Biochemistry and Cell Biology articles for United Kingdom (UK)

Time frame: 1 June 2025 - 30 May 2026

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Count: 317

Article ‘Count’ for Biochemistry and Cell Biology.

Journal Count Share
3 2.33
Engineered Coiled-Coils Convert Cholera Toxin B-Pentamers into Programmable Membrane Fusogens 0.73
Modular RNA:DNA Nanostructures Enable Nanopore Profiling of rRNA Processing and rRNA Variants 0.90
Mapping Epidermal Growth Factor Receptor-1 Sorting Domains in Endosomes with a Calibrated Three-Dimensional Expansion Microscopy Toolkit 0.70
1 0.22
Transient receptor potential vanilloid 4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm’s canal cells 0.22
2 0.70
Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder 0.51
Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies 0.19
1 0.02
Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor-positive Breast Cancer Cells 0.02
10 5.33
Isotope Decluttering Reduces Spectral Complexity while Maintaining Protein Structure 0.20
Chromatography-Free Analysis of Mixtures Using a Two-Dimensional Mass Spectrometry (2DMS)-Enabled Quadrupole Time-of-Flight (QToF) Analyzer 1.00
Phosphorylated Chemiluminescent Probe Based on Spiro-cyclobutyl-phenoxy-dioxetane for the In Situ Light-Activated Sensing of Alkaline Phosphatase 0.07
Cyclic Peptide–Polymer Conjugate Characterization Using 193 nm Ultraviolet Photodissociation Tandem Mass Spectrometry 0.97
Ion Mobility Separation of Isomeric Acyl-lysine Marks in Peptides 0.29
Single Molecular Anchor-Assisted Nanopore Profiling of DNA Abasic Site Reactivity Dynamics 0.11
Thermal Desorption Gas Chromatography–Mass Spectrometry Methods for Minimally Invasive Organic Residue Analysis of Archeological Potsherds 1.00
Multiplexed Fiber-Optic Fluorescence for Functional Monitoring of Perfused Hearts 0.88
Ion-Pairing Hydrophilic Interaction Chromatography for Impurity Profiling of Therapeutic Phosphorothioated Oligonucleotides 0.56
Improved ESI-MS Sensitivity via an Imidazolium Tag (DAPMI-ITag) for Precise Sialic Acid Detection in Human Serum and CMAH-Null Mouse Tissues 0.26
7 5.05
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases 0.50
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase 0.94
Near-Infrared Triggered Anion Transport Induces Cancer Cell Death 1.00
Triply Responsive Control of Ion Transport with an Artificial Channel Creates a Switchable AND to OR Logic Gate 1.00
Rational Engineering of a Pseudaminic Acid Synthase Enzyme Enables Access to a 3-Fluoro Sugar with Motility Inhibition in Bacterial Pathogens 1.00
Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators 0.30
AI.zymes: A Modular Platform for Evolutionary Enzyme Design 0.31
1 0.71
Post-transcriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML 0.71
1 1.00
Mathematical Modeling Quantifies “Just-Right” APC Inactivation for Colorectal Cancer Initiation 1.00
1 0.06
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis 0.06
1 0.13
IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner 0.13
2 2.00
Polymer-tethered glycosylated gold nanoparticles as versatile tools for bio-sensing 1.00
Synthetic cell preservation strategies enable their storage and activation at the point of use 1.00
12 7.37
An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery 0.97
Single-position ligand modifications tune CB2R activity by targeting the toggle switch 0.17
Simulating enzyme catalysis with electrostatically embedded machine learning potentials 0.30
Dynamic protein structures in solution: decoding the amide I band with 2D-IR spectral libraries and machine learning 1.00
Protein-encapsulated fluorogenic probes for the selective detection of endogenous O-GlcNAcase (OGA) 0.07
Design and optimization of caspase-1-responsive fluorescent probes for pyroptosis imaging and anti-pyroptosis drug screening 0.13
De novo designed 3-helix bundle peptides and proteins with controlled topology and stability 0.94
Elucidation of the mechanism of partial activation of EPAC1 allosteric modulators by Markov state modelling 0.83
Double crossed? Structural and computational studies of an unusually crosslinked haem in iMethylococcus capsulatus/i cytochrome P460 0.84
Bicyclic anionic receptors for carboxylates in water 1.00
Resonsive anion transport with a Hamilton receptor-based anionophore controlled by photo-activation and host–guest competitive inhibition 1.00
A screening approach unveils an unknown Mn2+-dependent endopolyphosphatase activity in yeast 0.13
3 1.31
A TRPV4-dependent calcium signaling axis regulates lamellipodial actin architecture to promote cell migration 0.17
Corrections in single-cell migration path in vivo are controlled by pulses in polar Rac1 activation 0.31
Integrins coordinate basal surface contraction and oriented cell growth to enable thickening of a curved epithelium 0.83
5 3.33
Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos 0.54
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants 0.06
Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish 1.00
Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis 0.94
ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair 0.80
1 0.17
Polymer Length Governs DNA Adsorption Dynamics on Mineral Surfaces 0.17
1 0.80
Reduction of Hexaazatrinaphthylenes by Masked Divalent Lanthanide Dinitrogen Reagents 0.80
8 6.54
Structural basis of the protein kinase PKN1 HR1 domain oligomerization and differential regulation by RhoA and Rac1 1.00
Assembly of a homohexameric minichromosome maintenance complex is dependent on ATP and DNA 1.00
Cellular and functional insights into FIH-mediated hydroxylation of TRPA1 0.97
Mechanisms of permselectivity of connexin hemichannels to small molecules 1.00
Endophilin–lamellipodin–VASP, key components in fast endophilin–mediated endocytosis, control actin polymerization within liquid-like condensates 0.22
Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding 0.92
Structural unification of diverse transmembrane acyltransferases reveals a conserved fold for the transmembrane acyl transferase (TmAT) superfamily 1.00
Understanding the substrate recognition and catalytic mechanism of 2-O-methyl fucosidases from glycoside hydrolase family 139 0.43
12 5.02
A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells 0.78
Mitochondrial presequences harbor variable strengths to maintain organellar function 0.20
A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking 0.93
Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation 0.73
Talin–tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation 1.00
Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors 0.08
Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in toxoplasma 0.03
ATG16L1 controls mammalian vacuolar proton ATPase 0.08
WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation 0.19
Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity 0.08
A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1 0.56
A collagen IV fluorophore knock-in toolkit reveals trimer diversity in iC. elegans/i basement membranes 0.38
1 0.17
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis 0.17
1 1.00
Obesity and Gut–Brain Communication: The Cholinergic-Endocannabinoid Link 1.00
5 3.16
NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells 1.00
Erg currents support electrical bursting in murine anterior pituitary corticotrophs 0.83
Myosin 7a is required for maintaining the transducing stereocilia and for force transmission to the MET channel during cochlear hair cell development 0.88
Transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve neurotransmitter exocytosis 0.20
Robust coupling between the C‐tactile afferent and the hair follicle in humans 0.25
6 2.86
Chemoenzymatic Synthesis of N-Linked Glycan Receptors of H1N1 Influenza Virus on Human Airway Epithelial Cells 0.20
Metallo-coiled Coil Stabilization via Chemical Cross-Linking: Implications for Gd(III)-Based MRI Contrast Agents 0.73
Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control 0.71
Cation-Controlled Assembly, Activity, and Organization of Biomimetic DNA Receptors in Synthetic Cell Membranes 1.00
Modulating the Binding Kinetics of Bruton’s Tyrosine Kinase Inhibitors through Transition-State Effects 0.04
Coprecipitated Enzyme-Encapsulated Covalent Organic Frameworks for Biocatalysis 0.18
1 0.14
Absence of glomerular IgA1 deposition despite overexpression of galactose-deficient IgA1 in the B cell c1galt1 knockout mouse 0.14
6 2.45
Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes 0.10
Design principles of a membrane-spanning ubiquitin ligase 0.30
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis 1.00
Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication 0.83
Interaction with AK2A links AIFM1 to cellular energy metabolism 0.05
An NADH-controlled gatekeeper of ATP synthase 0.18
1 0.13
Depression, but not anxiety, is associated with epigenetic age accelerations among Asian older adults 0.13
12 2.53
Human haematopoietic stem cells remember inflammatory stress 0.12
De novo design of miniproteins targeting GPCRs 0.04
Dynamics of genetic and somatic trade-offs in ageing and mortality 0.10
Glycerol-driven TNAP activation in thermogenesis and mineralization 0.02
Cell-type-targeted mitochondrial transplantation rescues cell degeneration 0.02
Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair 0.15
Thymic health consequences in adults 0.19
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling 0.15
A direct role for a mitochondrial targeting sequence in signalling stress 0.14
Hepatic zonation determines tumorigenic potential of mutant β-catenin 0.79
The role of metabolism in shaping enzyme structures over 400 million years 0.15
Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors 0.65
3 0.16
Artificial allosteric protein switches with machine-learning-designed receptors 0.10
Democratizing protein language model training, sharing and collaboration 0.01
Scalable secondary metabolite production in Streptomyces using a plug-and-play system 0.05
2 0.92
In situ cryo-ET defines the ultrastructure of ER exit sites in human cells 0.67
Tissue rigidity phase transition shapes morphogen gradients 0.25
3 0.74
Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 0.55
Accurate single-domain scaffolding of three nonoverlapping protein epitopes using deep learning 0.11
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis 0.09
1 0.08
Pseudokinases can catalyse peptide cyclization through thioether crosslinking 0.08
101 42.63
CryoWriter: a robotic solution for improved Cryo-EM grid preparation 0.07
Deciphering cytokine-driven ADP-ribosylation signaling networks via Af1521-based mass spectrometry analysis of labile Glu/Asp-linkages 0.15
Measuring morphogen transport over multiple spatial scales in live zebrafish embryos 0.14
Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation 0.77
Structural basis and physiological significance of non-canonical G coupling to the melatonin MT receptor 0.13
PromoterAtlas: decoding regulatory sequences across Gammaproteobacteria using a transformer model 1.00
A dual phospholipase system instructs membrane hydrolysis during the final stages of plant autophagy 0.12
Structural basis of Ku-mediated activation of WRN exonuclease activity 0.11
A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis 0.63
Evolutionary remodeling of ubiquinone biosynthesis in Toxoplasma gondii reveals an essential bi-functional monooxygenase 0.20
Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities 0.02
AAK1-mediated phosphorylation of PDLIM5 and Talin1 promotes focal adhesion disassembly to accelerate cell migration 0.28
Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi 0.60
(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation 0.75
SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis 0.08
Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles 0.07
Structural basis for phosphorylation and allosteric regulation of bacterial glycogen phosphorylase by histidine phosphocarrier protein 0.15
Seven complete comparative maps of allosteric mutations in a protein family 0.63
Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters 0.38
Slowed Gompertzian ageing in long-lived results from expansion of decrepitude, not decelerated ageing 1.00
RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis 0.07
ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity 0.93
The genetic architecture of an allosteric hormone receptor 0.13
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution 0.78
Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability 0.01
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers 0.09
A model for drug transport across two membranes of Gram-negative bacteria by an MFS tripartite assembly 0.18
MFF budding from mitochondria regulates melanosome size and maturation 0.13
Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite 0.22
Impaired -Synuclein aggregate clearance in neuronal cells drive their spread to microglia through tunneling nanotubes 0.05
Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors 1.00
Site-specific profiling of structure and function of Igµ B cell receptor glycans 0.08
Design-driven optimization of low-cost reagent formulations for reproducible and high-yielding cell-free gene expression 0.06
Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature 1.00
Adaptations in tubulin determine distinct microtubule architectures, mechanics and drug susceptibility 0.38
Post-catalysis structures of mitochondrial complex I with ubiquinol-10 bound in the active site 0.60
ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex 0.72
Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences 0.55
Structural and dynamic insights into agonist recognition and function of the thromboxane A receptor 0.42
Allosteric and energetic remodeling of a PDZ domain by protein domain extensions 0.25
From single-sequences to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 0.95
Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4 T cells 1.00
Versican expression from lung fibroblasts suppresses pulmonary fibrosis 0.03
Integrative epigenetics and transcriptomics identify aging genes in human blood 0.16
A disulfide redox switch mechanism regulates glycoside hydrolase function 0.18
Structure of the Gq-coupled adhesion receptor ADGRL4 1.00
Enantioselective protein affinity selection mass spectrometry (E-ASMS) 0.08
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes 0.45
Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways 0.94
Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins 0.07
Structural characterisation of the fungal Pmt4 homodimer 0.18
The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein 0.09
Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis 0.07
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions 1.00
The genetic and biochemical basis of human leading strand synthesis 0.92
Vacuolar-type H+-ATPase-mediated extra-organellar buffering resolves mitochondrial dysfunction 0.08
Tuneable ion selectivity in vermiculite membranes intercalated with unexchangeable ions 0.18
PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast 0.06
Investigating the neuronal role of the proteasomal ATPase subunit gene in neurodevelopmental proteasomopathies 0.03
The SMC Hinge is a Selective Gate for Obstacle Bypass 0.33
Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle 0.88
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex 0.14
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids 0.81
Global comparative structural analysis of responses to protein phosphorylation 0.15
Large transient assemblies of Apaf1 constitute the apoptosome in cells 0.29
Signal-strapping as a protein-sequence search method for the discovery of metalloproteins 1.00
Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks 0.09
ProFlex as a linguistic bridge for decoding protein dynamics in normal mode analysis 0.50
Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms 0.27
Stabilized D2R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes 0.86
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 0.46
EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers 0.83
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor 0.34
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank 0.76
The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication 0.08
A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses 0.22
Capturing nematic order on tissue surfaces of arbitrary geometry 0.20
The topological properties of the protein universe 0.14
Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling 0.06
SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse 0.94
Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo 0.67
Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation 0.60
Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects 0.05
Sequence-based virtual screening using transformers 0.79
Basement membrane perforations guide anterior–posterior axis formation 0.05
A new paradigm of islet adaptations in human pregnancy: insights from immunohistochemistry and proteomics 1.00
Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors 0.62
Foam film vitrification for cryo-EM 1.00
A multi-tiered mechanical mechanism shapes the early neural plate 0.88
DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation 0.04
Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI 0.13
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis 1.00
Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation 0.06
Enhancing autophagy by redox regulation extends lifespan in Drosophila 0.89
Iron deficiency causes aspartate-sensitive dysfunction in CD8 T cells 0.97
TRPML2 in distinct states reveals the activation and modulation principles of the TRPML family 0.04
Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R 0.23
Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux 0.03
An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins 0.28
Control of tissue flows and embryo geometry in avian gastrulation 0.60
Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET 1.00
2 1.51
Mutational scanning reveals oncogenic mutations have diverse effects on signaling 0.58
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation 0.93
2 0.57
Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire 0.06
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age 0.51
3 0.11
The exposome of brain aging across 34 countries 0.02
MRI-based multi-organ clocks for healthy aging and disease assessment 0.07
The exposome of healthy and accelerated aging across 40 countries 0.02
4 1.21
AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network 0.19
Clustering the protein universe of life using DIAMOND DeepClust 0.08
GPU-accelerated homology search with MMseqs2 0.05
CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy 0.89
1 0.03
Glycan atlassing enables functional tracing of cell state 0.03
1 0.04
Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment 0.04
1 0.33
The actin cortex acts as a mechanical memory of morphology in confined migrating cells 0.33
4 2.32
Global reorganization of genome architecture at the transition to gametogenesis 0.85
Filament formation and NAD processing by noncanonical human FAM118 sirtuins 0.39
Global analysis of translocon remodeling during protein synthesis at the ER 0.33
Cell cycle regulation has shaped replication origins in budding yeast 0.75
2 1.42
TMEM145 is a principal component of outer hair cell stereocilia 0.42
Dietary-dependent sensitization of neuronal leptin signaling promotes neural repair after injury via cAMP and gene transcription 1.00
11 7.76
Structural basis for hemoglobin scavenging by CD163 reveals mechanism of ligand promiscuity 1.00
Fine-tuning ERK activity enables proliferation-differentiation balance during lineage specification of human embryonic stem cells 0.06
Calcium signaling regulates apoptosis-induced proliferation in Drosophila 0.50
Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane 1.00
Calcium signaling is required for anterior patterning in the mouse embryo 0.93
Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period 1.00
Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163. 0.25
Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction. 0.92
Nondisruptive inducible labeling of ER-membrane contact sites using the Lamin B receptor 1.00
Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice. 0.11
Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation 1.00
1 1.00
Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions. 1.00
1 0.38
Topology-Controlled Microphase Separation and Interconversion of Twist and Writhe Domains in Supercoiled Annealed Polyelectrolytes 0.38
22 11.12
Measurement of atomic scattering factors by cryoelectron microscopy 0.92
Suppression rather than activation of the integrated stress response (GCN2–ATF4) pathway extends lifespan in the fly 0.80
Novel Knotted Solenoid fold with order-shifted coil arrangement leads to nontrivial 31 topology 0.08
ATP synthase activity boosts membrane proton acceptance and lateral diffusion 0.13
Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions 0.08
GSK-3β coordinates axonal microtubule organization through Shot and Tau 0.89
Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα–RMI1–RMI2 0.14
Liganded LolCDE structures reveal a common substrate-LolE interaction guiding bacterial lipoprotein transport 1.00
Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery 0.78
Proton-selective conductance and gating of the lysosomal cation channel TMEM175 0.03
Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter 0.08
Reconstructing Waddington’s landscape from data 0.50
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing 0.14
The mechanism of pathogenic α1-antitrypsin aggregation in the human liver 0.65
A cytoplasmic motif in HLA-E that drives clathrin-mediated endocytosis and VCP-associated postendocytic trafficking 0.86
Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM 0.25
Temporal and spatial coordination of DNA segregation and cell division in an archaeon 0.85
An extended network for regulation of heme homeostasis in cells 1.00
12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation 0.92
Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition 0.73
Establishment of cell size–dependent growth rate via differential scaling of metabolite uptake and release 0.13
A proteomic signature of healthspan 0.17
8 3.44
Evolution of error correction through a need for speed 0.07
Termination of the integrated stress response 1.00
Strengthening nucleic acid biosecurity screening against generative protein design tools 0.08
Altered translation elongation contributes to key hallmarks of aging in the killifish brain 0.11
Escherichia coli with a 57-codon genetic code 1.00
Genetics, energetics, and allostery in proteins with randomized cores and surfaces 0.19
Scalable emulation of protein equilibrium ensembles with generative deep learning 0.92
Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape 0.07
24 7.69
Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET) 0.14
Architecture of clathrin-independent AP3:ARF1-coated carriers 0.61
RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages 0.13
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis 0.46
CryptoBank: A resource for the identification and prediction of cryptic sites in proteins 0.05
Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo 0.50
Specific SLC25 carriers regulate mitochondrial protein synthesis 0.14
A transposase-derived gene required for human brain development 0.05
AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer–regulated axis 0.15
NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C 0.05
The mechanical response of vinculin 0.44
Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity 0.50
Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active proteoform that supports myocardial function 0.17
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing 0.11
The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis 0.11
Global conformations of Pichia pastoris complex I are distinguished by the binding of a unique interdomain bridging subunit 1.00
The mechanistic basis of cargo selection during Golgi maturation 0.63
Mechanochemical waves in focal adhesions during cell migration 0.05
Elucidating tissue and subcellular specificity of the entire SUMO network reveals how stress responses are fine-tuned in a eukaryote 0.95
Membrane curvature association of amphipathic helix 8 drives constitutive endocytosis of GPCRs 0.05
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex 0.19
Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis 0.05
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration 0.17
Regulation of PIEZO1 channel force sensitivity by interblade handshaking 1.00
1 0.24
Ritscher-Schinzel syndrome can be characterized as an endosomal recyclinopathy 0.24
10 5.44
Transmembrane domain switching controls PINK1 import and fate in mitochondria 1.00
Novel tissue mechanics-guided cellular flows drive the formation of feather follicles 0.08
Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair 1.00
Structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol and its dysfunction in disease 0.83
The mechanism of cell-cycle-dependent proteasomal degradation of archaeal ESCRT-III homolog CdvB in Sulfolobus 1.00
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin–mediated mitophagy 0.10
Glycogen phase-separation drives macromolecular rearrangement and asymmetric division in E. coli 0.09
HDAC6-dependent deacetylation of SAE2 enhances SUMO1 conjugation for mitotic integrity. 1.00
Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat. 0.25
ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains. 0.08
1 0.10
Inositol phosphates as an overlooked phosphorous source in marine ecosystems 0.10
3 1.09
A Transferable and Robust Computational Framework for Class A GPCR Activation Free Energies 0.04
The Arch from the Stones: Understanding Protein Folding Energy Landscapes via Bioinspired Collective Variables 0.05
Long-Range Allosteric Modulation of DNA Duplex Dynamics Induced by Pyrrole-Imidazole Polyamide Binding 1.00

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