estimate future cases may increase by 39–82% due to increasing ENSO events under human-induced warming.

Oxaloacetate is sensed by MDH1, which primes innate immune antiviral defence against influenza virus infection, thus resulting in the activation of ETS2 to promote TBK1-centred type I interferon signalling.

A layered hybrid lead halide intercalated with Ru(bpy)₃²⁺ is assembled through Pb²⁺-carboxylate coordination. The material has broad visible light absorption and drives photocatalytic CO₂ reduction to CO with a quantum yield of ~3.0% at 500 nm.

Agricultural machinery and supporting sectors such as energy, food processing, transportation and storage are quantified, demonstrating a sixfold increase in related health risks over the past 37 years in China, with disproportionately higher impacts on low-income populations.

On-demand drug secretion within patients is a long-standing goal of cell-based therapies. Here, the authors developed a trigger-inducible calcium importer to allow various trigger compounds of interest (e.g. FDA-approved drugs) to control exocytosis of insulin or other therapeutic proteins in vivo.

Water dissociation has proven power in tuning the behaviors of electrochemical CO₂ reduction. Here, the authors report the spontaneous water dissociation capability of the intermetallic electride LaCu_0.67Si_1.33 material that enables high rate electrosynthesis of methane from CO₂.

Benign airway stenosis (BAS) is characterised by acute and chronic inflammation of the trachea. Here the authors examine the function of cGAS-STING in BAS using mouse models and show involvement of macrophages and that inhibition of STING or macrophage depletion ameliorated BAS.

Ultrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser.

Here, the authors demonstrate a re-programmable metasurface that can produce arbitrary holographic images for optical encryption. The encrypted information is divided into two matrices and defined to the incident laser to produce arbitrary holographic images.

Ultraviolet photoacoustic microscopy in reflection mode can be used to intraoperatively evaluate undecalcified and decalcified thick bone specimens without sectioning them.

Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.

This study reveals the emission reduction potential of fleet electrification and road network development for road freight emissions in the port cities. It demonstrates that the integrated strategy significantly reduces peak emissions compared to electrification alone.

The complex interplay between magnetism and electronic band structure is pivotal in condensed matter physics, with CeSb devil’s staircase antiferromagnetic transition offering a unique exploration opportunity. Here, the authors use ARPES measurements and DFT calculations to reveal an unconventional band splitting arising from the intricate modulation of paramagnetic and antiferromagnetic layers, advancing our understanding of correlated electron systems.

Development of synthetic load bearing materials is important, but it can be challenging to achieve all the required properties. Here, the authors report the development of an organohydrogel from biobased materials, with favourable compressive strength and toughness.

Citrullus super-pangenome constructed using 27 telomere-to-telomere assemblies encompassing all seven Citrullus species highlights genomic diversity across wild and cultivated watermelons and the potential for crop improvement.

Genetic variation present in wild rice is a reservoir of useful genes for rice breeding. Here, the authors report the haplotype-resolved gapless genome assembly of wild rice, the development of two sets of chromosome segment substitution lines, and the cloning of a blast resistance gene originated from wild rice.

This study demonstrates that the adaptor protein AP-3β recruits the 19S regulatory particle (RP) of the proteasome to stress granules (SGs) after heat stress and promotes SG disassembly through RP-associated deubiquitylation process.

Here, the authors demonstrate the electrochemical unzipping of single crystalline black phosphorus into zigzag-phosphorene nanobelts, nanosheets, and quantum dots, via a top-down oxygen-driven mechanism.

Foreign investments in recent years drive the expansion of fossil fuel electricity generation in emerging economies, yet necessary quantification still lacks. This Article shows how overseas coal-fired power plants could drive future trajectories of CO₂ emissions in host countries.

The plant vacuole plays important roles in regulating growth and development. Now, the vacuole in Arabidopsis root cells is presented at nanometre resolution by 3D whole-cell tomography, suggesting a cellular mechanism for plant vacuole formation.

RNF214 ubiquitin ligase is understudied. Here the authors show RNF214 promotes hepatocellular carcinoma progression by inducing non-proteolytic ubiquitylation of TEADs and activating YAP signaling pathway.

Support Brønsted acid strength and density play important kinetically relevant roles in low temperature NH3-SCR over Cu-exchanged small pore zeolite catalysts. Here the authors demonstrate Brønsted acid sites facilitate hydrolysis and intercage transfer of Cu^II(NH₃)₄ intermediates.

One major technological obstacle for membrane-based alkaline water electrolyzer is the inefficient hydrogen evolution reaction. Here, the authors report a platinum/fullerene heterostructure catalyst, which shows enhanced activity for hydrogen production due to the diverse interface between platinum and fullerene.

High-income groups contribute significantly to air pollution through their food choices, but most of the associated health burden is borne by low-income groups living close to agricultural areas. This study measures this discrepancy along the Chinese food supply chain and examines pathways to reduce it.

The generation of cracks in polycrystalline Ni-rich layered lithium transition metal oxides presents numerous challenges for their use in batteries. Here, authors propose a gradiently distributed pores structure within the oxide secondary particles, reducing internal strain accumulation.

The authors study monolayer FeSe via scanning tunneling microscopy and simultaneous micron-scale-probe-based transport. They observe distinct superconducting phases in domains and on boundaries between domains, with different superconducting gaps and pairing temperatures.

The sources and sinks of Re and U in the modern ocean may be imbalanced, according to sedimentary porewater analysis and assessment of reductive Re and U removal on the continental shelf

By improving the sample quality of FeGe, the authors observe a long-ranged charge order accompanied with a first-order structural transition. They determine the distorted superstructure and show that occupational disorder is the origin of short-ranged charge order.

A recently proposed structure of an N₂-bound Mo-nitrogenase has sparked considerable attention, although the direct evidence for N₂ binding and sulfur mobilization during turnover has remained elusive. Now, additional spectroscopic and kinetic measurements further support this state and provide evidence that belt-sulfur displacement is an essential aspect of the nitrogenase mechanism.

Despite their promising optical properties, organolead halide perovskites are not frequently used in photocatalysis due to their low stability in water. Here, a long-lasting semiconductive organolead iodide layered crystalline material with the ability to perform overall water splitting is introduced.

NifB is a radical SAM enzyme involved in the biosynthesis of the Mo-nitrogenase cofactor, which is responsible for the ambient conversion of N₂ to NH₃. Here, the authors identify and uncover the function of a His43 residue as an essential nitrogen ligand of NifB in cofactor biosynthesis.

The Fe protein of nitrogenase contains a redox-active [Fe₄S₄] cluster that plays a key role in electron transfer and substrate reduction. Here, Hu and co-workers show that the Fe protein of Methanosarcina acetivorans can reduce CO₂ and CO to hydrocarbons under ambient conditions.

Ruthenium oxide has attracted recent interest as a non-superconducting material where superconductivity can be induced by epitaxial strain. Here, the authors explore strained (100)-oriented RuO₂ films on TiO₂(100) substrate and reveal strain-induced superconductivity similarly to strained RuO₂(110) films, providing insights into the thickness-dependence and electronic structure mechanisms of superconductivity.

A machine learning model for generating crop-specific and spatially explicit NH₃ emission factors globally shows that global NH₃ emissions in 2018 were lower than previous estimates that did not fully consider fertilizer management practices.

Palladium-catalysed C(sp³)–H amination reactions of carboxylic acids are challenging due to N-coordination often outcompeting the carboxylic acid directing effect. Now, the development of chlorinated pyridine–pyridone ligands for palladium-catalysed methylene C(sp³)–H lactamization and cycloamination is reported, enabling the synthesis of lactams and cyclic amines.

The iron protein components of bacterial nitrogenases are capable of reducing carbon dioxide (CO₂) to carbon monoxide (CO) in the absence of their catalytic partners, mimicking the activity of CO dehydrogenase.

Diffuse-type gastric cancer (DGC) accounts for 30% of gastric cancers and has few treatment options. Here the authors present a mutation and proteome dataset for 84 patients, identifying three major classes of DGC and indicating potential targets for therapy.

Common wisdom to improve ductility of bulk metallic glasses (BMGs) is to introduce local loose packing regions at the expense of strength. Here the authors enhance structural fluctuations of BMGs by introducing dense local packing regions, resulting in simultaneous increase of ductility and strength.

The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.

Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that inducing ferroptosis and suppressing TNF signaling reduce fibroblast numbers and ameliorate experimental arthritis.

A power generator exhibits enhanced output due to a dual-charge-carrier design. The voltage produced is constant yet competitive even under low relative humidity.

Electrons in uranium-based materials are often on the border between localised and itinerant behaviour, which can lead to unusual magnetic behaviour. Here the authors combine experiment and theory to show that USb₂ may be an unusually high temperature example of a singlet-ground-state magnet.