Bioinformatics and Computational Biology articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 1250

Article ‘Count’ for Bioinformatics and Computational Biology.

Journal Count Share
3 2.03
Quantum Dot Encoding for In-Solution Single-Molecule Biomarker Counting in Metastatic Prostate Cancer 0.93
Lung Cancer Cell–Macrophage Interaction System for Signal Pathway-Based Logic Analysis and Drug Testing 0.10
Chromato-Kinetic Fingerprinting Enables Multiomic Digital Counting of Single Disease Biomarker Molecules 1.00
2 1.06
Peptide Sequencing With Single Acid Resolution Using a Sub-Nanometer Diameter Pore 1.00
Rapid Single‐Cell Proteomics Using Nanoconfined Enzyme Reactors on a Microscale Digital Microfluidics Platform 0.06
1 1.00
Engineered Development: Directed Morphogenesis of an Embryonic Heart Tube 1.00
2 1.75
Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) 1.00
Impact of Comprehensive Lifestyle Interventions on Plasma Branched-Chain Amino Acid Concentrations: A Randomized Trial 0.75
1 1.00
Power and sample size calculations for testing the ratio of reproductive values in phylogenetic samples 1.00
61 50.91
Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14 1.00
A phenome-wide association study of CNVs genotyped from genome sequencing read depth in the UK Biobank 1.00
A next-generation episignature for Kabuki syndrome enables fine mapping of the impact of KMT2D variants to inform precision medicine 0.24
Principled measures and estimates of trait polygenicity 1.00
Sensitivity of HiFi long-read genome sequencing for difficult-to-detect pathogenic variants when applied to real-world clinical laboratory samples 1.00
Defining a tandem repeat catalog and variation clusters for genome-wide analyses and population databases 0.78
A flexible and unified framework for single- and multi-outcome Mendelian randomization using summary statistics 1.00
Putting polygenic scores in context: How intersectional factors affect relative and absolute genetic risk 1.00
Associations of genetic variants with gene expression factors reveal biological pathways underlying complex traits 0.80
Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies 1.00
Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants 1.00
Genetics of skeletal proportions across two different populations 0.59
Best practices for improving alignment and variant calling on human sex chromosomes 1.00
Inclusion bias affects common variant discovery and replication in a health-system linked biobank 1.00
MetaGLIMPSE: Meta-imputation of low-coverage sequencing data for modern and ancient genomes 0.67
Mind the gap: Characterizing bias due to population mismatch in two-sample Mendelian randomization 1.00
Higher eQTL power reveals signals that boost GWAS colocalization 1.00
Multiple-testing corrections in case-control studies using identity-by-descent segments 1.00
Expanded chromatin accessibility mapping explains genetic variation associated with complex traits in liver 1.00
Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues 0.05
Validation and context-dependent effects of a prostate cancer polygenic risk score in the All of Us Research Program 1.00
AncientProxy: A catalog of ancient proxies for modern genetic variants 1.00
A gene-specific variance-control approach corrects polygenicity-driven inflation observed in transcriptome-wide association studies 1.00
Functional analysis of NPR2 variants supports the therapeutic rationale for CNP in short stature 1.00
The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory 0.33
MIRAGE: A Bayesian statistical method for gene-level rare-variant analysis incorporating functional annotations 1.00
Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits 1.00
A deep dive into statistical modeling of RNA splicing QTLs reveals variants that explain neurodegenerative disease 1.00
Logica: A likelihood framework for cross-ancestry local genetic correlation estimation using summary statistics 1.00
A scalable framework for identifying allelic series from summary statistics 0.85
The utility of ultra-deep RNA sequencing in Mendelian disorder diagnostics 1.00
COMPADRE: Combined pedigree-aware distant relatedness estimation for improved pedigree reconstruction 0.81
Local ancestry-informed GWAS of warfarin dose requirement in African Americans identifies a CYP2C19 splicing QTL 1.00
Multiple-testing corrections in selection scans using identity-by-descent segments 1.00
Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits 0.80
Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program 1.00
Unveiling tissue heterogeneity through genomic interaction-encoded image representation of RNA-sequencing data 1.00
MosCoverY: A method to estimate mosaic loss of Y chromosome from sequencing coverage data 0.10
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies 1.00
Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution 0.14
Knockoff procedure improves susceptibility gene identifications in conditional transcriptome-wide association studies 1.00
Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications 1.00
Estimating gene conversion rates from population data using multi-individual identity by descent 1.00
Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyere 0.86
The Causal Pivot: A structural approach to genetic heterogeneity and variant discovery in complex diseases 1.00
Estimation of demography and mutation rates from one million haploid genomes 1.00
Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies 1.00
Rare-variant association studies: When are aggregation tests more powerful than single-variant tests? 0.78
Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components 1.00
A genealogy-based approach for revealing ancestry-specific structures in admixed populations 1.00
A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia 0.83
Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects 0.22
Haplotype analysis reveals pleiotropic disease associations in the HLA region 0.68
Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations 1.00
Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets 0.93
TransferTWAS: A transfer learning framework for cross-tissue transcriptome-wide association study 0.29
Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease 0.17
Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits 0.63
CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data 1.00
Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples 0.38
Beyond predictive R2: Quantile regression and non-equivalence tests reveal complex relationships of traits and polygenic scores 1.00
1 1.00
Genetic Associations with Placental and Pregnancy Proteins in Maternal Serum Identify Biomarkers for Hypertension in Pregnancy 1.00
5 4.33
Leveraging Kappa-Lambda Signatures in a Multistage Machine Learning Pipeline for B-Cell Lymphoma Detection by Flow Cytometry 1.00
Single-cell triomics analysis of tumor cells infiltrating patient-derived breast cancer scaffolds 0.33
Interpreting Deep Learning-based Prediction of BRAF V600E Mutation using Diagnostic Whole Slide Images in Skin Cutaneous Melanoma 1.00
Cross-Modality Learning for Predicting IHC Biomarkers from H&E-Stained Whole-Slide Images 1.00
Cross-Species Functional Genomic Screens Identify Novel Therapeutic Targets in Malignant Peripheral Nerve Sheath Tumors 1.00
1 0.15
Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index. 0.15
82 63.69
Determination from Nontargeted Metabolite Profiling Using Internal and External Standards 0.02
General Nuclear Magnetic Resonance Analysis Toolbox for Stats: A Comprehensive Module for Nuclear Magnetic Resonance-Based Chemometrics and Metabolomics 0.14
Single-Blood-Draw-Based Screening of Cancer Histotypes via Homologous Adhesion between Tumor Extracellular Vesicles and Bionic Microspheres 0.07
Rapid Noninvasive Classification of Prostatic Disease Using Paper Spray Ionization Mass Spectrometry (PSI-MS)-Based Nontargeted Metabolomics 0.67
Best Practices in GC–MS and GC × GC–MS-Based Metabolomics and Volatile Analyses: An International Survey 0.27
FlashMRM: An Automated Platform for MRM Method Generation and Iterative Optimization Based on High-Resolution Spectra 0.22
A Universal Framework for Blood Ionome Extraction and Intelligent Quality Control in 1H NMR Metabolomics 0.15
METLIN 960 K: An Empirical Tandem Mass Spectrometry Data Resource 1.00
Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry 1.00
Automating Middle-Down Mass Spectrometry Analysis for Extensive Antibody Characterization 1.00
Achieving Effective Batch-to-Batch Error Correction through Suppression Correction and Dual MSTUS Normalization 1.00
Automatic Blood Protein Enrichment by Magnetic-COF Polymers 1.00
Enhancing Sensitivity in Targeted Single-Cell Proteomics by Coupling a Dual Ion Funnel Interface with Triple Quadrupole Mass Spectrometer 1.00
Implementing Annotation Confidence Scoring in Untargeted Mass Spectrometry Workflows for Small Molecule Analysis 1.00
Artificial Intelligence-Based LC-OzESI-MRM for Isomer-Resolved Triacylglycerol Profiling by In-Source Ozonolysis 0.75
Mapping Cell Metabolic States by Image-Enabled Gating Metabolomic Cytometry 0.16
Lessons Learned in Orbitrap MS-Based Isotope Ratio Analysis of Organic Acid Mixtures 0.30
Untargeted Multiple Reaction Monitoring 0.67
Position-Specific Carbon Isotope Fingerprinting of Fluorinated Organics and Degradation Products 1.00
Ultra-High-Resolution MS1-Based Quantification with Chimeric Spectra Deconvolution Enables In-Depth Quantitative Proteomics and Application in Whole-Tissue Spatial Proteomics 1.00
Multidose Inline Size-Exclusion Chromatography–Flash Oxidation for Structural Analysis of Dynamic Protein–Ligand Interactions of Antithrombin III and Unfractionated Heparin 1.00
Ultrasensitive Detection of Tissue Lipids at the Femtomole Scale Using Low-Microflow Targeted Lipidomics 1.00
Exploration of Semiconductor Chip-Based Single-Molecule Protein Sequencing for Identification of Hemoglobin Variants 1.00
Uncertainty-Aware Learning of Multiple Conditions as a Framework for Streamlined Retention Time Prediction to Accelerate Method Development 1.00
Enhancing Proteoform Sequence Coverage Using Top-Down Mass Spectrometry with In-Source Fragmentation and Middle-Down Mass Spectrometry 1.00
Trend-Aligner: A Retention Time Modeling-Based Feature Alignment Method for Untargeted LC–MS Data Analysis 0.15
Comprehensive Curation and Harmonization of Small-Molecule MS/MS Libraries in Spectraverse 1.00
Quantitative Food Compounds Enable Dietary Ontology Referencing across 500 Foods and Human Plasma 1.00
Mass-Invariant Natural Log-Transformed Mass Spectra Enable Internal Calibration and De Novo Sequencing of Intact Proteins 1.00
Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona 1.00
Position-Specific Carbon Isotope Analysis of Glucose at Natural Isotope Abundance by Electrospray-Ionization Orbitrap Mass Spectrometry 1.00
Local Sample Cohesion Normalization: Preserving Inherent Biological Heterogeneity in Metabolomics Data 0.13
Coupling Liquid Chromatography to Orbitrap Isotope Ratio Mass Spectrometry: Overcoming Isotope Effects of Chromatography and Amount-Dependency by Peak Homogenization 0.17
NMR Spectral Alignment Utilizing a CryoEM Motion Correction Algorithm 1.00
Machine Learning-Assisted False Positive Detection in Metabolite Identification Workflows 0.29
xcms in Peak Form: Now Anchoring a Complete Metabolomics Data Preprocessing and Analysis Software Ecosystem 0.09
Analytical Considerations for the Development of Plate-Based Proteomics Platforms Using Isobaric Labeling 1.00
Multiplexed Data-Independent Acquisition-Based Proteomics Enabled by TMTpro Complementary Ions 1.00
Improving the Detection of Analyte Degeneracies in Untargeted Liquid Chromatography-Tandem Mass Spectrometry Data 1.00
Quantitative Assessment of the Target Engagement of a KRAS G12C Inhibitor in Formalin-Fixed Paraffin-Embedded Tumor Tissues Using Immunoaffinity Capture 2D-LC-MS/MS 1.00
Quantitative Native Proteomics by Capillary Zone Electrophoresis-Mass Spectrometry 1.00
Adaptive Modeling of Tandem Mass Spectrometry Data: Creation of the METLIN 960K MRM Database 0.88
High-Frequency Microfluidic Fractionation for Compound-Resolved Bioactivity-Based Metabolomics 0.11
CRB-FCC: A Standardized Nontargeted Analysis for Formula Assignment and Structure Annotation 0.08
High Dynamic Range Peptide Mass Spectrometry Using Segmented Precursor Ion Accumulation 1.00
Challenging the Database: Day-of-Analysis Calibration and UF Modeling for Reliable RRF Use in Medical Device Chemical Characterization 1.00
13-Plex DeAla Isobaric Reagents for High-Throughput Proteome Quantification 1.00
Plasma–Microdroplet Fusion for Online Post-Column Epoxidation: Toward Deep Lipidomics on Unmodified Mass Spectrometers 1.00
hxsparse: A Feature Extraction Algorithm for Hydrogen Exchange-Mass Spectrometry Based on a Linear Deuteration Model and LASSO Regularization 1.00
High-Throughput Top-Down Proteomic Analysis of Picogram-Level Complex Samples Using Multisegment Spray-Capillary CE-MS 1.00
Online Determination of mRNA Poly(A) Tail Length and Content 1.00
A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors 0.63
rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data 1.00
A New Approach to Large Multiomics Data Integration 0.05
CLAW-MRM: Comprehensive Lipidomics Automation Workflow for Multiple Reaction Monitoring Using Large Language Models 1.00
An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-Peptide 1.00
Reverse Spectral Search Reimagined: A Simple but Overlooked Solution for Chimeric Spectral Annotation 1.00
mzrtsim: Raw Data Simulation for Reproducible Gas/Liquid Chromatography–Mass Spectrometry-Based Nontargeted Metabolomics Data Analysis 1.00
Untargeted Discovery and Localization of Isomerized Residues in Neuropeptides 1.00
Online Coupling of Acoustic Droplet Levitation with Capillary Electrophoresis Mass Spectrometry Enables Midair Enrichment for Improved Proteomic Sensitivity 1.00
AUTO-SP: Automated Sample Preparation for Analyzing Proteins and Protein Modifications 1.00
High-Throughput Monoclonal Antibody Peptide Mapping Using 15-s HPLC Gradients Coupled with Cyclic Ion Mobility-Mass Spectrometry 1.00
Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling 1.00
Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset 0.42
Top-Down Proteomics for the Characterization and Quantification of Calreticulin Arginylation 1.00
High-Throughput Fluorescence-Guided Sequential Single-Cell MALDI-ICC Mass Spectrometry 1.00
Liquid Chromatographic and Mass Spectrometric Methods for Quantitative Proteomic Analysis from Single-Cell and Nanogram-Level Samples 1.00
Fast and Accurate Charge State Deconvolution of Protein Mass Spectra 0.80
Longitudinal Fragment Profiles Based on Multi-Collision Energy Tandem Mass Spectra Improve the Accuracy of Metabolite Identification in Untargeted Metabolomics 0.13
An Integrated Platform for High-Throughput Extraction and Mass Spectrometry-Based Quantification of Cholesterol and Sphingosine 1.00
Leveraging Complementary Ion Activation Methods with Proton Transfer Charge Reduction Reactions for Comprehensive Characterization of Monoclonal Antibody Heavy Chain Subunits 1.00
Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics 1.00
HyperXtract: Strategic Platform for Optimizing High-Bandwidth Nanopore Data Extraction Performance 1.00
Ultrafast Measurement of Circulating Ceramides in Human Cohorts 0.18
High-Throughput Screening of Amyloid Inhibitors via Covalent-Labeling Mass Spectrometry 1.00
Single-Cell Lipidomics by LC-MS Interlaboratory Study Reveals the Impact of X-ray Irradiation on a Pancreatic Cancer Cell Line and Its Bystanders 0.20
Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid Chromatography 1.00
Quantitative Determination of Click-Reactive Antisense Oligonucleotide and Its Reactivity in Rat Brains by Hybridization LC-MS/MS to Support Pretargeted PET Imaging 1.00
Ozonolysis Dissociation Kinetics for the Relative Quantification of Geometrical Phosphatidylcholine Isomers 1.00
TopLib: Building and Searching Top-Down Mass Spectral Libraries for Proteoform Identification 1.00
Improvements in Glycoproteomics through Architecture Changes to the Orbitrap Tribrid MS Platform 1.00
Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma 1.00
7 6.28
Expanding High‐Fidelity Multiplexing in Ultrasensitive Single‐Molecule Protein Detection via Proximity Barcoding 1.00
Single‐Injection Multi‐Omics Analysis by Direct Infusion Mass Spectrometry 1.00
Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet? 0.68
Intact Mass Profiling Reveals Phospho-Proteoforms of the Catenins (85–110 kDa) Regulated by Actomyosin Contractility 1.00
Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort 1.00
Real‐Time Eco–AI, Electrophoresis‐Correlative Data‐Dependent Acquisition with AI‐Based Data Processing Broadens Access to Single‐Cell Mass Spectrometry Proteomics 1.00
Integrating Ambient Ionization Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify RNA–Metabolite Correlations 0.60
1 1.00
Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program 1.00
2 1.79
Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis 0.99
Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk 0.80
1 0.09
Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes 0.09
4 2.30
Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance 1.00
A stem and progenitor cell–derived gene expression signature is prognostic for survival in myelofibrosis 0.10
Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women 1.00
Array Genotyping of Transfusion Relevant Blood Cell Antigens in 6946 Ancestrally Diverse Subjects 0.20
5 4.00
The NeuroBioBank whole-genome catalogue of human brain donors with central nervous system disorders 1.00
Repeat-associated ataxias in a German patient cohort analysed by targeted parallel long-read sequencing 0.01
Deep learning-based cell type profiles reveal signatures of Alzheimer’s disease resilience and resistance 1.00
Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer’s disease 0.99
Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome 1.00
4 1.35
The landscape of structural variation in pediatric cancer 1.00
IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma 0.04
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma 0.13
Gene context drift identifies drug targets to mitigate cancer treatment resistance 0.18
7 6.77
In Silico Reconstruction of Primary and Metastatic Tumor Architecture Using Geographic Information System–Augmented Spatial Transcriptomics 1.00
Path2Omics Enhances Transcriptomic and Methylation Prediction Accuracy from Tumor Histopathology. 0.77
BESTDR Enables Bayesian Quantification of Mechanism-Specific Drug Responses. 1.00
Modeling Early-Onset Cancer Kinetics Reveals Changes in Underlying Risk and the Impact of Population Screening. 1.00
Spatial Multi-omics Defines a Shared Tumor Infiltrative Signature at the Resection Margin in High-Grade Gliomas. 1.00
From Harmony to Discord: Multicellular Coordination in Tissues and Its Rewiring in Cancer. 1.00
Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification 1.00
28 16.45
Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects 0.88
D-SPIN constructs regulatory network models from scRNA-seq that reveal organizing principles of perturbation response 0.93
RegVelo: Gene-regulatory-informed dynamics of single cells 0.21
AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology 0.77
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome 0.10
Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles 0.19
Advancing precision health discovery in a genetically diverse health system 1.00
Whole-body molecular and cellular mapping of the laboratory mouse 0.64
Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis 0.03
CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response 0.05
Multimodal AI generates virtual population for tumor microenvironment modeling 1.00
An archaeal transcription factor bridges prokaryotic and eukaryotic regulatory paradigms 1.00
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells 0.80
Ancient RNA expression profiles from the extinct woolly mammoth 0.05
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution 1.00
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance 0.36
Reference genome choice compromises population genetic analyses 1.00
The genetic history of the Southern Caucasus from the Bronze Age to the Early Middle Ages: 5,000 years of genetic continuity despite high mobility 0.17
HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics 0.18
Coalescing single-cell genomes and transcriptomes to decode breast cancer progression 0.89
A de novo-originated gene drives rose scent diversification 0.08
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience 1.00
Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy 0.75
Human-specific gene expansions contribute to brain evolution 0.94
50,000 years of evolutionary history of India: Impact on health and disease variation 0.38
Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium 0.11
Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian tissue 1.00
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids 0.95
1 0.40
Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities 0.40
2 1.17
Framework for de novo sequencing of peptide mixtures via network analysis and two-dimensional tandem mass spectrometry 1.00
Transfer learning enables discovery of sub-micromolar antibacterials for ESKAPE pathogens from ultra-large chemical spaces 0.17
1 0.81
High-throughput Proteomics in Lymphangioleiomyomatosis: PMEL as a Diagnostic Biomarker, Construction of a Diagnosis Score and Evidence of Neutrophil Involvement. 0.81
1 0.29
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. 0.29
2 0.65
Utilizing Whole Genome Sequencing to Investigate a Coronavirus Disease 2019 Cluster Among Healthcare Workers in a Tertiary Care Facility in the Philippines: Insights and Implications for Infection Prevention and Control 0.50
Epidemiologic and Bacterial Factors Facilitating Long-Term Transmission of Multidrug-Resistant Tuberculosis in Shanghai, China 0.15
13 5.43
Adaptive genomic divergence parallels migratory behavior in Atlantic bluefin tuna 0.69
Gene flow from the European wild apple and selection shaped the domesticated apple genome 0.04
Rapid and repeated evolution of myosin copy number in threespine stickleback 0.88
Discovery of additional ancient genome duplications in yeasts 0.61
Population structure and domestication history of the Javan banteng 0.21
An early East Asian lineage with unexpectedly low Denisovan ancestry 0.07
Linear covariation between germline and somatic mutation rates across ciliates and mammals 0.38
Phylogenomics of enigmatic crustacean y-larvae reveals multiple origins of parasitism in barnacles 0.14
A new Cambrian stem-group echinoderm reveals the evolution of the anteroposterior axis 0.17
Shifts and critical periods in coral metabolism reveal energetic vulnerability during development 0.83
Population genomics of a sailing siphonophore reveals genetic structure in the open ocean 0.65
Independent evolutionary deterioration of the oxygen-transport system in Asian noodlefishes and Antarctic icefishes 0.20
Population histories of the Indigenous Adivasi and Sinhalese from Sri Lanka using whole genomes 0.56
2 1.10
Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo 1.00
TBX3 advances the developmental chromatin landscape toward the hepatic fate 0.10
4 2.18
Plasma Metabolite Associations for Risk and Laboratory Measures of Type 2 Diabetes in a Large-Scale Finnish Prospective Cohort. 0.40
Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention. 0.75
Integrative Metabolomics of Targeted and Non-Targeted Analyses in T2D Progression. 0.03
A Metabolomics Study of Cardiac Dysfunction in Hyperglycemia: Findings From the Atherosclerosis Risk in Communities (ARIC) Study and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) 1.00
1 0.78
Gene Family Expansions Provide Molecular Flexibility Required for Context‐Dependent Species Interactions 0.78
5 2.33
Unveiling Redox-Active Quinones in Pyrogenic Carbon by Nontargeted Metabolomics and Dual Chemical Tagging 0.82
Identifying Novel DNA Adducts in Amphipods and Developing Sample Preparation for Adductomics Using Dispersive Solid-Phase Extraction 0.14
Evolutionary Advantages of Multiple Arsenic Binding Sites in an ArsR Transcriptional Repressor 0.80
Quantitative Exposomics Targeting over 200 Toxicants and Key Biomarkers at the Picomolar Level 0.50
Using Environmental Mixture Exposure-Triggered Biological Knowledge-Driven Machine Learning to Predict Early Pregnancy Loss 0.07
6 2.96
Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure 0.08
Cardiac sarcoidosis: new insights beyond the granuloma using spatial proteomics 0.90
A polygenic risk score for peripheral artery disease and major adverse limb events 1.00
<atl>Automated patch clamp data improve variant classification and penetrance stratification for iSCN5A/i –Brugada syndrome</atl> 0.54
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease 0.15
Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension 0.29
1 1.00
DNA/RNA-Based Next-Generation Sequencing Improves the Early Diagnosis and Management of Neoplastic Bile Duct Strictures: A 6-Year, Prospective, Multi-Institutional, Real-Time Study 1.00
7 6.40
DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development 1.00
The eukaryotic homology search complex distorts donor DNA structure to probe for homology 1.00
MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis 1.00
MYOD represses gene expression from non-E-box motifs 0.76
A cell type-specific surveillance complex represses cryptic promoters during differentiation in an adult stem cell lineage 1.00
A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change 0.94
Restrictor slows RNAPII elongation to promote termination at noncoding RNA loci 0.70
64 50.05
Hash functions in nucleotide sequence analysis 1.00
Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity 0.73
Lignature provides a curated resource of ligand induced transcriptomic signatures for signaling inference 1.00
Centromeric instability and chromoanasynthesis observed in nine supernumerary marker chromosomes resolved with long-read genome sequencing 0.22
Parallel analysis of replication timing, gene expression and copy number with PARTAGE 1.00
Minimizing reference bias with an imputed personalized reference 1.00
Assessing the readiness of Oxford Nanopore sequencing for clinical genomics applications 0.11
spRefine denoises and imputes spatial transcriptomics with a reference-free framework powered by genomic language model 1.00
A systems view on DNA damage response kinetics in Tetrahymena 0.14
Autoencoders for genomic variation analysis 0.67
Read-level genotyping of short tandem repeats using long reads and single-nucleotide variation with STRkit 0.33
Quantifying pathological progression from single-cell transcriptomic data with scPSS 0.38
Stable genome structures in living fossil fishes 0.20
Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation 1.00
A spectral component approach leveraging Identity-by-Descent graphs to address recent population structure in genomic analysis 1.00
Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations 1.00
Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of Drosophila testis tumor stem cell–like cells 1.00
Genome-wide nucleosome and transcription factor responses to genetic perturbations reveal chromatin-mediated mechanisms of transcriptional regulation 1.00
ML-MAGES enables multivariate genetic association analyses with genes and effect size shrinkage 1.00
Joint imputation and deconvolution of gene expression across spatial transcriptomics platforms 1.00
Graph-based deep reinforcement learning for haplotype assembly with Ralphi 1.00
Unified integration of spatial transcriptomics across platforms with LLOKI 1.00
Label-free selection of marker genes in single-cell and spatial transcriptomics with geneCover 1.00
Partitioned Multi-MUM finding for scalable pangenomics with MumemtoM 1.00
Predicted protein 3D structure provides essential insights into the genetic architecture underlying phenotypic diversity in maize 0.58
BayesRVAT enhances rare-variant association testing through Bayesian aggregation of functional annotations 0.30
Epigenetic and evolutionary features of ape subterminal heterochromatin 1.00
Iterative improvement of deep learning models using synthetic regulatory genomics 0.75
Interpretable phenotype decoding from multicondition sequencing data with ALPINE 1.00
Integrative chromatin state annotation of 234 human ENCODE4 cell types using Segway 0.45
Strong bias in long-read sequencing prevents assembly of iDrosophila melanogaster/i Y-linked genes 0.33
Long-read reconstruction of many diverse haplotypes with devider 1.00
Recalibrating differential gene expression by genetic dosage variance prioritizes functionally relevant genes 0.53
ScisTree2 enables large-scale inference of cell lineage trees and genotype calling using efficient local search 1.00
Phylogenetic relatedness rather than aquatic habitat fosters horizontal transfer of transposable elements in animals 0.10
ERC2.0 evolutionary rate covariation update improves inference of functional interactions across large phylogenies 0.89
Robust 16S rRNA classification based on a compressed LCA index 1.00
Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy-chain locus 0.60
Pangenome-based genome inference using integer programming 0.33
Tree-based differential testing using inferential uncertainty for RNA-seq 1.00
Estimating the size of long tandem repeat expansions from short reads with ScatTR 1.00
Accurate detection of tandem repeats from error-prone sequences with EquiRep 1.00
Unveiling the functional fate of duplicated genes through expression profiling and structural analysis 0.20
Multicondition and multimodal temporal profile inference during mouse embryonic development 1.00
FocalSV enables target region-based structural variant assembly and refinement using single-molecule long-read sequencing data 1.00
Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation 1.00
Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy 1.00
Overcoming limitations to customize DeepVariant for domesticated animals with TrioTrain 1.00
Mitotic chromosomes harbor cell type– and species-specific structural features within a universal loop array conformation 0.43
The ggRibo single-gene viewer reveals insights into translatome and other nucleotide-resolution omics data 1.00
Aggregation of recount3 RNA-seq data improves inference of consensus and tissue-specific gene coexpression networks 1.00
Genetic variation in recalcitrant repetitive regions of the iDrosophila melanogaster/i genome 1.00
CGC1, a new reference genome for Caenorhabditis elegans 0.47
Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes 1.00
A map of enhancer regions in primary human neural progenitor cells using capture STARR-seq 0.95
Highly accurate assembly polishing with DeepPolisher 0.72
Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits 1.00
Spatial domain detection using contrastive self-supervised learning for spatial multi-omics technologies 1.00
Verkko2 integrates proximity-ligation data with long-read De Bruijn graphs for efficient telomere-to-telomere genome assembly, phasing, and scaffolding 0.71
Accurate short-read alignment throughir/i-index-based pangenome indexing 1.00
QuadST identifies cell-cell interaction-changed genes in spatially resolved transcriptomics data 0.67
Contiguous and complete assemblies ofiBlastocystis/igut microbiome–associated protists reveal evolutionary diversification to host ecology 1.00
Analytical validation of germline small variant detection using long-read HiFi genome sequencing 1.00
Dissecting multilayer cell–cell communications with signaling feedback loops from spatial transcriptomics data 0.25
1 0.31
Fortunian archaeocyath sponges acquired biomineralization in the beginning of the Cambrian explosion 0.31
1 0.99
Multiomics combined with machine learning defines unique molecular subtypes of cholangiocarcinoma and identifies TNK1 as a therapeutic target. 0.99
1 0.87
Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells 0.87
1 1.00
Estimating causal effects of C-reactive protein on disease and health outcomes using multivariable Mendelian randomization adjusting for heritable confounding 1.00
4 3.92
Genetic determinants of BMI, diet, and fitness interact to partially explain anthropometric obesity traits but not the metabolic consequences of obesity in men and women 1.00
Metabolic remodeling and the modulatory role of vitamin D deficiency in African American children and adolescents with obesity 0.96
Genetic regulation of exosome biogenesis pathway in human adipose and muscle tissue and association with obesity and insulin resistance 1.00
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci 0.96
1 0.25
Structure of the Genetic Risks for Psychiatric Disorders in Swedish Population-Based Registries. 0.25
1 1.00
Drug-Gene Interactions and Clinical Outcomes After Vascular Surgery in the Million Veteran Program 1.00
12 11.86
Glucose-6-phosphate dehydrogenase variants modify 3D genomic organization to suppress maladaptive gene expression and vascular disease 1.00
Constitutive activation of a hybrid two-component regulator reveals cross-regulation of polysaccharide utilization genes in Bacteroides 1.00
An artificial intelligence optimized hepatic differentiation unveils NR5A2 and AP-1 transcriptional regulation in hepatic maturation 0.86
Kinase signaling in liver disease via clinical-trial-on-a-PamChip: A distinctive methodology for drug mechanisms and personalized medicine 1.00
Phosphoregulation of RAD51AP1 function in homology-directed repair 1.00
Depletion of individual dietary amino acids induce distinct metabolic and chromatin states 1.00
Lineage-specific amino acids define functional attributes of the protomer-protomer interfaces for the Rad51 and Dmc1 recombinases 1.00
HMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription 1.00
Large-scale functional assessment of variants of the potassium channel Kir2.1: clinical and comparative insights 1.00
Transcriptome and chromatin accessibility divergence during differentiation of a bipotential progenitor cell population to erythroblasts and megakaryocytes 1.00
ATP hydrolysis-driven structural transitions within the S. cerevisiae Rad51 and Dmc1 nucleoprotein filaments 1.00
Leveraging RNA-seq deconvolution to improve complex in vitro model characterization 1.00
1 0.22
Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion 0.22
8 5.55
Association of genetic risk and physical activity with incident type 2 diabetes 0.14
Hypothalamic-pituitary deficiency after radiation in childhood cancer survivors is associated with rare variants in TNS2 1.00
Impaired arginine, citrulline, and glutamine metabolism in type 2 diabetes: insights from a stable isotope study 1.00
Biomarkers of Insulin Resistance and Their Performance as Predictors of Treatment Response in Overweight Adults 0.22
Multiplatform Molecular Testing as an Adjunct to Fine Needle Aspiration in the Evaluation of Pediatric Thyroid Nodules 0.88
Plasma Branched-Chain Amino Acid and Cardiovascular Disease Risk Factors: A Longitudinal Analysis of a Lifestyle Trial 0.90
Compartment-Specific Metabolic Alterations to Insulin Reflect Adiposity-Driven Variation and Predict Type 2 Diabetes 0.60
Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes 0.82
6 5.53
Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer 1.00
Alcohol use disorder-associated gene FNDC4 alters glutamatergic and GABAergic neurogenesis in neural organoids 1.00
The hematopoietic stem cell MYB enhancer is essential and recurrently amplified during T-cell leukemogenesis 1.00
The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia 0.88
Defective Notch1 signaling in endothelial cells drives pathogenesis in a mouse model of Adams-Oliver Syndrome 0.94
Gene-environment interactions modulate the phenotypic severity in mouse models of congenital craniofacial syndromes 0.71
1 0.31
Molecular-Based Ecosystem to Improve Personalized Medicine in Chronic Myelomonocytic Leukemia. 0.31
1 1.00
Genetic and non-genetic drivers of histological progression and regression in MASLD 1.00
1 0.64
Molecular Epidemiology of iMycobacterium tuberculosis/i Across 3 Distinct Geographic Sites in South Africa 0.64
1 0.20
An allostatic load domain‐specific metabolic profile in young adults: The African‐PREDICT study 0.20
1 0.87
Development of Gene-Expression Panel Predictive of Local Recurrence, Metastasis, and Overall Survival in Intermediate to High-risk Cutaneous Squamous Cell Carcinoma: A Cohort Study 0.87
6 5.42
A Broadly Accessible Approach to Elucidate the Carbon–Carbon Double Bond Position in Unsaturated Lipids by a Post-column In-Line Photochemical Reaction and Mass Spectrometry 1.00
Time-Resolved Native Mass Spectrometry for Direct Measurement of Biomolecular Kinetics 1.00
Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics 1.00
Unnatural Cytosine Analogs Potentiate a Customizable, Enzymatic Method for Integrated Epigenetic and Four-Base Genetic Sequencing 1.00
Chemical Proteomics Reveals Regulation of Bile Salt Hydrolases via Oxidative Post-translational Modifications 1.00
Intersegment Transfer and the Dynamical Architecture of Fis Protein–DNA Multimer Complexes 0.42
1 1.00
Genetic Testing in the Management of Adult CKD 1.00
2 2.00
Interaction of genetic and lifestyle risk scores on colorectal cancer risk across five racial and ethnic populations 1.00
Performance of multiple multi-cancer detection tests using a large independent reference set (Alliance A212102) 1.00
2 1.20
Statistical inference for cell type deconvolution 1.00
Root cause discovery via permutations and Cholesky decomposition 0.20
1 0.61
Nephrotic syndrome genomic discovery in the Mass General Brigham Biobank identifies monoallelic MEFV variants as a risk factor for focal segmental glomerulosclerosis 0.61
1 1.00
Toward a Liquid Biopsy: Greedy Approximation Algorithms for Active Sequential Hypothesis Testing 1.00
23 20.72
Chromatin architectures underlying plasmid-based assays for regulatory variant effects 1.00
Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia 0.95
Mutual antagonism between PRC1 condensates and SWI/SNF in chromatin regulation 1.00
Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption 0.82
Multi-site DMS probing reveals higher-order structure of RNA-protein complexes in living cells 1.00
Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes 1.00
Cell-free genomics reveals fundamental regulatory principles of the Mycobacterium tuberculosis transcription cycle 1.00
Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation 0.75
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability 0.78
BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation 1.00
Delineating the copy-number substructure of metastatic tumors with CopyKit 0.95
Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module 1.00
A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence 1.00
The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain 0.50
Requirements for establishment and epigenetic stability of mammalian heterochromatin 1.00
Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation 1.00
Single-stranded DNA-binding proteins are essential components of the architectural LDB1 protein complex 1.00
PALB2 and 53BP1 govern post-resection homologous recombination DNA repair 0.80
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA 1.00
Chromatin architecture mapping by multiplex proximity tagging 1.00
Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation 0.56
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability 0.61
FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate 1.00
13 7.22
Genetic investigation of the association between maternal dietary patterns and offspring ADHD 0.02
Convergent coexpression reveals shared biological mechanisms underlying common and rare variant risk in six neuropsychiatric disorders 1.00
Integrative GWAS identifies novel loci and genetic links between psychiatric and metabolic factors in anorexia nervosa 0.33
Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders 0.20
A large-scale DNA methylation study of alcohol use identified robust associations and cell-type specific insights 1.00
Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health 0.98
Within- and between-family genetic effects on educational achievement vary across countries and ages 0.20
Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals 0.83
Genome-wide meta-analyses of cross substance use disorders in diverse populations 1.00
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa 0.18
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study 0.94
Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology 0.44
Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression 0.10
2 0.39
Automated High-Throughput Raman Spectral Framework for Cellular Differentiation Monitoring 0.33
Revealing Single-Amino Acid Recognition and Cleavage Dynamics Using Plasmonic Biosensors 0.06
58 36.73
Distinct genetic architecture in the tails of complex traits 0.92
Mechanism of age-related accumulation of mtDNA mutations in human blood 1.00
Accelerating scientific discovery with Co-Scientist 0.67
Non-invasive profiling of the tumour microenvironment with spatial ecotypes 0.97
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup 0.96
Pervasive and programmed nucleosome distortion on single chromatin fibres 0.91
Chromosomal fusions trigger rediploidization of autopolyploid genomes 0.01
The evolutionary history and unique genetic diversity of Indigenous Americans 0.03
Transposable elements are driving rapid adaptation of Enterococcus faecium 0.92
Mapping convergent regulators of melanoma drug resistance by PerturbFate 1.00
Ancient DNA reveals pervasive directional selection across West Eurasia 0.85
Multiomics and deep learning dissect regulatory syntax in human development 0.93
Saturation editing of reveals distinct dominant and recessive disorders 0.23
A sorghum pangenome reference improves global crop trait discovery 0.76
Genome modelling and design across all domains of life with Evo 2 1.00
Largest Silurian fish illuminates the origin of osteichthyan characters 0.02
The oldest articulated bony fish from the early Silurian period 0.03
BCDX2–CX3 and DX2–CX3 complexes assemble and stabilize RAD51 filaments 1.00
Functional dissection of complex trait variants at single-nucleotide resolution 0.96
A disease model resource reveals core principles of tissue-specific cancer evolution 0.02
Single-cell and isoform-specific translational profiling of the mouse brain 1.00
Lasting Lower Rhine–Meuse forager ancestry shaped Bell Beaker expansion 0.33
Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes 0.15
Efficient near-telomere-to-telomere assembly of nanopore simplex reads 0.50
Biological insights into schizophrenia from ancestrally diverse populations 1.00
Insights into DNA repeat expansions among 900,000 biobank participants 0.86
An expanded registry of candidate -regulatory elements 0.96
Stress controls heterochromatin inheritance via histone H3 ubiquitylation 0.87
An integrated view of the structure and function of the human 4D nucleome 0.70
Causal modelling of gene effects from regulators to programs to traits 0.95
Mapping the genetic landscape across 14 psychiatric disorders 0.40
Estimation and mapping of the missing heritability of human phenotypes 0.53
Eight millennia of continuity of a previously unknown lineage in Argentina 0.33
Specificity, length and luck drive gene rankings in association studies 0.94
Evidence for improved DNA repair in long-lived bowhead whale 0.91
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes 0.08
The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies 0.00
Population-specific polygenic risk scores for people of Han Chinese ancestry 0.04
Hotspots of human mutation point to clonal expansions in spermatogonia 0.71
The formation and propagation of human Robertsonian chromosomes 1.00
A haplotype-based evolutionary history of barley domestication 0.06
Spatial joint profiling of DNA methylome and transcriptome in tissues 1.00
Multiple overlapping binding sites determine transcription factor occupancy 1.00
Single-cell transcriptomic and genomic changes in the ageing human brain 1.00
Thymic epithelial cells amplify epigenetic noise to promote immune tolerance 1.00
Elementary 3D organization of active and silenced E. coli genome 0.65
Whole-genome sequencing of 490,640 UK Biobank participants 0.20
Parent-of-origin effects on complex traits in up to 236,781 individuals 0.06
Novel assembly of a head–trunk interface in the sister group of jawed vertebrates 0.25
Mouse lemur cell atlas informs primate genes, physiology and disease 0.88
A molecular cell atlas of mouse lemur, an emerging model primate 0.88
Complex genetic variation in nearly complete human genomes 0.74
Pathology-oriented multiplexing enables integrative disease mapping 0.09
Ongoing genome doubling shapes evolvability and immunity in ovarian cancer 0.92
A haplotype-resolved pangenome of the barley wild relative 0.02
Cryptic variation fuels plant phenotypic change through hierarchical epistasis 0.69
Range extender mediates long-distance enhancer activity 0.82
In vivo mapping of mutagenesis sensitivity of human enhancers 1.00
22 19.90
Scoring gene importance by interpreting single-cell foundation models 0.97
TxPert: using multiple knowledge graphs for prediction of transcriptomic perturbation effects 0.50
Reference-free discovery with barcoded single-cell sequencing 0.82
Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics 1.00
Single-molecule peptide sequencing through reverse translation of peptides into DNA 1.00
Sensitive detection of cancer antigens enabled by user-defined peptide libraries 0.99
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM 1.00
Revealing a coherent cell-state landscape across single-cell datasets with CONCORD 1.00
Computational prediction of human genetic variants in the mouse genome 0.67
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles 0.99
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets 0.61
Mapping single-cell diploid chromatin fiber architectures using DAF-seq 1.00
Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut 1.00
KATMAP infers splicing factor activity and regulatory targets from knockdown data 1.00
Tissue and cellular spatiotemporal dynamics in colon aging 0.96
Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic 1.00
Translation efficiency covariation identifies conserved coordination patterns across cell types 1.00
Predicting the translation efficiency of messenger RNA in mammalian cells 1.00
Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases 0.78
Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state 1.00
Identification of non-canonical peptides with moPepGen 0.62
Improving gene isoform quantification with miniQuant 1.00
8 5.87
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm 1.00
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation 0.90
Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues 0.92
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets 0.92
CellNavi predicts genes directing cellular transitions by learning a gene graph-enhanced cell state manifold 0.04
Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin 1.00
RNA-binding proteins mediate the maturation of chromatin topology during differentiation 0.09
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate 1.00
368 244.71
Multi-ancestry transcriptome-wide association studies uncover insights into breast cancer genetics and biology 0.67
Brieflow: an integrated computational pipeline for high-throughput analysis of optical pooled screening data 1.00
Primer PICKR: literature-mined scoring platform for robust RT–qPCR primers 1.00
GWAS of extended prescription analgesic use identifies genetic loci in chronic pain 0.29
Accessing medically relevant complex regions with a pangenome graph of 20 near-complete Japanese haplotypes 0.44
qChIP-MS reveals the local chromatin composition by label-free quantitative proteomics 0.04
Benchmarking genome choice in functional genomics analyses 1.00
Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy 0.02
N-Orbit: towards a universal model and metric for comparing tissue microenvironments 0.67
PATTY corrects open-chromatin bias for improved bulk and single-cell CUT&Tag profiling 0.88
Ecological and genomic signatures of the convergent evolution of planktivory in fossil and living reef fishes over deep time 0.82
Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk 0.99
DGAT: a dual-graph attention network for inferring spatial protein landscapes from transcriptomics 1.00
Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes 0.01
Recurrent structural variation and recent turnover at the 17q21.31 locus in humans and great apes 0.61
Inferring stochastic dynamics by biophysical Neural ODE using single-cell transcriptomics 0.20
Decoding spatial transcriptomics across multicellular and subcellular resolutions 0.97
A long-read human pangenome initiative for comprehensive interpretation of nuclear-embedded mitochondrial DNA 0.07
Bridging sequence-structure motifs and genetic variants for genome-wide dynamic RNA-protein interaction profiling 0.10
Two distinct SWI/SNF complexes direct chromatin-linked transcriptional programs in Toxoplasma 1.00
Heterogeneous endocrine cell composition defines human islet functional phenotypes 1.00
Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram 0.78
Local graph estimation with pathwise false discovery control 1.00
Continental-scale genomic surveillance of Plasmodium falciparum malaria across sub-Saharan Africa with rapid nanopore sequencing 0.04
Multi-omics integration predicts the incidence of 17 diseases in the UK Biobank 1.00
CLASHub is an integrated database and analytical platform for microRNA-target interactions 1.00
Tumors hijack immune-privileging regulons via distinct cell types to confer T cell desertion and immunotherapy resistance across various cancers 1.00
The incomplete dominance of gene expression controlled by Trans-eQTL hotspots contributes to heterosis in maize 0.45
SCOTCH: isoform-level characterization of gene expression through long-read single-cell RNA sequencing 1.00
A versatile multi-components mixed model for bacterial-Genome Wide association studies 0.14
Enhancer placement impacts transcriptional dynamics in Drosophila embryos 1.00
Rapid adaptive increase of amylase gene copy number in Indigenous Andeans 0.76
Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries 0.04
Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system 0.07
BiGER: Bayesian rank aggregation in genomics with extended ranking schemes 0.83
SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration 0.05
Functional impact of genetic background on variable expressivity in neurodevelopmental disorders 0.75
Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT 1.00
Admixture-informed polygenic risk reporting using the ePRS framework 1.00
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients 0.53
Spatial transcriptomics atlas of inflammatory bowel disease to guide implementation in research consortiums and clinical trials 1.00
Dynamic partitioning of a critical elongation factor between LEC and SEC regulates cellular snRNA and proliferation-related mRNA transcription 0.20
Early and late RNA eQTL are driven by different genetic mechanisms 1.00
Chromatin accessibility landscape and its association with heterosis in maize hybrids 0.08
Integrating common and rare variants improves polygenic risk prediction across diverse populations 1.00
Improving genomic prediction accuracy of complex traits by integrating massive types of functional annotation information 0.08
szKendall: spatial-structural-zero-aware dissimilarity measures for subtype discovery using single cell Hi-C data 1.00
Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping 1.00
Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders 0.11
Prediction and functional interpretation of inter-chromosomal genome architecture from DNA sequence with TwinC 0.89
Igh nuclear speckle association promotes V(D)J recombination 1.00
Population differences of chromosome 22q11.2 duplication structure predispose differentially to microdeletion and inversion 0.69
UK BioCoin: swift trait-specific summary statistics regression for UK Biobank 0.09
Histone diversity in the archaeal domain of life 1.00
A multi-modal diffusion model with dual-cross-attention for multi-omics data generation and translation 0.20
Global impact of germline structural variation on the cancer proteome 1.00
RESCUE: recovery of unattributed expression patterns in spatial transcriptomics 1.00
Assembling unmapped reads reveals hidden variation in South Asian genomes 1.00
Combining multiplexed assays of variant effect for enhanced BRCA2 variant classification 0.95
Scaling up Bayesian population phylogenomics through virtual dimension reduction 0.20
RB loss modulates chromatin organization by regulating cohesin-dependent loops and enhancer-promoter interactions 0.95
African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children 0.17
Genetic architecture of lumbar spinal stenosis 0.23
Experimental assessment of AI-based interactome mapping 0.66
Collective behavior and memory states in flow networks with tunable bistability 0.80
Long-read assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function 0.53
Whole-proteome phage immunoprecipitation sequencing reveals germ cell tumor–specific immunosignature 1.00
An end-to-end generalizable deep learning framework to comprehensively analyze transcriptional regulation 0.08
MIC-Drop-seq: scalable single-cell phenotyping of mutant vertebrate embryos 1.00
Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling 1.00
The global phylogeography of rapidly expanding multidrug resistant Ural lineage 4.2 Mycobacterium tuberculosis 0.55
Determinants of chromosome-specific telomere lengths among 2573 All of Us participants 0.88
TONSOKU prevents the formation of large tandem duplications and restrains ATR–WEE1 checkpoint activation 1.00
An integrated germline and somatic genomic model for coronary artery disease 0.81
CRISPR tiling deletion screens reveal functional enhancers and allelic compensation effects (ACE) on transcription 1.00
LysG-driven transcriptional network rewiring underlies lineage-specific phenotypes in Mycobacterium tuberculosis 0.15
Transcriptional competence defines the heterochromatin nucleating potential of isolated MSR units 0.22
A single cluster of RNA Polymerase II molecules is stably associated with active genes 1.00
Celcomen: spatial causal disentanglement for single-cell and tissue perturbation modeling 0.05
Mapping the heritability of disease: a nationwide study 0.07
A blueprint for local and distal invasion programs in glioblastoma 0.70
Systematic background selection with BasCoD enhances contrastive dimension reduction in single cell genomics 1.00
Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome 0.75
Condensin accelerates long-range intra-chromosomal interactions 1.00
Extensive enhancer crosstalk controls activation during adipogenesis 0.25
EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles 0.47
Optimizing global genomic surveillance for early detection of emerging SARS-CoV-2 variants 0.17
mist: a hierarchical Bayesian framework for detecting differential DNA methylation dynamics in single-cell data 1.00
Exon inclusion signatures enable accurate estimation of splicing factor activity 0.43
scTWAS: a powerful statistical framework for single-cell transcriptome-wide association studies 1.00
Multimodal framework for the joint analysis of single-cell RNA and T cell receptor sequencing data predicts T cell response to cancer immunotherapy 1.00
Cell type-specific epigenetic regulatory circuitry of coronary artery disease loci 0.08
Regionalized regulation of actomyosin organization influences cardiomyocyte cell shape changes during chamber curvature formation 0.60
Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA 1.00
An H3K14ub-H3K9me3 feedback circuit governs heterochromatin spreading and inheritance in fission yeast 0.50
Linker histones consolidate heterogenous nucleosome fiber contacts by linking together multiple nucleosomes 0.13
Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis 0.18
Analysis of isobaric quantitative proteomic data using TMT-Integrator and FragPipe computational platform 0.95
Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis 0.06
Polymorphism and evolutionary origins of accessory chromosomes in the basidiomycete Tremella fuciformis 0.03
The dynamic distribution of genetic tandem amplifications in a heteroresistant Escherichia coli population revealed by ultra-deep long read sequencing 0.20
Reconstructing single-cell resolution from spatial transcriptomics with CellRefiner 1.00
Population genomics reveals association of transposable elements variants with climatic adaptation in wild Amur grape 0.09
iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostaining 1.00
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries 0.96
Sub-pangenome analysis reveals structural variants associated with fruit color and bacterial wilt resistance in eggplant 0.06
Tumor cell villages define the co-dependency of tumor and microenvironment in liver cancer 0.80
Shared Genetic Liability across Systems of Psychiatric and Physical Illness 1.00
Nonlinear genomic selection index accelerates multi-trait crop improvement 0.13
SamplingDesign: RNA design via continuous optimization with coupled variables and Monte-Carlo sampling 1.00
Genetic modifiers of -ε4-associated cognitive decline 0.95
Enhancing microbial metabolic capacity through high-energy electron beam-induced intense structural variations 0.06
FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling 1.00
Extrusion fountains are hallmarks of chromosome organization emerging upon zygotic genome activation 0.18
Combining xQTL and genome-wide association studies from diverse populations improves druggable gene discovery 1.00
eQTL in diseased colon tissue identifies potential target genes associated with IBD 1.00
KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans 0.22
XL-MSDigger: a deep learning-based, versatile solution for cross-linking mass spectrometry 0.24
High-throughput multi-organ proteomics workflow for drug efficacy and toxicity analysis 0.89
Radical footprinting in mammalian whole blood 1.00
Adgrg6/Gpr126 is required for compact wall integrity and establishing trabecular identity during cardiac trabeculation 0.10
scLong: a billion-parameter foundation model for capturing long-range gene context in single-cell transcriptomics 0.83
Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics 1.00
A multi-ancestry genetic reference for the Quebec population 0.04
Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC) 0.44
Dual promoter–enhancer activities reflect a unified regulatory logic 1.00
Phased-assembly-driven pangenome graphs for structural variant genotyping and complex trait mapping in dairy cattle 0.92
Supercharging-enhanced nDIA-MS enables global profiling of drug-induced proteome solubility shifts 1.00
Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping 0.03
Three open questions in polygenic score portability 1.00
Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform 0.09
Essential role of NONO-HOXA1-Wnt axis in cardiomyocyte differentiation 0.10
BiG-SCAPE 2.0 and BiG-SLiCE 2.0: scalable, accurate and interactive sequence clustering of metabolic gene clusters 0.38
NeoPrecis: enhancing immunotherapy response prediction through integration of qualified immunogenicity and clonality-aware neoantigen landscapes 1.00
Epigenome-wide analysis identifies DNA methylation mediators of treatment-related cardiometabolic risk in survivors of childhood cancer 1.00
Improving polygenic score prediction for underrepresented groups through transfer learning 0.86
Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development 0.04
Cross-ancestry comparison of aptamer and antibody protein measures 0.98
Evaluating single-cell ATAC-seq atlasing technologies using sequence-to-function modeling 0.11
PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells 1.00
Preventing premature deaths through polygenic risk scores 0.17
Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics 0.32
Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder 1.00
The ratio of circulatory levels of sphingolipids to steroids predicts asthma exacerbations 0.86
Genomic language model mitigates chimera artifacts in nanopore direct RNA sequencing 1.00
Robust characterization and interpretation of rare pathogenic cell populations from spatial omics using GARDEN 0.10
TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis 0.13
Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion 0.86
HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation 1.00
Inferring chromatin architecture at a single locus through probabilistic in situ DNA localization 1.00
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility 0.50
Simultaneous epigenomic profiling and regulatory activity measurement using e2MPRA 0.40
Global solidarity in genomic surveillance improves early detection of acute respiratory virus threats 0.04
The biomedical landscape of genomic structural variation in the qatari population 0.14
Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants 0.17
Rad51 determines pathway usage in post-replication repair 0.53
Functional implications of polygenic risk for schizophrenia in human neurons 1.00
A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men 1.00
Genomic dissection of the clonal background and global dissemination of hypervirulent CG23-KL57 lineage 0.06
Pulsed evolution shaped extant angiosperm pollen disparity 0.06
Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies 0.10
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations 1.00
Phylogenomic profile of exon-intron organization across angiosperms, their relationships with protein domains, and functional implications 0.38
Deep learning guided design of protease substrates 1.00
VACmap: an accurate long-read aligner for unraveling complex genomic rearrangements 0.11
Generating crossmodal gene expression from cancer histopathology improves multimodal AI predictions 0.06
CellScope: high-performance cell atlas workflow with tree-structured representation 0.43
The Health for Life in Singapore (HELIOS) Study: delivering precision medicine research for Asian populations 0.07
Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain 1.00
ALFA-K: Local adaptive mapping of karyotype fitness landscapes 1.00
Population structure reverses selection of variants with proportionally scaled birth and death rates 1.00
Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations 0.07
Mapping rare protein-coding variants on multi-organ imaging traits 1.00
Clair3-RNA: a deep learning-based small variant caller for long-read RNA sequencing data 0.30
Mapping cis- and trans-regulatory target genes of human-specific deletions 1.00
Chromosome-level haplotype-resolved assembly of highly heterozygous grass genomes with PhaseGrass 0.14
Circulating causal protein networks linked to future risk of myocardial infarction 0.41
Chromosome-level assembly and analysis of three hydroxy fatty acid-producing Physaria species 0.17
Widespread naturally variable human exons aid genetic interpretation 1.00
Accurate imputation of pathway-specific gene expression in spatial transcriptomics with PASTA 1.00
Genome-wide screen reveals dependence of break induced replication on several distinct checkpoints 1.00
A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry 0.08
Complex genetic effects linked to plasma protein abundance in the UK Biobank 0.28
Cost-effective non-additive GWAS across 2329 diseases in 500,349 individuals 0.60
Structural basis of double-stranded RNA recognition by the J2 monoclonal antibody 1.00
Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data 0.08
FastCCC: a permutation-free framework for scalable, robust, and reference-based cell-cell communication analysis in single cell transcriptomics studies 1.00
Cysteine-enabled cleavability to advance cross-linking mass spectrometry for global analysis of endogenous protein-protein interactions 0.57
Co-expression-wide association studies link genetically regulated interactions with complex traits 1.00
scDrugMap: benchmarking large foundation models for drug response prediction 1.00
CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igκ repertoire 1.00
Transformer-based deep learning enhances discovery in migraine GWAS 0.13
Patient-derived colon epithelial organoids reveal lipid-related metabolic dysfunction in pediatric ulcerative colitis 1.00
Airqtl dissects cell state-specific causal gene regulatory networks with efficient single-cell eQTL mapping 1.00
Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengths 1.00
CiFi: accurate long-read chromosome conformation capture with low-input requirements 0.73
Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits 0.09
Proteome-wide association study of prostate cancer risk across populations 1.00
PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias 0.12
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome 0.11
Acquisition of ampliconic sequences marks a selfish mouse -haplotype 0.33
Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk 0.68
Benchmarking DNA foundation models for genomic and genetic tasks 1.00
Expanding the utility of variant effect predictions with phenotype-specific models 0.54
Insights into natural neocentromere evolution from a cattle T2T X chromosome 0.13
Recessive variants in the intergenic locus cause monogenic kidney disease responsive to anti-proteinuric treatment 0.55
Enabling whole genome sequencing analysis from FFPE specimens in clinical oncology 0.78
Human plasma proteomic profile of clonal hematopoiesis 0.96
Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays 1.00
Transcription start sites experience a high influx of heritable variants fueled by early development 0.20
scGALA advances graph link prediction-based cell alignment for comprehensive data integration and harmonization 0.14
AI-augmented intraoperative decision-making workflows in diffuse midline glioma biopsy using cryosection pathology 0.07
Genetics and context for precision health in Greater Boston 0.96
Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits 0.89
3D spatial organization of heterogeneous + progenitors in the zebrafish heart field pre-patterns cardiovascular development 1.00
Comparative transcriptome atlas as an assistive modality for complex classification of rare kidney cancers 0.08
Explainable AI unravels sepsis heterogeneity via coagulation-inflammation profiles for prognosis and stratification 0.02
Targeted sequencing and iterative assembly of near-complete genomes 0.04
Multi-ancestry investigation of the genomics of erectile dysfunction 1.00
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology 0.50
Deriving consensus sepsis clusters via goal-directed subgroup identification in multi-omics study 0.07
Addressing the specific roles of histone modifications in transcriptional repression 0.44
Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation 0.96
Unveiling a pervasive DNA adenine methylation regulatory network in the early-diverging fungus Rhizopus microsporus 0.57
Genome architecture evolution in an invasive copepod species complex 0.89
Domestication shaped the chromatin landscape of grain amaranth 0.25
Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry 0.75
Inferring differential dynamics from multi-lineage, multi-omic, and multi-sample single-cell data with MultiVeloVAE 1.00
Cell line-matched reference enables high-precision functional genomics 0.15
G4mer: An RNA language model for transcriptome-wide identification of G-quadruplexes and disease variants from population-scale genetic data 1.00
Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues 1.00
A global soil plasmidome resource unveils functional and ecological roles of plasmids in soil microbiomes 1.00
DNALONGBENCH: a benchmark suite for long-range DNA prediction tasks 1.00
Conservation and variability of long-range interactions in structurally diverse maize genomes 0.38
Bacterial chromosome conformation and cell-free gene expression in synthetic 2D compartments 0.25
Developmentally regulated genes drive phylogenomic splits in ovule evolution 0.90
Augmenting microbial phylogenomic signal with tailored marker gene sets 1.00
ELLA: modeling subcellular spatial variation of gene expression within cells in high-resolution spatial transcriptomics 1.00
Genomic and epigenomic maps of mouse centromeres and pericentromeres 1.00
Gene expression signatures from whole blood predict amyotrophic lateral sclerosis case status and survival 1.00
Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells 0.73
Data navigation on the ENCODE portal 1.00
Long-read RNA-seq demarcates cis- and trans-directed alternative RNA splicing 1.00
Discovery of obesity genes through cross-ancestry analysis 1.00
A highly accurate risk factor-based XGBoost multiethnic model for identifying patients with skin cancer 1.00
UNICORN: Towards universal cellular expression prediction with a multi-task learning framework 1.00
Explicit error coding can mediate gain recalibration in continuous bump attractor networks 1.00
Image-based DNA sequencing encoding for detecting low-mosaicism somatic mobile element insertions 0.22
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations 0.97
A comprehensive benchmark of single-cell Hi-C embedding tools 1.00
Analysis of cfDNA fragmentomics metrics and commercial targeted sequencing panels 0.93
HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs 1.00
Dissecting regulatory non-coding GWAS loci reveals fibroblast causal genes with pathophysiological relevance to heart failure 1.00
The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities 0.59
Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus 0.08
HALO: hierarchical causal modeling for single cell multi-omics data 0.94
Improved allele frequencies in gnomAD through local ancestry inference 0.98
A deep single cell mass cytometry approach to capture canonical and noncanonical cell cycle states 1.00
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus 0.25
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations 0.94
Disentangling associations between complex traits and cell types with seismic 1.00
Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis 0.06
Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits 1.00
mcRigor: a statistical method to enhance the rigor of metacell partitioning in single-cell data analysis 1.00
The pericardium forms as a distinct structure during heart formation 1.00
TP53 variant clusters stratify phenotypic diversity in germline carriers and reveal an osteosarcoma-prone subgroup 0.08
Comparison of imaging based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed paraffin-embedded tumor samples 1.00
AI cancer driver mutation predictions are valid in real-world data 1.00
The genetic diversity of Indonesian cattle has been shaped by multiple introductions and adaptive introgression 0.16
Super-silencers are crucial for development and carcinogenesis in B cells 1.00
TEtrimmer: a tool to automate the manual curation of transposable elements 0.40
: a web-based application for in-depth exploration of multi-omics data with brightfield histology 1.00
Graph neural networks learn emergent tissue properties from spatial molecular profiles 0.07
Disease-linked regulatory DNA variants and homeostatic transcription factors in epidermis 1.00
Shared genetic architecture contributes to risk of major cardiovascular diseases 0.06
Mechanically activated snai1b coordinates the initiation of myocardial delamination for trabeculation 1.00
Learning the cellular origins across cancers using single-cell chromatin landscapes 0.80
The reference genome of the human diploid cell line RPE-1 0.23
Prediction of cellular morphology changes under perturbations with a transcriptome-guided diffusion model 0.35
Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma 1.00
A quadratic paradigm describes the relationship between phenotype severity and variation 1.00
A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types 0.76
Unveiling causal regulatory mechanisms through cell-state parallax 1.00
A graph homomorphism approach for unraveling histories of metastatic cancers and viral outbreaks under evolutionary constraints 0.83
Peripheral blood DNA methylation predicts the early onset of primary tumor in mutation carriers 0.32
Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging 1.00
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking 0.11
Modeling integration site data for safety assessment with MELISSA 1.00
SpaIM: single-cell spatial transcriptomics imputation via style transfer 0.88
Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department 1.00
Multi-scale and multi-context interpretable mapping of cell states across heterogeneous spatial samples 0.80
The chronODE framework for modelling multi-omic time series with ordinary differential equations and machine learning 1.00
TrimNN: characterizing cellular community motifs for studying multicellular topological organization in complex tissues 1.00
: AI generation of multiplex immunofluorescence staining from histopathology images 0.88
Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions 1.00
Biobank-scale genetic characterization of Alzheimer’s disease and related dementias across diverse ancestries 1.00
Multimodal spatial transcriptomic characterization of mouse kidney injury and repair 0.90
Modeling the genomic architecture of adiposity and anthropometrics across the lifespan 1.00
Microtubule mechanotransduction refines cytomegalovirus interactions with and remodeling of host chromatin 1.00
Reticulate allopolyploidy and subsequent dysploidy drive evolution and diversification in the cotton family 0.11
DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins 0.38
Epigenetic control of topoisomerase 1 activity presents a cancer vulnerability 0.64
Improving reproducibility of differentially expressed genes in single-cell transcriptomic studies of neurodegenerative diseases through meta-analysis 1.00
European and African ancestry-specific plasma protein-QTL and metabolite-QTL analyses identify ancestry-specific T2D effector proteins and metabolites 1.00
Computationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics 0.53
Uncovering hidden enhancers through unbiased in vivo testing 0.88
IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells 0.05
Sequencing a DNA analog composed of artificial bases 1.00
Thor: a platform for cell-level investigation of spatial transcriptomics and histology 1.00
PreMode predicts mode-of-action of missense variants by deep graph representation learning of protein sequence and structural context 1.00
Replisomes restrict SMC translocation in vivo 1.00
Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states 1.00
PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility 1.00
Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development 1.00
Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia 0.93
Causal mediation analysis for time-varying heritable risk factors with Mendelian randomization 0.75
Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA-enhancer gene guidance through direct RNA binding and RNP recruitment domains 1.00
Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling 0.21
SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts 1.00
Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC 0.97
Machine learning in Alzheimer’s disease genetics 0.01
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination 0.93
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing 0.93
Bering: joint cell segmentation and annotation for spatial transcriptomics with transferred graph embeddings 0.75
Genome-level selection in tumors as a universal marker of resistance to therapy 1.00
The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness 0.56
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets 0.20
Nucleosome spacing can fine-tune higher-order chromatin assembly 0.66
Combining phenomics with transcriptomics reveals cell-type-specific morphological and molecular signatures of the 22q11.2 deletion 1.00
High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics 1.00
Early detection of emerging SARS-CoV-2 Variants from wastewater through genome sequencing and machine learning 1.00
Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age 1.00
Automated cell annotation and classification on histopathology for spatial biomarker discovery 0.90
Cell Marker Accordion: interpretable single-cell and spatial omics annotation in health and disease 0.14
Phylogenetically informed predictions outperform predictive equations in real and simulated data 0.25
MR-link-2: pleiotropy robust Mendelian randomization validated in three independent reference datasets of causality 0.15
Distribution of copy number alterations and impact of chromosome arm call thresholds for meningioma 1.00
Pan-cancer copy number analysis identifies optimized size thresholds and co-occurrence models for individualized risk stratification 1.00
Scaling laws of bacterial and archaeal plasmids 1.00
Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects 1.00
GAUDI: interpretable multi-omics integration with UMAP embeddings and density-based clustering 0.94
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer 0.05
Mapping the nuclear landscape with multiplexed super-resolution fluorescence microscopy 1.00
Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues 1.00
Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data 1.00
DrFARM: identification of pleiotropic genetic variants in genome-wide association studies 0.71
Trioxane-based MS-cleavable cross-linking mass spectrometry for profiling multimeric interactions of cellular networks 1.00
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses 0.63
Transcripts with high distal heritability mediate genetic effects on complex metabolic traits 0.96
High-resolution detection of copy number alterations in single cells with HiScanner 0.83
Apollo: a comprehensive GPU-powered within-host simulator for viral evolution and infection dynamics across population, tissue, and cell 0.17
MORC2 is a phosphorylation-dependent DNA compaction machine 0.06
Bridging cell morphological behaviors and molecular dynamics in multi-modal spatial omics with MorphLink 1.00
Prevalent chromosome fusion in Vibrio cholerae O1 0.56
Facilitate integrated analysis of single cell multiomic data by binarizing gene expression values 1.00
ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets 0.81
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome 0.74
Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolution 1.00
LassoPred: a tool to predict the 3D structure of lasso peptides 0.64
MassCube improves accuracy for metabolomics data processing from raw files to phenotype classifiers 0.83
Divergence in a eukaryotic transcription factor’s co-TF dependence involves multiple intrinsically disordered regions 1.00
Switch-like gene expression modulates disease risk 0.78
Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas 1.00
Faster adaptation but slower divergence of X chromosomes under paternal genome elimination 0.14
Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions 1.00
A versatile information retrieval framework for evaluating profile strength and similarity 0.92
A naturally occurring SNP modulates thermotolerance divergence among grapevines 0.06
Sequential structure probing of cotranscriptional RNA folding intermediates 1.00
75 48.16
Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations 0.99
Non-Mendelian inheritance of DNA methylation patterns in mice 0.98
Patterns and drivers of 43,617 mosaic chromosomal alterations in blood 0.95
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs 0.24
Empirically determined baseline masking strategies and other considerations for gene-level burden tests 0.77
Population-level super-pangenome reveals genome evolution and empowers precision breeding in watermelon 0.51
Genetic association and machine learning improve the prediction of type 1 diabetes risk 1.00
Interpretable, flexible and spatially aware integration of multiple spatial transcriptomics datasets from diverse sources 1.00
Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states 1.00
De novo formation of -regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion 0.50
Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion 1.00
Genome-wide fine-mapping improves identification of causal variants 0.15
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity 0.37
Genomic, phenomic and geographic associations of leukocyte telomere length in the United States 0.75
Single-cell spatial transcriptomic analysis of human skin anatomy 0.96
A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders 0.74
Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk 0.60
Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila 0.56
Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation 1.00
Pan-cancer inference and validation of hypermorphic, hypomorphic and neomorphic mutations 0.71
Graph-based pangenome reveals structural variation dynamics during cucumber breeding 0.71
A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification 0.03
Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model 1.00
Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction 0.89
Impact and correction of segmentation errors in spatial transcriptomics 1.00
Compressive pangenomics using mutation-annotated networks 1.00
Protein–protein interactions shape -regulatory impact of genetic variation on protein expression and complex traits 1.00
MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data 0.85
Graph pan-genome illuminates evolutionary trajectories and agronomic trait architecture in allotetraploid cotton 0.06
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion 0.64
Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk 0.85
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction 0.40
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation 0.03
Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models 0.16
A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction effects 1.00
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform 0.64
Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease 0.05
Scalable and accurate rare variant meta-analysis with Meta-SAIGE 0.53
Computationally efficient meta-analysis of gene-based tests using summary statistics in large-scale genetic studies 1.00
Liability threshold model-based disease risk prediction based on electronic health record phenotypes 0.93
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy 0.97
Spatiotemporal gene expression and cellular dynamics of the developing human heart 0.05
Complete genome assemblies of two mouse subspecies reveal structural diversity of telomeres and centromeres 0.22
Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes 1.00
Locityper enables targeted genotyping of complex polymorphic genes 0.33
Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers 1.00
Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health 0.33
Limited overlap between genetic effects on disease susceptibility and disease survival 0.27
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects 0.99
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks 0.94
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes 0.28
Accelerated Bayesian inference of population size history from recombining sequence data 1.00
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution 0.02
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes 0.89
Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions 1.00
Genetic variants affecting RNA stability influence complex traits and disease risk 1.00
A multi-tissue single-cell expression atlas in cattle 0.11
DNA methylation influences human centromere positioning and function 0.23
Cross-biobank generalizability and accuracy of electronic health record-based predictors compared to polygenic scores 0.13
Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity 1.00
A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism 0.04
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize 0.40
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas 0.85
Noncoding rare variant associations with blood traits in 166,740 UK Biobank genomes 0.38
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution 0.00
Improved multiancestry fine-mapping identifies -regulatory variants underlying molecular traits and disease risk 1.00
A contextual genomic perspective on physical activity and its relationship to health, well being and illness 1.00
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy 0.86
Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs 0.25
Disruption of TAD hierarchy promotes LTR co-option in cancer 1.00
Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design 0.55
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations 0.09
Linking regulatory variants to target genes by integrating single-cell multiome methods and genomic distance 1.00
A map of blood regulatory variation in South Africans enables GWAS interpretation 0.44
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancer 1.00
2 0.20
Ancient DNA evidence for the history of the Albanians 0.10
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes 0.10
2 1.06
Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis 0.06
A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice 1.00
12 7.10
Proteomic risk score for early prediction of kidney disease progression in individuals with high-risk genotypes 0.88
An atlas of exposome–phenome associations in health and disease risk 1.00
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes 0.08
Clinical genetic variation across Hispanic populations in the Mexican Biobank 0.05
Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes 0.91
AI-enabled virtual spatial proteomics from histopathology for interpretable biomarker discovery in lung cancer 1.00
A consensus immune dysregulation framework for sepsis and critical illnesses 0.64
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities 0.60
The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health 0.82
Polygenic prediction of body mass index and obesity through the life course and across ancestries 0.33
Deep phenotyping of health–disease continuum in the Human Phenotype Project 0.03
Real-world deployment of a fine-tuned pathology foundation model for lung cancer biomarker detection 0.77
34 24.17
Decoding sequence determinants of gene expression in diverse cellular and disease states 0.96
StringTie3 improves total RNA-seq assembly by resolving nascent and mature transcripts 1.00
Orthrus: toward evolutionary and functional RNA foundation models 0.42
SNP calling, haplotype phasing and allele-specific analysis with long RNA-seq reads 0.72
Integration of alternative fragmentation techniques into standard LC-MS workflows using a single deep learning model enhances proteome coverage 0.22
CellVoyager: AI CompBio agent generates new insights by autonomously analyzing biological data 1.00
Scaffolds with optimized quaternary symmetry for de novo cryoEM structure determination of small RNAs 1.00
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny 0.06
Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus 1.00
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions 0.95
Pertpy: an end-to-end framework for perturbation analysis 0.11
Inferring cancer type-specific patterns of metastatic spread using Metient 1.00
Inferring cell differentiation maps from lineage tracing data 0.88
C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels 0.15
Monod: model-based discovery and integration through fitting stochastic transcriptional dynamics to single-cell sequencing data 1.00
Squidiff: predicting cellular development and responses to perturbations using a diffusion model 1.00
Improved reconstruction of single-cell developmental potential with CytoTRACE 2 0.93
PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories 0.08
scooby: modeling multimodal genomic profiles from DNA sequence at single-cell resolution 0.29
gReLU: a comprehensive framework for DNA sequence modeling and design 1.00
Deep generative modeling of sample-level heterogeneity in single-cell genomics 0.96
All-at-once RNA folding with 3D motif prediction framed by evolutionary information 1.00
Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem 1.00
Cancer subclone detection based on DNA copy number in single-cell and spatial omic sequencing data 1.00
Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE 0.91
MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries 0.19
Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions 1.00
Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing 0.10
DeepMVP: deep learning models trained on high-quality data accurately predict PTM sites and variant-induced alterations 1.00
High-throughput profiling of chemical-induced gene expression across 93,644 perturbations 0.04
Morphological map of under- and overexpression of genes in human cells 0.59
The Platinum Pedigree: a long-read benchmark for genetic variants 0.97
GeneAgent: self-verification language agent for gene-set analysis using domain databases 1.00
BEAST X for Bayesian phylogenetic, phylogeographic and phylodynamic inference 0.64
7 4.07
Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states 0.74
Optics-free spatial genomics for mapping mammalian brain aging by IRISeq 1.00
Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo 0.95
CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s disease 0.05
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders 0.10
Alzheimer’s disease transcriptional landscape in ex vivo human microglia 1.00
Fine-mapping genomic loci refines bipolar disorder risk genes 0.23
1 0.17
Spontaneous switching in a protein signalling array reveals near-critical cooperativity 0.17
12 9.44
Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types 0.83
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation 1.00
Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs 0.17
Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription 0.84
Evolution of promoter-proximal pausing enabled a new layer of transcription control 0.90
Kinetic control of mammalian transcription elongation 0.71
Dynamics of microcompartment formation at the mitosis-to-G1 transition 0.89
The mitotic STAG3–cohesin complex shapes male germline nucleome 0.16
DNA bendability regulates transcription factor binding to nucleosomes 1.00
GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion 1.00
Structural insights into transcriptional regulation by the helicase RECQL5 1.00
Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP 0.93
2 1.64
Enhancer dynamics and cellular architecture in the human spinal cord 0.77
Human brain vascular multi-omics elucidates disease-risk associations 0.88
1 0.10
Decoding Gene–Lifestyle Synergy in Diabetic Retinopathy Development: A Transethnic Prospective Cohort Study 0.10
8 4.11
Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta 0.82
Genotype-fitness mapping of adaptive mutants reveals shifting low-dimensional structure across divergent environments 1.00
Comparative gene annotation and orthology assignments across 301 species of Drosophilidae 0.63
A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation 0.13
Cell2Spatial is a computational framework that maps single cells to spatial transcriptomic spots to reconstruct tissue architecture 0.10
Simple scaling laws control the genetic architectures of human complex traits 1.00
The complex evolution and genomic dynamics of mating-type loci in Cryptococcus and Kwoniella 0.40
Systematic screen uncovers regulator contributions to chemical cues in Escherichia coli 0.04
39 31.60
mFABIO: An integrative multi-tissue TWAS fine-mapping approach to prioritize potentially causal genes and tissues underlying binary traits 1.00
MR2G: A novel framework for causal network inference using GWAS summary data 0.67
Tissue-specific transfer learning improves functional variant and therapeutic target discoveries in breast and prostate cancer 0.50
Potential Rad54 separation of function mutation highlights unique roles during homologous recombination 1.00
Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight 0.08
The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction 1.00
ADNP regulates chromatin architecture and lineage fidelity during neural differentiation 1.00
Functional interrogation of candidate cis-regulatory elements at the LDLR locus 1.00
Simplifying causal gene identification in GWAS loci 0.33
Machine learning identifies novel signatures of antifungal drug resistance in Saccharomycotina yeasts 0.70
Topological stratification of continuous genetic variation in large biobanks 0.11
Estimating the distribution of fitness effects of loss of heterozygosity (LOH) events using an engineered library of Saccharomyces cerevisiae 0.88
Polygenic risk scores and Parkinson’s disease in South Africa advancing ancestry informed disease prediction 0.50
The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection 1.00
Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies 1.00
High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification 0.92
Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue 0.14
A maize mutant in the glutamate receptor-like dwarf13 is modified by cis-acting natural variation and a Cornichon homolog 1.00
Decoding the germline genetic architecture of prostate cancer at a single cell resolution 1.00
Aberrant cohesin function in Saccharomyces cerevisiae activates Mcd1 degradation to promote cell lethality 1.00
Genomic evidence for a-α heterothallic and α-α unisexual mating and recombination in an environmental Cryptococcus deneoformans population 0.33
Genome-wide selection inference at short tandem repeats 1.00
Towards a transcriptomic biomarker for the classification of melanocytic neoplasms 1.00
Meta-evolutionary exome analysis identifies novel type 2 diabetes mellitus genes in the UK Biobank and all of us 1.00
Genome-wide association study provides novel insight into the genetic architecture of severe obesity 0.89
Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review 0.93
Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women 1.00
Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment 1.00
Detecting latent interaction effects when analyzing binary traits 0.13
Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction. 0.91
Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion 1.00
Gene dosage and protein valency impact phase separation and fungal cell fate. 1.00
The length and strength of compartmental interactions are modulated by condensin II activity. 1.00
Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans. 1.00
Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans 1.00
Sodium azide mutagenesis induces a unique pattern of mutations 0.92
Flipping the switch on some of the slowest mutating genomes: Direct measurements of plant mitochondrial and plastid mutation rates in msh1 mutants 0.67
Monkeyflower (Mimulus) uncovers the evolutionary basis of the eukaryote telomere sequence variation 1.00
Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations. 1.00
1 1.00
Identification of lipid quantitative trait loci linked with cardiometabolic disease in Asian Indians and Europeans: A genome-wide association study and Mendelian randomization 1.00
1 1.00
Invariant Measures in Time-Delay Coordinates for Unique Dynamical System Identification 1.00
1 1.00
Active Hydrodynamic Theory of Euchromatin and Heterochromatin 1.00
3 1.16
A Super‐Pangenome for Cultivated Citrus Reveals Evolutive Features During the Allopatric Phase of Their Reticulate Evolution 0.04
<atl>Haploid Mutation Mapping Identifies a Homoeologous Non‐Reciprocal Translocation Linked to Reduced Fibre and Enhanced Protein in scp iBrassica napus/i /scp</atl> 0.13
Populus PtrbHLH011 Is a Transcriptional Co-Regulator Involved in the Activation of Cell Wall Biosynthesis by Iron Deprivation 1.00
90 63.90
Theory of chromosome structural dynamics by processive loop extrusion 0.50
CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression 1.00
Genome-wide association mapping and targeted loss of function studies identify Shroom3 as a driver of hyperpolyploidy and ventricular dilation 0.89
Lineage-specific evolution of regulatory landscapes in a polyploid plant and its diploid progenitors 1.00
Sperm, egg, and embryo proteins critical for genetic adaptation of herring to low salinity in the Baltic Sea 0.02
Layer-specific genetic variation unlocks secondary metabolite diversity in long-lived clonal peppermint 0.86
RETRACTED: PKNOX2 gene is significantly associated with substance dependence in European-origin women 1.00
Observational epidemiological studies can mitigate genetic confounding with a genetic relatedness matrix 1.00
Quantifying direct genetic signal captured by principal component adjustment 1.00
Parallel algorithms for phylogenetic inference under a structured coalescent approximation 0.57
Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms 0.94
Simple biological controllers drive the evolution of soft modes 0.93
Emergence of genetic sex determination in an environmentally sex-determined animal 0.93
The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians 1.00
Evidence for strong purifying selection of human 47S ribosomal RNA genes 1.00
Deep learning framework for quantifying self-organization in Myxococcus xanthus 1.00
Coalescence and translation: A language model for population genetics 0.60
Resolving competing evolutionary histories in joint ancestral state reconstruction 1.00
Chromosome-specific drift under stabilizing selection generates polygenic barriers to sex chromosome turnover 1.00
Whole-genome combinatorial gene fusions generate novel genes for advanced microbial trait development 1.00
Graph statistics theory of individualized quantitative genetics under haplotype-resolved genome assembly 0.07
Background selection in recombining genomes and its consequences for the maintenance of variation in complex traits 1.00
Archaeogenetic insights into the demographic history of Late Neanderthals 0.05
Convergent evolution increases boron transport through SNPs and tandem duplications at BOR1 and BOR2 in Arabidopsis thaliana 0.08
A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals 0.15
Insights into cephalochordate genome and gene evolution from the early-diverging amphioxus Asymmetron lucayanum 0.11
Orthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis 0.14
A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis 0.91
Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes 1.00
Elucidating the design principles for engineering plant organ size 1.00
The DELAYED ABAXIAL TRICHOMES Helitron has dual functions in vegetative and pollen development in Arabidopsis thaliana 1.00
Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks 0.80
Genomes of the Golden Horde elites and their implications for the rulers of the Mongol Empire 0.28
Mining lysine post-translational modification sites by integrating protein language model representations with structural context 0.20
Identifying genome-by-childhood trauma interactions for depression using a forest-based approach in the UK Biobank and Adolescent Brain Cognitive Development Study 1.00
Bridging unpaired single-cell multimodal data for integrative analyses with SuperMap 0.08
Mutations and structural variants arising during double-strand break repair 1.00
Controlling for life-history traits in vertebrates reveals that effective population size does not affect mutation rate or genome size 1.00
Functional motifs in food webs and networks 0.50
Subcellular mass spectrometry reveals proteome remodeling in an asymmetrically dividing (frog) embryonic stem cell 1.00
Incomplete lineage sorting shaped mixed traits during a colobine primate radiation 0.04
A data-driven chromatin model reveals spatial and dynamic features of genome organization 0.93
Biological causes and impacts of rugged tree landscapes in phylodynamic inference 0.50
Mutation rate variability in viral populations: Implications for lethal mutagenesis 1.00
Early life-stage thermal resilience is determined by climate-linked regulatory variation 1.00
Predicting the unseen: A diffusion-based debiasing framework for transcriptional response prediction at single-cell resolution 1.00
Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium 0.86
Computationally efficient whole-genome quantile regression at biobank scale 0.44
HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity 0.15
Genome of venomous caterpillar Doratifera vulnerans reveals recruitment of immune peptides and their adaptation as pain-inducing toxins 0.17
Uncovering heterogeneous intercommunity disease transmission from neutral allele frequency time series 0.71
A general framework for branch length estimation in Ancestral Recombination Graphs 0.94
Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping 0.03
A chromatin-linked CPL2–PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing 0.44
Physical models reveal indirect reader protein interactions that facilitate epigenetic crosstalk 1.00
A unified framework for identification of cell-type-specific spatially variable genes in spatial transcriptomic studies 0.13
Machine-learning models based on histological images from healthy donors identify imageQTLs and predict chronological age 1.00
Proximity to explosive synchronization determines network collapse and recovery trajectories in neural and economic crises 0.55
Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements 0.75
Joint disruption of Ret and Ednrb transcription shifts cell fate trajectories in the enteric nervous system in Hirschsprung disease 1.00
Disrupted developmental signaling induces novel transcriptional states 1.00
Virulence hierarchies within the Mycobacterium tuberculosis complex 0.17
Mot1 regulation of promoter binding by TBP varies with stress and gene expression levels independently of coactivator dependence 1.00
Exceedingly low genetic diversity in snow leopards due to persistently small population size 0.37
Dynamic sensor selection for biomarker discovery 1.00
Targeting the 3D genome by anthracyclines for chemotherapeutic effects 0.29
Genetic, phenotypic, and environmental drivers of local adaptation and climate change–induced maladaptation in a migratory songbird 1.00
Distinguishing direct interactions from global epistasis using rank statistics 1.00
A reanalysis of population dynamics in the Casas Grandes region of Northern Mexico using mitochondrial DNA 0.88
Structural basis for Rad54- and Hed1-mediated regulation of Rad51 during the transition from mitotic to meiotic recombination 1.00
Factors underlying a latitudinal gradient in the S/G lignin monomer ratio in natural poplar variants 0.98
Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases 0.75
Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores 1.00
Inbreeding reduces fitness in spatially structured populations of a threatened rattlesnake 0.98
CRISPR–Cas9 screening reveals microproteins regulating adipocyte proliferation and lipid metabolism 1.00
How RAG1/2 evolved from ancestral transposases to initiate V(D)J recombination without transposition 0.33
Genomic origins and evolution of neo-sex chromosomes in Pacific Island birds 1.00
Bivalent interaction through an intrinsically disordered linker promotes transcription activation complex assembly in Notch signaling 1.00
Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming 0.10
Diploidization in a wild rice allopolyploid is both episodic and gradual 0.09
Comparative performance of viral landscape phylogeography approaches 0.11
Participation bias in the estimation of heritability and genetic correlation 0.50
Reactivation of an embryonic cardiac neural crest transcriptional profile during zebrafish heart regeneration 1.00
Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features 1.00
Generative prediction of causal gene sets responsible for complex traits 1.00
Evolution of gene order in prokaryotes is driven primarily by gene gain and loss 0.60
Bias-aware training and evaluation of link prediction algorithms in network biology 1.00
Cross-species modeling of plant genomes at single-nucleotide resolution using a pretrained DNA language model 1.00
Convergent expansions of keystone gene families drive metabolic innovation in Saccharomycotina yeasts 0.77
Population sequencing for phylogenetic diversity and transmission analyses 0.75
9 7.33
A marine stem-myriapod from the Silurian Waukesha Lagerstätte, Wisconsin, USA: terrestrial traits pre-date the transition to land 1.00
Analysis of multi-trait evolution across independently evolved cavefish populations reveals shared and independent evolution of suites of traits 0.94
Microfossil spiral teeth reveal mesopelagic Cyclothone (bristlemouths) fish evolved during the early Palaeogene greenhouse 1.00
Characterizing the informativeness of pathogen genome sequence datasets about transmission between population groups 1.00
A unifying theoretical framework for tick-borne disease risk to explain conflicting results of exclosure experiments across scales 1.00
Hermaphrodites have lower metabolic rates than gonochores. 0.25
Late Ordovician calcified peyssonnelialean red algae: systematics and evolutionary significance 0.20
Developmental lines of least resistance predict standing genetic covariation but do not constrain plasticity or rapid evolution. 1.00
Variation in self-compatibility among genotypes and across ontogeny in a self-fertilizing vertebrate, Kryptolebias marmoratus. 0.94
25 16.45
TranscriptFormer: A generative cell atlas across 1.5 billion years of evolution 1.00
Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load 0.92
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis 0.47
A deep-time landscape of plant cis-regulatory sequence evolution 0.68
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries 1.00
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform 1.00
Chromatin buffers torsional stress during transcription 1.00
Multispecies pangenomes reveal a pervasive influence of population size on structural variation 0.93
Multiscale structure of chromatin condensates explains phase separation and material properties 0.79
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function 0.81
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments 0.10
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR 0.36
A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness 0.33
A human pan-disease blood atlas of the circulating proteome 0.01
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes 1.00
Dual transposon sequencing profiles the genetic interaction landscape in bacteria 0.43
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness 1.00
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene 0.18
Adaptations to water stress and pastoralism in the Turkana of northwest Kenya 0.66
Genomic demography predicts community dynamics in a temperate montane forest 1.00
<atl>Genomic diversity of the African malaria vector iAnopheles funestus/i</atl> 0.03
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging 1.00
E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism 1.00
The MUC19 gene: An evolutionary history of recurrent introgression and natural selection 0.63
Origins and diversity of Greenland’s Qimmit revealed with genomes of ancient and modern sled dogs 0.11
34 26.88
Discovery of White Sea assemblage fossils from Laurentia 1.00
Evolution of a central dopamine circuit underlies adaptation of a light-evoked sensorimotor response in the blind cavefish 1.00
PSGRN: Gene regulatory network inference from single-cell perturbational data through self-training with synthetic gold standards 1.00
Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma 1.00
Targeted long-read RNA sequencing for rare disease diagnosis and variant interpretation 1.00
Historical and contemporary genomes of an endangered rodent reveal shifts in environmentally associated genes 1.00
Protein overabundance is driven by growth robustness 1.00
Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer 0.98
Accelerated discovery of cell migration regulators using label-free deep learning–based automated tracking 1.00
Diverse database and machine learning model to narrow the generalization gap in RNA structure prediction 0.92
Global maps of transcription factor properties reveal threshold-based formation of DNA-bound and mobile clusters 1.00
Silencer variants are key drivers of gene up-regulation in Alzheimer’s disease 1.00
Introgressed mitochondrial fragments from archaic hominins alter nuclear genome function in modern humans 0.12
Basis for lineage-determining pioneer factors targeting distinct repressed chromatin states 1.00
Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer’s disease 1.00
Humpback whale genomes reflect the increased efficiency of commercial whaling 0.25
CTCF-RNA interactions orchestrate cell-specific chromatin loop organization 1.00
TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction 0.08
Fifteen millennia of human mitogenome evolution in Sicily 0.05
Single-nucleus multi-omics identifies shared and distinct pathways in Pick’s and Alzheimer’s disease 1.00
Circulating tumor cells as predictive biomarkers in the risk stratification of DCIS: Evidence of early dissemination 1.00
Dynamic human admixture histories over the past ~1300 years at the northern Himalayan frontier 0.31
Uncovering the regulatory landscape of early human B cell lymphopoiesis and its implications in the pathogenesis of B-ALL 0.04
Pervasive sex-dependent effects in the genetic architecture of starvation resistance in Drosophila melanogaster 0.17
Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning 1.00
Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules 1.00
Indirect genetic effects among neighbors promote cooperation and accelerate adaptation in a small-scale human society 0.50
The ISW1 and CHD1 chromatin remodelers suppress global nucleosome dynamics in living yeast cells 1.00
Static three-dimensional structures determine fast dynamics between distal loci pairs in interphase chromosomes 1.00
Image-based inference of tumor cell trajectories enables large-scale cancer progression analysis 1.00
A narrow range of transcript-error rates across the Tree of Life 1.00
Loss of the PPE71-esxX-esxY-PPE38 locus drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis lineage 2 1.00
Discovery of unconventional and nonintuitive self-assembling peptide materials using experiment-driven machine learning 0.58
A lipid atlas of the human kidney 0.90
1 1.00
DeepHeme, a high-performance, generalizable deep ensemble for bone marrow morphometry and hematologic diagnosis 1.00
4 3.70
Mechanistic insights into coordinated var transcriptional switching in malaria parasites 1.00
Unique territorial and compartmental organization of chromosomes in the holocentric silkworm 0.70
Integrating endogenous TurboID and data-independent acquisition mass spectrometry for in vivo proximity labeling 1.00
Master transcription-factor binding sites constitute the core of early replication control elements. 1.00
1 0.24
Strain-level diversity of giant viruses infecting chlorarachniophyte algae in the subtropical North Pacific 0.24
1 1.00
Characterizing RNA Tetramer Conformational Landscape Using Explainable Machine Learning 1.00
7 4.62
Functional insights into dispensable genes using genome-wide loss-of-function burden tests in Arabidopsis 1.00
Replication timing uncovers a two-compartment nuclear architecture of interphase euchromatin 1.00
Gene and genome duplications have contrasting impacts on biosynthetic and flower developmental pathways in California poppy 0.50
Structure-guided discovery of protein functions in plants 0.07
<atl>Targeted genetic manipulation and yeast-like evolutionary genomics in the green alga iAuxenochlorella/i</atl> 0.96
The mitochondrial carrier CsTHS1 acts as a gatekeeper of theanine accumulation in late-spring new shoots of tea plants 0.09
Maize ibig embryo 6/i reveals roles of plastidial and cytosolic prephenate aminotransferases in seed and plant development 1.00

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