Clinical Sciences articles for Canada

Time frame: 1 May 2025 - 30 April 2026

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Count: 536

Article ‘Count’ for Clinical Sciences.

Journal Count Share
2 0.07
Ultrasmall Surface-Charge-Modified Tantalum Oxide Nanoparticles for the Assessment of Articular Cartilage Using Contrast-Enhanced Computed Tomography 0.04
Oral Nanoarmored Live Bacterial Biotherapeutics Bearing Polyphenol-Based Supraparticles Enhance Chemotherapy via Reestablishing Immuno-Oncology-Microbiome Axis 0.03
4 3.83
THE EFFECT OF PERFUSION WITH AND WITHOUT MECHANICAL LOADING ON AN IN VITRO MODEL OF THE OUTER ANNULUS FIBROSUS-CARTILAGE ENDPLATE INTERFACE 1.00
Biodegradable sodium citrate-treated hyaluronic acid microspheres for genicular artery embolization 1.00
Advanced polyelectrolyte complexes for ultrafast hemostasis and blood superabsorption 1.00
Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae 0.83
1 0.15
Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding 0.15
2 0.17
Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial 0.05
Arm circumference as a marker of muscle mass: cutoff values from NHANES 1999-2006 0.13
4 0.36
Low population penetrance of variants associated with inherited retinal degenerations 0.05
Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants 0.10
Bi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome 0.11
Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder 0.10
3 1.48
Trachelectomy in decline: national trends, outcomes, and academic output across 3 major databases 0.43
Vaginal hysterectomy versus laparoscopic hysterectomy for benign indications: complications and length of stay in a national analysis of contemporary data 0.09
Association of frailty with healthcare utilization and days alive at home in patients with gynecologic cancers: a population-based study 0.96
2 1.55
Matrix Gla Protein Expression in Pericytes and Myofibroblasts Contributes to Renal Fibrosis 1.00
Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages 0.55
6 1.27
Early mechanical reperfusion in high-risk pulmonary embolism supported by V-A ECMO: a multicenter international cohort study 0.02
The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis. 0.03
Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS) 0.50
Physiological Consequences of Breathing Effort According to the Mode of Ventilation During Acute Hypoxemic Respiratory Failure. 0.12
Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation (RESCUE-3). 0.05
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome 0.56
1 0.60
Toward “Receive-Only” Nuclear Magnetic Resonance Complementary Metal-Oxide-Semiconductor Microcoil Arrays for High-Throughput Analysis of Environmental Samples 0.60
9 5.02
Perspectives of children, parents and health care providers on outcomes following anesthesia for surgery:: An international mixed methods stakeholder engagement study from the Pediatric Perioperative Outcomes Group. 0.06
Evaluating The Statistical Robustness Of Randomized Controlled Trials Of Spinal Cord Stimulation For Pain Through The Use Of Fragility Index. 0.15
Pain as a driver of myocardial injury in hip fracture patients: a HIP fracture Accelerated surgical TreaTment And Care track (HIP ATTACK) Trial secondary analysis. 0.70
Sedation-Related Electroencephalographic Patterns in Acute Hypoxemic Respiratory Failure. 0.74
Evaluation of the potential for lung recruitment with the Recruitment-to-Inflation ratio during general anesthesia. 0.03
The association between preoperative depression and length of stay after major surgery: a systematic review and meta-analysis. 1.00
Ketamine-induced sustained modulation of GABAA receptor function in mouse hippocampal neurons following anesthesia. 1.00
Psychological Effects of Explicit Recall under Sedation and after Surgery (PEERS): a Prospective Cohort Study on 2500 Patients. 1.00
Analgesic benefits of motor-sparing fascial plane blocks in comparison to periarticular local infiltration analgesia for total hip arthroplasty: A network meta-analysis. 0.33
4 2.17
Sex Differences in Clinical Outcomes and Resource Utilization Among Emergency Department Patients With Unexplained Syncope or Presyncope: A Prospective, Observational, Cohort Study 0.08
Serious Cardiac Outcomes and Physician Estimation of Risk in Emergency Department Patients With Presyncope Versus Syncope 0.09
Accuracy of Published Screening Tools for Large Vessel Occlusion in Patients With Suspected Acute Ischemic Stroke: A Prospective Cohort Study 1.00
Derivation and Validation of a Clinical Rule to Detect Bacteremia Versus Contaminants in Positive Pediatric Blood Cultures: A Retrospective Cohort Study 1.00
1 1.00
Why Are Family Physicians Leaving Comprehensive Care? A Qualitative Study on Retention in Ontario. 1.00
7 4.23
The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial. 0.19
Effect of Nonmedical Cannabis Legalization and Exposure to Retail Stores on Cannabis Harms : A Quasi-experimental Study. 1.00
Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study. 0.79
Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis. 0.11
High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm. 0.81
Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery. 0.33
Confirmatory Testing for Primary Aldosteronism : A Study of Diagnostic Test Accuracy. 1.00
3 0.98
Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study 0.93
Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease 0.03
The Spectrum of Neurologic Phenotypes Associated With scpiNUS1/i/scp Pathogenic Variants: A Comprehensive Case Series 0.03
3 2.04
A Multicenter Randomized Controlled Trial on the Surgery of Fractured Ribs: The SOFRIB Trial. 0.10
International Consensus on Global Surgery Learning Objectives and Competencies. 1.00
Patient-Reported Symptom Burden Associated with Treatment Modality for Malignant Bowel Obstruction. 0.94
11 5.04
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study 0.09
Psoriatic dactylitis: the association with HLA genetic susceptibility markers 0.97
A phase 2, randomised, placebo-controlled study of guselkumab in adults with new-onset or relapsing giant cell arteritis 0.14
Antimitochondrial antibodies in systemic lupus erythematosus are associated with and predict nephritis, arterial vascular events, and mortality 0.41
CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study 0.88
Understanding the drivers of BASDAI and back pain scores in psoriatic arthritis 1.00
Inhibition of structural damage progression with the selective interleukin-23 inhibitor guselkumab in participants with active PsA: results through week 24 of the phase 3b, randomised, double-blind, placebo-controlled APEX study 0.17
SLE classification criteria item relationships: implications on SLE as a disease entity 0.20
A glossary of signs and symptoms of giant cell arteritis 0.14
Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus 1.00
Radiographic structural damage in axial spondyloarthritis: is there a preferred way to quantify progression over time? Comparison of blinded versus unblinded mSASSS scoring 0.05
3 3.00
The Impact of a Prior Traumatic Brain Injury & Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging 1.00
Effectiveness of the ProACTIVE SCI intervention on physical activity and psychosocial outcomes during the transition from rehabilitation to community among adults with spinal cord injury: A Pre-Post Trial 1.00
Does orthosis improve outcomes of conservative treatment in trigger fingers? A three-arm prospective randomized controlled trial 1.00
20 7.14
Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis within a Longitudinal Cohort 0.78
High‐resolution deep learning DIXON MRI of the sacroiliac joints is non‐inferior to standard MRI in patients with suspected axial Spondyloarthritis 0.04
Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study 0.34
18F‐Fluorodeoxyglucose Positron Emission Tomography Imaging Assessment within a Randomized Controlled Trial in Giant Cell Arteritis 0.08
Machine Learning to Predict Remission Between Six and 24 Months in Rheumatoid Arthritis: Insights from the JAK‐pot Collaboration 0.09
Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept Study 0.08
Validation of International Classification of Diseases Code–Based Case Definitions of Immune Checkpoint Inhibitor–Associated Inflammatory Arthritis From Administrative Health Data 1.00
Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study 0.96
Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis 0.11
Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Risk of Autoimmune Rheumatic Diseases 1.00
Measuring the Impact: MRI Response of Sacroiliac Joints to TNF Inhibitors in Youth with Axial Disease 0.11
The impact of non‐steroidal anti‐inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: 10‐year results from an inception cohort 0.06
Toward a treat‐to‐target strategy in juvenile dermatomyositis: what are the suitable targets and optimal timing of their achievement? 0.32
Effect of time to start of biologic therapy on treatment response in childhood arthritis: Results from the UCAN CAN‐DU study 0.31
Incidence of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis Treated With scpJAK/scp Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs: Data From an International Collaboration of Registries 0.03
Clinical Impact of Multiparametric Contrast‐Enhanced Dual‐Energy Computed Tomography in Arthritis Imaging: A Prospective Single‐Center Study 0.05
Differences in IgG Sialylation Distinguish Asymptomatic from Symptomatic Anti‐Nuclear Antibody Positive Individuals 1.00
Effect of Long‐Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies 0.40
Three‐Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular scpJIA/scp Consensus Treatment Plans Study 0.22
A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis 0.17
2 0.43
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease 0.07
Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer’s disease 0.36
3 1.85
Preoperative low-energy diets for patients with body mass index amp;gt;30kg/m2 undergoing non-bariatric surgery: A pilot feasibility randomized clinical trial and a systematic review and meta-analysis of efficacy data 0.86
Performance indicators for organ donation and transplantation programmes in Europe: modified Delphi consensus study 0.06
Impact of bariatric surgery on patients with chronic kidney disease and severe obesity: multiple-linked population-based cohort study 0.93
4 0.94
The spatiotemporal dynamics of postnatal vascularization in the mouse brain 0.15
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi 0.71
Genetic modifiers and ascertainment drive variable expressivity of complex disorders 0.03
A generative deep learning approach to de novo antibiotic design 0.05
2 0.26
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation 0.21
Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease 0.05
1 0.05
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication 0.05
1 0.13
Tri-specific molecularly imprinted lysosomal nanodegrader enables synergistic therapy of cytokine storm 0.13
5 3.15
Antimicrobial Treatment of Mild Mycobacterium avium Complex Pulmonary Disease Predicted to Increase Survival and Quality-Adjusted Life Years 0.75
Inspiratory effort and dynamic transpulmonary driving pressure in extremely preterm infants 0.11
Low tidal volume ventilation and mortality in patients with acute brain injury: a secondary analysis of an international observational study* 0.60
Anomalous differences between the Global Lung Function Initiative 2023 and 2012 spirometry reference values 0.75
Ultrathin bronchoscopy with radial endobronchial ultrasound and rapid on-site evaluation for the diagnosis of peripheral pulmonary lesions: a multicentre randomized controlled factorial trial 0.94
3 1.01
High-Dose vs. Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis. 0.02
Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. 0.07
Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. 0.92
5 2.93
Limited durability of improvements in infection prevention and control practices following reactive interventions leaves healthcare facilities vulnerable to Ebola virus transmission 0.75
Duration of Therapy for Pseudomonas aeruginosa Bacteremia—A Post Hoc Subgroup Analysis From the BALANCE Randomized Controlled Trial 0.71
<atl>Diagnostic Performance of New Commercial IGRAs for iMycobacterium tuberculosis/i Infection: An updated Systematic Review and Meta-analysis</atl> 0.40
Effectiveness of COVID-19 Vaccination and Prior Infections to Reduce Long COVID Risk During the Pre-Omicron and Omicron Periods 1.00
Characterizing Treatment Adherence Trajectories in the endTB Multisite Cohort of Drug-Resistant Tuberculosis Patients: An Application of Group-Based Trajectory Modeling 0.07
15 7.55
An Examination of Organ Donor Hemodynamic Variation and Warm Ischemic Times Stratified by Functional Thresholds. 1.00
Defining the Resolution of Acute Respiratory Distress Syndrome: A Delphi Consensus Study. 1.00
Sex-Specific Differences in Tidal Volumes and Mortality of Mechanically Ventilated Patients. 0.73
Fiberoptic Bronchoscopy Monitoring During Percutaneous Dilatational Tracheostomy: A Multicenter, Randomized, Controlled Trial. The FIBERTRACH Randomized Clinical Trial. 0.01
Predictive and Prognostic Performance of the Phoenix Sepsis Criteria and Phoenix Sepsis Score in PICU Patients With Suspected Infection: A Multicenter Prospective Study. 0.06
Identifying Research Priorities in Canadian Adult and Pediatric Critical Care: Results From a James Lind Alliance Priority Setting Partnership. 0.94
Association of Prolonged Emergency Department Length of Stay With Process of Care Measures for Critically Ill Patients. 0.88
Platelet Transfusion Thresholds for Children Supported by Extracorporeal Membrane Oxygenation: The Extracorporeal Membrane Oxygenation Hemostatic Transfusions in Children (ECSTATIC) Feasibility Clinical Trial. 0.08
Acute Respiratory Distress Syndrome in Trauma 2007-2019: Comprehensive Patient and Center-Level Retrospective Cohort Analysis. 0.07
Variability in Venovenous Extracorporeal Membrane Oxygenation Candidacy Decision-Making: An International Survey. 0.14
An IV Sodium Bicarbonate Shortage in the Critically Ill: An Interrupted Time-Series Analysis. 0.88
Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome. 0.16
Delirium Severity Trajectories in Critically Ill Adults Using the Intensive Care Delirium Screening Checklist: A Population-Based Cohort. 0.56
Persistent Critical Illness Among Intensive Care Patients in India: A Registry-Embedded Cohort Study. 0.13
Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy 0.94
4 3.38
Psilocybin induces sex- and context-specific recruitment of the stress axis 0.50
Neurogenesis-dependent transformation of hippocampal memory traces during systems consolidation 1.00
Disentangling prediction error and value in a formal test of dopamine’s role in reinforcement learning 0.88
A history of injury enhances affective and sensory responses to predator threat by sensitizing corticosterone release through TRPA1 receptor signaling 1.00
2 0.90
Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma 0.05
Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process 0.85
9 3.58
Ultrarapid Lispro (Lyumjev) Has an Improved Pharmacokinetic Profile for Exercise Compared With Humalog, Resulting in Less Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes on Open-Loop Continuous Subcutaneous Insulin Infusion. 0.43
Everyone or Just Some? Cost-Effectiveness of General Population Versus Targeted Screening Strategies for Type 1 Diabetes in Canada. 0.60
Gout-Related Medication Use After Initiating Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies. 0.23
Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial. 0.05
Dementia Risk in People With Type 1 Diabetes and Associated Risk Factors: A Nationwide, Register-Based Cohort Study. 0.10
Use of the Omnipod 5 Automated Insulin Delivery System Activity Feature Reduces Insulin Delivery and Attenuates the Drop in Glycemia Associated With Exercise in a Randomized Controlled Trial. 0.11
Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease. 1.00
Benefit of Semaglutide in Symptomatic Peripheral Artery Disease by Baseline Type 2 Diabetes Characteristics: Insights From STRIDE, a Randomized, Placebo-Controlled, Double-Blind Trial. 0.10
Capillary Ketone Level and Future Ketoacidosis Risk in Patients With Type 1 Diabetes Using Sodium-Glucose Cotransporter Inhibitors. 0.97
2 0.15
Associations of gestational and childhood urinary triclosan concentrations with atopic and allergic symptoms in Health Outcomes and Measures of the Environment (HOME) Study participants ages 1-12 years. 0.09
A Machine Learning-Based Clustering Analysis to Explore Bisphenol A and Phthalate Exposure from Medical Devices in Infants with Congenital Heart Defects. 0.06
2 1.36
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies 0.36
Benzotriazole UV-stabilizer exposure in ring-billed gulls from an urban, freshwater harbour in Lake Ontario, Canada: evaluating contaminant bioaccumulation and potential health impacts 1.00
4 1.97
Prenatal exposure to persistent organic pollutants and childhood adiposity: Findings from the MIREC cohort 1.00
Breast milk bisphenol concentrations in Canada and South Africa and associations with body size among South African infants 0.80
Exposure to triclosan and triclocarban are associated with estrogen metabolism in Chinese pregnant women 0.06
Parabens, bisphenols, and other environmental phenols exposure from cosmetics use in Korean adolescent girls: Findings from a 2-day intervention study 0.11
3 1.87
Approaching a 0% False Positive Rate for PFAS Determination Leveraging Only MS1 Data 0.07
Multiphase OH Oxidation of Bisphenols: Chemical Transformation and Persistence in the Environment 0.80
Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A 1.00
3 0.15
Cardiovascular adaptation to training load in endurance athletes: a longitudinal study 0.03
C-reactive protein and cardiovascular risk in the general population 0.09
Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study 0.03
2 0.05
RESECT: A Randomised Controlled Trial of Audit and Feedback in Non–muscle-invasive Bladder Cancer Surgery 0.01
Duration of Androgen Suppression with Postoperative Radiotherapy (DADSPORT) for Nonmetastatic Prostate Cancer: A Collaborative Systematic Review and Meta-analysis of Aggregate Data 0.04
4 0.39
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis 0.07
Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn’s Disease Recurrence 0.16
The ANTICIPATE-NASH Models Stratify Better the Risk of Clinical Events Than Histology in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients With Advanced Chronic Liver Disease 0.12
Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation 0.04
1 0.20
Lambdoid phages with abundant Chi recombination hotspots reflect diverse viral strategies for recombination-dependent growth 0.20
8 1.17
Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study 0.22
Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility 0.12
Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials 0.53
Acute upper gastrointestinal bleeding in the UK: 2022 audit update 0.12
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia 0.01
Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data 0.02
Global prevalence and gastrointestinal symptom burden of individuals with a history of cholecystectomy 0.11
Cold snare endoscopic resection for large colon polyps: a randomised trial 0.04
6 1.42
OCE-205, a selective V1a receptor mixed agonist-antagonist, for the treatment of hepatorenal syndrome-acute kidney injury: A phase 2 randomized trial. 0.14
Understanding hepatopancreatobiliary cancer risks in a population-based primary sclerosing cholangitis-inflammatory bowel disease cohort. 0.96
Predictors of fibrosis, clinical events and mortality in MASLD: Data from the Global-MASLD study. 0.03
Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study. 0.03
Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort. 0.21
Comparison of diagnostic accuracy and utility of non-invasive tests for clinically significant liver disease in a general population with metabolic dysfunction. 0.05
1 0.30
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity 0.30
1 0.50
School opening associated with lower test-adjusted COVID-19 case rates in children 0.50
5 1.74
Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes 0.09
Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease 0.89
Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes 0.04
Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis 0.45
Transfusion Strategy Effect on Quality of Life in Patients With Myocardial Infarction and Anemia 0.26
4 1.47
Long-Term Trends in Pediatric Self-Injury in High-Income Countries 1.00
Clinical Signs Associated With Mortality and Sepsis in Young Infants 0.09
Once-Weekly Navepegritide in Children With Achondroplasia 0.18
Acceptance and Commitment Therapy–Based Parenting Program in Children With Co-Occurring Asthma and ADHD 0.20
7 3.06
One-Year Actigraphy Study of Sleep and Rest-Activity Rhythms as Markers of Relapse in Depression 0.94
Mental Disorders as a Risk Factor of Acute Coronary Syndrome 0.91
Measures of General Intelligence and Risk for Alcohol Use Disorder 0.10
Progression of Transdiagnostic Stages From Childhood to Young Adulthood 0.07
Occurrence of Psychosis and Bipolar Disorder in Individuals With Attention-Deficit/Hyperactivity Disorder Treated With Stimulants 0.15
Mental Health Antecedents and Correlates of 2 Distinct Developmental Pathways to Suicidal Ideation 0.88
Framework for Brain-Derived Dimensions of Psychopathology 0.03
3 2.97
A Population-Level Evaluation of Emergency General Surgery Models of Care and Clinical Outcomes 0.97
A Predictive Tool for Ability to Remain at Home After Cancer Surgery in Older Adults 1.00
Familiarity of the Surgeon-Anesthesiologist Dyad and Major Morbidity After High-Risk Elective Surgery 1.00
8 1.90
Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough 0.13
Minor Papillotomy for Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum 0.06
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury 0.90
Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis 0.28
Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger 0.40
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score 0.06
Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults 0.03
Dalbavancin for Treatment of Staphylococcus aureus Bacteremia 0.04
2 1.77
The retaining Kdo transferase that synthesizes Escherichia coli K13 capsule is deeply divergent from structurally homologous enzymes 0.77
Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons 1.00
16 6.23
Survivorship of Femoroacetabular Impingement Surgery at Mean 10-Year Follow-up: A Prospective, Multicenter Cohort Study. 0.11
Outcomes and Complications of Vertebral Body Tethering in Skeletally Immature Patients with Idiopathic Scoliosis. 0.86
Periprosthetic Joint Infection Following Total Knee Arthroplasty Is Associated with a Significantly Elevated Risk of Mortality: A Population-Level Database Study. 1.00
Mild Lateral Femoral Condyle Cartilage Damage Does Not Affect the Outcomes of Medial Unicompartmental Knee Arthroplasty: A Mean 6-Year Follow-up Study. 0.11
A Dedicated Trauma Operating Room for Hand Surgery Reduces After-Hours Cases and Costs without Affecting Wait Times: A Retrospective Single-Center Cohort Study. 1.00
Infection and Nonunion Rates in Open Fractures 0.27
The Cost-Effectiveness of Continuous Pressure Measurement in the Diagnosis of Acute Compartment Syndrome. 0.50
Alcohol-Based Versus Aqueous Skin Antisepsis Before Surgical Fixation of Open Fractures 0.57
Performance of the OTA-OFC3 Classification System for Open Fractures 0.08
Deep Infections After Open and Closed Fractures 0.10
Differences in Practice Patterns in the Use of Temporary External Fixation for the Management of Open Lower-Extremity Fractures 0.09
Local Antibiotics and the Risk of Antimicrobial Resistance in Extremity Fractures Complicated by Fracture-Related Infection 0.18
Outcomes Associated with Choice of Prophylactic Antibiotics in Open Fractures 0.10
Chlorhexidine Gluconate Bathing Has Limited Ability to Prevent Surgical Site Infection Following Operative Fixation of Extremity and Pelvic Fractures 0.18
Higher Reoperation Rates in Planned, Staged Treatment of Open Fractures Compared with Fix-and-Close 0.08
Primary Total Knee Arthroplasty in Patients with BMI of ≥50 kg/m2: A Cohort Study with Long-Term Follow-up. 1.00
9 4.55
<atl>Integrative genetic and liver transcriptomic analyses identify iTRIB1AL/i as a target for steatotic liver disease</atl> 1.00
Implementation of a Spanish-Language, Direct-to-Patient Primary Aldosteronism Testing Program 0.06
Patient-Reported Outcomes in Palopegteriparatide-Treated Adults with Hypoparathyroidism: PaTH Forward Trial Extension 0.06
Secondary Hypogonadism and Effects of Testosterone Replacement Therapy on Cardiovascular Events 1.00
Adult Growth Hormone Deficiency, Replacement Therapy, and Outcomes in Long-Term Childhood Cancer Survivors 0.06
Association of IGF-1 levels with height from childhood to adulthood: An observational and Mendelian randomization study 0.79
Genetic and Clinical Characteristics of Monogenic Diabetes in Japan: A Nationwide Study by the Japan Diabetes Society 0.04
Course of Pregnancies and Occurrence of Acute Pancreatitis in Women With Chylomicronemia 0.55
Incidence of Adrenal Masses Eventually Discovered in Patients Screened for Primary Aldosteronism 1.00
2 0.83
Rapid and profound decay of inducible and intact HIV genomes in early treated Thai children 0.35
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes 0.48
2 0.38
Randomized Phase II Trial of Pazopanib Versus Placebo in Patients With Advanced Extrapancreatic Neuroendocrine Tumors (Alliance A021202). 0.07
Development and Validation of a Novel Prediction Model for Hearing Loss From Cisplatin Chemotherapy. 0.31
8 2.45
Global epidemiology of bacterial infections in patients with cirrhosis: A systematic review and meta-analysis 0.06
Utilization of liver grafts obtained from donation after medical assistance in dying: A Canadian multicenter experience 0.96
Refining the Baveno VII criteria for clinically significant portal hypertension: an individual-patient data meta-analysis 0.05
Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis 0.09
Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis 0.22
Impact of first and further decompensation in patients with compensated ACLD due to MASLD 0.03
Personalized survival benefit estimation from living donor liver transplantation with a novel machine learning method for confounding adjustment 0.96
Safety and efficacy of elafibranor in primary sclerosing cholangitis: The ELMWOOD phase II randomized-controlled trial 0.10
17 8.06
Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control 0.75
Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study 0.89
Incidence of Herpes Zoster Infection (Shingles) Among Adults Living With and Without HIV in British Columbia, Canada: A Population-Based Study 0.92
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia 0.02
Cross-reactive H5N1 neuraminidase antibodies by age and influenza A imprinting cohorts of the past century: population-based serosurvey, British Columbia, Canada 1.00
Estimating HIV-1 Viremic Time from Reservoir Sequence Diversity with Uncertainty Quantification 0.14
Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant Pseudomonas aeruginosa 1.00
Serum IgG1 and IgG3 Antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in Men of Subfertile Couples 0.29
The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial 0.80
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV 0.42
VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results 0.09
Molecular Epidemiology of Clinical Infections Caused by Serratia marcescens Complex in a Tertiary Care Hospital System: Insights From Whole-Genome Sequencing 1.00
Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial 0.05
Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial 0.01
Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool 0.50
Priming or Boosting iPlasmodium falciparum/i Transmission-Blocking Responses With Recombinant Vaccines or Gametocyte Extract 0.15
iStreptococcus pyogenes/i Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan 0.03
13 10.32
Manifold Interactions between the Action-Mode Network and Sensorimotor Cortex during Human Motor Learning 0.89
Integration of memory and sensory information in skilled sequence production 1.00
The tuned cortex: Convergent expertise-related structural and functional remodeling across the adult lifespan 1.00
Environmental enrichment preserves retrosplenial parvalbumin density and cognitive function in female 5xFAD mice 1.00
Dopamine responses in medial frontal cortex are more consistent with a generalized arousal signal than signed reward prediction errors. 1.00
Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients 0.83
Is the whole the sum of its parts? Neural computation of consumer bundle valuation in humans 0.33
Ventral striatal cholinergic interneurons regulate decision making or motor impulsivity differentially across learning and biological sex 1.00
Complementary yet dissociable influences of medial and lateral orbitofrontal cortex over cue-guided decisions involving reward magnitude and uncertainty 1.00
Reduction in Reward-Driven Behavior Depends on the Basolateral But Not Central Nucleus of the Amygdala in Female Rats 1.00
Motor Sequence Learning Involves Better Prediction of the Next Action and Optimization of Movement Trajectories 1.00
First application of a novel brain template: Motor training improves cortico-cerebellar connectivity in cerebellar ataxia 0.14
Impaired Online and Enhanced Offline Motor Sequence Learning in Individuals with Parkinson's Disease 0.13
14 8.27
Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers 0.13
Maximal exercise at high altitude does not exacerbate inflammation in the human brain 0.54
The effect of sildenafil on resting and exercise diffusing capacity in trained and untrained individuals: A randomized crossover trial 1.00
Exercise training induces mitochondrial biogenesis, while high‐fat diet increases the ability of mitochondria to use long and short‐chain fatty acids 1.00
Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males 0.83
Role of reactive oxygen species in mediating peripheral hypoxic vasodilation and sympathoexcitation at high altitude 0.09
Exercise and hypoxia independently stimulate platelet liberation of brain‐derived neurotrophic factor and platelet factor 4 0.44
Determinants of maximal oxygen uptake in highly trained females and males: a mechanistic study of sex differences using advanced invasive methods 0.11
Learning to stand with delays alters sensorimotor control but does not cause instability when returning to natural balance 1.00
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting iNotch1/i upregulation in an MDM2‐dependent manner 1.00
The hyperaemic and metaboreflex response of the diaphragm during fatiguing diaphragmatic work in humans 1.00
Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise 0.10
Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans 0.02
Mechanisms of sympathetic excitation during cycling exercise in heart failure with reduced ejection fraction 1.00
10 7.39
Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation 1.00
Impact of normothermic regional perfusion on ex vivo lung perfusion outcomes in donation after circulatory death lung donors 0.31
Sex-specific outcomes after thoracic aortic surgery 0.86
Randomized, Sham-Controlled Trial of Intraoperative Ticagrelor Removal to Reduce Perioperative Bleeding 0.25
More is not better: The role of the leukocyte filter in ex vivo lung perfusion 1.00
VALUE Trial: Phase 1 safety and feasibility study of same-day discharge after video-assisted thoracoscopic surgery lung resection 1.00
Improving timely transplantation while reducing cancellation of scheduled surgery 0.88
1,000 Cases of Ex Vivo Lung Perfusion for Lung Transplantation: A Single Centre Experience 1.00
Intercostal Cryoanalgesia for Acute Pain after VATS Lung Resection (CRYO-VATS): a randomized controlled preliminary trial 0.93
Diagnostic Effectiveness and Safety of Robotic-Assisted Bronchoscopy for Subsolid Pulmonary Nodules – A Multicenter, Prospective, Observational Study 0.17
1 0.08
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis 0.08
6 0.56
Topical combined 5-fluorouracil and calcipotriene for actinic keratosis and superficial keratinocyte carcinoma: Modified Delphi expert panel guidelines from ITSCC 0.06
Impact of early treatment of psoriasis on disease recurrence—Results from the STEPIn study 0.07
Efficacy and Safety of Ruxolitinib Cream in Patients With Mild to Moderate Hidradenitis Suppurativa: Results From a Randomized, Double-Blind, Vehicle-Controlled Phase 2 Study 0.20
Efficacy and Safety of Ruxolitinib Cream for the Treatment of Moderate to Severe Chronic Hand Eczema: Results From a 16-Week, Multicenter, Randomized, Double-Blind Study 0.11
Establishment of standardized definitions and a core set of outcome characteristics following hidradenitis suppurativa surgery developed by an expert Delphi consensus 0.03
Skin Clearance, Duration of Treatment-free Interval, and Safety of Tapinarof Cream 1% Once Daily: Results from ADORING 3, a 48-week Phase 3 Open-label Extension Trial in Adults and Children Down to 2 Years of Age with Atopic Dermatitis 0.08
1 0.70
Wall Teichoic Acids Are Direct Molecular Targets of Antimicrobial Peptides in Gram-Positive Bacteria 0.70
3 0.16
Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B 0.06
Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope A Randomized Sham-Controlled Trial 0.06
Early Increase in Serum Transthyretin by Acoramidis Independently Predicts Improved Survival in TTR Amyloid Cardiomyopathy 0.04
10 8.85
The Association Between Hospital Harms and 1‐Year Mortality Following a Hip Fracture in Ontario, Canada: A Cohort Study 0.95
Evaluating the Joint Effects of Dementia and Frailty on Burdensome Transitions Among Long‐Term Care Residents in Ontario, Canada 0.90
<atl>Variation in Psychotropic and Non‐Psychotropic Prescribing in Nursing Homes: A Multi‐Level scpEMR/scp ‐Based Retrospective Cohort Study</atl> 0.95
Association of Geriatric Consult Services With Geriatric Processes of Care and Clinical Outcomes in US Trauma Centers 0.05
A Retrospective Chart Review of the Prevalence, Characteristics, and Discharge Destinations of Patients Hospitalized as “Social Admissions” 1.00
Predictors of Advance Directive Changes in Ontario Nursing Home Residents: A Case–Control Study 1.00
Effectiveness of Exercise in Older Adults Discharged From the ER After Minor Injuries: The CEDeComS Stepped-Wedge Trial 1.00
Perceptions of Older Adults and Caregivers on the Life Story Questionnaire in the Transition to Long‐Term Care in Côte‐Nord Region 1.00
Potential Overtesting of Nursing Home Residents With Diabetes in Ontario, Canada 1.00
Identifying a Set of Quality Indicators for Older Adults Hospitalized After Injury: An Expert Consensus Study 1.00
8 1.89
Subclinical Primary Aldosteronism and eGFR Decline Over Time. 0.93
Erythroid ACKR1 Deficiency Aggravates Immune-Mediated Kidney Disease. 0.05
Validation of the Klinrisk Machine Learning Model for CKD Progression in a Large Representative US Population. 0.43
Genetic Variation and Ultrafiltration with Peritoneal Dialysis: A Genome-Wide Association Study. 0.12
Identification of Renal Transcripts Associated with Kidney Function and Prognosis in ANCA-Associated Vasculitis. 0.07
Predictive Value of the Oxford Classification for the Effect of Glucocorticoid Therapy in IgA Nephropathy. 0.18
Kidney Parameters with Tirzepatide in Obesity with or without Type 2 Diabetes. 0.08
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci. 0.04
4 0.49
FaceAge as a biomarker for prognosis and treatment stratification in large-scale oncology cohort 0.02
Liver fat and clinical outcomes in individuals with stage I-iii Colon or rectal cancer 0.17
Basal cell carcinoma risk prediction in survivors of childhood cancer 0.13
Colon, colorectal, and all cancer incidence increase in the young due to appendix reclassification 0.17
7 2.57
Reduced podocyte stiffness is a feature of proteinuric kidney disease 0.75
A population-based, regression discontinuity analysis examined the effects of nationwide alerting for acute kidney injury on health care and patient outcomes 0.29
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy 0.40
A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis 0.06
The Coming of Age for Polycystic Kidney Disease 0.13
Integrating estimated glomerular filtration rate and kidney replacement therapy criteria within the definition of kidney failure 0.86
The enzyme SMPDL3b in podocytes decouples proteinuria from chronic kidney disease progression in experimental Alport Syndrome 0.09
22 7.52
Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study 0.08
Characterization of the chromosome 7 locus associated with suicidal behavior 1.00
Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis 0.01
A longitudinal DNA methylation atlas and its link to brain structure and mental health 0.03
Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis 0.04
A genome-wide investigation of depression among individuals with and without irritability 1.00
Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression 1.00
Dynamic interactions between gut microbiome and host lipidome in antenatal depression: a large longitudinal study 0.04
Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors 0.03
Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis 0.05
Homeostatic scaling ensures behavioural stability during corticosterone negative feedback 0.92
Deliberate self-harm and suicide in individuals with cannabis-related hospital contacts in Ontario, Canada 0.97
Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium 0.04
MAO-B status in alcohol use disorder: a [11C]SL25.1188 PET imaging study of putative astrogliosis 0.98
Investigating the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences 0.04
Psilocybin mitigates chronic behavioral and neurobiological alterations in a rat model of recurrent intimate partner violence-related brain injury 0.54
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group 0.02
Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit 0.11
Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk 0.38
Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders 0.06
Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response 0.03
Long term safety of ADHD medication in patients with schizophrenia spectrum disorders 0.14
6 1.92
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones 0.04
A pore-forming antiphage defence is activated by oligomeric phage proteins 1.00
Prevalence of Alzheimer’s disease pathology in the community 0.06
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury 0.04
Prophages block cell surface receptors to preserve their viral progeny 0.70
Multi-timescale reinforcement learning in the brain 0.08
53 16.41
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network 0.09
Predicting individual differences of fear and cognitive learning and extinction 0.01
γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response 0.05
An anti-adhesive compound modulating the production of Staphylococcus aureus cell wall-anchored proteins 0.46
Multiomics characterization of acute child illness and mortality in Africa and South Asia 0.05
A deep representation learning model to predict response to vagus nerve stimulation 0.62
Complex temporal dynamics of phage-bacteria populations in an animal-associated marine system 0.27
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes 0.03
Small intestinal microbial fiber metabolism dysfunction in celiac disease 0.75
Pathogenic variants in the cohesin loader subunit MAU2 underlie a distinct Cornelia de Lange Syndrome subtype 0.05
IgA autoantibodies promote inflammation, Th17 polarization and fibrotic responses in hidradenitis suppurativa 0.08
Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention 1.00
A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication 0.40
Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices 0.27
A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity 0.25
Using the linear references from the pangenome to discover missing autism variants 0.01
Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome 0.08
Once and thrice weekly interval training in adults with central obesity: a randomized controlled trial 0.08
Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis 0.20
Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli 1.00
Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells 0.04
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations 0.06
PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis 0.89
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC 0.29
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels 0.17
Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity 0.08
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function 0.01
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database 0.02
Empathi: embedding-based phage protein annotation tool by hierarchical assignment 0.60
Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites 0.03
Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia 0.06
Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models 1.00
Molecular cartography of the human down syndrome and trisomic mouse brain 0.95
Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women 0.13
Neural correlates of human fear conditioning and sources of variability in 2199 individuals 0.02
DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge 0.05
Antimicrobial peptide class that forms discrete β-barrel stable pores anchored by transmembrane helices 0.36
Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems 0.50
Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities 0.17
Estimation-uncertainty affects decisions with and without learning opportunities 0.17
A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice 0.91
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge 0.05
Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP 0.83
Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial 1.00
Characterizing trachoma elimination using serology 0.01
Yanomami skin microbiome complexity challenges prevailing concepts of healthy skin 0.04
Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants 0.02
Role of the upper airway microbiota in respiratory virus and bacterial pathobiont dynamics in the first year of life 0.31
Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron 0.06
Impact of unequal testing on vaccine effectiveness estimates across two study designs: a simulation study 1.00
Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study 0.07
Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy 0.11
Tinnitus risk factors and its evolution over time 0.64
4 0.40
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling 0.04
Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression 0.02
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling 0.25
Genome-wide association study of long COVID 0.09
2 0.06
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size 0.02
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control 0.04
15 5.48
An international mega-analysis of psychedelic drug effects on brain circuit function 0.04
Deleterious coding variation associated with autism is shared across ancestries 0.01
Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo 0.09
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 0.42
Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy 0.07
Fecal microbiota transplantation plus immunotherapy in metastatic renal cell carcinoma: the phase 1 PERFORM trial 1.00
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial 0.67
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study 0.01
Eliminating opioid prescriptions from outpatient minimally invasive gynecologic surgery: a randomized trial 1.00
Characterizing the physiology of circulatory arrest in humans 0.94
Feasibility, acceptability and clinical outcomes of the BabyScreen+ genomic newborn screening study 0.06
Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial 0.07
Varicella-zoster virus reactivation and the risk of dementia 0.08
Adjunct-to-insulin therapy using SGLT2 inhibitors in youth with type 1 diabetes: a randomized controlled trial 0.77
An international Delphi consensus for reporting of setting in psychedelic clinical trials 0.25
2 1.56
Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI 0.83
HippoMaps: multiscale cartography of human hippocampal organization 0.73
2 0.19
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability 0.05
Autonomic physiological coupling of the global fMRI signal 0.14
1 0.50
Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual 0.50
5 2.05
Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex 0.04
Distinct interneuronal dynamics selectively gate target-specific cortical projections in drug seeking 0.12
Molecular mechanisms mediating engram ensemble retrievability state in mice 0.83
PV-dependent reorganization of prelimbic cortex sub-engrams during systems consolidation 1.00
Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum 0.06
2 0.48
Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors 0.46
Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms. 0.02
2 1.17
Rare diseases load through the study of a regional population 1.00
Deciphering the RNA-based regulation mechanism of the phage-encoded AbiF system in Clostridioides difficile 0.17
4 2.47
Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study 1.00
Oral preexposure prophylaxis use and the risk of bacterial sexually transmitted infections and HIV among African women: A prospective observational cohort study 0.06
Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study 0.96
Rapid molecular testing or chest X-ray or tuberculin skin testing for household contact assessment of tuberculosis infection: A cluster-randomized trial 0.45
14 8.97
NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium 1.00
Identification of somatostatin+ inhibitory engrams for extinction in the basolateral amygdala 0.05
Reprogrammed SimCells for antimicrobial therapy 0.07
Differential disease tolerance mediates sex-biased illness severity in sepsis 1.00
The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior 0.88
Micro-offline gains do not reflect offline learning during early motor skill acquisition in humans 0.20
Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria 1.00
De novo design of potent inhibitors of clostridial family toxins 0.58
Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child 0.26
Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission 0.07
Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level 1.00
Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain 1.00
The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury 1.00
Healthy sleep durations appear to vary across cultures 0.86
2 0.58
Integrating microclimate to understand vector development and disease patterns: challenges and lessons from plague in Madagascar’s Central Highlands 0.08
Homophily in a multi-group vaccination game and its impact on disease dynamics 0.50
4 1.11
C-FLAIR: Fluid-attenuated Inversion Recovery with Controlled Artifact Suppression in Brain MRI. 0.67
Standalone Endovascular Embolization versus Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations in Eloquent Brain. 0.01
Impact of LI-RADS CT and MRI Ancillary Features on Diagnostic Performance: An Individual Participant Data Meta-Analysis. 0.20
Diagnostic Performance of CT/MRI LI-RADS Version 2018 Major Feature Combinations: Individual Participant Data Meta-Analysis. 0.23
1 0.35
Attenuation of virulence in Yersinia pestis across three plague pandemics 0.35
8 4.84
Childhood immune imprinting shapes cohort and period influenza mortality 0.17
SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes 0.13
A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis 0.85
Bacteriophage-loaded microneedle patches for targeted and minimally disruptive foodborne pathogen decontamination 0.97
Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding 1.00
The discovery of a Legionella phage explains a key determinant of human disease 0.78
Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets 0.04
Genetic foundations of interindividual neurophysiological variability 0.90
5 1.36
AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy 0.71
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice 0.09
Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia 0.17
Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis 0.35
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates 0.04
4 0.64
Benefits and harms of ADHD interventions: umbrella review and platform for shared decision making 0.02
Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis 0.10
Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis 0.04
Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis 0.49
1 0.03
Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage 0.03
1 0.75
A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere 0.75
5 0.83
Bimekizumab long-term response in psoriasis: Mechanistic insights into efficacy level and durability 0.06
Epinephrine and Emergency Medical Services Activation Recommendations During Acute Allergic Reactions in Community Settings: International Consensus Report 0.08
Targeting IL-22RA1 with Temtokibart: A Novel Approach in Atopic Dermatitis: Phase 2a Monotherapy Study Results 0.15
Remibrutinib in chronic spontaneous urticaria: 52-Week results from two phase 3 studies 0.09
Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis 0.44
8 0.69
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on oral antiretroviral therapy: 48-week results of a phase 3, multicentre, randomised, open-label, non-inferiority trial 0.05
Surgical fixation versus non-surgical care for children with a displaced medial epicondyle fracture of the elbow (the SCIENCE study): a multicentre, randomised controlled, superiority trial and economic evaluation 0.02
Maternal and neonatal outcomes after infection with monkeypox virus clade I during pregnancy in DR Congo: a pooled, prospective cohort study 0.03
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial 0.08
Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis 0.02
Once-daily oral icotrokinra versus placebo and once-daily oral deucravacitinib in participants with moderate-to-severe plaque psoriasis (ICONIC-ADVANCE 1 & 2): two phase 3, randomised, placebo-controlled and active-comparator-controlled trials 0.13
Safety and efficacy of steroidal mineralocorticoid receptor antagonists in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of randomised controlled trials 0.28
Efficacy and safety of intravenous induction and subcutaneous maintenance therapy with guselkumab for patients with Crohn's disease (GALAXI-2 and GALAXI-3): 48-week results from two phase 3, randomised, placebo and active comparator-controlled, double-blind, triple-dummy trials 0.09
2 1.13
Once-weekly semaglutide 7·2 mg in adults with obesity and type 2 diabetes (STEP UP T2D): a randomised, controlled, phase 3b trial 0.13
The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada 1.00
1 0.50
Strategies to reduce antimicrobial resistance in newborns in low-income and middle-income countries: a systematic review and meta-analysis 0.50
2 1.13
Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments 0.20
Safety and effectiveness of the Walk ‘n Watch structured, progressive exercise protocol delivered by physical therapists for inpatient stroke rehabilitation in Canada: a phase 3, multisite, pragmatic, stepped-wedge, cluster-randomised controlled trial 0.93
2 0.86
First-episode psychosis and substance use involvement across birth cohorts in Canada: a retrospective longitudinal population-based study 0.82
Efficacy and safety of iclepertin for cognitive impairment associated with schizophrenia (CONNEX programme): results from three phase 3 randomised controlled trials 0.05
15 2.93
Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock 0.23
Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial 0.04
Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus 0.04
Finerenone in Type 1 Diabetes and Chronic Kidney Disease 0.05
Hematopoietic Stem-Cell Gene Therapy for Cystinosis 0.05
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes 0.04
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial 0.04
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy 0.05
Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents 0.13
Selective Decontamination of the Digestive Tract during Ventilation in the ICU 0.38
Belzutifan for Advanced Pheochromocytoma or Paraganglioma 0.08
Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes 0.20
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes 0.05
Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation 0.55
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline 1.00
2 0.42
L-norepinephrine induces community shift, oxidative stress response, metabolic reprogramming, and virulence potential in wastewater microbiomes 0.33
Bioluminescent-reporter phagosensor for quantitative detection of viable Escherichia coli in water 0.08

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