Physical Activity Interventions in Multiple Sclerosis

Physical activity is increasingly recognised as a critical component of comprehensive care for people with multiple sclerosis (MS). Interventions span aerobic and resistance training, balance and flexibility exercises, delivered individually, in groups or via digital platforms. Regular moderate-intensity exercise has been shown to alleviate fatigue, enhance mobility, improve mood and slow functional decline, in part by promoting neuroplastic adaptations and reducing inflammation. Behaviour-change strategies, including goal setting and peer support, are integral to overcoming barriers such as fatigue, fear of falling and limited access to specialised facilities. The advent of wearable sensors and remote monitoring enables real-time feedback and personalised adjustment of exercise prescriptions. Collectively, these approaches underscore the role of tailored physical activity programmes in improving quality of life, reducing comorbidity risk and supporting long-term engagement across the MS disease trajectory.

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Physical Activity Interventions in Multiple Sclerosis publication trend

The graph below shows the total number of articles in physical activity interventions in multiple sclerosis across all publications each year (not limited to Nature Index journals).

Technical terms

Neuroplasticity: The capacity of the nervous system to reorganise its structure and function in response to experience, learning or injury.

Fatigue: A pervasive sense of weariness or lack of energy commonly experienced in MS, which can significantly restrict daily activities.

Gait analysis: The systematic study of walking patterns, often utilising sensors to measure parameters such as speed, stride length and stability.

Self-efficacy: An individual’s belief in their ability to organise and execute the actions required to achieve specific performance goals.

Tele-rehabilitation: The delivery of rehabilitation services remotely via telecommunications technology, enabling access to exercise programmes beyond clinical settings.

References

1. Predicting Real-World Physical Activity in Multiple Sclerosis: An Integrated Approach Using Clinical, Sensor-Based, and Self-Reported Measures. Sensors (2025).
2. Results of the MOVE MS Program: A Feasibility Study on Group Exercise for Individuals with Multiple Sclerosis. International Journal of Environmental Research and Public Health (2023).
3. Exercise Training for Multiple Sclerosis: A Narrative Review of History, Benefits, Safety, Guidelines, and Promotion. International Journal of Environmental Research and Public Health (2021).