Concurrent tandem catalysis, with two or more catalysts conducting multistep reactions in the same reactor, would be beneficial for (bio)pharmaceutical and fine chemical manufacturing. Here, the authors report the co-immobilization of metal nanoparticles and a biocatalytic multienzyme system within a synthetic covalent organic framework capsule, COFcap-2, and employ it to prepare eleven homochiral amines using dinitrogen as a feedstock.
- Qianqian Zhu
- Peijie Dong
- Yao Chen