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In this Review, the authors examine the evidence for cognitive impairment in individuals with bipolar disorder, explore underlying mechanisms and potential treatments, and advocate for incorporating cognitive screening into routine clinical practice.
In this Review, the authors explore how psychedelics such as LSD and psilocybin may disrupt maladaptive circuits and enhance neuroplasticity in obsessive–compulsive disorder (OCD), potentially offering a therapeutic approach for OCD by resetting pathological patterns and improving network connectivity.
This Review synthesizes current evidence on the link between metabolic dysfunction and mental health outcomes, highlighting the importance of integrating metabolic screening into psychiatric care.
In this Review the authors integrate the latest evidence on predictive processing alterations across the continuum of psychosis and discuss its potential applications as a biomarker and in therapeutic interventions.
This Review provides a critical assessment of current mechanistic and clinical evidence on the interaction between the gut microbiota and mental health to differentiate causative, correlative and bidirectional roles of the gut microbiota in psychiatric disorders. It highlights current priority questions and provides recommendations for the standardization of future studies.
This Review provides a comprehensive overview of the principles, processes and procedures in the application of machine learning for psychiatry and mental health research.
This Review explores the link between mood disorders and circadian disruptions, including social jet lag and shift work, and offers new perspectives for therapeutic development in future chronobiology research.
This Review discusses the key factors that comprise the mental load of motherhood and the need to provide support for a healthy transition to motherhood.
In this Review, the authors discuss the neurobiological mechanisms of motor cortex-related analgesia, drawing insights from both experimental data and clinical data.
This Review discusses the specific challenges and strategies in supporting individuals with ADHD during the critical transition to adulthood and outlines arguments for engaging and training parents.
In this Review the authors address the intersection between mental illness and homelessness in high-income countries, and propose policy and practice priorities to reduce homelessness and to improve health outcomes.
Erritzoe et al. review the current evidence from neuroimaging studies on psychedelics and discuss how these data advance our understanding of their action.
In this Review, the authors outline the current evidence on a precision medicine approach to Alzheimer’s disease risk reduction and propose how to integrate personalized strategies into routine clinical practice.
In this Review, Hodes and Kropp discuss the lessons we have learned from using sex as a biological variable in stress and mood disorder research and how we should shape our questions to avoid sex-based disparities in mental health care.
This Review discusses the adverse consequences of phenotypic imprecision for discovering reproducible biological correlates of psychopathology and provides recommendations for precision phenotyping that will help to overcome these challenges.
This Review summarizes the advances in personalized medicine and drug discovery in psychiatry and suggests a framework for the development of clinically relevant biological subtypes in the field.
