Generative artificial intelligence is transforming how clinical evidence is generated and applied in clinical care by enabling real-time data integration, dynamic trial design and personalized decision support.
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References
Rajpurkar, P., Chen, E., Banerjee, O. & Topol, E. J. Nat. Med. 28, 31–38 (2022).
Sackett, D. L., Rosenberg, W. M. C., Gray, J. A. M., Haynes, R. B. & Richardson, W. S. BMJ 312, 71–72 (1996).
Greenhalgh, T., Howick, J. & Maskrey, N. BMJ 348, g3725 (2014).
Oh, S. S. et al. PLoS Med. 12, e1001918 (2015).
Ioannidis, J. P. A. Milbank Q. 94, 485–514 (2016).
Carini, C. & Seyhan, A. A. J. Transl. Med. 22, 411 (2024).
Riaz, I. B., Naqvi, S. A. A., Hasan, B. & Murad, M. H. Mayo Clin. Proc. Digit. Health 2, 361–365 (2024).
Ratwani, R. M., Sutton, K. & Galarraga, J. E. J. Am. Med. Assoc. 332, 1051–1052 (2024).
Huo, B. et al. JAMA Netw. Open 8, e2457879 (2025).
Gallifant, J. et al. Nat. Med. 31, 60–69 (2025).
He, J. et al. Nat. Med. 25, 30–36 (2019).
Ng Karen Ka, Y., Matsuba, I. & Zhang Peter, C. NEJM AI 2, AIra2400380 (2025).
Lekadir, K. et al. BMJ 388, e081554 (2025).
Ghassemi, M., Oakden-Rayner, L. & Beam, A. L. Lancet Digit. Health 3, e745–e750 (2021).
Ranji, S. R. JAMA Netw. Open 7, e2440901 (2024).
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The views expressed in this Comment are those of the authors and not necessarily those of the NIHR or Department of Health and Social Care.
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Imperial College London, the employer of L.T.C. and A.M., has received funding for research on AI via the NIHR Applied Research Collaboration NW London.
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Tudor Car, L., Wong, T.Y., Majeed, A. et al. Artificial intelligence and the future of evidence-based medicine. Nat. Health (2026). https://doi.org/10.1038/s44360-025-00002-z
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DOI: https://doi.org/10.1038/s44360-025-00002-z