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Intracortical microstimulation can elicit artificial sensations in persons who have lost sensation due to neurological injury or disease. This Review discusses intracortical microstimulation mechanisms, explores emerging approaches and notes challenges to current technologies.
This Review discusses how continuous monitoring technologies can enable early symptom detection, disease recurrence tracking and treatment response assessment, and how these technologies are being integrated into clinical practice.
This Review explores strategies for targeting and tracking RNA-LNP drugs, monitoring their in vivo behaviour, enhancing tissue-specific delivery, and using synthetic biology to control mRNA expression and protein localization.
A summary of CAR T-cell engineering approaches, including functional screening methods, gene editing and delivery advances, and optimization of metabolic fitness.
This Review discusses recent advances in vascular biology, biomaterials chemistry and 3D printing techniques for vascular patterning in engineered tissues.
This Review discusses the applications and clinical feasibility of established and upcoming strategies for the simultaneous imaging of multiple radiotracers.
This Review highlights recent progress in the development of molecular probes for the selective imaging of specific immune cells to aid understanding of the immune system, as well as disease diagnosis and prognosis.
This Review discusses how microfluidic and other fluidic devices can be leveraged at each stage of cell manufacturing for enhancing the potency, predictability and affordability of adoptive cell therapies.
This Review discusses genetic-engineering technologies for the rewiring of signalling networks in mammalian cells, including the recombination of native pathway components, cross-kingdom pathway transplantation and the development of de novo signalling.
This Review discusses strategies for the design of cell–drug conjugates, the techniques for their preparation, and their translational applications, particularly for the treatment of cancers and autoimmune diseases.
This Review discusses the characteristics of neural probes that are most likely to facilitate the clinical translation of invasive neural interfaces, the abiotic and biotic factors that contribute to their failure and emerging neural-interface architectures.
This Review discusses requirements—in cell sources, functional and safety testing, manufacturing and storage, and clinical-trial design—for the clinical advancement of cell therapies for Parkinson’s disease.
This Review highlights technological advances in exoskeleton technology from the past two decades, and challenges and opportunities in the exoskeleton-assisted rehabilitation of gait.
This Review discusses the advantages and limitations of self-supervised methods and models for use in medicine and healthcare, and the challenges in collecting unbiased data for their training.
This Review discusses the use of deep generative models, federated learning and transformer models to address challenges in the deployment of machine learning for healthcare.
This Review discusses established and emerging techniques for the multiplexed imaging of isolated tissues and cells and for non-invasive whole-body imaging.
This Review discusses the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal degeneration, as well as upcoming technologies for enhancing vision restoration.
This Review discusses the challenges and opportunities, biological and technical, of technologies for the analysis of cell-free DNA for the diagnosis of cancer.
