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Geometric quantum gates—engineered evolution paths for qubit control—promise noise resilience but have shown limited fidelity in prior implementations in semiconductor quantum computation. Here the authors demonstrate high-fidelity single-qubit gates in a single-hole quantum dot in Ge, outperforming conventional dynamical gates.

Bullous pemphigoid (BP) is a type 2 immunity associated skin inflammatory disease. Here the authors characterize the underlying immune-stromal crosstalk in this disease using scRNA sequencing to show that IL13-IL13RA1 signals are involved with fibroblast and DC mediated enhancement of Th2 responses.

Direct assembly of complex fluorinated motifs from simple fluorine sources is an attractive frontier of synthetic chemistry. Here the authors report a protocol for achieving tetrafluoroisopropylation by using commercially available CF₂HSO₂Na as a convenient source of the tetrafluoroisopropyl [(CF₂H)₂CH] group.

Zhang and colleagues characterize a subset of nerve-associated CX3CR1⁺ liver portal area macrophages that maintain immune homeostasis and attenuate nonalcoholic steatohepatitis.

The combination of crystallinity, porosity and processability make polymer- metal-organic frameworks interesting materials but their fabrication is challenging. Here, the authors fabricate these materials via an in situ molecular weaving strategy in which the alignment of cationic polymer chains within the metal-organic frameworks is guided by shear forces and coordination interactions.

The injection of straw into subsoils can increase soil organic carbon and crop yields substantially and could therefore provide an effective approach for subsoil management in croplands, according to 15 years of field experiments on rice–wheat croplands in China.

Elevated uric acid induces early erectile dysfunction by interacting with MLCK and by inhibiting its ubiquitin-mediated degradation. MLCK inhibitor ML-7 and uric acid-lowering therapy improve erectile function induced by hyperuricemia.

The high annealing temperature in two-step sequential deposition could lead to the desorption of self-assembled molecules at the buried interface. Here, the authors propose a low temperature sequential deposition method and achieve certified efficiency of 26.0% for perovskite solar cells.

This study provides structural and biochemical insight into how mammalian PIWI proteins use a limited supply of piRNAs to silence a vast array of ever-evolving transposons in the germline.

To push the boundary of sol-gel chemistry towards high quality organic membrane construction is challenging. Here, the authors show a controlled nanocrystal suturing strategy in sol-gel solutions to afford highly crystalline and free-standing covalent organic framework membranes.

Germ granules are cellular condensates that enrich gene-silencing factors in reproductive cells. Here, the authors uncover key proteins that anchor germ granules to nuclear pores and show how this spatial organization finetunes small RNA-based gene regulation.

This paper shows that nano-enabled dehydrogenation catalysis in biological systems induces a domino effect, including reductive stress, immunosuppression and tumour metastasis.

The molecular mechanisms of astroblastoma development are identified, whereby distinct gene fusions upregulate shared transcriptional networks to disrupt the normal development of ventral telencephalon neural progenitors, which leads to oncogenesis.

Continuous-flow biocatalysis with immobilized enzymes is a sustainable route for chemical synthesis, but inadequate biocatalytic efficiency caused by non-productive enzyme immobilization or enzyme-carrier mismatches presents a challenge for its application. Here, the authors report an approach for the fabrication of a high-performance enzymatic continuous-flow reactor via integrating scalable isoporous block copolymer membranes as carriers with an oriented one-step enzyme immobilization via a genetically fused material binding peptide.

Glycosphingolipids (GSLs) are abnormally expressed in cancer cells. Here, in addition to showing that inhibition of the synthesis of GSLs with eliglustat promotes anti-tumor immune responses in preclinical models, the authors report the results of a phase I trial of eliglustat and anti-PD-1 antibodies for the treatment of advanced cancers.

Iron-based nanozymes are promising for tumor catalytic therapy owing to their biocompatibility and peroxidase-like activity, but the concurrent catalase-like activity undermines the therapeutic efficacy. Here, the authors address this issue by developing a hemin–cysteine–Fe nanozyme, which exhibits catalytic selectivity and exclusive peroxidase-like activity.

The intestinal mucosal barrier can be reinforced via the oral administration of commensal bacteria coated with poly(ethylene glycol) to facilitate their penetration into mucus.

The study reveals defective maternal mRNA deadenylation in oocytes matured in culture dishes versus natural ones, potentially explaining lower fertility in assisted reproduction with immature oocytes.

Pannexin 2 plays critical roles in many physiological processes but its mechanism remain unclear. Here, authors report the cryo-EM structure of human Panx2 in the open state and identify critical residues for its gating.

The tumor suppressor GATA4 is frequently epigenetically silenced in lung cancer. In this study, Gao et al. demonstrate that GATA4 regulates the expression of TGFBR2 and that TGFRB1 inhibitors can synergise with chemotherapeutics to inhibit the growth of GATA4-deficient tumors in mice.

Keratinocytes require glucose for injury- or inflammation-driven but not homeostatic proliferation, and glucose-transport blockade blocks psoriasis-like pathology in experimental models.

Interactive robots can be used to study animal social behaviour. Imitation learning can be used to enable a rat-like robot to learn subtle templates of social behaviour, demonstrating that it can modulate the emotional states of rats through varied interaction patterns.

A new procedure for cataract removal that preserves lens epithelial progenitor cells in mammals, which require Pax6 and Bmi1 for their self-renewal, achieves lens regeneration in rabbits, macaques and in infants with cataracts.

AK-42 was reported as a specific inhibitor of ClC-2 but its working mechanism is not clear. Here authors report cryo-EM structures of apo ClC-2 and in complex with AK-42, revealing how it inhibits ClC-2 specifically.

One challenge in lignin valorization is that microorganisms possessing downstream metabolic advantages are unable to convert lignin. Here, the authors engineer the non-lignin-degrading bacterium Ralstonia eutropha to efficiently convert lignin into polyhydroxybutyrate using a self-enhanced autoregulation system.

Self-sufficient cytochrome P450 monooxygenases, which contain all redox partners in a single polypeptide chain, are of interest for biotechnological applications. Here, the authors present the crystal structure of full-length Thermobispora bispora CYP116B46 and discuss the potential electron transfer pathway.

LRRC31 links DNA repair and radiation efficacy Chen et al. perform a genome-wide CRIPSR screen and identify LRRC31, which interacts with Ku70/80 to suppress DNA repair and enhances the efficacy of radiation therapy in breast cancer brain metastasis.

The analysis of behavioural patterns from standardized video recordings of infants with varying degrees of visual impairment enables, via deep learning, classification of the infants by visual-impairment severity and by ophthalmological condition.

Preclinical characterization of the SARS-CoV-2 M^pro inhibitor RAY1216 shows improved in vivo pharmacokinetics compared with nirmatrelvir.

Pityriasis rubra pilaris (PRP) is a chronic immune‐mediated papulosquamous dermatosis and is caused by dysregulation of keratinocytes. Here the authors identify keratin 32 (KRT32) mutations associated with PRP which results in the inhibitory function of KRT32 towards NF-kB signalling and IKK complex formation being reduced.

Diterpene synthase VenA catalyses the synthesis of venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. Here, the authors report crystal structures of apo- and holo-VenA, provide mechanistic insights into its substrate selectivity and promiscuity, and engineer VenA into a sesterterpene synthase.

Recent evidence suggests the feasibility of neoadjuvant immune checkpoint inhibitors plus chemotherapy-based therapy for patients with early triple-negative breast cancer (TNBC). Here the authors report the results of a single-arm phase II trial of neoadjuvant camrelizumab (anti-PD-1) plus nab-paclitaxel and epirubicin for early TNBC.

Dalpiciclib is a CDK4/6 inhibitor, recently approved for treatment in advanced breast cancer patients in China. Here, the authors report the results of a phase II trial investigating oral dalpiciclib (CDK4/6 inhibitor) and pyrotinib (pan-HER inhibitor) in patients with HER2-positive metastatic breast cancer.

The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

RNA binding proteins can contribute to colorectal cancer (CRC) initiation and development. Here the authors show that PUMILIO proteins, PUM1 and PUM2 contribute to CRC growth by inhibiting p21 expression.

TREE1 and its homologue DAZ3 are expressed exclusively in Arabidopsis sperm, showing how genetic deficiencies can exert enduring paternal effects on specific plant organ differentiation and how parental-of-origin genes interact to ensure normal embryogenesis.

Here the authors report a crystal structure of a pseudoknot-containing hammerhead ribozyme. Catalysis is based upon a general base (G N1) and a general acid (G O2’). The structure is closely similar to the pistol ribozyme, but mechanistically different.

In Saccharomyces cerevisiae, the left arm of chromosome XII only requires 12 genes to maintain cell viability, whereas 25 genes are needed for robust fitness. Here the authors demonstrate that the entire arm can be replaced by a neochromosome with completely artificial sequences.