Medical Biotechnology articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 591

Article ‘Count’ for Medical Biotechnology.

Journal Count Share
33 26.60
Post-Conjugation Process for Antibody-Conjugated Lipid Nanoparticles Enabling Tunable Antibody Surface Density for Targeted RNA Delivery 1.00
Rational Synthesis of Virus-Mimicking Nanocarriers for Enhanced Intracellular Delivery through Polyvalent Interactions with Cells 1.00
Anomalous Fluorescence Dynamics Emerge in Densely Labeled Virus-Like Particles 1.00
A Multiplex Digital Polymerase Chain Reaction-Based Platform with a Unified Readout for Multiclass Biomarker Quantification from Low-Volume Blood 1.00
Glycan Chemical Structures Dictate Organ- and Cell-Specific Tropism and Immunomodulation of Lipid Nanoparticles 1.00
Receptor-Free Cellular Internalization of DNA Micelles Driven by Membrane Interaction 0.13
Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines 0.21
Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles 0.97
Polyanion Chemistry Engineers Ternary RNA Nanoparticle Structure/Function from the Inside-Out 0.13
High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain 1.00
Scalable Multiparametric Characterization of Aptamer–Target Interactions 0.13
Intracellular Localization of DNA-Wrapped Single-Walled Carbon Nanotube Sensors for Nitric Oxide Detection in Triple-Negative Breast Cancer Cells 1.00
An Assembly-Line Mechanism for In Vitro Encapsulation of Fragmented Cargo in Virus-Like Particles 0.71
Shape-Dependent Entropic Forces Govern Synergistic Bystander Nanoparticle Uptake 0.11
Mechanisms of Adeno-Associated Virus Serotype 9 Vector Characterization and Quality Control through Solid-State Nanopores 0.86
Double-Emulsion Perfluorocarbon Nanodroplets for Ultrasound and Photoacoustic Image-Guided Drug Delivery and Release 1.00
Customizable mRNA Lipid Nanoparticles for Transfection of Primary Human T Cells 1.00
Oxygenating Nanobubble Hydrogel for Accelerated Surgical Wound Closure and Restoration of Native Skin Architecture 1.00
Self-Assembling Protein Materials with Genetically Programmable Morphology and Size 1.00
Virus-Inspired mRNA Delivery Vehicle Enabled by a Multilayered Nucleic Acid Nanocapsule 0.91
The Structure and Morphology of Single-Component Oligomeric RNA Delivery Vectors Derived from Amphiphilic Charge-Altering Releasable Transporters 1.00
Synthetic Rewiring of Virus-like Particles via Circular Permutation Enables Modular Peptide Display and Protein Encapsulation 1.00
Selective Enrichment of Full Capsids of Adeno-Associated Virus 1.00
Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on Shewanella oneidensis by Compromising Membrane Protein Functionality 0.11
Time-Resolved Fluorescence Imaging and Correlative Cryo-Electron Tomography to Study Structural Changes of the HIV-1 Capsid 1.00
In2O3 Nanoribbon-Based Field-Effect Transistor Biosensors for Ultrasensitive Detection of Exosomal Circulating microRNA with Peptide Nucleic Acid Probes 0.81
Computer Simulations Show That Liquid–Liquid Phase Separation Enhances Self-Assembly 1.00
Kinetically Controlled Mesoporous Silica Films for Quasi-3D Nanoconfinement of Semicrystalline Polymers below Their Lamellae Dimensions 0.56
Characterization of a Single-Molecule Sensitive Digital Flow Cytometer for Amplification-Free Digital Assays 1.00
Membrane Fusion Drives Facile Uptake of Cell Membrane-Coated Nanocarriers 1.00
Nanocoding: Lipid Nanoparticle Barcoding for Multiplexed Single-Cell RNA Sequencing 1.00
Exploring the Subcellular Localization and Degradation of Spherical Nucleic Acids Using Fluorescence Lifetime Imaging Microscopy 1.00
Rational Design of Safer Inorganic Nanoparticles via Mechanistic Modeling-Informed Machine Learning 0.96
21 18.03
Non-invasive detection of local microstructural damage in tendon using Diffusion Tensor MRI 1.00
Virtual fluorescent labeling of engineered vascular networks with embedded tracer particles 1.00
Enhancing in vivo B cell gene delivery using targeted lentiviral vectors and transduction enhancers 1.00
Biopreservation of a tissue engineered nigrostriatal pathway for tract reconstruction in Parkinson’s disease 1.00
The effects of volume exclusion and viscosity on collagen fiber nucleation and network morphology 0.75
Human cell-derived dermal-specific interwoven extracellular matrix for diabetic wound healing 1.00
A pH-responsive hyaluronic acid hydrogel facilitates lesion-localized integrin α5β1 agonism to attenuate osteopontin signaling and fibrosis in intrauterine adhesions 0.22
Stent-Graft Compliance Modulates Regional Mechanical and Structural Remodeling of the Aorta 1.00
Sulfide-based, Pro-regenerative, Anti-inflammatory Vascular Grafts: Impregnation of Slow-released Sulfide Signals into Graft Implants 0.93
Minipig costal and knee cartilage structure-function relationships and their use as cell sources for tissue-engineered analogous cellular products for cartilage repair 1.00
Effect of stent-graft compliance on hemodynamics and aortic stiffening in an in vivo porcine study 1.00
A Facile Fabrication and Conjugation Approach for Biopolymeric‒Zwitterionic Hydrogel Microparticles toward Accurate Protein Quantification using Replica Molding and Peptide Ligand Conjugation 0.67
Three-dimensional magnetic torque stimulation enhances functional structural maturation in developing human cardiac organoids 0.03
Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening 1.00
Modeling of protein networks reveals factors affecting stiffness, yield stress, and strain stiffening in silk fibers 0.50
Local viscoelasticity of denaturing spider silk dope is governed by dynamic hierarchical intermolecular interactions 1.00
Imaging the mechanical properties of a developing embryonic tendon using Brillouin microscopy 1.00
Minimally Invasive Delivery of Engineered Heart Tissues Restores Cardiac Function in Rats with Chronic Myocardial Infarction 1.00
Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells 1.00
In Vitro and In Vivo Biocompatibility Study of Fluorinated Polyphosphazene Coatings for Blood-Contacting Medical Devices 1.00
Magnetic Capture of Autologous Mesenchymal Stem Cells Promotes the Rapid Endothelialization of Peripheral Venous Stents in Rabbits 0.94
17 12.40
Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA-Lipid Nanoparticle Stability When Dried in a Polymer Matrix 0.72
An Engineered E. Coli-Based Living Material Platform for Protease Biosensing 0.08
Self-Assembled Nanoclay Gel With Spheroid MSC-Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin-Targeting miRNA for Synergistic Osteogenesis 1.00
Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation 1.00
Biomimetic Woven Bone Organoids with Multifocal Centers for Retaining Stemness and Prolonging Osteogenic Activity 0.83
RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis 1.00
Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA‐Based Therapeutics 1.00
Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity 1.00
Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue 1.00
Crossbow Bioreactors for Studying the Effects of Time-Varying Mechanical Preload and Afterload on Engineered Cardiac Tissues 1.00
High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation 0.61
Simple Zinc Metallic Particle Doping Transforms Ceramic Bone Cement Therapeutic Performance 0.89
Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1 0.15
Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers 0.94
Engineering Hybrid Extracellular Vesicles for Functional mRNA Delivery 0.14
Label‐Free and Low‐Power Driven Cancer Biomarker Detection Enabled by 2D Hexagonal Titanium Oxide 0.04
Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury 1.00
13 8.57
Small Diameter Vascular Grafts Made in Minutes 0.36
Hydro‐Torsional Compaction for Scalable Production of Aramid Nanofiber Threads with Densely Assembled Double‐Helical Nanostructures 0.11
Surface-Capped Protein Nanoparticles for Nonviral Gene Delivery 0.97
High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering 1.00
Edge-Driven Fringe-Field Effects, Reduced Screening, and Bandgap Widening in Graphene Nanoribbons Enable Single‑Molecule Sensitivity 1.00
Potent Liver-Tropic mRNA Lipid Nanoparticles: ApoE-Mediated Delivery Through a Low-Density Lipoprotein Receptor Independent Uptake Mechanism 1.00
Thermoplastic Molding of Chitosan to Form Living Plastic Materials 0.83
Mesenchymal Stem Cell-Inspired Microneedle Platform for NIR-responsive Immunomodulation and Accelerated Chronic Wound Healing 0.05
3D Spatiotemporal Electrophysiology of Cardiac Organoids Using Shell Microelectrode Arrays 1.00
A Readily Synthesized All‐In‐One Nanowire Hydrogel: Toward Inhibiting Tumor Recurrence and Postoperative Infection 0.15
Mass‐Manufactured Gradient Plasmonic Metasurfaces for Enhanced Mid‐IR Spectrochemical Analysis of Complex Biofluids 0.93
Engineered Virus‐Like Nanoparticles Enable Multimodal Protein Degradation for Enhanced Tumor Therapy 0.17
Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas 1.00
1 0.73
Association of blood-based neurodegenerative biomarkers with cognitive functioning and dementia in India (LASI-DAD) and the United States (HRS) 0.73
2 2.00
The D2.B10-Dmd mdx /J mouse model of DMD exhibits a severe mitochondrial deficiency not observed in the C57BL/10ScSn-Dmd mdx /J mouse 1.00
Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies 1.00
3 2.20
Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary TB in Brazil 0.20
Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis 1.00
Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT). 1.00
38 26.40
Deep-UV Resonance Raman Spectroscopy Enables Direct Quantification of mRNA in Intact Lipid Nanoparticle Formulations 1.00
Dual Paper-Based Electrochemical Device for Multiplex Detection of Triple-Negative Breast Cancer miRNA Signatures 0.10
Sortase-Mediated Dual-Display Phage Bioluminescent Immunoassay for Detection of Vibrio parahemolyticus Using Affinity-Enhanced Nanobody 0.11
Quantitation of Diastereomer Content in PS-Modified Synthetic Oligonucleotides using cIMS-MS 1.00
Robust Radical-Mediated Electrical Enzyme Assay (REEA) Cartridge FET Sensor toward Practical Applications 1.00
Immunomagnetic Sample Preparation Targeting Host- and Viral-Derived Antigens for HIV-1 Isolation from Limited Plasma Volumes 0.88
Smartphone-Based Peptide Nucleic Acid (PNA) Probe-Assisted Potentiometric Biosensor for Point-of-Care Testing of SARS-CoV-2 Nucleic Acid 0.13
Rapid and Specific Detection of Gastric Cancer EVs Using a Cas12a-Powered Aptasensor with a Novel Targeting Aptamer 0.04
Detection of Aerosolized Protein Using a Condensation Growth Tube Coupled with an Electrochemical Immunoassay on Screen-Printed Carbon Electrodes 1.00
Sponge-Based Flow Control in Laminate Capillary-Driven Electrochemical Microfluidic Devices for Viscous Sample Analysis 0.50
Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing 1.00
DNA-Fueled Molecule Machine-Mediated Atom Transfer Radical Polymerization Amplification for 17β-Estradiol Assay in Clinical Samples 0.20
DNAzyme-Powered Rolling Circle Amplification for the Synthesis of Hairpin DNA-Templated Fluorescent Copper Nanoclusters: A Label-Free miRNA Sensing Platform 0.60
Exploring the Feasibility of Paper-Based Substrates for User-Friendly Electrochemiluminescent Sensors 0.06
Extraction-Free Scalable Sample Preparation for the Rapid Detection of HIV in Blood Plasma 1.00
Encapsulation of mRNA in Therapeutics Like Lipid Nanoparticles Probed by Deep-UV Resonance Raman Spectroscopy 0.75
Utilizing Engineered Monobodies for the Electrochemical Quantification of Lysozyme 1.00
Hierarchically Porous Amino-Functionalized Microporous Organic Networks Coated Fiber for Sensitive Breath Metabolite Profiling: A Noninvasive Strategy for Gastric Cancer Diagnosis 0.25
Rapid Phenotypic Antimicrobial Susceptibility Testing with Multichannel Large-Volume Scattering Imaging and a Bayesian Gaussian Process Model 1.00
Interrogation of Small Molecules to Surface-Bound Aptamer Binding Kinetics with Electrochemical Aptamer-Based Sensors Using Intermittent Pulse Amperometry 1.00
Integrated Workflow for the Quantification of Urinary Exosomes Isolated via C–CP Fiber Tips with Lanthanide Chelation Labeling and ICP-MS Detection 1.00
Paper Matters: Technical Evaluation of Paper-Based Substrates for Enhanced Preconcentration of Biomolecules in Liquid Biopsy Diagnostics 0.03
Capillary Flow-Driven, Disposable Device for Dissolved Oxygen Sensing in Water Samples 0.75
Monitoring Vaccine-Induced Antibody Levels Using Carbon Nanotube-Based Field-Effect Transistors 1.00
Streamlined Probe-Melt PCR for Multiplex Detection of Wheat Fungal Pathogens 1.00
Tile-Based Fisher Ratio Analysis with Support Vector Machine Regression Modeling of GC×GC-TOFMS Data of VOCs Produced by Malassezia pachydermatis Grown at Variable pHs 1.00
Hydrogel-Bead Particles Enable Activity-Based Identification of Nucleic Acid Aptamer Enzyme Inhibitors 1.00
A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates 1.00
Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action 1.00
Acryloyl Gelatin as Polymer Additive to Droplet Digital LAMP for DNA Quantification 0.17
Rapid and Continuous Simultaneous Monitoring of Interleukin-6 and Lactate Using a Bioelectronic Sensor Platform: toward Early Sepsis Prediction 1.00
Fast, Simple Electrochromic Biosensors for Point-of-Use Infectious Disease Diagnosis 1.00
Metabolism-Driven Colorimetric “Read-to-Answer” Sensor Array for Bacterial Discrimination and Antimicrobial Susceptibility Testing 1.00
Simultaneous Bioelectrochemical Detection of Nitrate and Nitrite with a Whole-Cell Hydrogel Electrode 0.06
A Paper/Polymer Hybrid Microfluidic Nanosensing Rotary Chip: From Efficient Reagent Delivery to Multiplexed Detection of Toxins 1.00
An All-in-One Microfluidic Device for Blood Plasma Separation and Fluorescence Detection of Cocaine in Whole Blood 1.00
Development of an Electrochemical Biosensor to Detect miRNA Encapsulated in Lipid Nanoparticles 0.04
Diagnosis On-Demand: Field Evaluation of Microfluidic Paper Device for the Detection of Asymptomatic Malaria 0.75
7 5.09
Mitochondria-Targeting Moieties Based on N-Tethered Pyridinium Cations 0.11
Molecule by Molecule Characterization of a Polymer Molecular Mass Distribution via Mass Photometry 1.00
Enhanced-mRNA Delivery Using Ultrasound-Delivered Anchors for Bioorthogonal Ligation 1.00
DNA Glass: Encasing Diffraction-Quality, Mesoporous DNA Crystals in Architected Silica 0.73
A Modular Platform for Enhanced Drug Delivery to Glioblastoma Using Targeted Multidomain Protein Assemblies 1.00
Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions 0.25
Synthesis of Sensitive RNAs Using Fluoride‐Cleavable Groups as Linkers and Amino‐Group Protection 1.00
8 6.72
Association between Plasma P‐tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease 1.00
Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media 1.00
Electrical Impedance Myography Detects Disease Progression over 12 to 24 Months in Facioscapulohumeral Muscular Dystrophy 0.93
When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ-PET Centiloid 15, Mean Age of 66 Years 0.28
Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease 1.00
Predictive Value of Plasma Biomarkers in Tau-PET Transitions 0.67
Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau scpPET/scp Clocks 0.85
Co‐Opting scpMBNL/scp‐Dependent Alternative Splicing Cassette Exons to Control Gene Therapy in Myotonic Dystrophy 1.00
1 1.00
Blocking the neonatal Fc receptor as a novel approach to prevent cardiac neonatal lupus: a proof-of-concept study 1.00
10 6.18
High-dimensional spatiotemporal single-cell atlas and 3D imaging of the bone marrow microenvironment during CML progression 0.24
Defective cerebrovascular development in mice lacking TFPI is restored by activated protein C 0.97
Nucleoplasmic ZNF467 condensates boost hematopoietic stem cell engraftment via ICAM1-mediated mechanical reprogramming 0.17
A compartmentalized inflammatory landscape and macrophage plasticity regulate Tet2+/−-mediated clonal hematopoiesis 1.00
CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis 1.00
Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease 1.00
Factor IXa and Factor X Influence Factor VIIIa Stability and Inactivation Mechanisms In Vitro and In Vivo 1.00
Marstacimab Prophylaxis in Hemophilia A/B Without Inhibitors: Results from the Phase 3 BASIS Trial 0.41
Tracking iclusterin/i expression in hematopoietic stem cells reveals their heterogeneous composition across the life span 0.02
Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study 0.37
5 2.93
Plasma pTau 217:β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology 0.70
Combined magnetic resonance imaging and serum analysis reveals distinct multiple sclerosis types 0.10
Neurofilament light chain as a prognostic marker in cerebral adrenoleukodystrophy 1.00
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum 0.13
Neuropathologic correlates of distinct plasma biomarker profiles in community-living older adults 1.00
1 1.00
Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions 1.00
8 5.54
Hyperinnervation inhibits organ-level regeneration in mammalian skin 1.00
Fertilization triggers early proteomic symmetry breaking in mammalian embryos 0.55
RNA innate immunity constitutes a barrier for interspecies chimerism 0.76
Tumors hijack macrophages for iron supply to promote bone metastasis and anemia 1.00
Fibroblast bioelectric signaling drives hair growth 0.15
A percolation phase transition controls complement protein coating of surfaces 1.00
Senescence-resistant human mesenchymal progenitor cells counter aging in primates 0.08
Neuroendocrine cells orchestrate regeneration through Desert hedgehog signaling 1.00
1 1.00
Divergent viral phosphodiesterases for immune signaling evasion 1.00
2 2.00
The gut microbiota shapes the human and murine breath volatilome 1.00
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury 1.00
8 5.09
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience 0.08
Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness 1.00
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling 0.98
Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs 0.06
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling 0.95
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling 0.02
An inducible model of human post-implantation development derived from primed and naive stem cells 1.00
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity 1.00
2 2.00
A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox 1.00
FLOWER: a frequency-locked optical whispering evanescent resonator for label-free molecular detection 1.00
2 1.29
A platform to design and optimise fluorogenic scFvs for detection of interleukin 33 0.29
Ultrasound-triggered prodrug activation via sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold 1.00
2 1.20
MR-ProADM Predicts Mortality and Heart Failure Events in ATTR Cardiac Amyloidosis. 0.20
Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction. 1.00
6 3.32
Performance Evaluation of the Xpert® HCV test on Fingerstick Blood in a Prospective Observational Clinical Study at CLIA-Waived Sites in the United States 1.00
Diagnostic Accuracy of Molecular Testing on Saliva and Oral Swabs for Pulmonary Tuberculosis 0.17
Microbial Detection in Community Acquired Pleural Space Infection Using the BioFire Joint Infection Panel and Individual PCR Assays 0.67
Predicted Preferences for Tuberculosis Point-of-Care Tests among Tuberculosis-Affected Individuals in Five High Burden Countries 0.32
Independent Testing to Accelerate the Development of Lateral Flow Assays for Influenza A, Influenza B and SARS-COV-2 1.00
Cost-effectiveness of Targeted Next-Generation Sequencing for Tuberculosis Drug-resistance Testing as an Alternative to the Standard of Care in South Africa 0.17
1 1.00
Diagnostic Performance of Point-of-Care Immunoassay Measurements of Pancreatic Stone Protein for Sepsis Detection in ICU Patients: A Prospective, Multicenter, Biomarker-Blinded Study. 1.00
7 5.80
Songbird connectome reveals tunneling of migratory neurons in the adult striatum 0.50
Drift of positional identity drives reproductive aging in a long-lived regenerative animal 1.00
Totipotency and high plasticity in an embryo with an invariant, fate-specifying cleavage program 1.00
Ectopic head regeneration after nervous system ablation in a sea anemone 0.30
Ultrastructural reconstruction of the endodermal nerve net of Hydra vulgaris 1.00
Transcriptional interference gates monogenic odorant receptor expression in ants 1.00
Live imaging endogenous transcription factor dynamics reveals mechanisms of epiblast and primitive endoderm fate segregation 1.00
4 3.54
A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy 0.63
MYRF controls mesothelium specification, signaling, and plasticity in lung development 1.00
Efficient stem cell-derived mouse embryo models for environmental studies 0.91
TAF1 is required for fetal but not adult hematopoiesis in mice 1.00
1 0.38
Baseline Risk and Longitudinal Changes in kidneyintelX.dkd and Its Association With Kidney Outcomes in the CANVAS and CREDENCE Trials. 0.38
1 1.00
Advancing Exposomics: From Concept to Practice in Environmental Health Sciences. 1.00
2 1.04
Nucleation-Mode-Particle Emissions from Biosolid Processing Plants 1.00
Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials 0.04
1 0.09
Heart allograft rejection: molecular diagnosis using intra-graft targeted gene expression profiling 0.09
1 0.57
KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity 0.57
2 1.61
OMKar automates genome karyotyping using optical maps to identify constitutional abnormalities 0.75
A gene regulatory element modulates myosin expression and controls cardiomyocyte response to stress 0.86
1 0.94
Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis 0.94
1 1.00
Benefits and Harms of Dementia Screening for Family Members of Older Adults 1.00
9 8.71
A comprehensive discovery platform for ELOVL1 small-molecule inhibitors targeting very long-chain fatty acid synthesis in adrenoleukodystrophy 1.00
Profiling of fatty acids and lipids in animal and human tissues yields new leads for disease progression biomarkers of X-linked adrenoleukodystrophy 1.00
Sustained β-catenin activation via GSK3 inhibition promotes direct fibroblast-to-cardiomyocyte reprogramming 1.00
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines 1.00
Transient receptor potential vanilloid four in macrophages mediates TGF-β activation to drive myofibroblast differentiation and pulmonary fibrosis 1.00
Scalable purification enables high-quality virus-like particles for therapeutic translation 0.71
Mutations in Hsp40 co-chaperone change the canonical interdomain interactions stimulating LGMDD1 myopathy 1.00
The impact of pH on proteolytic activity in wound fluid: Implications for acid therapy 1.00
Discovery of thiacyanine dyes as a new class of potent coronavirus inhibitors that suppress viral RNA synthesis 1.00
3 1.63
Comparative Efficacy of Surgical Versus Nonsurgical Management for Acute Achilles Tendon Rupture in a Novel Mouse Model. 0.17
Sex-Based Differences in Cell Types and Gene Expression within the Anterior Cruciate Ligament. 1.00
Bezeotermin Alfa (rhBMP-6) Administration in Lumbar Interbody Fusion Surgery Using a Posterior Approach 0.47
1 0.57
Insulin Receptor Family Autoantibodies in Patients with Type B Insulin Resistance 0.57
18 16.69
Deficiency of muscular dystrophy-related gene JAG2 causes NOTCH signaling dysfunction in muscle stem cells 1.00
Modulation of WNT and FGF18 enhances yield and subtype identity of hPSC-derived midbrain dopamine neurons 0.89
Transient p53/p21 activation selectively protects healthy human hair follicles and their stem cells from chemotherapy 0.63
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice 0.21
Hyperactivation of mTORC1 signaling mediates folliculin deficiency–induced pulmonary cyst formation in Birt-Hogg-Dubé syndrome 1.00
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell mediated regeneration 1.00
Targeting lymphatic vessels enhances bone regeneration by augmenting osteoclast activity in mouse models of amputation 1.00
PDGFRβ signaling restrains myocyte function to limit the regenerative capacity of skeletal muscle 1.00
Lnk Deficiency Enhances Translesion Synthesis to Alleviate Replication Stress and Promote Hematopoietic Stem Cell Fitness 1.00
Staphylococcus aureus accessory gene regulator quorum-sensing system inhibits keratinocyte lipid enzymes and delays wound repair 1.00
Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice 1.00
Five-year analysis of efficacy and safety of a bidirectional AAV gene therapy in Tay-Sachs sheep 1.00
Peripherally administered androgen receptor-targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model 1.00
Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice 1.00
Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss 1.00
The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice 1.00
Sarcospan protects against LGMD R5 via remodeling of the sarcoglycan complex composition in dystrophic mice 0.97
Expression of full-length dystrophin reverses muscular dystrophy defects in young and old mdx4cv mice 1.00
2 1.19
Canine Olfaction Combined With Bayesian Modeling for Multicancer Detection From Breath Samples: A Phase II Study in India. 0.19
Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026). 1.00
2 1.83
Mechanometabolism instructs hematopoietic stem cell specification 0.93
Leukemogenic Kras mutation reprograms multipotent progenitors to facilitate its spread through the hematopoietic system 0.90
2 1.89
Noninvasive suppression of responses to threat using focused ultrasonic waves 1.00
The Development of Neural Inhibition across Species: Insights from the Hurst Exponent 0.89
3 2.83
Transcranial photobiomodulation with near‐infrared laser induces analgesia in rats 1.00
Early adaptive and late degenerative tendon response to overload in rat model of synergist ablation 0.83
Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons 1.00
20 18.27
Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity 1.00
Ultrasensitive Enzyme-Free Detection of Proteins on Magnetic Beads 1.00
High-Throughput Aptamer Characterization via Real-Time Nuclease Digestion 1.00
Nanobody-Based Bioconjugates as Potent and Broadly Active Inhibitors of HIV Entry 1.00
Characterizing the Impact of the Cell Cycle on mRNA Lipid Nanoparticles 1.00
A General Approach to Stereoregular Pseudo-Polysaccharides: Cationic Ring-Opening Polymerization of Monosaccharide Cyclic Thionocarbonates 1.00
Quantum Defects Engineered in Chirality Pure Single-Wall Carbon Nanotubes for Enabling Ratiometric Sensing of Insulin 1.00
Computationally Aided Design of Ionizable Cholesteryl Lipids for Lipid Nanoparticles to Modulate Hepatic mRNA Accumulation 0.43
Cleavable Hydrophobic Anchors Optimize Immunomodulatory Effects of Oligonucleotides 1.00
Spatial Conformation of Ionizable Lipids Regulates Endosomal Membrane Disruption 0.77
Programming Aptamer–Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure 1.00
Localized 2′-OH Acylation at Poly(A) Extends RNA Translation 1.00
Exploring the Structural Divergence of HIV and SRLV Lentiviral Capsids 1.00
Ultrasound-Activatable Lipid Nanoplatform for Region-Confined Innate Immune Stimulation and mRNA Vaccination Therapy of Cancer 0.07
Controlled Dimerization of Cellular Nanodiscs via Click Chemistry to Enhance Immune Compatibility 1.00
De Novo Design of High-Performance Cortisol Luminescent Biosensors 1.00
Speed Matters: Directed Assembly of Icosahedral HPV Virus-Like Particles 1.00
DNA Aptamer-Guided Glycomimetics for Developmental Stage-Specific Glycocalyx Engineering to Control Stem Cell Differentiation 1.00
Harnessing the Electron-Withdrawing Inductive Effect of One-Component Ionizable Amphiphilic Janus Dendrimers Unveils Cation−π Interactions and Their Important Roles to Targeted mRNA Delivery 1.00
A Multi-Threshold Micelle Improves Tumor Accumulation and STING Immunotherapy 1.00
1 0.46
<atl>Longitudinal Associations Between Neurodegenerative Biomarkers and Cognitive Decline in Older Adults: Insights From the scpLASI/scp ‐ scpDAD/scp Study</atl> 0.46
1 0.13
Robust Artificial Spider Silk via Synergistic Cross-Linking of Slide-Ring and Covalent Bonds 0.13
2 1.04
Capsid restructuring activates semi-conservative dsRNA transcription in cystovirus ɸ6 0.10
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development 0.95
3 1.28
Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing 0.92
Lineage specification into GABAergic, glutamatergic, dopaminergic, and astrocytic phenotypes using MUSE stem cells: a novel approach for modeling neurodegenerative and psychiatric disorders 0.05
Diagnostic performance of Alzheimer’s disease blood and CSF biomarkers in a Brazilian cohort with low educational attainment 0.31
15 11.85
Nanocarrier-Based Cell Nucleus Delivery of Therapeutic Proteins 0.17
Chemotaxis of ATPase-Powered Nanoparticles up Extra- and Intracellular ATP Gradients 1.00
High-Curvature Features Improve Targeting of Nanoconstructs with Small-Molecule Ligands 1.00
Nanoconfinement of Hydrophobic Domains Facilitates Strong Mesoscale Networks in Silk-Inspired Materials 1.00
Toward Breath-Based Diagnostics via Water-Mediated Capture of Synthetic Breath Biomarkers in SERS-Active Plasmonic Nanogaps 1.00
Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal–Organic Framework Nanoparticles 1.00
Continuous and Scalable Production of Multifunctional Phenolic Resin Beads in a Flow System for Portable Water Treatment 1.00
RNA Resolution in an Electric Double Layer Generated by Metal–Organic Frameworks 0.05
Engineering the Size of Bicontinuous Nanospheres via Multi-Inlet Vortex Mixing 0.94
Silica Nanobottles Filled with Photo-cross-linked GelMA for the Sustained Release of Hydrophilic Biomacromolecules 1.00
All-Polymer and Adhesive Electrodes as Electroceuticals for Chronic Wound Healing 0.13
Smartphone-Based Immune Response Measurement Using a Colorimetric Self-Assembled Plasmonic Biosensor 0.82
High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH) 0.75
Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair 1.00
Acoustic Field Enabled Polymeric Nanoparticle Deposition onto Vessel Walls for Enhanced Drug Delivery 1.00
6 4.73
De novo design of quasisymmetric two-component protein cages 0.99
Design of one-component quasisymmetric protein nanocages 0.86
Multicentre gene therapy for -related deafness followed up to 2.5 years 0.02
Rete ridges form via evolutionarily distinct mechanisms in mammalian skin 0.86
Haematopoietic stem cell number is not solely defined by niche availability 1.00
Therapeutic genetic restoration through allogeneic brain microglia replacement 1.00
11 10.50
mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression 1.00
Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments 1.00
In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery 0.73
Hemodynamics-driven magnetoelastic vascular grafts for stenosis diagnosis 1.00
An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery 1.00
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity 0.86
Selective RNA sequestration in biomolecular condensates directs cell fate transitions 1.00
Elucidating lipid nanoparticle properties and structure through biophysical analyses 1.00
Derivation of embryonic stem cells across avian species 0.91
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes 1.00
Lipid nanoparticle screening in nonhuman primates with minimal loss of life 1.00
7 4.92
Transcription-independent induction of rapid-onset senescence is integral to healing 0.14
Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour 1.00
A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures 0.75
Programmable macromolecule delivery via engineered trogocytosis 1.00
Inhibiting ferroptosis enhances ex vivo expansion of human haematopoietic stem cells 1.00
Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing 1.00
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells 0.03
1 1.00
Programmable fluorescent aptamer-based RNA switches for rapid identification of point mutations 1.00
110 77.53
Long-term comparative analysis of AAV9-mediated gene replacement therapies for spinal muscular atrophy in mice 1.00
The perijunctional zone is a molecularly distinct muscle subdomain altered in Duchenne muscular dystrophy 1.00
Global protein-ligand binding affinity profiling via photocatalytic labeling 1.00
Alzheimer’s Disease blood biomarkers measured through remote capillary sampling correlate with cognition in older adults 0.17
Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods 1.00
Heritable immunization of mice against Lyme disease enables ecological disease prevention 1.00
Circulating extracellular microRNAs as tissue-specific biomarkers of human health and disease 0.65
GWAS meta-analysis of cerebrospinal fluid Alzheimer’s biomarkers reveals loci regulating lipids, brain volume and autophagy 0.24
Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity 1.00
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults 0.99
Mitophagy promotes lung repair and regeneration by restoring epithelial metabolic fitness 0.08
Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer’s disease continuum 0.36
BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation 0.05
Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging 0.14
Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs 0.86
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation 0.83
Engineering multiple levels of specificity in an RNA viral vector 1.00
Preventing peritendinous adhesions using lubricious supramolecular hydrogels 1.00
Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs 1.00
Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration 1.00
Aptamers with magnetically tunable affinity for divalent cobalt ions 0.29
Olfactory cleft biopsy analysis of Alzheimer’s disease pathobiology across disease stages 1.00
Compact mid-infrared fiber probe for in vivo multi-compound monitoring demonstrated using ex vivo human skin 1.00
Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment 1.00
Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool 1.00
Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling 0.75
PRICE: direct and robust detection of microRNAs at single-nucleotide resolution 0.08
FOXF2 regulates pericyte–endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury 0.55
Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis 0.50
Virus glycoprotein nanodisc platform for vaccine analytics 0.99
Inhibition of TGF-β signaling in microglia stimulates hippocampal adult neurogenesis and reduces anxiety-like behavior in adult mice 0.77
A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina 0.98
Zebrafish macrophages convert physical wound signals into rapid vascular permeabilization 1.00
Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model 0.95
Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair 0.08
Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery 0.53
In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis 0.49
RoboA reinforces planarian stem cell fate through FoxA and Anosmin1a 1.00
Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer’s disease 0.79
CHAMP1 is an essential regulator for human myoblast fusion and muscle development 1.00
Transcriptomic signature-guided depletion of intermediate alveolar epithelial cells ameliorates pulmonary fibrosis in mice 0.92
Uncertainty-aware machine learning to predict non-cancer human toxicity for the global chemicals market 0.17
Highly efficient expression of DNA-peptide conjugates in growth-arrested cells 1.00
Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones 1.00
Tumor agnostic drug delivery with dynamic nanohydrogels 1.00
Structure and immunogenicity of an engineered soluble prefusion-stabilized EBV gB antigen 1.00
Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trial 0.05
A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases 1.00
Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy 0.27
IL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3 1.00
Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea 1.00
Transcytotic transportation of size-controlled nanocarriers into dystrophic skeletal muscle leads to therapeutic outcome in mice 0.35
Wnt signaling restores evolutionary loss of robust foot regeneration rates in Hydra 0.90
Multiplexed detection of febrile infections using CARMEN 0.71
The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity 0.91
Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity 0.09
Plastic hepatocyte states limit liver cancer development 0.72
Directed rescue strategy for enhanced implant osteointegration in aged rats 0.08
Transient overexpression of hPKM2 in porcine cardiomyocytes prevents heart failure after myocardial infarction 1.00
Thermally programmed one-pot CRISPR assay for on-site pandemic surveillance 0.22
Multiscale red blood cell hitchhiking for targeted deep tissue gene delivery in lungs 0.94
Epithelial-mesenchymal cell competition coordinates fate transitions across tissue compartments during lung development and fibrosis 1.00
Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia 0.08
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA 1.00
Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation 0.03
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics 0.27
A multimodal cross-species comparison of pancreas development 0.20
CRISPR anti-tag-mediated room-temperature RNA detection using CRISPR/Cas13a 0.86
A molecular circuit regulates fate plasticity in emerging and adult AT2 cells 0.95
Large-scale serum protein biomarkers discovery associated with function and clinical milestones in Duchenne muscular dystrophy 0.60
Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions 1.00
EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases 1.00
Ddx61-enriched condensates refine heart regeneration programs 1.00
Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo 0.39
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models 1.00
Engineered exosomes with Kras specific siRNA in pancreatic cancer: a phase I study with immunological correlates 1.00
Stage-specific and cell-autonomous functions of Delta-like 1 in skeletal muscle stem cells and myogenesis 0.94
Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo 1.00
Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties 0.02
Sensitive pathogen DNA detection by a multi-guide RNA Cas12a assay favoring trans- versus cis-cleavage 0.21
Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk 0.21
Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease 1.00
The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration 0.58
Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis 0.97
Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity 1.00
Multiplex bead assays enable integrated serological surveillance and reveal cross-pathogen vulnerabilities in Zambezia Province, Mozambique 0.47
Engineering kidney developmental trajectory using culture boundary conditions 1.00
Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations 1.00
drives a fate switch between hair cells of different mechanosensory organs 1.00
BMI1 regulates human erythroid self-renewal through both gene repression and gene activation 1.00
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents 0.09
Murine hematopoietic progenitor cell lines with erythroid and megakaryocyte potential 1.00
A genetically tractable non-vertebrate system to study complete camera-type eye regeneration 1.00
Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells 0.96
The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth 1.00
Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms 1.00
Raised Leptin and Pappalysin2 cell-free RNAs are the hallmarks of pregnancies complicated by preeclampsia with fetal growth restriction 0.55
Stem and progenitor cell proliferation are independently regulated by cell type-specific genes 1.00
Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway 1.00
Kit hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution 1.00
Immunocompetent cell targeting by food-additive titanium dioxide 0.03
Heterogeneity of IL-15-expressing mesenchymal stromal cells controls natural killer cell development and immune cell homeostasis 0.10
Epitenon-derived progenitors drive fibrosis and regeneration after flexor tendon injury in a spatially-dependent manner 1.00
Immunomics-guided biomarker discovery for human liver fluke infection and infection-associated cholangiocarcinoma 0.28
Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation 0.91
An mRNA vaccine encoding five conserved Group A Streptococcus antigens 0.24
A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity 0.38
In vivo self-renewal and expansion of quiescent stem cells from a non-human primate 0.73
Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC 0.97
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke 0.05
3 1.09
Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung 0.17
Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination 0.85
Peptide codes for organ-selective mRNA delivery 0.07
11 7.61
Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks 0.96
A multimodal sleep foundation model for disease prediction 0.69
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer’s disease pathology 0.08
Cardiotropic AAV gene therapy for heart failure: a phase 1 trial 0.95
Safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies in healthy adults: a phase 1 trial 1.00
Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions 0.50
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial 1.00
A personal health large language model for sleep and fitness coaching 1.00
AAV gene therapy for autosomal recessive deafness 9: a single-arm trial 0.05
A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics 0.37
AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial 1.00
5 4.67
Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines 1.00
Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation 1.00
Designing lipid nanoparticles using a transformer-based neural network 0.90
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape 0.97
Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications 0.80
1 0.75
An open science resource for accelerating scalable digital health research in autism and other neurodevelopmental conditions 0.75
1 0.39
Hierarchical materials from fused silk 0.39
1 0.75
Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases 0.75
4 2.23
SVASCilia is an open-source, deep learning-based tool for 3D analysis of cochlear hair cell stereocilia bundles 0.96
The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice 0.13
The planarian dorsal–ventral boundary regulates anterior–posterior axis growth and patterning 1.00
Multispecies characterization of immature neurons in the mammalian amygdala reveals their expansion in primates 0.14
4 3.31
Oculopharyngeal muscular dystrophy (OPMD) associated alanine expansion impairs the function of the nuclear polyadenosine RNA binding protein PABPN1 as revealed by proximity labeling and comparative proteomics 1.00
Zebrafish genetic model of neuromuscular degeneration associated with Atrogin-1 expression 0.77
Dynamic transcriptional and epigenetic changes define postnatal tendon growth 1.00
The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice 0.55
2 2.00
Systemic Delivery of Functional Proteins Into Plants Using an Engineered Membrane Translocation Domain 1.00
Toward Translation of Cowpea Mosaic Virus Intratumoral Immunotherapy With a Scalable Production Process 1.00
54 42.39
HHIP’s dynamic role in epithelial wound healing reveals a potential mechanism of COPD susceptibility 1.00
Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo 0.94
TGFb signaling instructs a conserved fibrosis-associated cell state marked by LRRC15 0.74
A human cardiomyocyte screen identifies optimized lipid nanoparticles for in vivo cardiac gene editing 1.00
Self-adjuvanting α-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors 0.95
Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides 0.60
Alternative splicing of the Rbm24 gene is essential for cochlear hair cell stereocilia integrity and hearing function in mice 0.11
A regulatory axis for tonotopic MYO7A expression in cochlear hair cells 0.63
Humanized extracellular vesicles for efficient RNA delivery 1.00
Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential 1.00
Convergence of external and internal stressors on a stress-responsive enhancer of the Sonic hedgehog gene to induce hair disorders 0.06
Versatile SMAD2 and SMAD3 epitope–tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9–SMAD2/3 targets 0.63
Fibro-adipogenic progenitor cells from murine SMA muscles are intrinsically adipogenic 1.00
Phosphorylation and DNA damage resolution coordinate SOX2-mediated reprogramming in vivo 1.00
SonoPIN enables precise, noninvasive, and efficient intracellular delivery of PROTACs 1.00
Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly 0.50
Identification of CD164 as an essential entry receptor for divergent adeno-associated viruses 1.00
Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification 0.01
Persistent adaptation through dual-timescale regulation of ion channel properties 1.00
Unraveling the maturation pathway of a eukaryotic virus through cryo-EM 0.29
In vitro sex-specific function–structure relationship in neonatal rat cardiac monolayers 1.00
Lipid nanoparticle GM-CSF replacement for autoimmune pulmonary alveolar proteinosis 1.00
A c-Cbl/Cbl-b antagonist inhibits EGFR ubiquitylation and sustains EGFR phosphorylation to enhance corneal re-epithelialization 1.00
CCR5 marks a subset of mouse hematopoietic stem cells that are myeloid primed and expand with age 1.00
Multiple modes of AFM reveal distinct mechanical properties for dystrophin and utrophin not manifest by small fragments 1.00
A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1 0.58
Assessing cerebral capillary function and stalling using single capillary reporters in ultrasound localization microscopy 0.11
Targeting C1q signaling in fibro-adipogenic progenitors prevents regenerative fibrosis of aged muscle 0.91
Optimizing mRNA delivery with targeted elastin-like polypeptide–based LENN formulations: Insights into the endocytosis mechanism 1.00
Fluorinated lipid nanoparticles enable real-time tracking of mRNA delivery and uncover spatiotemporal mechanisms of immune activation 0.08
Lineage tracing of both quiescent G0 and active Hoxb5+ LT-HSCs that actively contribute to homeostatic mouse hematopoiesis 1.00
Lrig1-expressing quiescent stem cells maintain vocal fold mucosal homeostasis via Notch signaling 1.00
VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment 0.82
Multipotent progenitors with distinct origins, clonal lineage fates, transcriptomes, and surface markers yield two hematopoietic trees 0.14
An adipo-osteoprogenitor population in the endosteal niche contributes to bone and fat formation in adult mouse bone marrow 0.94
Pollen-inspired biopolymer-based multifunctional films 0.40
Glycolipid nanoparticles target the spleen and detarget the liver without charge 1.00
Controlling intracellular processing to enhance spherical nucleic acid immune stimulation 1.00
Synthetic bottlebrush block copolymer prevents disease onset in Duchenne muscular dystrophy 1.00
Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice 1.00
The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size 1.00
Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models 1.00
Circular RNA lipid nanoparticle vaccine against SARS-CoV-2 0.73
The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development 0.45
Measuring the selective packaging of RNA molecules by viral coat proteins in cells 1.00
Can we still use the Michaelis–Menten model for enzymatic microneedle sensors? 1.00
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo 0.88
SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing 0.25
Osteoinductive low-dose 3D porous calcium phosphate graphene oxide–integrated matrices enhance osteogenesis and mechanical properties 1.00
Retinoic acid receptor assembly dynamics governs dual functions in cochlear organogenesis 1.00
A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells 0.67
Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis 1.00
A skin-interfaced wireless wearable device and data analytics approach for sleep-stage and disorder detection 1.00
MyD88 knockdown by RNAi prevents bacterial stimulation of tubeworm metamorphosis 1.00
1 1.00
Microbubble-based Radiosensitization of Hepatocellular Carcinoma: Evaluation of Safety and Efficacy in a Phase II Randomized Trial. 1.00
8 6.05
Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase 1.00
B lymphocyte protein factories produced by hematopoietic stem cell gene editing 0.85
Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration 0.11
Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction 0.91
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation 0.93
Deep generative models design mRNA sequences with enhanced translational capacity and stability 0.31
Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA 1.00
High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer 0.94
33 22.43
Active protein-capturing hydrogel for broad-spectrum pathogen defense 1.00
Hepatitis C virus infection dynamics, treatment, and lipid nanoparticle–mediated infection in humanized liver chimeric mouse models 0.50
Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation 0.95
One-component ionizable amphiphilic Janus dendrimers as a delivery platform for efficient mRNA vaccine development 0.81
Immunometabolic resistors of aging in long-lived golden spiny mice 0.54
E711-19 placement and orientation dictate CD8+ T cell response in structurally defined spherical nucleic acid vaccines 1.00
Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism 0.97
Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians 0.82
Facile active gel–enhanced synthesis of molecular-sieving membranes with record-breaking performance 0.17
Asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus 0.71
Rbfox2 selectively governs hematopoietic stem cell self-renewal by regulating proteostasis 1.00
Distinguishing active HIV-1 infection from vaccine-induced seropositivity in HIV vaccine trial participants 0.97
Role of CEBPa in trophectoderm competence installment 0.04
Ultrasonic cavitation shock wave exfoliation dynamics of 2D materials revealed in situ by MHz XFEL imaging and multiphysics modeling 0.02
Porcine airway tissue explant culture at a hydrogel-air interface to model submucosal glands in cystic fibrosis progression and therapy 1.00
Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture 1.00
Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging 0.30
A multistep platform identifies spleen-tropic lipid nanoparticles for in vivo T cell–targeted delivery of gene-editing proteins 1.00
Activation of the coagulation cascade as a mechanism for selective nanoparticle-mediated RNA delivery to the endothelium in vivo 0.83
GENRISE-induced superior extracellular vesicles for scalable therapeutic cargo delivery 0.06
Spatiotemporally controlled delivery of biological effectors from nanofiber scaffolds accelerates skin wound healing in porcine models 0.11
Replacing cholesterol and PEGylated lipids with zwitterionic ionizable lipids in LNPs for spleen-specific mRNA translation 1.00
Enhancing mRNA therapy through iterative delivery 1.00
Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing in colonic diseases 0.06
From disorder to icosahedral symmetry: How conformation-switching subunits enable RNA virus assembly 0.67
The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles 0.17
Retinal gene therapy using epiretinal AAV-containing fibrin hydrogel implants 1.00
Dual-function polyester nanoparticles for amplified anti-inflammatory effects 1.00
A streamlined CRISPR-based test for tuberculosis detection directly from sputum 0.92
Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity 0.25
Anabolic indices of matrix proteins identify regenerative small RNA intrinsic to human cartilage 0.67
Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors 0.90
Tuning hydrogen bonds and electrostatics with convection for purifying mRNA: A paradigm shift 1.00
9 6.96
Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models 1.00
HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment 0.01
Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects 1.00
A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models 0.03
Blood-brain barrier opening with neuronavigation-guided focused ultrasound in pediatric patients with diffuse midline glioma 1.00
Incorporation of 5-methylcytidine alleviates RIG-I–mediated innate immune responses to a self-amplifying RNA vaccine 1.00
Extracellular vesicle–mediated gene editing for the treatment of nonsyndromic progressive hearing loss in adult mice 0.92
Periadventitial delivery of mesenchymal stem cells improves vascular remodeling and maturation in arteriovenous fistulas 1.00
Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer 0.98
5 1.27
Quiescent neural stem cells transiently become neuron-like to coordinate long-range reactivation 0.17
Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development. 0.11
Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate 0.11
Epiblast-derived CX3CR1+ progenitors generate cardiovascular cells during cardiogenesis. 0.81
A capsular myofibroblastic niche maintains hematopoietic stem cells in the spleen 0.07
2 1.56
Distinct Dimerization Mechanisms in Silkworm and Spider Silk Proteins Revealed by Mass Photometry 1.00
The Deprotonation Sites of Gas Phase Uridine and Pseudouridine: Implications for mRNA Vaccines 0.56
2 0.59
Overall survival with relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): a phase 3 randomised controlled trial 0.29
Relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial 0.30
1 0.08
Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial 0.08
1 0.02
Colorimetric RT-LAMP for SARS-CoV-2 detection from nasopharyngeal swabs or crude saliva: a multicountry diagnostic accuracy study in Africa 0.02
4 1.85
Integration of plasma eMTBR-tau243 and p-tau217 in the diagnosis and stratification of Alzheimer's disease: a prospective cohort study 0.41
Safety and efficacy of fordadistrogene movaparvovec in ambulatory participants with Duchenne muscular dystrophy (CIFFREO): a phase 3, double-blind, randomised, placebo-controlled study 0.57
Blood phosphorylated tau for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis 0.20
Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study 0.66
1 0.71
Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial 0.71
8 4.78
Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery 1.00
Mim8 Bispecific Antibody Prophylaxis in Hemophilia A with or without Inhibitors 0.07
Final Analysis of a Study of Etranacogene Dezaparvovec for Hemophilia B 0.69
Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk 0.56
DB-OTO Gene Therapy for Inherited Deafness 0.82
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia 0.30
Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia 0.86
Sustained Clinical Benefit of AAV Gene Therapy in Severe Hemophilia B 0.46

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