Abstract
Although the devastation of war is well recognized, no study has combined conflict intensity, humanitarian access, environment and infrastructure to assess their collective impact on health vulnerability. Here, using spatial and suitability models, we evaluated multidimensional vulnerabilities in Ukraine during the Russian invasion, including mental health, environmental stressors and infrastructure disruptions. We developed a multi-source database (news sources, UNICEF and Ukrainian ministries) on conflict-related health impacts, integrating data from a national survey (4,675 Ukrainian households) on sleep, mental health and casualties. Data were cleaned, geolocated across 461 cities (hromadas) and analysed using inverse distance weighting interpolation. We applied logistic and spatial regression to assess how conflict exposure and living conditions influence mental health, sleep loss and cold-related injury, creating a composite vulnerability index via weighted principal component analysis. Areas facing intense conflict, inadequate housing, power outages, food shortages, and limited healthcare and aid access showed heightened vulnerability. Cold, damp conditions, damaged housing and scarce resources sharply worsened household living conditions in eastern and northern Ukraine. Mental health burdens varied, with cold, damp, crowded housing, food insecurity and power outages as key drivers. Post-traumatic stress disorder, depression and insomnia were highest in regions with harsh winters, poor infrastructure and limited aid. War’s effects go beyond violence, with interacting conflict, environmental stressors and infrastructure damage shaping health and well-being outcomes.
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The data supporting this study’s findings will be available on request from the corresponding author.
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Acknowledgements
We thank all participants in Ukraine. This study was supported by the National Institute of Environmental Health Sciences Center (grant no. P30ES005022).
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U.H. and E.S.B. contributed to the conceptualization, data curation and initial drafting of the manuscript. U.H., S.T. and M.H.B. led the formal analysis and developed the figures. S.W., N.F., A.L.R. and J.P. supported the manuscript through critical review and editing. In addition, U.H. played a central role in the study’s conceptualization, methodological design, figure development, supervision and manuscript revisions. All authors had full access to the data, with data verification performed by U.H. The decision to submit the manuscript for publication was made collectively by all authors.
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Haque, U., Tayebi, S., Bukhari, M.H. et al. Geospatial insights of health vulnerability during the Ukraine war. Nat. Health 1, 326–337 (2026). https://doi.org/10.1038/s44360-026-00064-7
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DOI: https://doi.org/10.1038/s44360-026-00064-7


