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  • Despite widespread development of national physical activity policies over the past 20 years, global levels of physical activity have been largely unchanged (with around one in three adults and four in five adolescents not meeting recommended physical activity levels since 2012). This gap between policy development and real‑world impact highlights the need for stronger political prioritization, clearer leadership and effective multisectoral implementation.

    • Andrea Ramírez Varela
    • Adrian Bauman
    • Michael Pratt
    Policy Brief
  • This Perspective describes the Colombo Call to Action, a roadmap for countries in South-East Asia to accelerate diabetes prevention and care, aiming to close treatment gaps and meet 2030 coverage targets by setting urgent and actionable priorities.

    • Pradeep Joshi
    • Rahat Iqbal Chowdhury
    • Nalika Gunawardena
    Perspective
  • A large-scale school-based trial in China demonstrates that brief, culturally adapted training equips teachers to act as effective gatekeepers for youth suicide prevention by reducing stigma and enhancing willingness to intervene.

    • Guiyu Jiang
    • Lan Guo
    News & Views
  • A study using a large electronic health record database found that patients with colour vision deficiency had lower survival rates for bladder cancer, possibly because they may not be able to detect gross haematuria in time.

    • Masahito Jimbo
    News & Views
  • Large language models (LLMs) are emerging as powerful tools in healthcare, with a growing role in global health, particularly in low- and middle-income countries. This Perspective examines the current progress, challenges and prospects of LLMs in addressing health system disparities and supporting achievement of the Sustainable Development Goals.

    • Jasmine Chiat Ling Ong
    • Yilin Ning
    • Nan Liu
    Perspective
  • Environmental nanoplastics and microplastics enter the human gut where they encounter biological-selective barriers; the plausibility of plastics crossing these barriers is reviewed based on an understanding of the physiochemical properties of drug-delivery nanoparticles.

    • Cristina Di Fiore
    • Pasquale Avino
    Review Article
  • In this Perspective, Gao argues that the air comprises a complex mixture of pollutants and microorganisms that are not adequately measured in human exposome research.

    • Peng Gao
    Perspective

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