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This review summarizes the role of FOXP3 in Treg plasticity, stability and function in axial spondyloarthritis, proposing that Treg dysregulation may contribute to disease pathogenesis and clinical manifestations.
Neural ODEs unify continuous dynamics and neural networks to model cellular dynamics in single-cell omics. This review surveys applications from trajectory modling to gene regulatory network inference, highlighting technical innovations from Optimal Transport to Flow Matching.
We synthesize advances in Acinetobacter T6SS biology, revealing how non-canonical structural solutions and multilayered regulation create an adaptable system for competition, persistence, and host immune modulation.
This Review article explores shared epigenetic mechanisms linking addictive drug use and depression, highlighting DNA methylation, histone modifications and non-coding RNAs as key contributors to their comorbidity.
A review of targeted single-cell RNA sequencing methods provides a practical guide to help researchers select the method most suited for their own experiments.
This Review examines experimental models for evaluating nucleic acid therapeutics, emphasizing the need for effective preclinical models to assess molecular and phenotypic efficacy at each stage of development.
A review summarizes the preparation and regenerative functions of mesenchymal stem cell-derived extracellular matrix (mECM) as a biomimetic material for bone, cartilage, muscle, tendon, and nerve repair, alongside its clinical translation prospects.
This review summarizes how molecular chaperones enable structures of small inactive-state GPCRs by improving particle alignment and effective molecular weight, delivering high-resolution cryo-EM insights and guiding community decisions on stabilization strategies.
This review summarizes how catabolic rewiring lets tumors harvest fuels and why dietary interventions have limited impact on nutrient supply but meaningful endocrine and immune benefits that burden tumor metabolism and complement standard care.
Our review summarizes recent advances in understanding the diverse roles of nuclear lamins in mitosis and discusses how their dysregulation - observed in several diseases - could affect this essential process required for faithful genome inheritance.
A review of recent innovations driving low-input phosphoproteomics, focusing on miniaturized workflows, multiplexed labelling, automated enrichment, and advanced acquisition methods for scarce biological material.
This Review highlights how extremophile microbiomes and synthetic biology approaches could support Martian terraforming by driving biogeochemical cycles, regolith transformation, and future life-support ecosystems.
This review applies the allostasis framework to complex diseases, linking chronic stress and allostatic load to drug addiction, immune diseases, and cancer, and highlights multi-omics, iPSC, and organoid technologies as emerging tools to study them.
This review outlines how mammalian cells adapt to cold via ion channels, uncoupling proteins, epigenetic changes, and RNA-binding proteins, with insights from hibernators highlighting therapeutic potential in metabolism and neuroprotection.
This review explores the genomic diversity, ecology, and functional potential of the bacterial family Endozoicomonadaceae in marine symbioses, highlighting their mutualistic to parasitic spectrum and key gaps to be addressed in future research.
This review summarizes the current progress on linguistic neural decoding from a machine learning perspective, focusing on the extraction and generation of text and speech information from brain activity patterns.
A review summarizes the knowledge about the role of redox homeostasis in the functioning of skin melanocytes and about the possibilities of influencing this status by natural compounds, including vitamins, as well as polyphenols or phytocannabinoids.
