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In this Review, Xia et al. discuss the potential of colchicine as a therapy for atherosclerotic cardiovascular disease, highlighting evidence from clinical trials and mechanistic studies showing its effects on vascular inflammation, plaque stability, and immune and vascular cell function. They also emphasize that mixed results in recent cardiovascular and cerebrovascular trials highlight the need to integrate mechanistic insights with clinical evidence to refine colchicine use and guide precision anti-inflammatory strategies.
Zhou et al. review recent technological advances in mRNA-based biotechnologies for cardiovascular disease, examining preclinical applications, clinical trial outcomes, and the key challenges and future directions of these approaches.
Yeow et al. review the pathogenesis of rheumatic heart disease, discuss the role of valve biology in the progression of the disease, highlight ongoing research to address the critical healthcare burden and describe recent advances into the underlying pathogenic mechanisms.
Patsy et al. review the relationship between the heart and the nervous system during development and the functional consequences of cardiac innervation. They describe the generation of cardiomyocytes and autonomic neurons and propose a roadmap toward the development of cardiac innervation models.
McDonald et al. review studies of lymphatic vessels in the dural layer of the meninges and discuss the role of lymphatics in the function and maintenance of the central nervous system, aging, neuroimmunity and the progression of neurological disorders such as Alzheimer’s disease and Parkinson’s disease.
Fujimoto et al. provide a review of studies with serial coronary imaging in patients with lipid-lowering therapy and discuss the time course of the changes in plaque composition and burden.
Rogers et al. review the current imaging modalities to investigate the mechanisms of cardiac arrhythmias and discuss the future impact of machine learning and artificial intelligence on digital imaging.
Fankhauser et al. provide an in-depth review of preclinical mouse models used to study immune checkpoint inhibitor-associated myocarditis (ICI-myocarditis). They discuss potential improvements to the field that could, in the future, strengthen our understanding of ICI-myocarditis.
Nahlawi, Ptaszek and Ruskin review the implications of classic psychedelic use on the cardiovascular system and highlight their safety profiles and potential concerns to accompany their growing use in the clinic.
Lin et al. review the phenotypic shifts in vascular smooth muscle and endothelial cells that both drive and result from the chronic inflammation characteristic of atherosclerosis progression. Their review provides insights into potential therapeutic strategies aimed at modulating plaque cell phenotypes to improve clinical outcomes.
Haghighat et al. provide an overview of the newest advances in heart failure drugs, describing their mechanisms of action and performance in recent clinical trials, and discuss the most promising future directions for the field.
Gallerand et al. review the main human and murine macrophage populations, highlighting their phenotypic and functional diversity and how they contribute to cardiovascular health by regulating the inflammatory response.
Kiss et al. review preclinical and clinical evidence illustrating how sleep impacts the nervous, metabolic and immune systems, ultimately influencing the development and progression of atherosclerotic cardiovascular disease.
Carpenter and Maryanovich explore how hematopoietic homeostasis, governed by local niche and systemic mechanisms, is impacted by environmental and immune stressors like stress, sleep patterns, aging and inflammation and examine the implications for cardiovascular diseases.
Fleetwood et al. review the role of immune cell dysfunction and inflammation in cardiovascular diseases. Their Review explores immune cell metabolic reprogramming in response to environmental cues, offering insights into potential therapeutic strategies for cardiovascular diseases.
Eschenhagen and Weinberger provide a concise and comprehensive overview of the perspectives and challenges of heart repair with pluripotent stem cell-derived cardiomyocytes.
Goerlich et al. review the current knowledge of the cardiovascular complications of the post-COVID condition, including postural orthostatic tachycardia syndrome, myocardial injury, heart failure, myocarditis and arrhythmias, highlighting currently available and potential treatments.
Xie et al. discuss the strengths and limitations of induced cardiomyocyte-like cell reprogramming, the progress made in the past decade, with a focus on single-cell '-omics' research, and the obstacles that remain to be overcome for clinical application.
Raposo-Gutiérrez et al. review the recent knowledge on adaptive immunity in atherosclerosis, the identity of antigens driving the immune response and how to exploit antigen specificity in possible immunomodulatory strategies, including vaccination.
