Immunology articles

Time frame: 1 May 2025 - 30 April 2026

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Count: 1577

Article ‘Count’ for Immunology.

Journal Count
22
Universal Nanovial Screening Enables Functional Discovery of Metabolite-Reactive T-Cell Receptors for Cancer Therapy
Single-Cell Sequencing Analysis-Driven Nanomedicine Design for Mimicking Endogenous Immune Repair in Myocardial Infarction
Adrenomedullin Antagonist Nanoparticles Inhibit Breast Cancer Brain Metastasis by Immunomodulating Monocytes/Macrophages
Charge-Adaptive Nanoparticle Attenuates Inflammation via Targeting Neutrophil Extracellular Traps (NETs) and Breaking NETs–Macrophage Crosstalk
Leveraging Naturally Assembled Tumor Extracellular Vesicles as Self-Adjuvanting Nanovaccines to Potentiate Cancer Immunotherapy via cGAS/STING Activation
Drug-free Immunotherapeutic Biomimetic Nanoparticles for Treating Triple-Negative Breast Cancer
Cellular Nanoparticle–Probiotic Biohybrid for Multimodal Oral Therapy of Food Allergy
Promoting Endogenous Danger Signals Accumulation by a Hierarchical Nanoinducer for Amplifying STING Pathway Activation-Mediated Tumor Immunotherapy
Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury
Programmed Cell Death Protein 1 Engagement Impairs Cytoskeletal Forces and Nuclear Mechanotransduction in T Cells
Natural Macrophage Membrane-Coated Nanoparticles as a Multifaceted Sepsis Therapeutic to Sequester Inflammatory and Toxic Mediators
Proinflammatory Macrophage-Targeted Nanoparticles Rejuvenate Aged Macrophages and Their Phagocytic Capacity
mRNA-Based Vaccination Drives in Vivo Dendritic Cell Reprogramming and Selective Cytotoxic T Lymphocyte Modulation for Enhanced Antitumor Immunity
Pulmonary Surfactant Protein-Hitchhiking Inhalable Vaccines Augment Mucosal and Systemic Antiviral Immunity
Magnetic-Responsive Semilifeform for Protecting Peritumoral T Lymphocytes and Precise Tumor Eradication
Picroside II-Encapsulated Nanoformulations as Pyroptosis Inhibitor Alleviate Cytokine Storms and Remodel Gut Microbiota Disturbances
An Antigen-Free Nanovaccine-Enabled Holo-Immunotherapy for Establishing Robust Memory Immune Tolerance in Autoimmune Diseases
Reprogramming Macrophage Function via Cholesterol Modulation and Redox Signaling Using a Multifunctional Nanoplatform for Postoperative Breast Cancer Management
Reprogramming Macrophage via an Antigen Phagocytosis-Presentation Nanoenhancer for Improved Cancer Immunotherapy
In Situ Tumor Surface Modification with Antibody Fragments for Antigen-Independent Versatile Cancer Immunotherapy
Focused Acoustic Vortex-Activated Dual-Stimuli Nanoplatform Synergizes with Checkpoint Blockade to Enhance Macrophage Phagocytosis and Antitumor Immunity
Artificial Tolerogenic Dendritic Cell-Derived Vesicles Prepared by High-Pressure Homogenization for Potent Immunotherapy of Type 1 Diabetes
9
Hydrogel Viscoelasticity Regulates Human Monocyte-derived Macrophage Morphology and Phenotype in 2D Culture
Tunable Wrinkled Topographies Direct Dendritic Cell Maturation and Immune Phenotypes
Hydrogels with hierarchical hydrogen bonds enable tunable stress relaxation to direct macrophage-driven immunoregulation
Nanobody-based high-performance multitarget immunosorbents protect against sepsis by concurrently adsorbing endotoxins and inflammatory cytokines
Quantum sensing to monitor changes in free radical generation by intracellular vesicles of polarized macrophages
IL-21R-Targeted Nano-immunosuppressant Prevents Acute Rejection in Allogeneic Transplantation by Blocking Maturation of T Follicular Helper Cells
Mitochondria-targeted manganese-based mesoporous silica nanoplatforms trigger cGAS-STING activation and sensitize anti PD-L1 therapy in triple-negative breast cancer
Engineered probiotics remodel the intestinal epithelial barrier and enhance bacteriotherapy for inflammatory bowel diseases
Immuno-engineered macrophage membrane-coated nanodrug to restore immune balance for rheumatoid arthritis treatment
9
A “Depolarization‐Activation” Strategy Targeting Microglia: Cuproptosis‐Mediated Immune Re‐Sensitization Nanoplatform in Glioma Therapy
Nanodisc-Based Platform for HLA Antibody Identification
Sonodynamic/Mechano‐Induced cGAMP Biosynthesis Enables In Situ STING Activation for Enhanced Cancer Immunotherapy
Targeting Microglia Extracellular Traps via an “Internal‐External” Synergistic Strategy to Reshape the Dysregulated Microglia‐Neuron Axis for Spinal Cord Injury Recovery
Multi‐Target Nanoscavengers for Interrupting the Feed‐Forward Inflammatory Cycle in Autoimmune Diseases
Genetically Programmable Biohybrid Nanoplatform Enables Cuproptosis-Immunotherapy via Spatiotemporal Control of Macrophage Polarization and Copper Flux
Inhibiting Senescence‐Associated Macrophage‐Epithelia Cell Communication via siPLAU Gene‐Patch for Colorectal Cancer Treatment
Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy
Flow-Induced Vascular Remodeling on-Chip: Implications for Anti-VEGF Therapy
11
In Situ Peptide Self-Assembly Augments Antibody Recruitment for Tumor Immunotherapy
Serum-Inert Tandem-Locked Fluorescent Probe for Specific Imaging of Intratumoral Complement System
Reengineering Aligned D‐Orbital Energy Levels in FeMn Dual‐Atom Nanozyme Inhibits Pyroptosis for Effective Alleviation of Inflammatory Diseases
Unique Dual‐Affinity Strategy for Specific Lipopolysaccharide Clearance in Sepsis Therapy: Peptide‐Conjugated Molecularly Imprinted Polymers via Emulsion Interfacial Polymerization
Macrophages Mediate Mesoscale Brain Mechanical Homeostasis
Ultrasound‐Activated Piezoelectric Nanoparticles Targeting and Activating NK Cells for Tumor Immunotherapy
Fueling IgA-Dominated Humoral Immunity with an Intranasal Hybrid Tumor Vaccine to Opsonize and Strike Epithelial Breast Cancer
Liver‐Targeted Tolerogenic Vaccines: A Nano‐Membrane Coupled Approach for Autoimmune Disease Therapies
Intranasal and Intravenous Sequential Administration of Survivin Peptide‐CpG Nanovaccines Elicits Potent Immunity Toward Glioblastoma
A Single-Cell Atlas-Inspired Hitchhiking Therapeutic Strategy for Acute Pancreatitis by Restricting ROS in Neutrophils
Differential Optical Imaging of Antigen Presentation Machinery Using Molecular Optical Reporters
1
Thyroid autoimmunity and the subsequent development of islet and celiac autoimmunity in the TEDDY study
8
Elevated CD45+CD11c+CX3CR1+ Cells in Optic Nerves and Their Relation to Optic Nerve Function in an Experimental Autoimmune Encephalomyelitis Model
Macrophages Are Critical Inducers of Bleomycin-Induced Fibrosis in a Systemic Scleroderma Model
Stimulator of Interferon Genes Is a Fine-Tuner, but Not a Prime Mover, of Kidney Inflammation
KLF Transcription Factor 5/Lysophosphatidic Acid Receptor 5 Induced M2 Macrophage Activation and Inflammation by Modulating Phosphorylation of Mitogen-Activated Protein Kinase Kinase Kinase 7 in Pediatric Asthma
PGE2 signaling triggers CD31-independent transendothelial migration in vitro and in vivo.
Characterizing Kupffer Cell Production of CD5L and Its Function on Regulating Migration of Natural Killer T Cells
Notch signaling aggravates Helicobacter pylori-induced inflammation by promoting macrophage activation and pro-inflammatory Th1/Th17 responses
Effect of Fibroblast Signaling on Macrophage Polarization
5
Interleukin-6 is a mediator of therapeutic efficacy in acute lung injury
Self-propagating nature of pathogenic extracellular vesicles associated with smoking and chronic obstructive pulmonary disease
STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome
ARDS Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes.
Rademikibart Treatment for Moderate-to-Severe Uncontrolled Asthma: A Phase 2B Randomized Clinical Trial
5
Label-Free Raman Spectral Identification of NK and NKT Cells in Immune Heterogeneous Cell Populations
Aptamers Generated by Multi-Strategy Selection Target FcγRI and Block IgG Fc-FcγRI Interaction
A Versatile Tool for Imaging Neutrophil Elastase in Diabetic Complication
IL-2 and IFN-γ Secretion of Activated Jurkat T Cells via a Microdroplet-SERS based Single-Cell Immunoassay (Drop-SCIA)
Evaluation of Antiviral Activity of Lactoferrin in Bovine Milk Toward Fondaparinux Using Ordered Porous Layer Interferometry
7
4-Dimethylaminophenol: A ‘Smaller’-Molecule PPI Inhibitor Targeting the PSD95 GK Domain Against Ischemic Stroke
Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors
Engineered Biomimetic Nanoparticles With Targeted Delivery of Chlorothiazide for the Treatment of Inflammatory Bowel Disease
Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide
Persistent Membrane‐Anchored Oligomeric Peptides with Nanopore Formation for Targeted Immune Modulation
Glycosylation‐Dependent Stability of Human Pentraxin‐2 Revealed by Surface‐Induced Dissociation and Ion Mobility Mass Spectrometry
Restoring Cell–Cell Communication to Elicit Bystander Effect Using a DNA‐Based Nanocomplex for Robust Immunotherapy
4
DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study
Pro-Inflammatory c-Met+ CD4 T Cells in Multiple Sclerosis
Comparative Safety Profiles of Ocrelizumab and Rituximab in Multiple Sclerosis Treatment Using Real‐World Evidence
Effect of Cumulative Exposure to Ocrelizumab on Memory B‐Cell Repopulation Dynamics in Multiple Sclerosis
13
Dual dynamics of persistence and recruitment characterise the ACPA-expressing B cell response in rheumatoid arthritis
A pathogenic gut lipoglycan drives systemic thromboinflammation in lupus nephritis
CD40-CD40L inhibition attenuates platelet-neutrophil interaction and neutrophil extracellular trap release in primary antiphospholipid syndrome
Dimerization as a key feature of autoreactive IgA antibody responses
Frequent genetic alterations in myositis autoantigen genes in cancer-associated dermatomyositis
A human-STING specific macrocyclic peptide suppresses cGAS-STING-induced inflammation
Clinical and biologic predictors of thrombosis in persistently antiphospholipid antibody-positive patients: Prospective analysis of the International APS ACTION Clinical Database and Repository (‘Registry’)
Insights from a novel monogenic autoinflammatory disease: overview of a multicentric European cohort of 38 patients with COPA syndrome
Autoreactive T cells identified in patients with anti-Jo1+ antisynthetase syndrome recognise a new epitope on histidyl t-RNA synthetase
IL-2 signalling sustains pathogenic age-associated B cell homeostasis in lupus
Genetically modified CD19-targeting IL-15 secreting NK cells for the treatment of systemic lupus erythematosus
Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome
Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis
16
The potential role of synovial T‐cell infiltration following knee joint injury in symptoms and progression to osteoarthritis
Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis
Interleukin‐2 deprived state of regulatory T cells and their recovery by low‐dose interleukin‐2 in patients with inflammatory myopathies
Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus
Type I Interferon Signature is Associated With Lung Disease, Drug‐Associated Immune Reactions, and Genetic Variation in Interferon‐Linked Pathways in Still Disease
Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function
<atl>Single‐cell scpRNA/scp sequencing informs precision targeting of monogenic lupus associated with scp iIKZF1/i /scp haploinsufficiency</atl>
Molecular stratification of antiphospholipid syndrome through integrative analysis of the whole‐blood RNA transcriptome
Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome
MDSC-derived IFN-β promotes T follicular helper cell response and exacerbates lupus development
Lifelong evolution of autoreactive plasma cell numbers, affinity and anatomical location in arthritic K/BxN mice
Diagnostic implications and correlates of plasma ADA2 activity and ADA2 variants
Comparative efficacy and safety of anakinra and canakinumab in patients with scpVEXAS/scp syndrome – an international multicenter study
Prognostic value of lupus anticoagulant and anti‐β2 glycoprotein I antibody in adverse pregnancy outcomes.
Sustained Interferon Signature Suppression With Anifrolumab in a Patient With STING‐Associated Vasculopathy with Onset in Infancy Refractory to scpJAK/scp Inhibitor and Dazukibart Therapy
Loss of Tripartite Motif–Containing Protein 21 and UVB-Induced Systemic Inflammation by Regulating DNA-Sensing Pathways
30
Targeting donor XCR1+ and CD11b+ dendritic cells prevents Th1- and Th17-dependent GVHD within the gastrointestinal tract
Silencing of PAI-1 using siRNA-lipid nanoparticles reduces thrombosis and prolongs life span in murine models
CDK8/CDK19 inhibition restores T-cell homeostasis in primary immune thrombocytopenia
Plasmin modulates neutrophilic inflammation and alveolar macrophage function, protecting mice from pneumococcal pneumonia
DC-SIGN binding to the surface immunoglobulin oligomannose-type glycans promotes follicular lymphoma cell adhesion and survival
The C/EBPα-(PU.1-LOUP) regulatory circuit regulates monocyte/macrophage development and immune functions
Selective depletion of ABO-responsive B cells by T-cell–engaging bispecific antibody conjugates for ABOi transplantation
Predicting development of pediatric chronic immune thrombocytopenia at disease onset using a statistical risk model
Gastrin for the treatment of acute graft-versus-host disease of the stomach
RGI-2001 for the prophylaxis of acute graft-versus-host disease after allogeneic HCT
A single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD
The T follicular helper/T follicular helper regulatory pathway in FVIII immune responses in mice
Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT
Outcomes of allogeneic HCT in Hodgkin lymphoma in the era of checkpoint inhibitors: a joint CIBMTR and EBMT analysis
The neutrophil antigen 3a/b polymorphism in SLC44A2 unexpectedly encodes the Csa/Csb red cell antigens
Deciphering opsonized zymosan-induced phosphorylation of p47phox and NADPH oxidase activation in human neutrophils
Plasminogen as a Ribonucleoprotein: Regulatory small RNA Cargo Modulates Fibrinolysis and Inflammation
Clinical and molecular features of immunodeficiency in patients with telomere biology disorders
Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis
Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone
The bone marrow NK-cell profile predicts MRD negativity in patients with multiple myeloma treated with daratumumab-based therapy
RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury.
A first-in-class JAK/ROCK inhibitor, rovadicitinib, for glucocorticoid-refractory or -dependent chronic GVHD
Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study
HLA-haploidentical stem cell transplantation for chronic granulomatous disease: an EBMT-IEWP retrospective study
Platelet NLRP6 protects from microvascular thrombosis in sepsis
Low rates of chronic graft-versus-host disease with ruxolitinib maintenance following allogeneic HCT
Defining pathogenic IL-17 and CSF-1 gene expression signatures in chronic graft-versus-host disease
Augmented CD47 expression impairs alloreactive T cell clearance after allo-HCT
Expansions of circulating plasmablasts producing commensal-reactive IgA antibodies are predictors for chronic GVHD
5
Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyelitis optica from multiple sclerosis
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis
CD21lo B-cell subsets are recruited to the central nervous system in acute neuromyelitis optica
Plasma periaxin is a biomarker of peripheral nerve demyelination
Altered T-cell reactivity in the early stages of Alzheimer's disease
8
Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas
DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
Subclonal immune evasion in non-small cell lung cancer
A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread
23
LINE-1 Retrotransposon Protein ORF1p Forms Condensates That Drive cGAS-Induced Immune Evasion in Lung Squamous Cell Carcinoma
Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells
Artificial Intelligence and Multimodality Data Integration Decipher Tertiary Lymphoid Structure Maturity in Gastric Cancer.
Surgery-Induced Neutrophil Extracellular Traps Promote Tumor Metastasis by Reprogramming Cancer Cell Lipid Metabolism
circADAMTS12 Inhibits the Antitumor Activity of Microglia to Enable Metastatic Colonization in the Brain
ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion
Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti–PD-1 Immunotherapy
Hypoxia Induces Immunosuppression by Silencing STING in Cancer
Pro-tumor Macrophage Polarization Mediated by BMP2/4-ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment During Tumor Initiation.
SPP1+ Neutrophils Mediate Resistance to Immune Checkpoint Blockade in BAP1-Inactivated Tumors
Response to Immune Checkpoint Blockade is Enhanced in the Presence of Hematopoietic TET2 Inactivation.
USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Co-evolution in Pancreatic Cancer.
Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer.
ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes.
Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis.
A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma that Drives Antitumor Immunity.
Targeting Innate Immune Checkpoint TREX1 Is a Safe and Effective Immunotherapeutic Strategy in Cancer
Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T-cell–Mediated Tumor Control
Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells.
Antigen Cross-Presentation by Type-2 Innate Lymphoid Cells Facilitates the Activation of Antitumor CD8+ T Cells
Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin
SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T-cell Activity in Hepatocellular Carcinoma
20
Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
STING signaling modulation by COPII cargo recognition
Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin
In vivo detection of immune responses via cytokine activity labeling
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
Dendritic cells regulate the innate-adaptive balance in lymph nodes for optimal host defense
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity
Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells
Generation of antigen-specific paired-chain antibodies using large language models
SARM1 senses dsDNA to promote NAD+ degradation and cell death
CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success
Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity
Highly conserved Betacoronavirus sequences are broadly recognized by human T cells
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Structure of gut microbial glycolipid modulates host inflammatory response
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity
12
Bacterial 2′,3′-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication
Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues
An image-based transcriptomics atlas reveals the regional and microbiota-dependent molecular, cellular, and spatial structure of the murine gut
Gut DNA virome enterotype dictates inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn's disease
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier
Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity
A CLOCK-targeting lncRNA induces trained immunity against tuberculosis
Lantibiotic-producing bacteria impact microbiome resilience and colonization resistance
Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication
Veillonella intestinal colonization promotes C. difficile infection in Crohn’s disease
Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism
Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis
1
Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
1
In vivo CAR-Tfh cell reprogramming restores tolerance in a mouse model of autoimmune hepatitis
1
A dual-site fluorescent probe for tracing the interaction between ATP and NE in neuroinflammation
4
In situ released bacterial membrane vesicles activate the STING pathway via boosting the intracellular DNA pool for immunotherapy
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds
Odoribacter splanchnicus lipooligosaccharide: an uncommon structure with weak immunostimulatory activity
TRAP: a contrastive learning-enhanced framework for robust TCR–pMHC binding prediction with improved generalizability
1
Posttransplant Cyclophosphamide Reduces Bronchiolitis Obliterans Syndrome Risk Through Chronic Graft vs Host Disease Prevention
4
HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance.
Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1.
Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Mitochondrial 1-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis.
17
De Novo Cancer in Liver Transplant Patients With Human Immunodeficiency Virus Infection: A Multicenter Nationwide Cohort Study
Respiratory Syncytial Virus Vaccination in Solid Organ Transplant Recipients: Interim Findings From a Phase 3 Trial of mRNA-1345
Integrating genomic data into test-negative designs for estimating lineage-specific COVID-19 vaccine effectiveness
Safety and Immunogenicity of a Fourth Dose of Omicron-BA.1-Adapted BNT162b2 COVID-19 Vaccines in Adults 18‒55 Years Old
Infections After Kidney Transplantation From Donors With Human Immunodeficiency Virus (HIV) to Recipients With HIV
Cytomegalovirus-specific cell-mediated immunity for prediction of post-prophylaxis CMV disease in a phase 3 trial of letermovir vs valganciclovir prophylaxis in donor CMV-seropositive recipient CMV-seronegative kidney transplant recipients
An Analysis of Cytomegalovirus-Specific Cell-Mediated Immunity in a Phase 3, Randomized, Placebo-Controlled Trial of Letermovir Prophylaxis in Cytomegalovirus-Seropositive Recipients of an Allogeneic Hematopoietic Cell Transplant
IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes
A Phase 3, Randomized Trial Investigating the Safety, Tolerability, and Immunogenicity of V116, an Adult-Specific Pneumococcal Conjugate Vaccine, in Pneumococcal Vaccine-Naïve Adults 18–64 Years of Age at Increased Risk of Pneumococcal Disease, STRIDE-8
Safety, Tolerability, and Immunogenicity of Revaccination With mRNA-1345, an mRNA Vaccine Against RSV, Administered 12 Months Following a Primary Dose in Adults Aged ≥50 Years
Immunogenicity and Safety of the Coronavirus Disease 2019 Messenger RNA Vaccine Coadministered With Influenza and 23-valent Pneumococcal Polysaccharide Vaccines
Cytomegalovirus Vertical Transmission Rate According to IgG Avidity Value and Valacyclovir Treatment of Maternal Primary Infection in the First Trimester of Pregnancy
Long-term protection against invasive meningococcal B disease and gonococcal infection five years after implementation of funded childhood and adolescent 4CMenB vaccination program in South Australia: an observational cohort and case-control study
Effectiveness and safety of Autologous Virus-Specific T Cell Therapy for Persistent COVID-19 in People with Immunocompromise: A Clinical Trial Study
The Effect of Live-Virus Vaccines on Tests for Tuberculosis Infection During the US Immigration Medical Examination: Are Vaccines Causing False-Negative Results?
Transfer of Herpes Simplex Virus Type 1 (HSV-1) Specific T Cells in a Pediatric Patient Post-HSCT With Severe, Acyclovir-resistant HSV-1 Infection
Virus-Specific T-Cell Therapy for Prophylaxis and Treatment of Cytomegalovirus Infections After Transplantation: a Scoping Review
4
Interleukin-6-Associated Pyroptosis, Apoptosis, and Necroptosis via JAKs/STAT3-RIPK1 Axis: A Potential Mechanism for CD4+ T-Cell Depletion in Bacterial Sepsis.
Early T-Lymphocyte Depletion Predicts Mortality in Critically Ill Children With Severe Infections: An Exploratory Analysis of Cytokine Pathways.
Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis.
Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure.
2
Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi
Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila
5
MITA/STING-driven CD38 induction in Siglec-Flow macrophages promotes regulatory T cell survival and non-small cell lung cancer progression
Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses
Inchworm migration facilitates amoeboid cell adaptation to high-adhesion environments
Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis
Targeting VSIG4+ tissue-resident macrophages enhances T cell cytotoxicity and immunotherapy efficacy in cancer
7
Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial.
Use of Teplizumab to Modulate Stage 2 Type 1 Diabetes in Two Individuals With Autoimmune Polyendocrine Syndrome 1.
Generalizability of Progression Risk in the TN-10 Trial to a European Population With or Without a First-Degree Relative With Type 1 Diabetes.
Clinical Characteristics in Swedish Children With and Without Autoantibodies at the Time of Type 1 Diabetes Diagnosis.
Thyroid, Celiac, and Other Autoimmune Diseases and the Risk of Incident Type 1 Diabetes in Young Adulthood.
DNA Methylation Smoking Scores and Risk of Islet Autoimmunity and Type 1 Diabetes.
Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in Type 1 Diabetes: Prospective Longitudinal Study in Japanese Type 1 Diabetes (TIDE-J).
2
Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line
Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line.
13
Post-embryonic consequences of embryonic exposure: Mechanisms of Developmental Toxicity Induced by selective serotonin re-uptake inhibitors and tributyltin in Daphnia magna
Mechanism of neuroinflammation and cardiovascular toxicity induced by tributyltin: Evidence from zebrafish (Danio rerio) models and network toxicology studies
Multi-omics Analysis and Preliminary Experimental Validation of Acetyl Tributyl Citrate (ATBC) Promoting Bladder Cancer Progression via the AKR1B1/EMT Axis
ERα-mediated endoplasmic reticulum stress drives 4-tert-octylphenol–induced cardiac developmental toxicity in zebrafish
Trichloroethylene induces cardiomyocyte senescence through an AhR–ROS–IL-1 axis and amplified by Wnt/β-catenin suppression
EBV-driven rewiring of Drp1-Mediated mitophagy exacerbates trichloroethylene-induced hypersensitivity syndrome
Preliminary insights into methylation patterns in Agent Orange exposed thyroid cancers: a pilot study
Short-chain fatty acids alleviated fluoride-induced neuroinflammation via the gut-brain axis in rats
AhR/PPARγ mediates hepatic lipid metabolism disorders induced by exposure to 16 priority-controlled PAHs at environment related doses
Investigating the mechanisms of Triclocarban-induced liver injury: A comprehensive analysisbased on network toxicology and in vivo experiments
Genome-wide alterations of DNA methylation and hydroxymethylation in uroepithelial cells revealed potential carcinogenicity of halobenzoquinone disinfection byproducts
Steroid hormones and their combinations affect circadian rhythm pathway in F0 Gambusia affinis using transcriptome sequencing: validation by life-long exposure of F1 offspring and molecular dynamics
Screening and prediction of potential androgen receptor agonists in indoor dust
10
Oxidative Stress as a Pathway Linking Maternal Phthalate and Bisphenol Exposure to Childhood Allergy and Lung Function: Mediation and Interaction Analyses
Cytogenotoxic effects of polycyclic aromatic hydrocarbons complex mixture in human peripheral blood, lung A549 and liver HepG2 cells: Translation of a real-scenario exposure to in vitro
Associations of Serum PFAS with COVID-19 Antibody Levels among Fully Vaccinated Adults
Contribution of AhR-mediated activation of the AC/cAMP/PKA cascade to 6PPDQ-induced cardiac defects in zebrafish
Retraction notice to ‘T-2 toxin induces dermal inflammation and toxicity in mice: The healing potential of menthol’ [Environ. Res. 228 (2023) 115838]
Redox Imbalance and NF-κB Activation Drives 1,3-diphenylguanidine (DPG)-Induced Hepatotoxicity in Grass Carp (Ctenopharyngodon idella): HSP70 as a Protective Therapeutic Target
Metabolism exploration of disinfection byproducts halonitromethanes (HNMs) by cytochrome P450 enzymes and toxicity evaluation
Isothiazolinone biocides as aromatase inhibitors: Hormonal disruption, and in silico docking and SAR/QSAR analysis
1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, induces hepatic fibrosis: New insights into crosstalk between macrophage extracellular traps and stellate cell activation
17β-Trenbolone increases circulating myeloid-derived MMP8 in CSDS-induced mice and drives depressive tendencies to social threat
14
Mechanistic Insights into the Cardiotoxic Effects of Dextromethorphan and Its Metabolite Dextrorphan in Zebrafish Using Network Toxicology and Molecular Dynamics
Conformation of CD40LG and ANXA5 as Key Events of 2,7-Dibromocarbazole-Induced Cardiotoxicity Using in Vivo and in Vitro Models
Transgenerational Hazards Evade Traditional Safety Thresholds: ryr1b Hypermethylation Mediates Azoxystrobin-Induced Transgenerational Developmental Toxicity in Zebrafish (Danio rerio) at Subthreshold Exposure
Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents
Azocyclotin Binds CDK4 to Disrupt DNA Methylation in Zebrafish Epigenetic Transgenerational Inheritance
Aryl Hydrocarbon Receptor Activation Mediates Acute Lethality and Developmental Toxicity of Polychlorinated Diphenyl Ethers in Vertebrates: Mechanistic Insights and Implications for Toxicity Equivalency Factor Frameworks
PPARα Activation-Mediated Testosterone Reduction as the Key Adverse Outcome Pathway for Cd-Induced Male Infertility: A Novel Integrated Approach
Exploring the Androgen Receptor Binding Affinity of Azole Derivatives through Multiscale Computational and Experimental Approaches
Discovery of the Insecticide Chlorantraniliprole as a Thyroid Hormone Receptor β Antagonist Reinforcing Thyroid-Liver Metabolic Disruption to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease
Indoor Dust Increases the Risk of Iron-Loading Anemia in Mice through Exogenous Iron-Induced Ineffective Erythropoiesis
Genetic Polymorphisms in Nuclear Receptors Drive Variations in Responses to Environmental Exposures
Beyond Competitive Binding: New Biochemical Insights Challenge Endocrine Disrupting Chemical Screening Paradigms
Cellular Response to Halobenzoquinone Disinfection Byproducts Mediated by Aryl Hydrocarbon Receptor: Integrated Metabolomic and Transcriptomic Analysis
Development and Cross-Validation of a Zebrafish Quantitative Adverse Outcome Pathway Model on Aromatase Inhibition Leading to Reproductive Dysfunction
2
Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure
Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis
2
Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes
Quorum-Sensing Molecules Are Elevated in Long-Standing Ulcerative Colitis and Are Linked to the Development of Colitis-Associated Cancer
2
Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance
Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus
3
A genome-wide survey reveals that a diverse array of enhancers coordinates the Drosophila innate immune response
Genomic regulatory landscape underlying the antiviral response of Atlantic salmon
Genotyping of selected germline adaptive immune system loci using short-read sequencing data
8
CD16+ γδ T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection
RNA binding protein CAPRIN1 suppresses STAT1 translation and interferon signalling to promote HBV replication
CAV1-DOT1L axis in TAM-derived EVs orchestrates VM and sensitises PDAC to combined VM and VEGF targeting
Impairment of Rab7-dependent STING degradation hampers HBV replication but accelerates disease progression in chronic hepatitis B comorbid with MASLD
CD48 is a novel immune checkpoint on tumour‐associated macrophages in hepatocellular carcinoma
<atl>iParasutterella excrementihominis/i exacerbates experimental colitis and colitis-associated colorectal cancer via pathogenic NETosis activation</atl>
Enterococcus faecalis hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn’s disease by inducing gut dysbiosis
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis
6
FYN/LCK kinase balance as a metabolic switch orchestrates progenitor exhausted T Cell differentiation in hepatocellular carcinoma.
The role of OSM/OSMRβ axis in shaping the tumor microenvironment favouring MASLD-Related HCC immune evasion.
Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 Axis to prevent MASH.
Tumor-migrating peripheral Foxp3-high regulatory T cells drive poor prognosis in hepatocellular carcinoma.
Tertiary lymphoid structures in hepatocellular carcinoma: Influence on immune cell profiles in tumors and on efficacy of adjuvant PD-1 inhibitor therapy after hepatectomy.
Serum amyloid A1-Induced intrahepatic regulatory T cell dysfunction drives autoimmune hepatitis progression.
2
Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an iex vivo/i human testis model
Oncostatin-M: a novel leukocyte-derived factor facilitating the ovulatory process in the human ovary
68
Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer
An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment
Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control
Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation
Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone
Perinatal infection elicits clonally restricted T follicular helper cell responses that drive antibody-mediated viral control
Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation
Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration
Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection
A hierarchical Rorc(γt) cis-regulatory cascade orchestrates differentiation of RORγt⁺ innate immune cells
Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis
HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes
A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria
Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection
Antibody-mediated feedback modulates interclonal competition in the germinal center
The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors
Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes
B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells
Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing
Opposing functions of distinct regulatory T cell subsets in colorectal cancer
Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation
The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration
A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement
Clonal persistence dominates homeostatic intestinal IgA responses
Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors
Myeloid cells mediate interferon-driven resistance to immunotherapy in advanced renal cell carcinoma
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors
Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures
Primate resident memory T cells activate humoral and stromal immunity
The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells
Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes
A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer
Integrin CD103 expression in naive CD8+ T cells promotes cytokine-driven acquisition of memory phenotype and effector function
Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity
Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence
Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1 test
Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment
The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity
Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota
DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis
Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells
Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets
A conserved immune dysregulation signature is associated with infection severity, risk factors prior to infection, and treatment response
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B
Heterozygosity for Crohn’s disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses
Somatic hypermutation unlocks antibody specificities beyond the primary repertoire
Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation
1
Early-life exposure to ambient temperature and polycystic ovary syndrome: a nationwide cohort study
2
γδ T cell exhaustion is associated with obesity in individuals with type 2 diabetes
Single-cell transcriptome atlas and genome-wide Mendelian randomization reveal chemokine involvement in diverse immune cells in type 2 diabetes
1
Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections
1
Risk Factors for the Development of Food Allergy in Infants and Children
3
Precision Immunotherapy to Improve Sepsis Outcomes
Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment
Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 Years
48
Potassium suppresses allosteric activation of ZAP-70-dependent T cell receptor signaling
Stress-induced glucocorticoid signaling impairs enteric neurotrophin BDNF–TrkB pathway and drives gastrointestinal dysmotility
Extracellular ATP drives tryptophan metabolism and aryl hydrocarbon receptor activation to promote cellular senescence
Allelic variation alters expression and antigen presentation of MR1 allomorphs
A unique echinoderm NLR triggers Vibrio phagocytosis by promoting microtubule severing to facilitate microfilament polymerization
Interferon Stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing
The ASC-c isoform as a modulator of inflammasome activation: insights into molecular mechanisms and therapeutic applications
Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens
Molecular Basis of Fibrinogen Recognition by the Innate Immune Receptor LILRA2
RNA-binding protein tristetraprolin inhibits Th2 cell activation and differentiation in allergic rhinitis by promoting TRIM18 mRNA decay
High-density lipoprotein mediates silica nanoparticle recognition by the multi-ligand receptor SR-B1
HIF-2α induction in de novo lipogenesis in metabolic dysfunction-associated steatohepatitis is dependent on IL-21 signaling
Antagonist nanobodies prevent protease inhibition by CD109
Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1
HMGB1 Binds to and Disrupts the Hairpin Structure of RNA15 and Inhibits Toll-like Receptor Activation
IRF1 is a Context-Dependent Homeostatic Gatekeeper of Basal Immunity and Antiviral Readiness
The long non-coding RNA MALAT1 encodes a micropeptide that promotes influenza A virus replication by suppressing innate immune responses
β2-Integrins regulate dendritic cells through nuclear deformation and activation of phospholipase A2 and DNA damage–inducible GADD34
Lipopeptide ligands captured by MHC class I molecules undergo dynamic conformational changes that affect their antigenic strength
Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity
Dynamic control of bacterial antiphage defense through the CdnG–Cap5 cyclic oligonucleotide–based antiphage pathway in Vibrio cholerae
A CD25–chemokine receptor complex initiates noncanonical IL-2 signaling
The Hippo Kinases MST1/2 Integrate Sterile and Infectious Signals to Regulate Macrophage Cell Death
Elongator is required for pattern recognition receptor and type I interferon signaling in macrophages.
MARCH8-mediated ubiquitination regulates expression of the antiviral protein IFITM3
Extravesicular Chloride Ion Regulates the Uptake of ATP, Sulfate, and Inorganic Phosphate by Membrane Vesicles from Bovine Adrenal Chromaffin Granules
Histone Deacetylase 6 Inhibits STING-Dependent Antiviral Immunity via Site-Specific Deacetylation
Structural and molecular dynamics insights into the competitive inhibition of the platelet-activating factor receptor by acyl-PAF
Nitric oxide attenuates PI4P accumulation at the ER membrane to inhibit encephalomyocarditis virus replication selectively in β-cells
Surface emergence and persistence of MHC class I free heavy chains
Molecular basis of IFN-γ–induced STAT3 phosphorylation stimulated by Sendai virus C protein
Nitric oxide regulates phagocytosis through S-nitrosylation of Rab5
Annexin A2 interferes with complement regulation within the glomerulus
Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus
Identification and characterization of nanobodies specific for the human ubiquitin–like ISG15 protein
IL4I1 overexpression protects against nonalcoholic fatty liver disease in part by inhibiting the AKT/FOXO1 pathway-mediated Th17 cell differentiation
Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2
TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail
Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain
Mannose-modified hemocyanin enhances pathogen endocytosis by crustacean hemocytes
Prediction of KIR3DL1 and human leukocyte antigen binding
Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison
The ability of SAMHD1-deficient monocytes to trigger the Type I IFN response depends on cGAS and mitochondrial DNA
An anti-CD47 antibody binds to a distinct epitope in a novel metal ion-dependent manner to minimize cross-linking of red blood cells
A molecular basis underpinning TRBV28+ T cell receptor recognition of MR1-antigen
Crystal structure and mutagenesis of a nucleic acid–binding BRCT domain in human PARP4
MicroRNA-129-5p-mediated translational repression of microglial ROCK1 leads to enhanced phagocytosis
Molecular basis for presentation of N-myristoylated peptides by the chicken YF1*7.1 molecule
8
uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells
CD47 inhibits phagocytosis through Vav dephosphorylation
Contact-dependent incorporation of endoplasmic reticulum into retraction fibers and migrasomes
Galectin-9 regulates dendritic cell polarity and uropod contraction by modulating RhoA activity
Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis
B cell mechanotransduction via ATAT1 coordinates actin and lysosomal dynamics at the immune synapse
Ecdysone regulates phagocytic cell fate of epithelial cells in developing iDrosophila/i eggs
STIM1/2 maintain signaling competence at ER-PM contact sites during neutrophil spreading
2
Relative maternal protection against type 1 diabetes: A combined analysis of 5 observational studies
Relationship Between Hypothyroidism, Risk of Small Intestinal Bacterial Overgrowth, and Duodenal Microbiome Alterations
71
DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation
Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis
T cell–intrinsic VISTA expression promotes resistance to CTLA-4 blockade by restricting CD8+ T cell responses
Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis
Characterization of intestinal immune responses in generalized human and murine lipodystrophy
A CD138+ tumor-associated macrophage-Siglec-F+ neutrophil feedforward loop promotes immune evasion in pancreatic cancer
Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients
TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress
Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling
CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic and tolerogenic properties
Galectin-3 mediates lysosome-related inflammation within monocyte-derived macrophages in a mouse model of ischemic brain injury
Pathobiont-triggered induction of goblet cell response drives regional susceptibility to Inflammatory Bowel Disease
GSDME/IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneration
Inflammation- and resolution-programmed myeloid circuits govern therapeutic resistance in epithelial and mesenchymal triple-negative breast cancer
The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers
Type I IFN–dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections
PARP inhibitors restore NK cell function via secretory crosstalk with tumor cells in prostate cancer
Intranasal DC-targeting vaccine booster elicits durable and cross-clade protective immunity against sarbecoviruses in mice
Lysophosphatidic acid-mediated NF-κB activation promotes FOXC2 expression essential for lymphatic valve development
T cell receptor-engineered T cells targeting the TP53R248Q neoantigen elicit antitumor effects in human cancer models
Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development
Tumor-derived neutrophil extracellular trap–associated DNA impairs treatment efficacy in breast cancer via CCDC25-dependent epithelial-mesenchymal transition
Mutant p53 promotes clonal hematopoiesis through generating a chronic inflammatory microenvironment
Cooperative ETS transcription factors are required for lymphatic endothelial cell integrity and resilience
UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes
Immobilized IgG-containing immune complexes require platelets to recruit neutrophils during inflammation
CARD9-dependent macrophage plasticity regulates effective fungal clearance
TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal Pneumonia
Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models
Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation
A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis
Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models
Targeting STING–induced immune evasion with nanoparticulate binary pharmacology improves tumor control in mice
Cancer-associated fibroblasts enhance colorectal cancer lymphatic metastasis via CLEC11A/LGR5-mediated WNT pathway activation
Aryl hydrocarbon receptor restrains tonic cytokine responses by inhibiting microbiota sensing in monocytes
S-acyl transferase ZDHHC13 modulates tumor microenvironment interactions to suppress metastasis in melanoma models
Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes
A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection
Maintenance DNA methylation is required for induced Treg reparative function following viral pneumonia in mice
Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9
UBA1-depleted neutrophils disrupt immune homeostasis and induce VEXAS-like autoinflammatory disease in mice
IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2–mediated immunosuppression
A20’s linear ubiquitin–binding motif restrains pathogenic activation of Th17 cells and IL-22–driven enteritis
Myeloperoxidase-anchored ENO1 mediates neutrophil extracellular trap DNA to enhance Treg differentiation via IFITM2 during sepsis
Loss of tumor cell MHC class II drives MAPK inhibitor insensitivity of BRAF-mutant anaplastic thyroid cancers
SAA1/FPR2 signaling between keratinocytes and neutrophils sustains chronic inflammation in Sweet syndrome
IFN-γ is a direct driver of crypt hyperplasia in celiac disease
TET3 is a common epigenetic immunomodulator of pathogenic macrophages
ST8Sia6 overexpression protects pancreatic β cells from spontaneous autoimmune diabetes in nonobese diabetic mice
CD300a immunoreceptor regulates ischemic tissue damage and adverse remodeling in the mouse heart and kidney
CDK12/13 inactivation triggers STING-mediated anti-tumor immunity in pre-clinical models
Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s
Organ-specific features of human kidney lymphatics are disrupted in chronic transplant rejection
cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models
Treg activation during allograft tolerance induction requires mitochondrial-induced TGFβ1 in type 1 conventional dendritic cells
Type 1 Classical Dendritic Cells Govern Long-term Cardiac Allograft Acceptance
ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis
Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine
Tumoral RCOR2 promotes tumor development through dual epigenetic regulation of tumor plasticity and immunogenicity
Blocking immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response
Hepcidin sustains Kupffer cell immune defense against bloodstream bacterial infection via gut-derived metabolites in mice
Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity
Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines
Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice
PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung
Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection
Autophagy is an upstream mediator of chromatin dynamics in normal and autoimmune germinal center B cells
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis
LAG3 regulates antibody responses in a murine model of kidney transplantation
Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis
CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell–mediated alloimmunity
5
Safety and Clinical Outcomes of Pooled Donor, Nonengrafting Expanded Progenitor Cells in Single-Unit Cord Blood Transplantation.
Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant.
Sirolimus and Cyclosporine With Post-Transplant Cyclophosphamide or Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis in Unrelated Donor Hematopoietic Cell Transplantation.
Primary Results From Blood and Marrow Transplant Clinical Trials Network 1702: Clinical Transplant-Related Long-Term Outcomes of Alternative Donor Allogeneic Transplantation.
Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation.
69
Nasal germinal centers and IgA class-switch recombination depend on CCR6 and B cell receptor affinity
IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself
Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes
Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke
Central neurons encode interleukin-1β signals and mediate stress-induced inflammation
The STING HAQ haplotype and clinical non-penetrance in COPA syndrome
Zbtb32 promotes CD8+ T cell differentiation and function in cancer
A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T cell signaling and differentiation
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells
Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance
The antigen-presenting molecule MR1 binds host-generated riboflavin catabolites
<atl>SpeckSeq enables high-throughput functional stratification of iMEFV/i variants in autoinflammatory diseases</atl>
Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes
Notch interaction with RUNX factors regulates initiation of the T-lineage program
Chimeric MHC class I– and II–restricted non-self epitopes broaden antitumor T cell reactions
A circadian checkpoint relocates neutrophils to minimize injury
pDCs amplify tissue-resident memory CD8+ T cell responses during viral reinfection
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis
FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes
Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin
Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance
Heterologous mucosal vaccine boosting enhances mucosal and systemic immunity by distinct mechanisms
Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans
Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells
Lung tissue–resident memory T cells optimize protection by IL-10 regulation of innate immunity
Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity
Invariant TCR-triggered protein kinase D activation mediates NKT cell development
CD2 and its ligands are involved in development and activation of MAIT cells
Type I IFN drives neutrophil swarming, impeding lung T cell–macrophage interactions and TB control
Human CD4+ T cells recognize iMycobacterium tuberculosis/i–infected macrophages amid broader responses
DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts
Identification of lymphatic vessels in skull periosteum but not bone marrow reveals skull channel heterogeneity
Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action
Dominant negative iADA2/i mutations cause ADA2 deficiency in heterozygous carriers
Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn’s disease
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages
Brain-infiltrating ILC2s boost poststroke angiogenic initiation through α-CGRP production
TLR2 supports γδ T cell IL-17A response to ocular surface commensals by metabolic reprogramming
ALK2/3 recruitment to the immunological synapse is required for T cell activation and death
Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity
Repertoire, function, and structure of serological antibodies induced by the R21/Matrix-M malaria vaccine
ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma
The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency
S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum
Intestinal lymphatic vasculature is functionally adapted to different drainage regions and is altered by helminth infection
Epitope and HLA specificity of human TCRs against iPlasmodium falciparum/i circumsporozoite protein
Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination
A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis
A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors
RORγt eTACs mediate oral tolerance and Treg induction
Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
Factor XII–driven coagulation traps bacterial infections
IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy
CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy
Enteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits iSalmonella/i
KLF2 expression in IgG plasma cells at their induction site regulates the migration program
KLF family members control expression of genes required for tissue macrophage identities
Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection
PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion
3
Genetically engineered pig-to-human liver xenotransplantation
Molecular signatures discriminating different types of rejection in human liver transplants
Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD
28
<atl>The tyrosine kinase receptor EphA2 in alveolar macrophages provides a protective role in host defense against iPneumocystis/i pneumonia</atl>
Restoration of Mucosa-Associated Invariant T-Cell Function in Healthcare-Associated Bacterial Infections Supports Recovery of Carbapenem Efficacy Against Resistant Bacteria Ex Vivo
Comparison of CD4 T cell response in Plasmodium falciparum and vivax malaria
Impact of COVID-19 Monoclonal Antibody Therapy on Subsequent Vaccine-Elicited SARS-CoV-2 Immune Responses
Single-Cell Sequencing Reveals Varying Cell-Mediated Immunity Profiles in Individuals with Distinct Antibody Responses Following Ad5-nCoV Booster
Antibody-Dependent Neutrophil Phagocytosis of Plasmodium falciparum–Infected Erythrocytes Is Mediated by FcγRIIa
<atl>TLR4–MyD88–NF-κB signaling in the airway epithelium promotes iAcinetobacter baumannii/i clearance</atl>
Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway
Lack of S100A8 Impairs Lung-Protective Immunity Against Streptococcus pneumoniae
The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children
Intracellular Ganciclovir Tri-Phosphate Concentrations in Children with Congenital Cytomegalovirus Infection
A Test-Negative Design for Immune Correlates Approximates a Traditional Exposure Proximal Design but Requires Far Fewer Blood Samples
Safety and immunogenicity of a SARS-CoV-2 spike, subunit vaccine stabilised in the prefusion conformation by second generation Molecular Clamp evaluated in adults aged 18–55 years: a randomised, double-blind, active comparator, Phase I trial
Vaccination against pathogens targeting cell-derived cryptic antigens
National- and state-level SARS-CoV-2 immunity trends from January 2020 to December 2023: a mathematical modeling analysis
The Major Outer Membrane Protein P5 Binds Vitronectin to Mediate Serum Resistance in Nontypeable iHaemophilus influenzae/i
Role of Activin A–Mediated KAT8 Expression in Regulating Ferroptosis During iMycobacterium tuberculosis/i Infection
Mycobacterium tuberculosis PE_PGRS62 Protein Inhibits Type I Interferon Responses to Promote HIV-2 Replication by Directly Interacting With Interferon Regulatory Factor 3
Vaccine-Induced Antibodies to a C-Terminal Plasmodium falciparum Circumsporozoite Protein Epitope Associated With Protection Against Malaria Challenge
A Multivalent Peptide Vaccine Against Malaria, Targeting iPlasmodium/i Circumsporozoite Protein and Mosquito AgTRIO
Plasmodium falciparum Parasitemia Does Not Diminish Neutralizing Antibody Responses After mRNA COVID-19 Booster Vaccination in HIV-infected Adults
Elevated Spleen Tyrosine Kinase in Low-Density Neutrophils During Bacterial Sepsis in a Nonhuman Primate Model
Sex Differences in Vaccine-Induced Immunity and Protection Against Mycobacterium tuberculosis
A Functional Polymorphism in IL-36β Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis
B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients
HIV Superinfection in Kidney Transplant Recipients With HIV Who Received Organs From Donors With HIV
iPrevotella intermedia/i Synergistically Exacerbates Pneumonia Induced by Oral Streptococci
Association of Human Leukocyte Antigen Class I Repertoire Score With Severity of Human Cytomegalovirus Infection in Patients Undergoing Transplantation
4
Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats
Ascl3+ ionocytes in murine salivary gland ducts are innervated sensory cells that display unique calcium signalling characteristics and contribute to the composition of saliva
Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels
Control of lymphatic pacemaking and pumping by mechanobiological signals
4
Clinical characteristics, subtype classification, and prognostic factors of ophiasis: A retrospective study of 150 patients with therapeutic implications
Switching between Janus kinase inhibitors for treatment of alopecia areata: A Multi-Center Retrospective Review
Characterization and treatment outcomes of rituximab therapy in super-responders and rituximab-refractory pemphigus patients: A single-center retrospective study
Ivarmacitinib for the Treatment of Adults with Severe Alopecia Areata: Results from a Phase 3 Trial
12
Structurally Resilient Peptide Assembly Regulates Pathogenic Galectin-10 Crystallization To Mitigate Crystallopathy Inflammation
Transmembrane DNA Nanochannel-Engineered Artificial Receptors for Navigating NK Cell Immunotherapy in Solid Tumors
Chemical Synthesis of Native ADP-Ribosylated Oligonucleotides Enables Analysis of DNA ADP-Ribosylation Hydrolase Specificity
SELEX-HTCFQ Platform: Developing DNA Enhancers of ADAR1 to Suppress ZBP1-Dependent Immunopathology
A Candidalysin-Neutralizing Nanomodulator Enhances Colorectal Cancer Immunotherapy by Targeting Fungi–Macrophage Crosstalk
Responsive Photosensitizer Precursors Reverse Drug-Induced Secondary Immunosuppression
Activatable Fluorescent Probes for In Vivo and Ex Vivo Dynamic Profiling of Virus-Infected Macrophages
Genetically Engineered Biomimetic Nanoparticles for Synergistic Activation of Glioma-Associated Macrophages against Glioblastoma
Macromolecular Diamidobenzimidazole Conjugates Can Activate Stimulator of Interferon Genes
NIR-Switched DNA Shutter Enables Reversible Intermittent cGAS-STING Activation for Enhanced Antitumor Immunity
Chemically Inducible Cyclic Dinucleotides as Self-Deliverable STING Agonists with Enhanced Antitumor Immunity
Spatiotemporally Resolved Imaging of Adenosine in the Mouse Brain Links Depression and Inflammation
6
CLUH Inhibition by Lipocalin-2 Orchestrates Mitochondrial Disruption and Contributes to Kidney Disease
CFHR3*B Haplotype, Complement Activation, and Risk of IgA Nephropathy
Effects and Mechanism of 2′-AMP on Renal Vascular Resistance
Glutathione Synthesis via the Cystine/Glutamate Transporter Promotes the Formation of Tertiary Lymphoid Structures in the Kidney.
Detection of Kidney Allograft Rejection Using Urinary Chemokines.
mTOR Inhibitors and Vaccine Response in Kidney Transplant Recipients.
15
The splenic norepinephrine–β2-adrenergic receptor axis aggravates sepsis-associated acute kidney injury via neutrophil-mediated immunosuppression
Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy
Complement activation drives a compartmentalized innate immune response in C3 glomerulopathy contributing to the disease phenotype
Mechanistic insights from transcript analysis of long-term pig to non-human primate kidney xenografts
A single-arm phase 2 trial of an investigational RNA therapeutic to complement factor B sefaxersen for treatment of IgA nephropathy
Preclinical evaluation of antigen-specific B-cell depletion for phospholipase A2 receptor membranous nephropathy with chimeric autoantibody receptor T-cells.
Single-cell spatial transcriptomics reveal intraglomerular cell activation and ligand-receptor relationships in chronic, active antibody mediated rejection
Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy
Macrophages mediate acute kidney allograft rejection via a toll-like receptor 4-dependent mechanism
Revisiting proliferative glomerulonephritis with monoclonal immunoglobulin deposits through immunoglobulin repertoire sequencing
Multi-omic factor analyses uncovered cross-compartment complexity of biological processes in kidney transplantation
A systematic literature review and meta-analysis evaluated modifiable risk factors for the development of BK polyoma virus-associated complications
Quantifying association of early proteinuria and estimated glomerular filtration rate changes with long-term kidney failure in C3 glomerulopathy and immune-complex membranous proliferative glomerulonephritis using the United Kingdom RaDaR Registry
A multicenter prospective cohort study evaluating impact of an active delisting strategy to enable kidney transplantation in wait-listed candidates with calculated Panel Reactive Antibody ≥ 99.9%
A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients
1
Mass Vaccination Scheduling: Trading Off Infections, Throughput, and Overtime
9
Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF
ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA
Molecular mechanism of MDA5 nucleation and filament formation by LGP2
Chromatin folding principles underlying the generation of antibody diversity
RNA anti-CRISPRs deplete Cas proteins to inhibit the CRISPR-Cas system
Lipid-regulated phosphorylation hierarchy of the T cell receptor tyrosine motifs
MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction
Regulation of somatic hypermutation by higher-order chromatin structure
Structural basis for OAS2 regulation and its antiviral function
5
Liver-derived complement component 3 promotes the susceptibility to stress-induced depression by impairing blood-brain barrier integrity
ATP release from the amygdala-prefrontal pathway regulates vulnerability to social stress in male mice
Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer’s disease mouse models
Cerebellar microglia-derived IL-17A mitigates autism-related behavioral and synaptic deficits
Upregulation of adenosine A2A receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits
4
Nanoscale Mapping Reveals Periodic Organization of Neutrophil Extracellular Trap Proteins
DNA Origami Tension Sensors (DOTS) for Single-Molecule Force Measurements at Fluid Intermembrane Junctions
Tiny Clusters for Big Impact in T Cell Activation
Intervention in the Crosstalk between the cGAS-STING Pathway and Autophagy Using an Oligonucleotide-Based Bioorthogonal Platform for Amplifying Immunotherapy
46
Submicrometre sampling of living cells by macrophages
Linear RAG scanning mediates editing of Igκ variable region repertoires
mRNA vaccines engage unconventional pathways in CD8+ T cell priming
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Parasites trigger epithelial cell crosstalk to drive gut–brain signalling
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity
Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
A mechanism to initiate emergency type 2 myelopoiesis
Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist
SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer
Targeting excessive cholesterol deposition alleviates secondary lymphoedema
PtdIns(3,5)P is an endogenous ligand of STING in innate immune signalling
Atlas-guided discovery of transcription factors for T cell programming
Regulation of STING activation by phosphoinositide and cholesterol
Ontogeny and transcriptional regulation of Thetis cells
Environmentally driven immune imprinting protects against allergy
Fibroblastic reticular cells direct the initiation of T cell responses via CD44
The transition from monocyte to tissue-resident macrophage requires DHPS
Neuro-epithelial circuits promote sensory convergence and intestinal immunity
Human gut M cells resemble dendritic cells and present gluten antigen
Erythropoietin receptor on cDC1s dictates immune tolerance
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity
Architecture of the neutrophil compartment
iHALT unlocks liver functionality as a surrogate secondary lymphoid organ
Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells
Multi-omics analysis of a pig-to-human decedent kidney xenotransplant
Physiology and immunology of pig-to-human decedent kidney xenotransplant
Niche-specific dermal macrophage loss promotes skin capillary ageing
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling
Proteotoxic stress response drives T cell exhaustion and immune evasion
Ribonucleotide incorporation into mitochondrial DNA drives inflammation
Myeloperoxidase transforms chromatin into neutrophil extracellular traps
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Amplifying antigen-induced cellular responses with proximity labelling
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
WSTF nuclear autophagy regulates chronic but not acute inflammation
Rescuing dendritic cell interstitial motility sustains antitumour immunity
Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation
RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1
SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunity
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells
Concurrent loss of the Y chromosome in cancer and T cells impacts outcome
A coordinated cellular network regulates tolerance to food
10
Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours
An SP110–SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity
Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment
Target cell cortical tension regulates macrophage trogocytosis
WDR4 drives tumour-associated macrophage reprogramming and tumour progression via selective translation and membrane cholesterol efflux
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer
MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy
Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation
4
Munc13-4–STX7 inhibitors impair endosomal TLR activation and systemic inflammation
A druggable redox switch on SHP1 controls macrophage inflammation
Cysteine allostery and autoinhibition govern human STING oligomer functionality
Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome
1
Tumour-specific STING agonist synthesis via a two-component prodrug system
279
A Muribaculaceae-enriched microbiota exacerbates TLR4-dependent Acinetobacter baumannii-induced hyperinflammatory sepsis
The mannose receptor on sinusoidal lining cells mediates two-step bacterial clearance in the human spleen
Complement inhibition by a unique cluster of immunomodulatory outer surface proteins of Borrelia recurrentis
Molecular architecture of the fungal-specific potassium channel TOK1
RPSA-OLFM4 axis governs neutrophil migration against bacterial infection and sepsis
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control
Allogeneic hematopoietic cell transplantation in mature T- or NK-lymphomas: a phase II clinical trial
Type I interferon drives T cell responses to amyloid beta in the central nervous system
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
The GFI1–FOXO1 axis regulates NK cell maturation and function
Poor sleep impairs immune responses and influenza vaccine protection
Structural Mechanism of Receptor-Triggered MyD88 Oligomeric Assembly in Innate Immune Signaling
NKG2A inhibition promotes NK cell-CD8+ T cell interactions to improve anticancer immunity in ovarian carcinoma
CD4+ T cell protection against murine Salmonella infection is female-specific and estrogen-dependent
Early life exposure to -nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice
Multiomics-guided discovery of protective microbiome signatures in lupus-prone mice treated with Faecalibacterium prausnitzii
A phage-encoded sponge protein suppresses bacterial TIR-Caspase immune signaling
β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction
Maternal antibodies regulate the establishment of murine oral and salivary mucosal immunity
Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue
Tree shrew immune cell atlas identifies NR1H3⁺ tissue macrophages with conserved anti-inflammatory function
Chitinase-like proteins de-N-glycosylating CD36 modify cholesterol metabolism in atherosclerotic macrophages
Dissecting PGE2-driven inhibition of T cell activation using single-cell multi-omic and inflammatory bowel disease genetic association analysis
Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling
Tim-3 agonist restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway
A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy
Compartmentalized cytoplasmic tradewinds direct soluble proteins
The CD4+ T cell population partners with Tpex CD8+ T cells to mediate antitumor immunity in the tumor microenvironment
Polymersomes preventing brain infiltration of CD177+ neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis
Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV)
Antigen-specific immunotherapy with a CD4+ T cell neoepitope restrains CD8+ T cell differentiation in murine pancreatic islet grafts
CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hosts
Tuft cells shape airway remodeling by eliciting OXGR1- and SOX9-dependent stem cell programs
DC-CD4 bispecific tolerogenic nanovesicles induce antigen-specific regulatory T cells and ameliorate collagen-induced arthritis in mice
Spatial heterogeneity of MDSCs mediated by ANXA1-FPRs signaling drives immune suppression in OSCC progression
Reactivating exhausted tumor-infiltrating T cells by a bispecific DC-T cell engager in mice
Mining antibody functionality via AI-guided structural landscape profiling
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells
TYK2 mediates neuroinflammation in Alzheimer’s disease brains with TDP-43 pathology
A conserved, immune-regulated peritrophin promotes Vibrio cholerae colonization of the arthropod intestine
Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits
Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly
Conducting polymer-stabilized nanozymes alleviate sepsis-induced myocardial injury by inhibiting iron accumulation and lipid peroxidation
CD8 T cell loss induces autoinflammation in inborn errors of cell death
NCX1 reverse mode promotes calcium-dependent Neutrophil Extracellular Trap formation and lung damage in chronic obstructive pulmonary disease
DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis
Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma
Lyn governs the establishment and maintenance of B cell anergy by suppressing PI3K signaling
VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity
Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination
Tumor-associated CD19 macrophages induce immunosuppressive microenvironment in hepatocellular carcinoma
Idiotype-specific CD4+ T cells chronically stimulate autoreactive B cells to develop into B lymphomas in mice
Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes
The landscape of tissue-resident microbiota across normal, polyp, and colorectal cancer tissues
Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice
A multi-center clinical trial of allogeneic hematopoietic stem cell transplantation in transfusion-dependent thalassemia
The transcription factor EHF promotes the maturation and immunosuppression of conventional dendritic cells
Telomeric repeat-containing RNA G-quadruplexes trigger ZBP1-mediated cell death
RORγt APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis
Adoptive γδ T cell therapy controls cytomegalovirus infection in preclinical transplantation models
Dipeptidylpeptidase 4 inhibition attenuates gestational pathologies via immune homeostasis restoration in the pulmonary-uterine axis
Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen
High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion
Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer
Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathway
Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn’s disease
STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways
Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression
Negative feedback regulation of STING signaling by TAX1BP1-directed Golgiphagy
Positive cooperativity between RAS-binding and cysteine-rich domains regulates RAF membrane binding kinetics via lateral rebinding
Triple targeting of STING, TGF-β, and PD-L1 boosts CXCL16–CXCR6 signaling for potent antitumor response
CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8+T cell-mediated anti-tumor immunity
Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer
The genetic driver of Acute Necrotizing Encephalopathy, , regulates the inflammatory response to Influenza A virus infection
Acute peritonitis-induced adipose CD127 ILC1s express PD-L1 and ameliorate inflammation in mice
An mRNA-delivered consensus allergen induces a neutralizing IgG response against food and pollen allergens
Human type-1 innate lymphoid cells control leukemia stem cell differentiation and limit acute myeloid leukemia development
Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming
Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA
Circadian fluctuation of soluble CD26 dictates the impact of the timing of cord blood transplantation on acute graft-versus-host disease
Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection
Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation
A spatially resolved atlas of gastric cancer characterises a lymphocyte-aggregated region
A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation
Atypical pericapillary Ly6G⁺Nur77⁺ macrophages initiate type-2 immune responses to allergens in the mouse lung
SAMSN1 restrains NK cell mediated anti-tumor immunity in hepatocellular carcinoma
Evolution of the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones
Intelectin-2 is a broad-spectrum antimicrobial lectin
A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation
DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID
TIGIT disruption rescues the antitumor activity of low avidity TCR-engineered T cells by increasing TCR signal strength
Butyrophilin 2A2 promotes T cell immunoregulation via CD45 phosphatase activation and protects against murine autoimmune glomerulonephritis and pregnancy loss
Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous tracking
The inflammatory path toward type 1 diabetes begins during pregnancy
Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming
Sideways lipid presentation by the antigen-presenting molecule CD1c
Defective cell-autonomous signalling and antigenic polyreactivity of B-cell receptors from chronic lymphocytic leukaemia stereotyped subset 1
Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1 cDC1 infiltration and activates anti-tumor immunity
γδ T cell receptor recognition of CD1d in a lipid-independent manner
GBP2 condensates promote ferroptosis to sensitize anti-PD-L1 immunotherapy in melanoma
IL-33 expands plasma cells, disrupts germinal centers, and increases autoantibody production in mice
Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration
Integrating protein language and geometric deep learning models for enhanced vaccine antigen prediction
Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface
Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans
Resistance potential of the HLA-A2-restricted immunodominant SARS-CoV-2-specific CD8+ T cell receptor repertoire to antigenic drift
Dysfunctional CD4 T cells in an oncovirus-specific TCR-transgenic in vivo model
Structural insights into C3 convertase activity of the classical pathway of complement
Genetic and dietary determinants of gut microbiome-bile acid interactions in the BXD genetic reference population
Ataxin-2-like promotes translation of nonpolyadenylated reovirus mRNA
Agonist signaling drives neutrophil subpopulations to promote/inhibit colorectal cancer liver metastasis
The resting and ligand-bound states of the membrane-embedded human T-cell receptor–CD3 complex
Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming
Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer
Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4
Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells in mice
Primary SARS-CoV-2 exposure by vaccination or infection shapes immune responses to omicron variants among a Spanish cohort
Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease
The long non-coding RNA UGDH-AS1 encodes an NK-cell-inhibiting micropeptide in triple-negative breast cancers
Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets
Structural basis of PANX1 permeation and positive modulation by mefloquine
Double stranded RNA sensing is silenced during early embryonic development
Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates
Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes
ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
Discovery of a small molecule TLR3 agonist adjuvant
Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor
Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice
Characterization of Anopheles gambiae immune cells through genetic and functional immunophenotyping
Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity
APIP regulates the priming of canonical NLRP3 and non-canonical Caspase-11/4 inflammasomes by binding to TRAF6
Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of infection
A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice
Physiological activation of Aryl hydrocarbon receptor by food-derived ligands is essential for the efficacy of anti-PD1 therapy
The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors
mTORC1 signaling in group 2 innate lymphoid cells coordinates neuro-immune crosstalk in allergic lung inflammation
Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability
A scalable reinforcement learning approach for screening large peptide libraries for bioactive peptide discovery
Deleterious variants in the autophagy-related gene /FIP200 impair immunity to SARS-CoV-2
Continuous indices to assess the phenotypic spectrum of kidney transplant rejection
GPR43 in eosinophils suppresses the emergence of pathogenic Siglec-Fhi neutrophils in allergic airway inflammation in mice
Atomic mechanisms of full-length ASC-mediated inflammasome assembly
A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models
Epigenetic and transcriptional programming of murine eosinophils in the esophagus
Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation
Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy
Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer
Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma
A taxon-specific measurement of disruption in a multi-modal study of microbiomes and metabolomes reveals system-wide dysbiosis preceding HIV-1 infection
Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults
Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses
Reconstruction of the lymphatic system by transplantation of a centrifuge-based bioengineered lymphatic tissue
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice
Breast cancer remodels lymphatics in sentinel lymph nodes
Human intestinal fungus attenuates colitis through Pyruvate decarboxylase-derived Indole-3-ethanol
Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection
A monoclonal antibody that inhibits the shedding of CD16a and CD16b and promotes antibody-dependent cellular cytotoxicity against tumors
Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis
Deep immune profiling delineates hallmarks of disease heterogeneity in extrapulmonary tuberculosis
Molecular basis for selection and inhibition of HIV-1 escape virus by T cells and KIR2DL2NK cells
Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function
A Rho GTPase-effector ensemble governs cell migration behavior
Gut bacterial dysbiosis in pediatric severe malaria associates with post-discharge mortality
Specification curve analysis of the TEDDY study reveals large variation in microbiome-based T1D predictive performance
Stage-specific roles of clonally expanded CD8+ T cells in regulating amyloid pathology in Alzheimer’s disease models
Tissue localization of natural killer cells dictates surveillance of lung metastasis
APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling
A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions
Dendritic cell progenitors engineered to express extracellular-vesicle–internalizing receptors enhance cancer immunotherapy in mouse models
A SARS-CoV-2 variant‑adjusted threshold of protection model for monoclonal antibody pre-exposure prophylaxis against COVID-19
Global disparities in the introduction, scale-up, and effectiveness evaluation of COVID-19 vaccines
Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice
Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve–neutrophil axis
Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV
Artificial Intelligence (AI)-assisted readout method for the evaluation of skin prick automated test results
Long-persisting SARS-CoV-2 spike-specific CD4+ T cells associated with mild disease and increased cytotoxicity post COVID-19
Age is an intrinsic driver of inflammatory responses to malaria
Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation in mice
Immunogenicity of fractional and standard dose COVID-19 vaccine boosters among healthy adults in Indonesia: twenty four month follow-up from a randomised controlled trial
A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut
Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis
GM-CSF-dependent CD301b+ mouse lung dendritic cells confer tolerance to inhaled allergens
Mechano-crosstalk between living and artificial cells
A loss-of-function human ADAR variant activates innate immune response and promotes bowel inflammation
Physiologic Homeostasis in a Living Human after Pig Kidney Xenotransplantation
A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes
Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host disease in HLA-haploidentical transplants
NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor
Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued maturation and migration of intestinal cDCs in homeostasis
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors
Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3
Molecular basis of potent antiviral HLA-C-restricted CD8 T cell response to an immunodominant SARS-CoV-2 nucleocapsid epitope
Interferon-stimulated gene screening identifies CCND3 as a host restriction factor against emerging high-pathogenic bandaviruses
scIVNL-seq resolves in vivo single-cell RNA dynamics of immune cells during infection
SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2
Randomized phase I trial outcomes show safe and sustainable inhibition of classical and lectin complement pathways by empasiprubart
H2A.Z primes an epigenetic landscape for memory CD8 T cell recall response
CD4+T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death
A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis
Epigenetic modulation with nanosatellite triggers tumoricidal immunity for hepatocellular carcinoma treatment
Development of conformation-selective antibodies targeting human SLC15A4
Urinary Complement proteome strongly linked to diabetic kidney disease progression
Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target
Sensitive neoantigen discovery by real-time mutanome-guided immunopeptidomics
Structural insights into polymerase-catalyzed FAD capping of hepatitis C virus RNA
The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra
B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells
TLR4group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases
Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition
The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice
Macrophage-T cell interactions promote SLAMF1 expression for enhanced TB defense
Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients
Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands
Enrichment of decidual CD11c + CD8 + T cells with altered immune function in early pregnancy loss
Integrin CD103 reveals a distinct developmental pathway of autoreactive thymocytes in TCR transgenic mice
Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice
A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection
Type 1 innate lymphoid cell–immature neutrophil axis suppresses acute tissue inflammation
Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells
Imaging of macrophage accumulation in solid tumors with ultrasound
Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18
Viruses hijack FPN1 to disrupt iron withholding and suppress host defense
Elevated nitric oxide during colitis restrains GM-CSF production in ILC3 cells via suppressing an AhR-Cyp4f13-NF-κB axis
Autophagy controls differentiation of Drosophila blood cells by regulating Notch levels in response to nutrient availability
Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts
Generating combinatorial diversity via engineered V(D)J-like recombination in Saccharomyces cerevisiae
Highly ordered clustering of TNFα and BAFF ligand-receptor-intracellular adaptor complexes on a lipid membrane
Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses
Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity
Orthosteric STING inhibition elucidates molecular correction of SAVI STING
Budesonide-incorporated inhalable lipid nanoparticles for antiTSLP nanobody mRNA delivery to treat steroid-resistant asthma
Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant
Developmental features and unique characteristics of peptide-specific PLZF innate-like T cells in mice
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations
Identifying T cell antigen at the atomic level with graph convolutional network
Androgens inhibit protective CD8 T cell responses against pre-erythrocytic malaria parasites in mice
Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro
CD200R1-CD200 checkpoint inhibits phagocytosis differently from SIRPα-CD47 to suppress tumor growth
Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans
Metabolic modeling reveals a multi-level deregulation of host-microbiome metabolic networks in IBD
Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes
Early mucosal responses following a randomised controlled human inhaled infection with attenuated Mycobacterium bovis BCG
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
Dietary advanced glycation end-products promote food allergy by disrupting intestinal barrier and enhancing Th2 immunity
Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly
Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling
Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models
CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors
Comparative duration of neutralizing responses and protections of COVID-19 vaccination and correlates of protection
Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice
Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses
Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site
USP2 inhibition unleashes CD47-restrained phagocytosis and enhances anti-tumor immunity
Integrating antigen capturing nanoparticles and type 1 conventional dendritic cell therapy for in situ cancer immunization
Gfi1 controls the formation of effector-like CD8+ T cells during chronic infection and cancer
Targeting Setdb1 in T cells induces transplant tolerance without compromising antitumor immunity
Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolution
Blocking plasma cell fate enhances antigen-specific presentation by B cells to boost anti-tumor immunity
TRIM23 mediates cGAS-induced autophagy in anti-HSV defense
A high-performance fluorescent sensor spatiotemporally reveals cell-type specific regulation of intracellular adenosine in vivo
SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases
Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4+ T cells in head and neck cancer
ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis
Structural insight into TLR4/MD-2 activation by synthetic LPS mimetics with distinct binding modes
PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses
An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models
4
High-content CRISPR activation screens identify synthetically lethal RNA-based mechanisms to sensitize cancer cells to targeted T cell cytotoxicity
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1 macrophages
Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation
94
Cytosolic CTH senses bacterial lipoproteins and drives noncanonical inflammasome activation
IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma
Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets
BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition
A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation
ZFP148 is a transcriptional repressor of cytolytic effector CD8 T cell differentiation
MHC class I on target cells regulates CD4 T cell-mediated immunity
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors
Chemokine-defined macrophage niches establish spatial organization of tumor immunity
Tissue-restricted secondary TCR engagement drives the transition from stem-like to CD200 Egr2 arthritogenic Th17 cells
Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome
Targeting NK cell CLEC12B enhances cancer immunotherapy
Tissue-specific clonal selection and differentiation of CD4⁺ T cells during infection
Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection
HLA class I signal peptide variation predicts strength of NKG2A NK cell response to missing-self and risk of human disease
Long-term inhibition of protease hypersensitivity by initial immunological cross-regulation and epigenetic memory in lung stromal cells
TOX drives CD4 T1 effector function, antitumor immunity and autoimmune pathology
Sparcl1 mitigates abdominal aortic aneurysm through inhibiting lymphangiogenesis-mediated TLS formation
Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity
Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation
The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas
Phosphorylation of Runx protein controls helper CD4+ T cell versus cytotoxic CD8+ T cell lineage choice
2′--Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity
IL-4–STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis
γδ T cell-derived IL-4 initiates CD8+ T cell immunity
CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation
TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs
Unraveling CD8 lineage decisions reveals that functionally distinct CD8+ T cells are selected by different MHC-I thymic peptides
Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID
Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs
Temporal and spatial atlas of eosinophil specialization across tissues
The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types
The IL17REL gene encodes a decoy receptor of IL-17 family cytokines to control gut inflammation
Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity
Lymphotoxin-dependent elevated meningeal CXCL13:BAFF ratios drive gray matter injury
Tissue-resident exhausted and memory CD8 T cells have distinct ontogeny, function and roles in disease
Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF
Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors
DC subsets and states unraveled across human juxtatumoral and malignant tissues
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
Neuroepithelial VIP–VIPR1 interactions differentially control enteric type 1 and type 2 immunity
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate
Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche
Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer
TSLP links intestinal nutrient sensing with amplification of the ILC2–tuft cell circuit
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness
Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Transcriptional regulator SATB1 limits CD8+ T cell population expansion and effector differentiation in chronic infection and cancer
The co-inhibitory receptor TIGIT promotes tissue-protective functions in T cells
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells
Transient tissue residency and lymphatic egress define human CD56 NK cell homeostasis
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections
Chemotherapy-induced CA-repeat DNA fragments in breast cancer trigger antitumor immune responses
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor
Epigenetic imprinting in innate lymphoid cell precursors directs the lineage segregation of innate lymphoid cells
Lymph nodes fuel KLF2-dependent effector CD8+ T cell differentiation during chronic infection and checkpoint blockade
Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription
Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors
SATB1 is a key regulator of quiescence in stem-like CD8 T cells
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
A STUB1–CHIC2 complex inhibits CD8+ T cells to restrain tumor immunity
TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells
Lymph-node-derived stem-like but not tumor-tissue-resident CD8+ T cells fuel anticancer immunity
PD-1 is requisite for skin TRM cell formation and specification by TGFβ
Secretogranin 2 binds LILRB4 resulting in immunosuppression
Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages
DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts
Migrating immune cells globally coordinate protrusive forces
IL-4 impairs the formation of skin-resident memory CD8 T cells
CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming
Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis
Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
Neuroprotective liver portal area macrophages attenuate hepatic inflammation
CARD11 signaling regulates CD8+ T cell tumoricidal function
IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes
PD-1 receptor deficiency enhances CD30+ Treg cell function in melanoma
GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer
1
Mechano-induced patterned domain formation by monocytes
11
Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial
Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial
Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial
Interpretable inflammation landscape of circulating immune cells
Immune profiling in a living human recipient of a gene-edited pig kidney
Influenza vaccine strain selection with an AI-based evolutionary and antigenicity model
Pig-to-human lung xenotransplantation into a brain-dead recipient
Immune cell landscape in a human decedent receiving a pig liver xenograft
A microRNA-based dynamic risk score for type 1 diabetes
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma
Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial
3
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing
ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chains
Genetically encoded biosensor for monitoring spatiotemporal dynamics of CCR2 ligands in culture and in vivo
1
Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens
1
Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development
2
More than microglial depletion: PLX5622 activates the hepatic constitutive androstane receptor to alter anesthesia and addiction
Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency
2
Synthesis of Adenosine Diphosphate Ribose Histidine
An Integrated Solubilizing-Tag-Free Strategy for Chemical Synthesis of Mirror-Image Interleukin-6
11
Structure of the human P2X3 receptor reveals the basis for subtype-selective inhibition by sivopixant
Genomic and functional adaptations in the guanylate-binding protein 5 highlight specificities of bat antiviral innate immunity
Specificity and recognition of the ADP-ribosyl-ubiquitin modification in the DNA damage response
Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a
Disrupting CD22-cis-ligand interactions ameliorates type 1 diabetes and graft rejection by expanding regulatory B cells
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells
IL-17 stimulates erythropoiesis in vivo by amplifying the response of erythroid progenitors to erythropoietin
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity
A model of early-life interactions between the gut microbiome and adaptive immunity provides insights into the ontogeny of immune tolerance
Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression
Two distinct subpopulations of human stem-like memory T cells exhibit complementary roles in self-renewal and clonal longevity
2
mTOR signaling regulates demand-adapted hematopoiesis and metabolic reprogramming required for an effective cellular immune response in Drosophila melanogaster larvae
Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body
3
Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study
Estimating the population impact of new tuberculosis vaccines depending on efficacy against infectious asymptomatic tuberculosis: A modelling study.
Immunogenicity and safety of DS-5670d, an omicron XBB.1.5-targeting COVID-19 mRNA vaccine: A phase 3, randomized, active-controlled study
1
Optimal Distributions of Receptors on Arbitrarily Shaped Cell Surfaces
1
Structural Design and Immunogenicity of a Novel Self-Adjuvanting Mucosal Vaccine Candidate for SARS-CoV-2 Expressed in Plants
153
An Ad5-vectored platform generating self-assembling VLPs elicits potent mucosal immunity against influenza A virus and SARS-CoV-2
Cytochrome P450 1B1 directs pathogenic Th17 cell generation and autoimmune disease by fine-tuning redox homeostasis and mitochondrial integrity
TLR1 deficiency associates with immune dysregulation and colitis
Computational design of HLA class I superbinders for broad T cell immunogenicity
Design principles of the cytotoxic CD8+ T cell response
The intestinal microbiota impacts nutritional immunity and resistance to Acinetobacter baumannii pneumonia
SCD1 licenses STING signaling through fatty acid desaturation–mediated membrane remodeling
Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection
Deep learning–enabled scaffolding of spatial arrays of PfCSP epitopes
Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing
Phage display–mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila
Single-cell insights: Mosquito Toll activation enhances granulocyte differentiation and immune surveillance via Notch suppression
Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis
R-loop disruption triggers irreversible topoisomerase 1–DNA cleavage complex formation during AID-dependent IgH gene diversification
Chronic infection perturbs the affinity hierarchy of antiviral B cells
WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity in triple-negative breast cancer
NLRP1B is an integrated decoy that subverts Shigella flexneri E3 ligase activity to promote effector-triggered immunity
Inhibition of coronaviral exoribonuclease activity by TRIM-mediated SUMOylation
CD47 stabilizes ROBO2 to regulate glioblastoma progression by preventing ITCH-mediated ubiquitination
KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3
Spatially structured inflammatory response in the presence of a uniform stimulus
Tim-3-targeted vaccines overcome tumor immunosuppression and reduce cDC1 dependence to elicit potent anti-tumor immunity
Monkeypox virus protein OPG188 antagonizes cGAS–STING antiviral signaling pathway to mediate immune evasion
C4b-binding protein as an antigenic target in the pathogenesis of antiphosphatidylethanolamine autoantibodies
An autoimmunity-associated allele of PTPN22 enhances innate antiviral immunity to protect against acute coronavirus infection
Invertebrate miRNA pva-small RNA-11881/pva-miR-11881 as a potential RNA-based therapeutic against white spot syndrome virus in infected shrimp
Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2
Mixed-mobility supported lipid bilayers uncover the role of immobilized ICAM1 on T cell activation and immune synapse organization
N6-methyladenosine modification of FZR1 mRNA positively regulates antiviral innate immunity by targeting the MAVS–TRAF3/6 axis
Immune cells employ intermittent integrin-mediated traction forces for 3D migration
The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion
Adhesion forces between macrophages and cancer cells promote early tumor development
ABCC1 protects skin dendritic cells from FITC-induced toxicity by efflux and extracellular glutathione buffering
Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis
Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism
The Crohn’s disease–related RNF123 prevents NLRP3 inflammasome assembly by catalyzing unanchored K63-linked ubiquitination on NEK7
Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis
Dual inhibition of mTOR and calcineurin pathways mitigates missing self–induced NK cell–mediated microvascular rejection
Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease
Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection
A framework integrating multiscale in silico modeling and experimental data predicts CAR-NK cell cytotoxicity across target cell types
Dynamics of memory B cells and plasmablasts in healthy individuals
FcγRIIB functions as an IgG transporter in the mammary gland
Mapping targetable sites on the human surfaceome for the design of novel binders
A temporal and spatial atlas of adaptive immune responses in the lymph node following viral infection
Broad beta-CoV immunity and transmission blockade by a single-dose live-attenuated vaccine with atypical codon usage
α2-macroglobulin function of thioester-containing proteins guards Drosophila from a bacterial protease via two immune-induced peptides
Functionally heterogeneous intratumoral CD4+CD8+ double-positive T cells can give rise to single-positive T cells
Shigella OspF blocks rapid p38-dependent priming of the NAIP–NLRC4 inflammasome
Multiomics identifies a cholesterol–TFEB–PLD3–TLR9 axis driving immunosuppressive tumor-associated macrophage polarization in esophageal squamous cell carcinoma
Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis
T-bet-expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape
Constitutively high levels of endogenous soluble ST2 inhibit food allergic responses in mice
Design of solubly expressed miniaturized SMART MHCs
Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection
A PSAT1 buff of YBX1 transcriptionally sustains HLA-E-mediated evasion of NK immunity
Convergent mutation trajectories convert functional self-tolerance in IGHV4-34 B cells to genetic tolerance encoded in the antibody
Turncoat antibodies unmasked in a model of autoimmune demyelination: From biology to therapy
Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively
Endogenous forms of ATP–ATP4− and MgATP2−—orchestrate distinct pathophysiological signaling via biased activation of P2X3 receptors
IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis
WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route
Identification of an IRF–ZBP1–caspase-8–NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease
Prostaglandin E2-EP2/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth
Machine learning enables de novo multiepitope design of Plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody
Endothelial cells sialylate IgG within the FcRn-mediated recycling pathway
Using a mental model approach to undercut the effects of exposure to mRNA vaccination misconceptions: Two randomized trials
Modulation of the PGRMC1/NLRP7/HLA-C axis by autophagy is linked to both spontaneous preterm birth and gestational choriocarcinoma
Rroid2 regulates effector-to-memory CD8+ T cell differentiation during infection in vivo
Engineering a spatiotemporal macrophage circuit via STING phase separation to override immune suppression in pancreatic cancer
Dynamics and variegation in the Treg response to Interleukin-2
High-throughput screening for class I peptide MHC binding via yeast surface display
A binary-distributed effector modulates fungal host preference for drosophilids by targeting a lineage-specific immune factor
PAK2-driven cytoskeleton–endosome dynamics control macrophage hyperphagia and SIRPA engagement
eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling
Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell–generated cGAMP
Local control of T cell fate in lymph nodes safely and durably reverses myelin-driven autoimmunity
cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity
Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid–like structures and enhance antitumor immunity
Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells
Cytosolic proliferating cell nuclear antigen (PCNA) orchestrates neutrophil hyperactivation in COVID-19
TMEM16F phospholipid scramblase regulates tumorigenesis by modulating the tumor immune microenvironment
Linking the production of reactive oxygen species to the expression of antimicrobial peptides through aquaporin in an arthropod
T cell receptor specificity landscape revealed through de novo peptide design
TCR signal–enhancing mutation alters lipid metabolism of thymocytes and impairs antitumor immunity of mature T cells
Natural history of liver fluke infection underpins epidemiological patterns of biliary cancer
The integrated stress response suppresses antiviral RNA interference by autophagy-mediated degradation of the RNA-induced silencing complex
Regulation of an lncRNA irf8 by the Ikzf1/Myb complex drives neutrophil development
A time-gated PKA–CREB signaling circuit licenses IL-12 responsiveness and Th1 fate in CD4+ T cells
Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility
Parallel reactions on a single T cell receptor offer a robust kinetic proofreading mechanism
PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors
Nanoscale restructuring of the immune synapse with an engager enhances NK cell function
C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer’s disease and mediates synapse pruning
Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation
Structurally diverse viral inhibitors converge on a shared mechanism to stall the antigen transporter TAP
Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer
Posttranscriptional control of the B cell receptor by HuR is essential for innate B cell maintenance and function
The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis
Synovial MS4A4A correlates with inflammation and counteracts response to corticosteroids in arthritis
Inflammation awakens dormant cancer cells by modulating the epithelial–mesenchymal phenotypic state
HLA-B*15:01-positive severe COVID-19 patients lack CD8+ T cell pools with highly expanded public clonotypes
Tumor-expressed GPNMB orchestrates Siglec-9+ TAM polarization and EMT to promote metastasis in triple-negative breast cancer
Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus
AhR signaling in skin-resident CD207+ cells is involved in UV-B-induced amelioration of neuroinflammation
CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response
Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice
Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis
Melanocyte-dependent macrophage redistribution enhances skin immunity upon acute stress
ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability
Elucidating the role of Campylobacter concisus–derived indole metabolites in gut inflammation and immune modulation
Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy
Intranasal measles virus– and mumps virus–based SARS-CoV-2 vaccine candidates prevent SARS-CoV-2 infection and transmission
Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature
Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse
Early-life human CD8+ T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape
Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan
Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes
Synergy between membrane topography and domains to control signaling protein localization in mast cells facilitates their activation
Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism
A noncanonical cGAS–STING pathway drives cellular and organismal aging
SARS-CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells
BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza
Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy
DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers
Human milk IgA promotes normal immune development by limiting Th17-inducing Erysipelatoclostridium ramosum in the infant gut
Tandem ssDNA in neutrophil extracellular traps binds thrombin and regulates immunothrombosis
The transcription factor Bcl11a is essential for B-1a cell maintenance during aging
FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells
Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
SARS-CoV-2 nucleocapsid protein directly prevents cGAS–DNA recognition through competitive binding
An endosymbiotic origin of the crimson pigment from the lac insect
Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices
RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ
Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders
Proofreading and single-molecule sensitivity in T cell receptor signaling by condensate nucleation
An electrostatic network with strong connectivity is a phospho-sensor for regulating affinity of Syk–receptor association
Nanoimmunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer’s disease treatment
Alternative cGAS signaling promotes herpes simplex encephalitis
HCK regulates NLRP12-mediated PANoptosis
CD83 suppresses endogenous March-I-dependent MHC class II ubiquitination, endocytosis, and degradation
Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation
Molecular determinants of sialylated IgG anti-inflammatory activity
Trehalose dimycolate inhibits phagosome maturation and promotes intracellular Mycobacterium tuberculosis growth via noncanonical SNARE interactions
Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant
Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells
Social dominance in rats is a determinant of susceptibility to stress
Structure of the human TWIK-2 potassium channel and its inhibition by pimozide
Hdac1 as an early determinant of intermediate-exhausted CD8+ T cell fate in chronic viral infection
De novo DUOX2 expression in neutrophil subsets shapes the pathogenesis of intestinal disease
1
Functional characterization of Paillotin: an immune peptide regulated by the Immune deficiency (Imd) pathway with pathogen-specific roles in Drosophila immunity.
25
Disordered protein LAT encodes relative levels of signaling pathways in T cell activation
Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering
Mucosal vaccination in mice provides protection from diverse respiratory threats
Transcription factor Etv3 controls the tolerogenic function of dendritic cells
Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response
Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation
Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation
<atl>Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4 sup+/sup T cells</atl>
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Rebalancing viral and immune damage versus repair prevents death from lethal influenza infection
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors
MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists
Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens
Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
De novo design and structure of a peptide–centric TCR mimic binding module
Design of high-specificity binders for peptide–MHC-I complexes
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Membrane topology inversion of GGCX mediates cytoplasmic carboxylation for antiviral defense
A wave of Thetis cells imparts tolerance to food antigens early in life
Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition
98
Conserved noncoding sequence-9 regulates NFATc1-mediated IL-10 expression in B cells to control inflammatory responses
RNA binding protein Pcbp1 maintains mitochondria integrity to promote antibody production and germinal center response
CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4+ T cells
Dissection of the T cell infiltrate in mouse pancreatic tumors reveals an extensive and diverse tumor-reactive T cell repertoire
Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices
Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center
Pathogenic GM-CSF drives functional diversification of inflammatory macrophages in autoimmune arthritis
Integrated reiterative pipeline for rapid epitope-based pan-alphavirus vaccines
Persistent antigen is essential for sustaining Leishmania major–specific memory CD4+ T cells and long-term immunity
Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome
Host iron deficiency protects against Plasmodium infection and drives parasite molecular reprofiling
PROTAC-based synthetic lethality strategy endogenously activates systemic STING to boost antitumor immunity
The conserved noncoding sequence CNS11 is a master control region for Rorc transcription in type 17 immune cells
KIT supports small intestinal tuft cell hyperplasia
12R-HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46+ ILC3 development
cPLA2α targeting to exosomes connects nuclear deformation to LTB4-signaling during neutrophil chemotaxis
Complement C3 recognition by C3 convertases
Magnetoelectric nanoparticles drive TAF9B+ TH2 cell expansion to alleviate inflammation
Identification of a type 1 diabetes–associated T cell receptor repertoire signature from the human peripheral blood
Discovery and preclinical evaluation of monoclonal antibodies and bispecific engagers targeting the NKG2A inhibitory receptor
Longitudinal monitoring of type 1 diabetes progression to disease onset
Granuloma dual RNA-seq reveals composite transcriptional programs driven by neutrophils and necrosis within tuberculous granulomas
TDRD3, a Tudor domain-containing protein, regulates Klf2-dependent Treg differentiation and function to modulate immune tolerance
CD318 expression defines a novel subset of human CD8+ regulatory T cells
RSV temporally reprograms apoptosis and pyroptosis to balance immune evasion and replication
Resident CD49a+CD103+NKG2C+ NK cells restrict HIV infection in human lymphoid tissue explants
CXCR5 identifies stem-like resident memory CD8⁺ T cells enriched for latent EBV specificity in tonsils
A distinct subset of stem-cell memory is poised for the cytotoxicity program in CD4+ T cells in humans
Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance
Human FcRL5 is an Fc receptor that simultaneously engages two IgGs
Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors
LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation
Architectural principles of transporter-chaperone coupling within the native MHC I peptide-loading complex
STING/type I interferon pathway is required for antigen-containing PLGA nanoparticle- and apoptotic cell–induced CD4+ T cell tolerance
Unconventional CD8+ T cell surveillance of cytomegalovirus via Qa-1/HLA-E–restricted epitope recognition
A poxvirus model reveals general correlates of antigen presentation and immunogenicity for viral CD8+ T cell epitopes
VNUT-mediated ATP release suppresses T helper 1 (TH1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade
Immune control of functional memory CD8 T cells in normal-appearing vitiligo skin
Droplet-based single-cell pairing for high-throughput interaction mapping of antigen-receptor combinations
Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells
Decoding the CHI3L1/IL-13Rα2 signaling nexus in MASH-fibrosis pathogenesis
T-SCAPE: T cell immunogenicity scoring via cross-domain aided predictive engine
VAPB is a negative regulator of STING-mediated innate immune signaling
B cell–reactive neoantigens boost antitumor immunity
Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost
Antigen-specific B cell response regulation by IL-10–producing tolerogenic dendritic cells
Small things matter: Lack of extraislet β cells in type 1 diabetes
TH1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata
Quantitative and large-scale investigation of human TCR-HLA cross-reactivity
Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis
Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness
Ligand-receptor interactions induce and mediate regulatory functions of BATF3+ B cells
B cell extracellular vesicles influence melanoma response to immune checkpoint therapy
Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin
STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity
Development of SARS-CoV-2 as a viral vector: A novel intranasal bivalent vaccine for SARS-CoV-2 and RSV
Human precursor T follicular regulatory cells are primed for differentiation into mature Tfr and disrupted during severe infections
Endoplasmic reticulum junctions serve as a platform for endosome-lysosome interactions through their stop-and-go motion switching
Single-cell multiome and spatial profiling reveals pancreas cell type–specific gene regulatory programs of type 1 diabetes progression
Bispecific antibodies cross-link and redirect CD8+ T cells to kill cytomegalovirus-infected cells
CD8+HLA-DR+CD27+ T cells define a population of naturally occurring regulatory precursors in humans
Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis
IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas
STAT3 haploinsufficiency is associated with autosomal dominant hyper-IgE syndrome
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
A Dapl1+ subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors
Prdm12 governs an epigenetic checkpoint linking neuroimmune cross-talk to CD8+ T cell exhaustion-suppressed antitumor immunity
USP30 inhibition augments mitophagy to prevent T cell exhaustion
A human NK cell progenitor that originates in the thymus and generates KIR+NKG2A− NK cells
A two-step mechanism for RIG-I activation by influenza virus mvRNAs
The β2-adrenergic receptor (Adrb2) entrains circadian gene oscillation and CD8+ T cell differentiation in response to virus infection
BACH2 drives the development and function of group 2 innate lymphoid cells
Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade
BLIMP1 negatively regulates IL-2 signaling in T cells
Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing
Complex I inhibition combined with TLR activation in the breast tumor microenvironment educates cytotoxic neutrophils
PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells
Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon
Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)–vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial
Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine
Engineered CD4 TCR T cells with conserved high-affinity TCRs targeting NY-ESO-1 for advanced cellular therapies in cancer
In vitro and in vivo evaluation of chemically synthesized, receptor-biased interleukin-4 and photocaged variants
Phage display enables machine learning discovery of cancer antigen–specific TCRs
Armored human CAR Treg cells with PD1 promoter-driven IL-10 have enhanced suppressive function
AbEpiTope-1.0: Improved antibody target prediction by use of AlphaFold and inverse folding
A major ecological niche of eosinophils in evolving Schistosoma granulomas challenges the eosinophil view as “helminth killer” cells
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Diverse developmental pathways of lymphoid conventional dendritic cells with distinct tissue distribution and function
Fecal metabolite profiling identifies critically ill patients with increased 30-day mortality
Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy
Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma
Celluloepidemiology—A paradigm for quantifying infectious disease dynamics on a population level
Mac-1 regulates disease stage–specific immunosuppression via the nitric oxide pathway in autoimmune disease
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction
Massive experimental quantification allows interpretable deep learning of protein aggregation
29
Keratin 16 inhibits type I interferon responses in differentiating keratinocytes of stressed and diseased skin
Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset
Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors
The vaccine platform used for COVID-19 primary immunization shapes the quality of the human B cell response to a vaccine boost
Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation
A peptide immunomodulator activates MST1 to expand and stabilize murine and human regulatory T cells for immune tolerance
Phase 1 and preclinical studies reveal safety, pharmacokinetics, and efficacy of intranasal delivery of the influenza antibody CR9114
FcγR-targeted tuftsin clusters rejuvenate macrophages in preclinical sepsis–associated secondary infection
Farm exposure in infancy is associated with elevated systemic IgG4, mucosal IgA responses, and lower incidence of food allergy
A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice
Bruton’s tyrosine kinase inhibitors rescue neuronal impairment caused by B cell–mediated lymphotoxin-α release
Conversion of pathogenic T cells into functionally stabilized Treg cells for antigen-specific immunosuppression in pemphigus vulgaris
Severe asthma is characterized by a sex-specific ILC landscape and aberrant airway profile that is suppressed by anti–IL-5/5Rα biologics
Longitudinal antibody titers measured after COVID-19 mRNA vaccination can identify individuals at risk for subsequent infection
Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans
Follicular regulatory T cells promote experimental autoimmune encephalomyelitis by supporting B cell egress from germinal centers
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo
PIEZO1-activated donor lymphatic remodeling integrates with autologous lymphangiogenesis to enhance vein graft patency in mice
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer
Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice
Donor-recipient mismatch at the SIRPA locus adversely affects kidney allograft outcomes
S100A8/A9 perturbation in bone marrow blunts antitumor immunity by promoting protumorigenic myelopoiesis in mouse models
Myeloid MAS–driven macrophage efferocytosis promotes resolution in ischemia-stressed mouse and human livers
Synthetic biology–driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans
IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models
MicroRNA-142-3p shuttling in extracellular vesicles marks regulatory T cell dysfunction in multiple sclerosis
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection
1
Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia: multicentre, randomised, placebo controlled, phase 2 trial
27
T-cell protrusions enable fast, localised initiation of chimeric antigen receptor signalling
CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation
Mechanistic basis for selective Csm6-2 activation by cyclic penta-adenylate in a type III CRISPR-Cas system
FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster
Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission
The lysosomal LAMTOR-Rag complex functions as a checkpoint for antiviral interferon production
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells
Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens
The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage
Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation
Structural insights into the atypical filament assembly of pyrin domain-containing IFI16
Somatic hypermutation patterns are shaped by both motif position and sequence grammar
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
Single-molecule imaging of transcription dynamics, RNA localization and fate in human T cells.
Shigella type-III secretion system effectors counteract the induction of host inflammation and cell death.
Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.
The twist-and-squeeze activation of CARF-fused adenosine deaminase by cyclic oligoadenylates
VH-replacement shapes the antibody repertoire by removing the genes of non-functional heavy-chains
PARP7 is a proteotoxic stress sensor that labels proteins for degradation
Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells
Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion.
Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11.
Transcription factor IRF-5 regulates lipid metabolism and mitochondrial function in murine CD8+ T-cells during viral infection.
Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.
A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection
2
Milk IgA promotes symbionts and limits pathobionts in the early life gut
Silibinin-derived microbiota enrich (R)-2,3-dihydroxy-isovalerate and ameliorate colitis via the GAT-3/RARβ/RORγt axis
52
Hereditary Angioedema iPSC Models Implicate ER-Associated Degradation as a Potential Therapeutic Target
AZD8630/AMG 104, an inhaled Anti-TSLP antibody fragment, for moderate-to-severe asthma: a phase 1 randomized controlled trial
Expression of CD25 in human lung mast cells and its regulation by IL-33
Group 2 innate lymphoid cells program pulmonary adaptive immunity via granulocyte-macrophage colony-stimulating factor
Complement C3 links epithelial remodeling and macrophage metabolic reprogramming in allergic rhinitis
Comprehensive single-cell transcriptomic profiling of the scalp from patients with moderate-to-severe alopecia areata
Soluble FcεRI is increased in advanced mastocytosis and acts as a negative regulator of mast cell expansion and activation
Functional assessment of a convergent gene network underlying allergic diseases and IgE
SIGLEC-1 expression on monocytes as a diagnostic biomarker in pediatric type I interferon-mediated diseases
Heterozygous variants in DOCK2 leading to susceptibility to viral illnesses
A clinically validated assay for rapid determination of type I and type II interferon activity in systemic inflammatory diseases
Complex Mast Cell CCL2-Chemokine Trafficking Patterns During Local Allergic Responses
Alpha-gal-specific human IgE promotes both alpha-gal-induced and antigen-independent allergic effector cell activation
First-in-human study for londamocitinib (AZD4604), an inhaled, selective JAK1 inhibitor
Interactions between host genetics and gut microbiome influence susceptibility to childhood asthma and lung function
B-cell lymphocytosis and reprogramming due to biallelic CARD11 mutations
CCR8+ST2+ tissue-resident regulatory T cells constrain type 2 immunity to environmental allergens in the lungs
IRF1 is an Upstream Regulatory Transcription Factor of Eosinophils in Type 1 Environments
Fabs targeting a Cε2 epitope disassemble IgE-receptor complexes and suppress anaphylaxis
Epidemiology and Management of Malignancies in Patients with Inborn Errors of Immunity - An ESID Registry Study of 19,959 Patients
Oral immunotherapy suppresses peripheral blood transcriptomic response to peanut in peanut allergy
Utilization of the All of Us Research Program in study of genetics in Yao syndrome
Basophils Activate Oncostatin M Receptor-expressing Vagal Sensory Neurons.
Immunological biomarkers of non-infectious complications and overall survival in common variable immunodeficiency
Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation
High-affinity omalizumab variants with optimized disruptive potency prevent anaphylaxis in vivo
Longitudinal T and B cell recall responses following vaccination with the Pfizer-BioNTech mRNA vaccine BNT162b2
Decreased anaphylaxis by probiotic E. coli overexpressing Siglec ligand and peanut allergen
BTK modulates systemic immune activation to bacterial translocation in primary antibody deficiencies
Late Effects After Haematopoietic Stem Cell Transplantation in patients with HLH: A Histiocyte Society, PDWP, IEWP and TCWP EBMT Study
Genetic Determinants of the Complement and Coagulation Pathways in Invasive Meningococcal Disease
Unraveling Mechanisms of Allergen Sensitization and Allergic Rhinitis via the Nasal Transcriptome
Abatacept Restores Dysregulated Transcriptomic and Proteomic Profile in Disorders of CTLA-4 Insufficiency
A scoping review of clinical management guidelines in inborn errors of immunity
Long-term prophylactic treatment with deucrictibant for angioedema due to acquired C1-inhibitor deficiency
IgE-activated human lung mast cells preferentially release Prostaglandin D2, Tromboxane A2 and Cysteinyl-Leukotrienes
Effect of Dupilumab on Small Airways Measured by Airway Oscillometry in VESTIGE
Anti-KIT antibody, briquilimab, induces mast cell apoptosis and depletion in non-human primates
Autosomal dominant Roquin-1 immunodeficiency and hyper-inflammation
Autoantibodies in patients with 22q11.2 deletion syndrome and psychosis
Heterozygous loss of MAP4K1 causes immune dysregulation by amplifying T cell responses
The Bruton’s tyrosine kinase inhibitor acalabrutinib aborts ongoing acute food-induced anaphylactic reactions in humanized mice
Preclinical and Phase I Randomized Study of a Potent Inhalable Nanobody Targeting TSLP for the Treatment of Airway Inflammation
T cell and autoantibody profiling for primary immune regulatory disorders
Positionally distinct interferon-stimulated dermal immune-acting fibroblasts promote neutrophil recruitment in Sweet’s syndrome
Mast cells modulate macrophage biology through release of pre-stored CSF1
Introduction of Allergenic Foods After Treatment with Omalizumab
Mast cells activated in vitro can modulate macrophage polarization and antibacterial responses
Ingestion of mast cell granules boosts macrophages and drives atypical programming
Human Airway Epithelial BAFF is Reduced in Early Life but Virally-induced via JAK/STAT
Regulation of immune cell metabolism by therapeutic normal IgG intravenous immunoglobulin
The impact of allogeneic hematopoietic stem cell transplantation on pulmonary complications in adults with inborn errors of immunity
3
Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial
Oral iptacopan therapy in patients with C3 glomerulopathy: a randomised, double-blind, parallel group, multicentre, placebo-controlled, phase 3 study
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial
2
Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework
Non-autoimmune, insulin-deficient diabetes in children and young adults in Africa: evidence from the Young-Onset Diabetes in sub-Saharan Africa (YODA) cross-sectional study
15
A Phase 2 Randomized Trial of Mezagitamab in Primary Immune Thrombocytopenia
Immunogenicity and Safety of vYF, a Yellow Fever Vaccine — A Phase 2 Trial
Iptacopan in IgA Nephropathy — Final 24-Month Data
Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia
Ianalumab plus Eltrombopag in Immune Thrombocytopenia
Prime Editing for p47phox-Deficient Chronic Granulomatous Disease
Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN
Noninferiority of One HPV Vaccine Dose to Two Doses
Engasertib versus Placebo for Bleeding in Hereditary Hemorrhagic Telangiectasia
Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine
Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency
RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults
Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin
BCG Revaccination for the Prevention of Mycobacterium tuberculosis Infection
3
Airway microbiota in young people across four continents differ by country, asthma status and inflammatory phenotype
Interferon gamma applied ex vivo restores function to neutrophils from critically ill patients
Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial

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