Medicinal and Biomolecular Chemistry articles for United States of America (USA)

Time frame: 1 June 2025 - 30 May 2026

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Count: 412

Article ‘Count’ for Medicinal and Biomolecular Chemistry.

Journal Count Share
2 1.04
Selective Identification of Allosteric Inhibitors and Co-Drug Combinations Targeting Kinases by Using a Nanopore Tweezer Approach 1.00
Self-Assembly of Accumulated Sphingolipids into Cytotoxic Fibrils in Globoid Cell Leukodystrophy and Their Inhibition by Small Molecules In Vitro 0.04
3 0.27
Conformation-driven mechanical duality: viscoelastic and poroelastic switching in protein hydrogels 0.20
Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice 0.05
Elevated calneuron-1, an accessory subunit of muscarinic receptors, induces frontotemporal dysconnectivity and schizophrenia-like deficits 0.02
1 1.00
The Anisotropic Adsorption of De Novo Allosteric Two-Component Protein Fibers on Mica Surfaces 1.00
1 1.00
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide 1.00
15 12.09
Assessment of Protein Conformation via Diazirine-Promoted Oxidation of Methionine and Tryptophan Residues 1.00
Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA–Protein Cross-Links: Formation and Repair in Human Cells 1.00
Elucidation of the Effects of Electrostatic Interactions on Protein Structures at Buried Solid/Liquid Interfaces: A Combined Study with Experiment, Simulation, Isotope Labeling, and Spectra Calculation 0.89
Cross-Linking and Covalent Labeling Mass Spectrometry Reveal Proteoform-Driven Conformational Changes in Alpha Synuclein 1.00
Characterization of Cell–Surface Interactions of Ligands Using 19F NMR and DNP Hyperpolarization 1.00
NanoBRET-Based Biosensor for High-Throughput Screening of RAB11A–FIP2 Interaction Inhibitors 0.17
Lasso Peptide Syanodin I: Loop-Pulling Two-Step Thermal Unthreading Mechanism 0.63
Selective Probing of Acidic Amino Acid Residues for Protein Structural Analysis by Covalent Labeling and Mass Spectrometry 1.00
Sulfoxide-diazirine (SODA) as a Cleavable Photoaffinity Group To Enable the Identification of Photolabeled Modification Sites via LC–MSsup3/sup 0.33
Beyond Traditional airPLS: Improved Baseline Removal in SERS with Parameter-Focused Optimization and Prediction 1.00
Paired Analyses of Nuclear Protein Targets and Genomic DNA by Single-Cell Western Blot and Single-Cell PCR 1.00
Stable Isotope Labeling in Bacteria Enables Characterization and Quantification of Frataxin Protein in a Friedreich’s Ataxia Zebrafish Model 1.00
The Critical Need for Implementing RRF in the Accurate Assessment of Impurities in Peptide Therapeutics 1.00
Unraveling Ribonucleic Acid Unfolding: A Quantitative Comparison of Solution and Gas-Phase Unfolding 1.00
Detection of Protein Polysulfidation Using a β-(4-Hydroxyphenyl)ethyl Iodoacetamide-Derived Biotin Tag HPB 0.07
20 14.40
Generalized Analysis of Electrophilic Small Molecules 1.00
Precise Synthesis of Highly Branched Angelica dahurica Polysaccharides up to 66 Units Reveals a Minimal Motif for Wound Repair 0.08
Photochemically Generated Sulfenylnitrene Unlocks Chemoselective Activation of Conventional Thioglycosides for Stereocontrolled Furanosylations 1.00
A Convergent Hybrid Gram-Scale Synthesis of Tirzepatide: Tangential Flow Filtration Assisted Native Chemical Ligation-Desulfurization Approach 1.00
Coexistence of G‐Quadruplex and i‐Motif Within a DNA Duplex is Tolerated by a PCBP2‐Assisted Replisome 0.04
Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities 0.06
Cyclometalated Gold(III)-Mediated Cysteine Arylation: A Bioorthogonal Platform for Covalent Targeting of Intrinsically Disordered Proteins 1.00
Fully‐Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome 1.00
De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor 0.97
Discovery of a Cryptic Pocket in EcDsbA Opens New Opportunities for Antibacterial Discovery 0.14
Iron-Catalyzed Highly Stereospecific Glycosylation with Glycal Epoxides 1.00
Topologically Tunable α‐Helix Mimetics for Targeting Protein–Protein Interactions 1.00
Total Synthesis of Feglymycin Using Umpolung Amide Synthesis 1.00
Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE 1.00
Divergent Synthesis of ΔAA‐Peptides Using a Bioorthogonal ipro/i‐Amino Acid and Aqueous Flavin Photocatalyst: Green Light Enhances Catalyst Performance and Product Selectivity 1.00
Reengineering of a Proteomimetic Pan‐Ras Inhibitor into a Ras Degrader 1.00
Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins 1.00
Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding 0.06
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain 0.06
Conformationally Locked Peptide–DNA Nanostructures for CRISPR‐Amplified Activity‐Based Sensing 1.00
1 1.00
Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood 1.00
5 3.77
Nuclear speckles enable processing of RNA from GC-rich isochores 0.20
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens 1.00
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases 0.92
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates 0.65
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress 1.00
7 4.92
Forces behind N- and C-capping of peptidic helices 0.60
β-barrels from short macrocyclic peptides 1.00
Backbone nitrogen substitution restricts the conformation of glycine residues in β-turns 1.00
Conditional disorder in proteins: functional transitions between order and disorder 0.25
Iron-catalyzed iodonium ion promoted activation of conventional thioglycosides for stereoselective 1,2-icis/i furanosylations 1.00
Thioglycoside functionalization ivia/i chemoselective phosphine acceleration of a photocatalytic thiol–ene reaction 1.00
Comparative analysis of sulfated l-idose and l-iduronic acid in neoproteoglycan cell surface engineering 0.07
8 5.09
Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media 1.00
Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils 0.17
Simulations reveal a balance between protein–protein and protein–lipid interactions during condensation on membrane surfaces 1.00
The ‘ins’ and ‘outs’ of amidines in β-sheet folding and fibril disaggregation 1.00
Light responsive hydrogen selenide (H2Se)/hydrogen diselenide (H2Se2) donors: applied for protein S-selenylation on PRDX6 0.60
The contribution of cyclic imide stereoisomers on cereblon-dependent activity 1.00
Water entropy at the threonine-rich surface of antifreeze and ice-nucleating proteins: small changes make a big difference 0.25
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates 0.08
2 1.75
Insolubilome profiling defines molecular features that influence protein insolubility with aging 1.00
Nuclear lamina phase separation orchestrates stress-induced transcriptional responses in plants 0.75
1 0.50
Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli 0.50
1 1.00
A new proof of Chen’s theorem for Markoff graphs 1.00
38 37.67
Structural basis for selective thymidine binding by the Borrelia burgdorferi substrate-binding protein BmpA 1.00
Direct interaction between human DDX1 and SARS-CoV-2 Nucleocapsid protein is regulated by phosphorylation 1.00
Protein loops are major contributors to DNA strand separation and high-fidelity substrate recognition for DNA methyltransferase CcrM 1.00
Cleavage at the nsp5/nsp6 site of SARS-CoV-2 main protease intermediate precursor is faster from a monomer than a dimer form 1.00
The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition 1.00
The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation 1.00
Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4–NOT deadenylase complex to repress mRNAs 1.00
Domain-selective folding of the tandem β-propeller protein Coronin 7 (Coro7) by the chaperonin CCT/TRiC 1.00
Phosphorylation-dependent regulation of serine/arginine-rich proteins and U2AF1 interactions in early spliceosome assembly 1.00
Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites 1.00
Tryptophan metabolites 3-hydroxykynurenine (3HK) and 3-hydroxyanthranilic acid (3HAA) increase oxidative stress and impair osteoblastic bone formation 1.00
The nucleotide exchange factor, GrpE, modulates substrate affinity by interaction of its N-terminal tails with the DnaK substrate–binding domain 1.00
Hydrogen sulfide increases intracellular oxygen and inhibits the HIF response 1.00
Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates 1.00
PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS 0.94
Spontaneous Dimerization of the Hepatitis C Virus 3′X RNA 1.00
Bacillus subtilis encodes three N-acetylcysteine deacetylase enzymes that can catalyze the final step in S-(2-succino)cysteine breakdown 1.00
A split luciferase system for studying coronavirus Mpro dimerization in vitro and in living cells 1.00
A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases 1.00
Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3 1.00
Sp100A isoform promotes localization of the histone chaperone HIRA to PML nuclear bodies 1.00
Missense mutations in intrinsically disordered protein regions link pathogenicity and phase separation 1.00
APP family is a regulator of endo-lysosomal membrane vulnerability 1.00
Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase 1.00
Cryo-EM study and in vivo chemical mapping of the Methanosarcina acetivorans ribosome and its dimerization via a repurposed enzyme and translation factor 1.00
Hydrogen sulfide–dependent activation of human sulfide quinone oxidoreductase 1.00
Deciphering mutational effects on inducible NO synthase conformational dynamics via quantitative cross-linking mass spectrometry and AlphaFold2 subsampling 1.00
BR-bodies facilitate adaptive responses and survival during copper stress in Caulobacter crescentus 1.00
Lipid bilayer properties govern substrate engagement and extraction by the AAA+ ATPase Msp1 1.00
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides 1.00
Nuclear basket proteins Nup2 and Mlp1 drive heat shock–induced 3D genome restructuring downstream of transcriptional activation 1.00
Molecular determinants of picornavirus 3C protease binding to phosphoinositide-enriched lipid membranes 1.00
Integrating deep learning for post-translational modifications crosstalk on Hsp90 and drug binding 1.00
The impact of RNA chemical probing reagents on RNA-binding proteins 1.00
Bioluminescence-based assays for quantifying endogenous protein interactions in live cells 1.00
How short is too short for amyloid fibrils?: molecular dynamics of oligomers of infectious prion core structures 1.00
Molecular consequences of SCA5 mutations in the spectrin-repeat domains of β-III-spectrin 1.00
The phosphatase activity of the PPP2R5D-PP2A holoenzyme modulates liprin-α1 liquid-liquid phase separation 0.73
1 1.00
Of Mice and Men: Temporal Comparison of Femoral Shaft Fracture Healing After Intramedullary Nailing: Retrospective Observational Study of Modified Radiographic Union Scores for Tibia. 1.00
3 2.14
Stress-induced nucleolar rejuvenation via chaperone-mediated segregation in a filamentous fungus 1.00
Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways 1.00
Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics 0.14
2 1.85
The liver regulates ectopic calcification in Abcc6-deficient models of Pseudoxanthoma Elasticum 1.00
Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis 0.85
1 0.10
Hydrogen Cyanide Generation by Pseudomonas aeruginosa Blunts the Host Innate Immune Response 0.10
3 3.00
Restoration of sFRP3 preserves the neural stem cell pool and spatial discrimination ability in a mouse model of Alzheimer’s disease 1.00
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer’s Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration 1.00
Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia 1.00
1 0.60
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks 0.60
53 50.33
Anomer-Selective Vorbrüggen Reaction for the Catalytic Synthesis of C2-Deoxynucleoside Analogues 1.00
A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease 1.00
Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer 0.92
Mechanism of Aggregation of the NACore of α‑Synuclein: Stable Oligomer Formation Competes with Fibril Formation with Implications for the Etiology of Parkinson’s Disease 0.88
Catalyst-Controlled Chemoselective β-Mannosylation of Phenols Via Attractive Noncovalent Interactions 1.00
Interface Architecture of a VHL-PROTAC Complex with and without Cullin-2 1.00
Probing Supramolecular Motion with Nuclear Magnetic Resonance in Bioactive Scaffolds that Promote Neural Regeneration in the Central Nervous System 1.00
Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent Ribonucleic Acid Modulation 1.00
Bridging Heterocycle-Mediated Hydrogen Bonding Facilitates Permeability of Polar Macrobicycles 0.78
Nicotine-Inspired, De Novo-Designed SARS-CoV‑2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad 1.00
A Versatile Strategy for Head-to-Tail Macrocyclization and Traceless Backbone Editing of Short Peptides 1.00
Determination of α‑Synuclein Protein Interactions by μMap Photoproximity Labeling 1.00
Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape 1.00
Molecular Dynamics-Guided Design and Chemoproteomic Profiling of Covalent Kinase Activity Probes 1.00
Repositioning the Leader Peptide in Graspetide Biosynthesis 1.00
Macrocyclic Peptides Containing an Imidazopyridinium (IP+) Unit Display Enhanced Passive Cell Permeability 1.00
Aromatic Interactions Select for Homodimeric Assembly in a Quadruply Hydrogen-Bonded DADA 1,2-Azaphosphinine Dimer 1.00
Structural Heterogeneity and Hydrodynamics of an Intrinsically Disordered Protein Condensate 1.00
Mesostructured Water Enhances Stability of ProteinMPNN-Designed Ubiquitin-Fold Proteins 0.27
Polysaccharide Meets Polyoxazoline: Regio- and Stereodefined β-1,2-Linked Pseudo-polysaccharides via Controlled Cationic Ring-Opening Polymerization 1.00
Measurement and Control of Crossed Potentials in a Flavoprotein 1.00
Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology 1.00
Merging Enzymatic Catalysis with Iron Catalysis for Highly Stereoselective Heparan Sulfate Oligosaccharide Assembly 1.00
The [4Fe-4S] Cluster of HydF Is Essential for [FeFe]-Hydrogenase Maturation 1.00
Development, Scope, and Catalyst Selection in Boron-Catalyzed Iterative Glycosylation 1.00
Unbiased RNA Degrader Identification Uncovers an LC3B-Recruiting Chimera for COL15A1 mRNA Degradation 1.00
Structural Heterogeneity of the Membrane-Interacting Region of the HIV-1 Envelope Glycoprotein 1.00
Cooperation and Competition of Base Pairing and Electrostatic Interactions in Mixtures of DNA Nanostars and Polylysine 1.00
Rate-Tunable, Metal-Mediated Amide Bond Cleavage for the Controlled Release of Pharmaceuticals 1.00
Heterochiral and Heterotypic Self-Assembly of Intrinsically Disordered Peptides Confers Peptide Supercoils with Exceptional Proteolytic Stability 0.83
Anfinsen Redux: Ribonuclease Folding in the Single-Molecule Regime 1.00
Nucleotide-Specific RNA Conformations and Dynamics as Precursors to Ribonucleoprotein Condensates 1.00
The Mechanism of Mineral Nucleation and Growth in a Mini-Ferritin 1.00
Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design 0.87
Retention and Rearrangement of Membrane Protein Complexes’ Higher Order Structure by Collisionally Activated Dissociation- and Electron Capture Dissociation-Mass Spectrometry 1.00
Hydration (Hsub2/subO and Dsub2/subO) Dictates the Stabilities and Conformational Entropy of Transthyretin Tetramers 1.00
Discovery of Macrocyclic Peptide Binders, Covalent Modifiers, and Degraders of a Structured RNA by mRNA Display 1.00
Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders 1.00
A Conserved Cia1–Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron–Sulfur Cluster Assembly Pathway 1.00
Bifunctional Catalysis of Aldol Reactions by Foldamer Dihydrazides: Assessment of Conformational Preorganization 1.00
Intrastrand Peptide Staples That Promote β-Sheet Folding, Self-Assembly, and Amyloid Seeding 1.00
Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ2 0.88
Pushing Sensitivity and Specificity Limits in Native Structural Biology: sup19/supF Multinuclear Dynamic Nuclear Polarization with Magic Angle Spinning 0.50
NMR-Guided Studies to Establish the Binding Interaction between a Peptoid and Protein 1.00
Single-Entity Resolution Single-Cell Nanosensor Reveals Reactive Oxygen Species at Stress Granules Are Formed by Interfacial Redox Chemistry 0.56
Small Molecule Catalyst for Peptide Synthesis 1.00
Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission 0.86
Design and Application of Cereblon-Recruiting Prodegraders 1.00
Sequence Programmable Order–Disorder Transitions in Supramolecular Assembly of Peptide Nanofibers 1.00
μMap-FFPE: A High-Resolution Protein Proximity Labeling Platform for Formalin-Fixed Paraffin-Embedded Tissue Samples 1.00
Overcoming the Hydrolytic Susceptibility of Thiol-Reactive Reversible Warheads through the Development of Substituted Phenyl Cyanoacrylamides 1.00
Kinetic Dissection of Proton-Coupled Conformational Transitions in Nucleic Acids by Integrating pH-Dependent NMR and Chemical Modifications 1.00
Amyloid Oligomers: Expediting Crystal Growth and Revisiting the Corkscrew Structures 1.00
2 2.00
A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease 1.00
Heat shock protein 70s are modifiers of endothelial function in Fabry disease 1.00
18 12.98
Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication 0.21
High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects 1.00
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes 0.15
2′-O-Methylation maintains ribosome structural and translation integrity 0.83
NAC promotes co-translational protein folding at the ribosomal tunnel exit 0.19
Herpes simplex virus 1 fluidizes the nucleus, enabling condensate formation 0.90
RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions 0.69
Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network 0.93
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains 1.00
Mechanical forces regulate the composition and fate of stalled nascent chains 0.75
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs 0.92
Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery 0.68
Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations 1.00
Modulating synaptic glutamate receptors by targeting network nodes of the postsynaptic density condensate 0.13
Single-molecule live imaging of subunit interactions and exchange within cellular regulatory complexes 1.00
Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function 1.00
Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation 1.00
A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization 0.61
3 2.27
Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer’s disease and epilepsy 0.27
Histone demethylase PHF2 regulates inflammatory genes in Alzheimer’s disease 1.00
Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms 1.00
2 1.72
Raman and Terahertz Spectroscopy of Low-Frequency Chiral Phonons in Amino Acids 0.89
Geometric Confinement in Solid-State Nanopores Enables Single-Molecule Discrimination of Ferritin Subunits and Translocation Bias 0.83
8 5.92
Large-scale discovery, analysis and design of protein energy landscapes 0.87
Identification of an allosteric site on the E3 ligase adapter cereblon 0.84
NAC controls nascent chain fate through tunnel sensing and chaperone action 0.38
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency 1.00
Covariation MS uncovers a protein that controls cysteine catabolism 1.00
Diffusing protein binders to intrinsically disordered proteins 0.83
Mapping and engineering RNA-driven architecture of the multiphase nucleolus 0.82
Probing condensate microenvironments with a micropeptide killswitch 0.17
2 1.07
Genome-wide mapping of RNA-protein associations through sequencing 1.00
Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis 0.07
8 5.73
Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection 0.05
RNA-specific local translation is patterned by condensates for multinucleate cell growth 1.00
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions 0.14
The G3BP stress-granule proteins reinforce the integrated stress response translation programme 1.00
Hierarchical interactions between nucleolar and heterochromatin condensates are mediated by a dual-affinity protein 0.72
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins 0.85
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome 0.98
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis 0.98
7 5.74
Posttranslational modifications remodel proteome-wide ligandability 1.00
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine 1.00
High-throughput ligand diversification to discover chemical inducers of proximity 0.79
NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation 0.14
Photosensitizer proximity labeling captures the lipid and protein interactomes 0.97
Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5 1.00
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning 0.84
4 3.20
Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics 0.86
Profiling the proteome-wide selectivity of diverse electrophiles 0.33
Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines 1.00
Homotypic RNA clustering accompanies a liquid-to-solid transition inside the core of multi-component biomolecular condensates 1.00
72 52.54
A labile sulfur ligand in a three-cysteine-coordinated [2Fe−2S] cluster mediates sulfide sensing in NreB 0.06
Gene-in-gene coding generates dual-isoform Fha condensates to control type VI secretion system assembly 0.17
Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1 0.06
The polymerized protein response (PPR) is activated by genetic variants that polymerize in the ER and is mediated by NFκBp50 1.00
Newton’s cradle-like allosteric mechanism explains regulatory RsmE RNA binding 0.11
A framework for the exploration of subcellular compartmentalization of RNA-binding proteins 0.02
Genotype-by-inhibitor interactions to dissect enterovirus replication 1.00
A molecular switch in NAC prevents mitochondrial protein mistargeting by SRP 1.00
Optically driven control of mechanochemistry and fusion dynamics of biomolecular condensates via thymine dimerization 0.20
RF-SIRF reveals a replication stress-specific epigenetic code by spatio-temporal mapping of reversed forks 0.67
Oligomerization-competent PIF4 drives thermomorphogenesis through functional redundancy in transactivation and DNA binding 1.00
Dynamic control of IDP interaction network via diverse binding pathways 1.00
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 0.17
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease 1.00
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation 0.56
Decoupling phase separation and fibrillization preserves activity of biomolecular condensates 1.00
Sclerostin deficiency sensitizes white adipocytes to thermogenic signals that induce beiging in mice 1.00
Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy 0.71
A high-throughput, flow cytometry approach to measure phase behavior and exchange in biomolecular condensates 1.00
Lucerastat, an oral therapy for Fabry disease: results from a pivotal randomized phase 3 study and its open-label extension 0.23
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis 0.08
Chemotherapy-induced adipo-lineage cell senescence drives bone loss 1.00
Coordination of chromosome segregation and cell division in the archaeon Sulfolobus acidocaldarius 1.00
Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response 1.00
A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality 1.00
Structural and catalytic diversity of coronavirus proofreading exoribonuclease 1.00
Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks 0.89
A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells 0.42
Microgliopathy as a primary mediator of neuronal death in models of Friedreich’s Ataxia 1.00
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in mutant mice, a genetic model of schizophrenia and bipolar disorder 0.99
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain 1.00
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity 0.49
In vivo conformational space and defects of misfolded CFTR variants by covalent protein painting 1.00
Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation 0.13
Structures of human organellar SPFH protein complexes 1.00
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage 1.00
FUS nanoclusters are a distinct state within the dilute phase 1.00
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain 0.13
Development of a targeted BioPROTAC degrader selective for misfolded SOD1 0.03
Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15 0.13
Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases 1.00
Molecular landscape of the fungal plasma membrane and implications for antifungal action 1.00
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma 1.00
COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale 1.00
Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein 0.71
Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression 0.04
Phosphorylation toggles the SARS-CoV-2 nucleocapsid protein between two membrane-associated condensate states 1.00
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging 0.36
Visualizing dynamic tubulin folding in chaperonin TRiC from nonnative nucleus to final native state 1.00
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation 0.89
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation 0.70
Quantifying collective interactions in biomolecular phase separation 0.09
Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis 1.00
Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping 0.83
Trans-synaptic molecular context of NMDA receptor nanodomains 1.00
Structure guided functional analysis of the S. cerevisiae Mre11 complex 0.87
YAP charge patterning mediates signal integration through transcriptional co-condensates 1.00
A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides 1.00
SON-dependent nuclear speckle rehabilitation alleviates proteinopathies 1.00
Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function 1.00
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration 1.00
Unveiling the hidden interactome of CRBN molecular glues 1.00
Arrest Peptide Profiling resolves co-translational folding pathways and chaperone interactions in vivo 0.83
Structural insights into the roles of PARP4 and NAD binding in the human vault cage 1.00
ATP plays a structural role in Hsp90 function 1.00
Anti-sense oligonucleotide probing as a structural platform for studying ribonucleoprotein complex assembly 1.00
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma 0.06
Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome fragment 0.96
Activated GDF11/8 subforms predict cardiovascular events and mortality in humans 0.90
Structural basis for catalysis by human lipoyl synthase 1.00
Mechanism of nascent chain removal by the ribosome-associated quality control complex 1.00
Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair 0.07
1 0.03
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation 0.03
1 0.37
Effects of volenrelaxin in worsening heart failure with preserved ejection fraction: a phase 2 randomized trial 0.37
4 3.90
Generating 3D models of complex carbohydrates with GLYCAM-Web 0.90
Orthogonal RNA-regulated destabilization domains for three-color RNA imaging with minimal RNA perturbation 1.00
RNA-stabilized coat proteins for sensitive and simultaneous imaging of distinct single mRNAs in live cells 1.00
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq 1.00
1 1.00
Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates 1.00
2 2.00
The filamentous ultrastructure of the PopZ condensate is required for its cellular function 1.00
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry 1.00
8 6.77
Access to Rare d- and l-Hexoses from C1 Nucleophiles via Anomeric Acylation 1.00
Phenylthioethyl (Pte)/Phenylsulfonylethyl (Pse) as Safety Catch Protecting Groups for Peptide Synthesis 0.17
Stereoselective Organocatalytic Fucosylation with Isothioureas 1.00
SN2 Glycosylation Enabled by a Directing-Group-on-Leaving-Group Strategy: Highly Stereoselective Synthesis of Glycosyl Carboxylates 1.00
Synthesis of Insulin-desB30 Analogs via an Enzymatically Removable N-Terminal Solubilizing Tag 1.00
Development of a Diastereoselective Csp2–Csp3 Cross-Coupling Reaction Inspired by Macrocyclic RiPP Natural Products 1.00
Stereospecific Oxidative Contraction of Anomeric Nucleophiles 1.00
Total Synthesis of Pedopeptin C 0.60
7 4.56
Polyphosphate modulates the stress-responsive formation of functional RNA-protein condensates in bacteria and mammalian cells 1.00
The m6Am methyltransferase PCIF1 promotes osteogenic differentiation of mesenchymal stem cells through stabilization of Wnt-related transcripts 0.43
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms 1.00
RNA-binding protein IMP1/ZBP1 directs local translation in microglial processes to regulate motility and phagocytosis during inflammation 0.04
Cross‐species rescue reveals sequence requirements for a rapidly evolving intrinsically disordered region 1.00
Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization 1.00
Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer's disease 0.09
2 1.06
Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains 0.93
Tissue-specific consequences of tag fusions on protein expression in transgenic mice. 0.13
1 0.22
Torsion-Driven Plectoneme Formation During Nanopore Translocation of DNA Polymers 0.22
48 40.05
amyloid-predict and LLPS-predict: Predicting phase separation propensities in the intrinsically disordered proteome 1.00
Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the extracellular HMGB1 protein 1.00
Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains 1.00
Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners 1.00
Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress 0.87
Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates 1.00
Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function 0.22
Selective control of ligand binding through a distal mutation that alters the protein native ensemble 0.29
Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium 1.00
Coordination of cell organelles to promote metabolon formation 1.00
Droplet growth, Ostwald’s rule, and emergence of order in Fused in Sarcoma 0.90
GFP-free live neuron quantitative imaging reveals compartmentalization and growth dynamics of polyQ aggregates 1.00
Measuring bridging forces in protein–DNA condensates 1.00
Sticky interactions govern sequence-dependent dynamics in biomolecular condensates 1.00
Polymer conformational entropy as the driver of complex coacervation 0.11
Polyserine domains are toxic and exacerbate tau pathology in mice 1.00
Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations 0.33
Nucleic acid base pair open states by hydrogen exchange 1.00
Cystathionine γ-lyase is a major regulator of cognitive function through neurotrophin signaling and neurogenesis 0.88
Arg–Tyr cation–π interactions drive phase separation and β-sheet assembly in native spider dragline silk 0.93
Multiplex mapping of protein–protein interaction interfaces 1.00
Interprotomer communication and functional asymmetry in H/ACA snoRNPs 0.75
A machine learning protocol for predicting structural distributions of amyloid-forming proteins from 2D IR spectra 0.14
Inhibition of ice recrystallization with designed twistless helical repeat proteins 0.56
Molecular drivers of RNA phase separation 1.00
The RANK/RANKL axis controls vascular dynamics in the bone marrow 0.13
Programming cellular condensates for living materials using an intrinsically disordered protein display platform 0.75
Driving forces of RNA condensation revealed through coarse-grained modeling with explicit Mg2+ 1.00
Global conformation of the Rag GTPase heterodimer governs eukaryotic amino acid sensing 1.00
Structure of a transient protein-folding intermediate by pressure-jump NMR spectroscopy 1.00
Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo 1.00
An unusual Co–S bond links B12 chaperones in an interprotein complex 1.00
In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA 1.00
A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system–exported toxins 0.14
3D pattern formation of a protein–membrane suspension 1.00
Microglia-to-neuron signaling links APOE4 and inflammation to enhanced neuronal lipid metabolism and network activity 1.00
Diverse thioether macrocyclized peptides through a radical SAM maturase 1.00
Definition of the components required for selective packaging of coronavirus genomic RNA 1.00
Immiscible proteins compete for RNA binding to order condensate layers 1.00
Identification of an on-pathway intermediate illuminates the kinetic competition between protein folding and misfolding 1.00
Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair 0.93
De novo design of D-peptide ligands: Application to influenza virus hemagglutinin 1.00
PLAA/UFD-3 regulates P-bodies through its intrinsic disordered domain 1.00
Gut sulfide metabolism modulates behavior and brain bioenergetics 1.00
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses 0.98
Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution 1.00
Spatially resolved DNP-assisted NMR illuminates the conformational ensemble of α-synuclein in intact viable cells 1.00
Material properties of biomolecular condensates emerge from nanoscale dynamics 0.13
1 0.15
Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning. 0.15
8 6.94
Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 1.00
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration 0.93
Pearling drives mitochondrial DNA nucleoid distribution 0.50
Unstructured transcription factor interactions enable emergent specificity 1.00
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy 1.00
Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation 1.00
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders 0.72
Design of intrinsically disordered region binding proteins 0.79
13 9.25
A balance between nucleating and elongating actin filaments controls deformation of protein condensates 1.00
Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling 0.16
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress 0.16
Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease 1.00
Proteome-wide computational analyses reveal links between protein condensate formation and RNA biology 1.00
Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy 1.00
ASPL couples the assembly of stress granules with their VCP-mediated disassembly 0.96
Bi-handed assembly chaperones regulate protein complex assembly through an intramolecular handover mechanism 1.00
Cotranslational protein folding through non-native structural intermediates 0.40
An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS 0.15
Non-native entanglement protein misfolding observed in all-atom simulations and supported by experimental structural ensembles 0.85
CHI3L1/YKL-40 signaling inhibits neurogenesis in models of Alzheimer’s disease 0.57
Sequestration of ribosome biogenesis factors in HSV-1 nuclear aggregates revealed by spatially resolved thermal profiling 1.00
2 1.66
Endothelial cell–released CD93 contributes to podocyte injury in idiopathic nephrotic syndrome 0.72
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease 0.95
7 5.23
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly 0.05
Short autoinhibitory sequences control phase separation of an essential bacterial transcription termination factor 1.00
ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences 1.00
ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation 1.00
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation 1.00
Bacterial ubiquitin ligase engineered for small molecule and protein target identification 1.00
RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein. 0.18
11 6.74
Design Principles for β-Solenoid Stability via Covalent and Electrostatic Capping Motifs 0.35
Chain Length as a Molecular Determinant of Hydrogen-Bond Dynamics in Biocondensates 1.00
Infrared Spectra of the Thymidine 13C2 and 13C4 Isotopes in H2O and D2O 0.67
Atomic Structure of GNNQQNY Nanocrystals: A Validated Approach for Polymorphic Amyloids 1.00
Molecular Insights into the Dual Mechanism of Bepristat 2a on Protein Disulfide Isomerase (PDI) Activity 0.11
Native Folding Stability of the Main Protease of Coronavirus SARS-CoV-2 on a Gold Surface 0.20
Nanoscale Mechanical Force Primes NOD1-LRR for Efficient Pathogen Recognition 0.05
Chiral Matching between Nucleic Acids and Polypeptides Facilitates Liquid–Liquid Phase Separation 1.00
Beyond Electrostatic Interactions: H-Bond Dynamics in Arginine- versus Lysine-Rich Biocondensates 1.00
RNA Structural Complexity Dictates Its Ion Atmosphere 1.00
Emergence of Compact Oligomers inside the Small-World Network of TDP-43 Condensates 0.37

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