Quality of Life and Patient Outcomes in Severe Asthma
Summary
Severe asthma imposes a profound multidimensional burden on patients, affecting physical functioning, emotional well‐being and social participation. Despite high‐dose inhaled therapies and systemic corticosteroids, many individuals experience persistent symptoms, frequent exacerbations and treatment side effects that degrade overall quality of life. The intersection of respiratory impairment, comorbidities and medication toxicity drives considerable heterogeneity in patient outcomes. Advances in targeted biologic therapies, multidisciplinary rehabilitation, structured education and novel patient‐reported outcome measures are reshaping both clinical management and the evaluation of treatment benefit. A holistic approach that integrates pharmacological optimisation, personalised self‐management support and robust measurement instruments is critical to improving well‐being and reducing healthcare utilisation in this population.
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Quality of Life and Patient Outcomes in Severe Asthma publication trend
The graph below shows the total number of articles in quality of life and patient outcomes in severe asthma across all publications each year (not limited to Nature Index journals).
Technical terms
Severe asthma: Asthma that remains uncontrolled despite high‐dose inhaled treatment and often requires systemic corticosteroids or biologics.
Quality of life (QoL): A multidimensional concept encompassing physical health, psychological state, social relationships and functional ability.
Oral corticosteroids (OCS): Systemic steroid medications used to control severe inflammation but associated with significant adverse effects.
Biologics: Targeted therapies—typically monoclonal antibodies—directed against specific inflammatory mediators such as interleukin‐5 in asthma.
Pulmonary rehabilitation: A structured programme of exercise training, education and self‐management support designed to improve respiratory health.
Patient-reported outcome measure (PROM): An instrument for capturing the patient’s own assessment of symptoms, functional status or quality of life.
References
- Long-Term Weight Changes After Starting Anti–IL-5/5Ra Biologics in Severe Asthma: The Role of Oral Corticosteroids. The Journal of Allergy and Clinical Immunology In Practice (2023).
- Validation of the CaReQoL asthma: a patient reported outcome measure for monitoring the perceived effects of pulmonary rehabilitation in adult patients with severe refractory asthma. Respiratory Research (2023).
- Positive change in asthma control using therapeutic patient education in severe uncontrolled asthma: a one-year prospective study. Asthma Research and Practice (2021).
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