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Achieving versatile, tunable, real-time topological photonic system is challenging. Now this is accomplished by designing superlattices of WS₂ and a polymer embedded in a microcavity.

Depletion of circulatory asparagine (Asn) by L-asparaginase (ASNase) has been used for clinical treatment of leukemia. Here this group develops core-shell structured cascade-responsive nanoparticles for sequential modulation of exogenous Asn supply and endogenous Asn production, thereby achieving the amino acid depletion therapy against solid tumors.

Detecting early allopolyploidy events and understanding the specific subgenomic evolution contributing to the origin of adaptive innovations for species radiation are challenging. Here, the authors address these problems by analyzing nine newly assembled genomes of Salicaceae species from different genera.

IrO2 catalysts typically feature rutile structures with multiple facets. The authors develop an ammonia-induced method to synthesize single-faceted CuO₂ monolayers with the theoretically optimal (101) facet, resulting in high oxygen evolution activity and stability (>10,000 h) in a water electrolyser.

Here the authors identify the granin hormone SCG2 as a ligand for the inhibitory receptor LILRB4. They show that SCG2 released from tumors can suppress antitumor immune responses via this interaction, indicating possible therapeutic strategies.

Next-generation proton exchange membrane electrolyzers rely on high-performance anodes. Here, the authors report a metal-oxide-based molecular self-assembly strategy toward a support-free iridium hydroxide catalyst for an advanced anode with low-iridium loading and enhanced mass transport.

Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather pathological information for timely interventions. Here, the authors introduce a biodegradable and restorative neural interface for wireless real-time tracking.

CAD, a de novo pyrimidine synthesis pathway enzyme, is known to promote chemotherapy resistance. Here, the authors shed light into this mechanism of chemoresistance, showing that chemotherapeutic drugs can promote the degradation of CAD following cleavage by activated caspase-3 on its Asp1371 residue.

Electroreduction of nitrate or nitrite offers an appealing route for hydroxylamine synthesis but remains challenging due to its intermediate nature. Here, authors present a selective and fast electrosynthesis of hydroxylamine by tuning metal phthalocyanine activity and removing side reaction sites.

The monitoring of vital physiological parameters exemplified by intracranial pressure is of paramount importance. Here, the authors propose an ultrasensitive multimodal biotelemetric system to monitor ICP, respiratory, and heart rate.

Protein O-GlcNAcylation is involved in regulating gene expression and maintaining cellular homeostasis. Here, the authors develop a chemical reporter-based strategy for the proteomic profiling and genome-wide mapping of genotoxic stress-induced O-GlcNAcylated chromatin-associated proteins.

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

Efficient oxygen evolution relies on the development of promising catalysts. Herein, the authors demonstrate that cobalt tetrahedra, stabilized over the surface of YBCo₄O₇ material, can catalyze oxygen evolution reaction efficiently.

Current wrinkling processes for pattern formation cannot be easily controlled, resulting in deformation or detachment of patterns from substrates. Here, Zhong et al. report a wrinkling strategy for creating patterned structures with long-range order and resistant to force relaxation.

A biodegradable electronic bandage that applies pulsed and d.c. electrostimulation can accelerate the healing of intestinal wounds in mice via transfection of cells and stimulation-induced secretion of healing factor from those cells.

Chemokine receptors are G protein-coupled receptors (GPCRs) involved in immune responses and characterized by ligand promiscuity Here, the authors characterize signaling through chemokine receptors CXCR4 and CXCR7, with insights into intrinsic-bias encoded in the CXCR4-CXCR7 system.

Indoxyl sulfate is a key risk factor in the progression of chronic kidney disease, but cannot be removed from the blood by hemodialysis. Here, the authors report the use of a covalent organic framework for the removal of indoxyl sulfate precursor from the intestine.

Splitting water into its component elements, oxygen and hydrogen gas, provides a carbon-neutral fuel source, although the availability of cheap, earth-abundant catalysts is lacking. Here, the authors demonstrate antiperovskite-derived materials as high-performance water oxidation electrocatalysts.

Precise control of water oxidation activity calls for the mastery of surface reconstruction of electrocatalysts. Here, the authors identify the structural origin of surface reconstruction on spinel oxides and report a criterion to evaluate the reconstruction degree, which enable the design of spinel pre-catalyst with controlled reconstruction ability.

A MATL gene mutation was found to induce haploids in maize. Now, knocking out the MATL orthologue in rice results in haploid induction at a rate of 2–6%, suggesting the functional conservation of MATL, and represents an advance for rice breeding.

High-capacity and structural stable cathode materials are challenges for sodium-ion batteries. Here, the authors report a layered P2-Na_0.612K_0.056MnO₂ with large-sized K⁺ riveted in the Na-layers to enable 0.9 Na⁺ (de)insertion with a reversible phase transition of P2-P’2.

While water splitting provides a renewable means to store energy, the sluggish O₂ evolution half-reaction limits applications. Here, authors examine a silicon-incorporated strontium cobaltite perovskite and correlate lattice oxygen participation in O₂ evolution to the oxygen ion diffusivity.

While water splitting could provide a green means to store energy, there are few materials that can sustain high water oxidation half-reaction rates in acidic electrolytes. Here, authors design a perovskite oxide that generates high performance under-coordinated iridium sites during electrocatalysis.

Water may serve as a renewable hydrogen fuel source to replace fossil fuels, although such electrolysis requires highly active catalysts. Here, authors explore Ruddlesden−Popper oxides as hydrogen evolution electrocatalysts that feature an unusual synergistic effect to promote high activity.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

The Digital Brain platform is capable of simulating spiking neuronal networks at the neuronal scale of the human brain. The platform is used to reproduce blood-oxygen-level-dependent signals in both the resting state and action, thereby predicting the visual evaluation scores.

Oxygen electrocatalysis is key for energy conversion and storage technologies such as fuel cells and water electrolysers. However, the measurement of the performance of electrocatalysts is not standardized. This Comment addresses emerging pitfalls in performance evaluation and discusses best practices for oxygen electrocatalysis.