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Understanding environmental exposures in early life for lifelong health

Understanding early-life environmental exposures is crucial for protecting lifelong health and should be prioritized in developing exposomics studies and infrastructures worldwide.

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Fig. 1: Exposome research can underpin early-life interventions to improve lifelong disease trajectories.
The alternative text for this image may have been generated using AI.

References

  1. Godfrey, K. M., Gluckman, P. D. & Hanson, M. A. Trends Endocrinol. Metab. 21, 199–205 (2010).

    Article  CAS  PubMed  Google Scholar 

  2. Di Renzo, G. C. et al. Int. J. Gynaecol. Obstet. 131, 219–225 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lange, P. et al. N. Engl. J. Med. 373, 111–122 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Twig, G. et al. N. Engl. J. Med. 374, 2430–2440 (2016).

    Article  PubMed  Google Scholar 

  5. Fuller, R. et al. Lancet Planet. Health 6, e535–e547 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Miller, G. W., Banbury Exposomics Consortium. Science 388, 356–358 (2025).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Warembourg, C. et al. Environ. Int. 146, 106174 (2021).

    Article  CAS  PubMed  Google Scholar 

  8. Güil-Oumrait, N. et al. JAMA Netw. Open 7, e2412040 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Montazeri, P. et al. Environ. Health Perspect. 131, 107006 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Maitre, L. et al. Nat. Commun. 13, 7024 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Guimbaud, J. B. et al. Commun. Med. 4, 98 (2024).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Jaddoe, V. W. V. et al. Eur. J. Epidemiol. 35, 709–724 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Gudi-Mindermann, H. et al. Environ. Res. 233, 116485 (2023).

    Article  CAS  PubMed  Google Scholar 

  14. Yang, T. C. et al. Curr. Environ. Health Rep. 10, 184–214 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Fernandes, A. et al. Int. J. Environ. Res. Public Health 20, 1746 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

ISGlobal acknowledges support from grant CEX2023-0001290-S funded by MCIN / AEI / https://doi.org/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program.

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Correspondence to Martine Vrijheid.

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The author declares no competing interests.

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Vrijheid, M. Understanding environmental exposures in early life for lifelong health. Nat. Health (2026). https://doi.org/10.1038/s44360-026-00130-0

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