Ozone Therapy Applications in Periodontal Treatment

Ozone therapy has emerged as a versatile adjunct to conventional periodontal care, leveraging the strong oxidative and antimicrobial properties of ozone gas or ozonated formulations to target pathogenic biofilms and modulate host responses. Delivered as gaseous ozone, ozonated gels or oils, and aqueous ultrafine bubble suspensions, it offers broad-spectrum activity against bacteria, fungi and viruses implicated in periodontitis. Beyond direct antimicrobial effects, ozone stimulates local circulation, enhances oxygen metabolism in periodontal tissues and can promote fibroblast proliferation and collagen synthesis. When combined with scaling and root planing, ozone therapy may accelerate pocket reduction, improve clinical attachment levels and reduce bleeding on probing, while avoiding some drawbacks of chemical antiseptics such as staining or resistance. Its ease of application, minimal invasiveness and potential immunomodulatory benefits have driven interest in both chairside and domiciliary protocols, with growing evidence supporting its global relevance as a cost-effective and sustainable option in modern periodontal management.

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Ozone Therapy Applications in Periodontal Treatment publication trend

The graph below shows the total number of articles in ozone therapy applications in periodontal treatment across all publications each year (not limited to Nature Index journals).

Technical terms

Scaling and Root Planing (SRP): Mechanical removal of plaque and calculus from tooth roots and periodontal pockets.

Probing Pocket Depth (PPD): Measurement in millimetres of the depth between the gingival margin and the base of the periodontal pocket.

Clinical Attachment Level (CAL): Sum of probing depth and gingival recession, indicating the position of the periodontal support apparatus.

Bleeding on Probing (BoP): Clinical sign of inflammation assessed by the presence of bleeding upon gentle probing of the sulcus or pocket.

Photobiomodulation (PBM): Use of low-level light therapy to stimulate cellular activity and enhance tissue healing.

References

1. Ozonized gels vs chlorhexidine in non‐surgical periodontal treatment: A randomized clinical trial. Oral Diseases (2023).
2. The Gaseous Ozone Therapy as a Promising Antiseptic Adjuvant of Periodontal Treatment: A Randomized Controlled Clinical Trial. International Journal of Environmental Research and Public Health (2022).
3. Management of Periodontal Disease with Adjunctive Therapy with Ozone and Photobiomodulation (PBM): A Randomized Clinical Trial. Photonics (2022).
4. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts. Science and Technology of Advanced Materials (2019).