Pharmacology and Pharmaceutical Sciences articles for China

Time frame: 1 June 2025 - 30 May 2026

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Count: 836

Article ‘Count’ for Pharmacology and Pharmaceutical Sciences.

Journal Count Share
96 90.93
Endoplasmic Reticulum-Targeted Biomimetic Nanoparticles Potentiate the Immunotherapy of Triple-Negative Breast Cancer by Improving Immunogenicity and Eliminating Immune Resistance 1.00
Nose-to-Brain Delivery of mRNA-Loaded Lipid Nanoparticles Bypasses the Blood–Brain Barrier for Effective Brain Disease Therapy 1.00
Endolysosomal-Targeting Nanovaccine Coordinates Antigen-Adjuvant Delivery to Enable Cross-Protective Immunity against Multidrug-Resistant Enterococci 1.00
Injectable NIR-II Photothermal Hydrogels for Image-Guided Adipose Remodeling and Antiobesity Therapy 1.00
Dual-Scale Liposomal Assembly Enables Alveolar Macrophage-Targeted Gene Delivery in High-Altitude Pulmonary Edema and Acute Lung Injury 1.00
Zwitterionic Lipid Nanotherapeutics from Mulberry for Oral Treatment of Diabetic Colitis 0.70
Logic-Gated Bioorthogonal In Situ Synthesis of Proteolysis-Targeting Chimeras for Precise Protein Degradation and Synergistic Immunotherapy 1.00
A Topology-to-Therapy Map for Prodrug Nanoassemblies 1.00
Reversing Cuproptosis Tolerance with Twinborn Metallic Polymer Nanoparticles for Enhancing Efficacy of Chemo-Immunotherapy 1.00
MicroRNA-Governed Autocatalytic Fenton Nanoplatform for Cancer-Selective Theranostics 1.00
A Bone Marrow-Targeted Nanomodulator as a Histone Lactylation Inhibitor for Reversing Immune Tolerance in Multiple Myeloma 1.00
Spatiotemporally Orchestrated Cardiac Microneedle Patch Modulates Post-Infarction Immunity and Fibrosis 1.00
Chiral Bismuth Molybdate Nanoparticles Recruiting and Activating Group 3 Innate Lymphoid Cells to Suppress Gastric Cancer 1.00
Cationic Polymer–Photothermal Agent Conjugates with Enhanced Light Absorption and Tumor Accumulation for Efficient Phototherapy of Osteosarcoma 1.00
Triple-Targeted Peptide–Photosensitizer–Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma 1.00
Accelerating Multi-Elemental Catalyst Discovery with Interpretable Machine Learning and Automated Experimentation 1.00
In Vivo-Assembled Artificial Base-Albumin Platform for Tumor-Targeted General Drug Delivery 1.00
<atl>Tumor-Selective Autophagy Blockade of Renal-Clearable Bi sub2/sub S sub3/sub Nanoflowers for Precise Photothermal Therapy</atl> 1.00
Deciphering Apolipoprotein A4 in the Protein Corona of Ligand-Modified Liposomes for Tumor Targeting and Penetration 1.00
Atorvastatin-Driven Methuosis in Glioblastoma: A Biomimetic Nanodrug for Targeted Tumor Therapy 1.00
Coassembled Prodrug Nanoparticles Mitigating the Acquired Resistance to Protein Degradation Therapy 0.91
Enhanced Immunotherapy for Glioblastoma Using a Cholesterol Oxidase-Loaded, Pd-Doped Cu3N Nanozyme-Based Multimodal Nanoplatform 1.00
Biomimetic Microenvironment Nanomodulators for Reactive Oxygen Species-Responsive T1-T2 Dual-Modal Magnetic Resonance Imaging and Visualized Treatment of Atherosclerosis 1.00
Cellular Adaptive Component-Mediated Targeting of Chylomicron-Mimic Nanoemulsion to Hepatic Stellate Cells for Liver Fibrosis 1.00
Engineered Peptide Coassembly Enables Precision Delivery of As(III)-Peptide Complexes and Counteracts Inflammation-Dependent Therapeutic Resistance in High-Risk Neuroblastoma 1.00
In Situ Needle-Free Injection of Multiretention Micelles for Melanoma Therapy with Multiomics Insights into Tumor Targeting and Immune Modulation 1.00
A Redox-Responsive Selenium-Containing Nanomedicine Enables Dual Antioxidant System Inhibition to Overcome Platinum Resistance and Enhance Immunotherapy in Bladder Cancer 0.89
A Multifunctional Calcium Phosphate Nanoplatform Inducing Synergistic Copper/Calcium Overload and Antiangiogenesis for Enhanced Cancer Therapy 0.33
Natural Antioxidant Lipoic Acid Constructed Nanodrug for Oral Therapy of Inflammatory Bowel Disease 1.00
High-Entropy Oxide-Phosphomolybdic Acid Ultrathin Nanoleaves with Lattice Strain and Periodic Heterostructures for Enhanced Synthetic Catalytic/Sonodynamic/Immune Therapy 1.00
Intranasal Conformal Patch for Sustained Levodopa Delivery and Reactive Oxygen Species Scavenging in Parkinson’s Disease 1.00
Chiral Polyproline Enables Functional Stealth for Simultaneous Long Circulation and Endoplasmic Reticulum-Targeted Antigen Presentation 0.82
Structure-to-Therapeutic Transformation of Nanohydrogels Triggers Calcium Overload for Potentiated Boron Neutron Capture Therapy 1.00
In Vivo Programmed Assembly of Polymer–Peptide Conjugates to Overcome Multistage Drug Delivery Barriers 1.00
Water Confinement in Hollow Fe-TA Nanoparticles Synergistically Enhances Photothermal-MRI Theranostics 1.00
Redefining Tumor Vascular Permeability through Deep Learning-Guided Microneedle Delivery 1.00
Natural Compound-Driven Nano-Self-Assembly for Multimechanistic Transdermal Antiobesity Therapy 0.58
Stiffness-Tunable Phenolic Nanocapsules Loaded with J-Aggregates for Near-Infrared II Imaging-Guided Phototherapy of Bacterial Infections 1.00
Deciphering the Hepatic Cellular Interactions of PEGylated Iron Oxide Nanoparticles 1.00
Phase-Separation Engineered Nanomotors Enable Spleen-Tumor Dual Targeting to Reverse T-Cell Exhaustion 1.00
Dynamic Covalent Dual Prodrug Assemblies for Endometritis Therapy via Inflammation Alleviation, Tissue Repair, and Reproductive Function Restoration 0.94
A Dual Glutathione-Depleting Nanoparticle Loaded with Porcine Pancreatic Elastase for Neoadjuvant Chemotherapy of Triple Negative Breast Cancer 1.00
Self-Propelled Nanoreactors for Enhanced Cascade Catalytic Cancer Therapy through NIR-II Fluorescence Imaging-Guided Readministration 1.00
Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery 1.00
Supramolecular Metallacycle Enables Esterase-Responsive and Endoplasmic Reticulum-Associated Pathway Activation for Synergistic Photothermal Immunotherapy 1.00
Fusion Aptamer-Lactoferrin Delivery System for Targeted Delivery to Adipose Tissue and the Amelioration of Obesity 1.00
Jigsaw Puzzle-Designed Polyphenol-Macromolecular Supramolecular Networks for Noninvasive Therapy of Deep-Tissue Oral Disease 0.97
Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy 0.64
Precision-Architected Drug-Stabilized Cu5 Clusters Mediate Multimodal Therapeutic Intervention in Colitis 0.86
Central Nervous System Targeting Nanovesicles for Trans-Barrier Delivery and Spinal Cord Injury Treatment 1.00
Remodeling the Tumor Microenvironment: An Emerging Paradigm for Reinvigorating Immunologically Cold Tumors and Advancing Cancer Immunotherapy 1.00
Optimizing Exosome Lipid Hybrid Nanoparticles for Enhanced siRNA Delivery and Improved Therapeutic Anticancer Efficacy In Vivo 0.33
Transporting via Neutrophil as a Key Mechanism for Nanoparticle Redistribution to Tumor and Spleen 1.00
Tuning the Needling Length of Copper Single-Atom Nanozyme for Enhanced Cellular Uptake and Chemodynamic Therapy 0.77
Piezoelectricity-Potentiated Bioorthogonal Catalysis Disrupts Cholesterol Metabolism for Tumor Immunotherapy 1.00
An In Situ Self-Solidifying Poly(Lipoic-Acid) Liquid Adhesive Forms Pathogen-Resistant Barrier for Ulcerative Colitis Therapy 1.00
Biomimetic Self-Guiding Nanomotors Boost Active Immunotherapy 1.00
Amyloid-like Protein-Metal Sulfide Nanocoatings for Synergistic Photothermal and Antibacterial Implant Surface Protection 0.72
A CRISPR-Customizable Copper-Coordinated DNA Nanoplatform Potentiates Cuproptosis Through Circadian and Metabolic Pathway Manipulation 1.00
Endogenously Activated Multiple DNAzyme-Encoded Nanoflowers for High-Contrast Imaging of Long Noncoding RNA and Cancer Therapy 1.00
Engineered Magnetic Resonance Nanoprobes for Visualizing Tumor Programmed Cell Death Ligand 1 Level and Enhancing Synergistic Radio Immunotherapy 1.00
Nanoparticle-Mediated “Cut-Off and Clean-Up” Strategy for Neutrophil Manipulation in Acute Lung Injury Therapy 1.00
Fluorinated Proteolysis Targeting Chimeras-Sorafenib Nanoassembly for Epigenetic Remodeling to Combat Multi-Pathway Drug Resistance in Hepatocellular Carcinoma 1.00
Solvation-Layer Mediated Interfacial Assembly for Surface Topological Engineering of Mesoporous Microcarriers 1.00
X-ray-Activated Nanoneutrophils for Orthotopic Glioma Immunotherapy 1.00
AI-Validated Brain Targeted mRNA Lipid Nanoparticles with Neuronal Tropism 0.02
Tannic Acid–Iron Complex-Based Nanozyme Ameliorates Parkinson’s Disease via Relieving Oxidative Stress and Neuroinflammation 0.91
Nanoparticles Induce Protein Corona Conformational Change to Reshape Intracellular Interactome for Microglial Polarization 1.00
Metallothionein 2A-Silencing Antimonene-Based Nanoagonist for Amplifying the Photothermal Immunotherapy of Gynecologic Malignancy 1.00
Self-Driven, Stretchable Drug Delivery Electronics for Acne Treatment 0.86
Carrier-Free Nanoprodrug Mediating Laser-Activable Chemotherapeutic Immunomodulation against Cancer 1.00
Programmable Nanostructure Assembly of a Paclitaxel Derivative Enables Tunable Anticancer Therapy via Hydrogen Bond Engineering 0.84
Surface-Engineered Nanoshuttles Hijack Macrophages In Vivo to Boost Blood–Brain Barrier Penetration and Immunomodulation for Targeted Glioblastoma Therapy 1.00
Protein Corona-Detachable Microwave Ablation Amplifiers Actuate Pyroptosis to Repolarize Immortal Cancer into Senescent Ones 1.00
Machine Learning-Driven Optimization of Therapeutic Substance Composition for High-Hardness, Fast-Dissolving Microneedles for Androgenetic Alopecia Treatment 1.00
Biomineralized Albumin-Macrocyclic Conjugates for Synergistic Metal Ion-Based Combination Therapy in Cancer Treatment 1.00
Molecular Stacking@Infinite Coordination Polymer Nanocomposites for Tumor Continuous High-Intensity Photothermal–Thermodynamic Alternate Cycle Therapy and Chemotherapy 1.00
A Colon-Targeted Oral Nanosystem Disrupts the Inflammatory Loop in Enteric Glia to Alleviate Ulcerative Colitis 1.00
Near-Infrared-IIb Fluorescent Nanozymes with Surface Charge Flipping Ability for Imaging-Guided Therapy of Inflammatory Bowel Disease 1.00
Ce6-DNAzyme-Loaded Metal–Organic Framework Theranostic Agents for Boosting miRNA Imaging-Guided Photodynamic Therapy in Breast Cancer 0.92
Biomimetic Immunoregulators for the Multi-Target Inflammation Interruption in Autoimmune Diseases 1.00
Glucose-Responsive Polyzwitterionic Nanoparticles with Enhanced and Targeted Intestinal Epithelial Absorption for Oral Insulin Delivery 1.00
Photodynamic-Photothermal Switching in Osmium-Ferritin Nanoplatform Activates Near Infrared-Driven Tumor Immunity Reprogramming 1.00
Acoustofluidic Fabrication of Calcium Pyrophosphate-Enzyme Nanocatalysts for Oral Treatment of Metabolic Disorders 1.00
Biomimetic Nanoparticles Simultaneously Targeting Modulation of Lipid Metabolism and Phenotype of Macrophages for Programmed Atherosclerosis Management 1.00
Transcytosis-Enabled Paclitaxel Prodrugs for Potentiated Chemotherapy 1.00
Tetrahedral Deoxyribonucleic Acid-Engineered Multivalent Lysosome-Targeting Chimera for Enhanced and Dual Membrane Protein Degradation 1.00
Oral Administration of a Tetrahedral Framework DNA-Based Nanoshot Attenuates Liver Fibrosis via Targeting Galectin-3 1.00
Integration of Bone-Targeted Delivery and Crosstalk Modulation of Liver-Bone Axis for Improved Osteoporosis Therapy 1.00
Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping 1.00
Mesoporous Silica-Based Nanomotors Loaded with Rapamycin for Synergistic Treatment of Rheumatoid Arthritis 1.00
Cancer Cell Membrane-Coated Homodimer Prodrug Nanoassemblies to Simultaneously Deliver Prodrugs and Immune Adjuvants for Combined Chemo-Immunotherapy 0.92
Near-Infrared Light-Triggered In Situ Construction of 3D “Fishing Net” Polymer Networks Using Upconversion Nanoparticles for Tumor Therapy 1.00
Direct Modulation of Host Cells and Gut Microbiota by Orally Delivered Antioxidant Nanocages for Colitis Treatment 1.00
Harnessing Surface Hydrophilicity of Inhalable Nanoparticles for Precision Delivery of Glucagon-like Peptide-1 Receptor Agonists or Anti-Asthmatic Therapeutics 1.00
Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine 1.00
32 30.58
Ultrasound-responsive bacteria-nanocomplex reverses tumor resistance to sensitize chemotherapy/chemodynamic therapy in triple-negative breast cancer 1.00
Chaotrope-guided protein microneedles with high drug-loading capacity, ultrafast dissolution, and high mechanical strength 1.00
Antimicrobial-potentiated colorectal cancer therapy with synchronized tumoricidal immunity via a self-deliverable nanopeptide 1.00
Chirality of Poly(γ-glutamic acid) Directs Calcium Nanoparticle Assembly and Adjuvant-Like Immune Activation 1.00
Macroporous-channel hollow microneedles enable vacuum-free interstitial fluid sampling and on-patch sensing 1.00
Biomimetic zwitterionic micelles for efficient mucus penetration and pulmonary targeting in acute lung injury 1.00
Multifunctional pH-responsive nanocarrier for targeted azithromycin delivery and immune modulation in bacterial sepsis 0.66
Size-Transformable Amphiphilic Dendrimer-based Drug Nanomicelles for Enhanced Tumor Penetration in Cancer Chemotherapy 1.00
Transmucosal delivery of a dendritic cell-targeting intranasal nanovaccine boosts HIV-1 specific mucosal and systemic immune responses 1.00
Visible tumor-targeting biohybrid vehicles reprogram cancer-associated fibroblasts to potentiate photothermal immunotherapy 1.00
A Metal-Free Cascade Nanoreactor Reprograms the Cystine-Glutathione Axis for Disulfidptosis-Pyroptosis Therapy 1.00
DNA damage-driven cGAS-STING activation via a nuclear-targeted probe enables potent near-infrared theranostics in breast cancer 1.00
Sulfatase-responsive phase-separating peptide coacervates target stress granules to reverse sorafenib resistance in hepatocellular carcinoma 1.00
Engineered acid-regulating liposomal nanovesicles for synergistic photodynamic pyroptosis and immunotherapy 1.00
ROS-sensitive nanocarriers for synergistic X-PDT/chemo/immunotherapy of triple-negative breast cancer and metastasis 1.00
Trojan horse natural killer cells enhance targeted drug delivery and boost memory T cell-mediated immune responses in triple-negative breast cancer 1.00
A solvent-free ropivacaine-loaded composite hydrogel assembled from pH-sensitive micelles and a thermosensitive injectable hydrogel for prolonged local anesthesia 1.00
Virus-inspired nanocages potentiate glioblastoma sonochemotherapy via structure-function mimicry 1.00
Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery 1.00
Sulfhydryl-modified nanocarriers enhance corneal retention and ocular anti-inflammatory efficacy in dry eye therapy 1.00
Dual-mechanism mucoadhesive hydrogel integrating pH-independent barriers and autophagy-driven immunotherapy for the treatment of ulcerative colitis 1.00
A pH-responsive polycarbonate nanoplatform enables sequential drug release for enhanced apoptotic cascade synergy in non-small cell lung cancer therapy 1.00
Toward preclinical evaluation of a thermosensitive PEG-poly(L-alanine) hydrogel: A study on sterilization, storage stability, and in vivo performance 1.00
A Co-Catalytic Nanosystem Based on Molybdenum Disulfide and Prussian Blue for Synergistic Chemodynamic and Photothermal Therapy through Mitochondrial Damage and Ferroptosis 0.20
Genetically engineered sericin hydrogels for the delivery of human adiponectin in treating ulcerative colitis in mice 1.00
A Drug Reservoir Strategy for Long-Acting Cancer Therapy Using Morphologically Transformed Amphiphilic Polymeric Nanoparticles 1.00
Redox-responsive dendritic copolymer-drug conjugates enhance therapeutic mitophagy through coordinated microtubule destabilization for synergistic triple-negative breast cancer therapy 1.00
A biomimetic nanoplatform mediates hypoxia-adenosine axis disruption and PD-L1 knockout for enhanced MRI-guided chemodynamic-immunotherapy 1.00
PCL-PEtOx-based Crystalline-core Micelles for the Targeted Delivery of Paclitaxel and Trabectedin in Ovarian Cancer Therapy 1.00
A Self-Assembling Chimeric Peptide Gear-Set with "Three-in-One" Function for Precision Photodynamic Therapy 1.00
Phosphorous dendrimer-mediated biomineralization for synergistic blockade therapy and hypoxia-activated chemotherapy of tumors 0.72
Metabolic reprogramming by chemo-gene co-delivery nanoparticles for chemo-immunotherapy in head and neck squamous cell carcinoma 1.00
60 58.27
Targeting Gasdermin D-Mediated Pyroptosis With Microglial Membrane-Coated Single-Atom Nanozymes for Immune Microenvironment Reprogramming and Early Brain Injury Mitigation After Subarachnoid Hemorrhage 1.00
Multifunctional Responsive Nanoplatform as Immunotherapeutic Regulator to Target Triple‐Negative Breast Cancers via Mechanotransduction 1.00
Co‐Delivery of Cationic Polymeric Sonosensitizer and Antimicrobial Peptide Mimic by Polymeric Nanoparticle for Enhanced Therapy of Lethal Bacterial Pneumonia 1.00
Structural Topology of Prodrug Nanoassembly: First Steps Toward Nano‐QSAR 1.00
Stem Cell‐Laden Magnetic Hydrogels for Liver Fibrosis Reversal via Synergistic Magneto‐Mechanical Stimulation 1.00
Seleno‐Amino Acid Nanotherapeutics Upregulates Selenoproteins to Inhibit Oxidation and Neuroinflammation for Spinal Cord Injury Recovery 1.00
Hydrophilic Ligand-Assisted Synthesis of Water-Dispersible Transition Metal Sulfide Nanoparticles 1.00
A Magnetic Resonance Imaging Reportable Strategy for In Situ CuET and Mn2+ Generation to Boost Antitumor Immunity 0.80
Responsive Liquid Crystal Double Emulsion for On-Demand Cargo Release and Its Application in Bacteria Detection and Elimination 0.75
Mitochondrial-Targeting DNA Origami Delivering TIPE-2 mRNA for Microglial Metabolic Reprogramming and Neurological Recovery in Intracerebral Hemorrhage 1.00
Kinetics-By-Design: On-Demand Fabrication of Personalized Drug-Release Profiles Using Multi-Material 3D Printing 1.00
Ginsenoside‐Engineered Lipid Nanoparticles in Microbeads Enable Oral siRNA Delivery and Targeted Therapy for Ulcerative Colitis 1.00
Aggregation-Induced NIR-II Emission Luminogens Integrated into Cu2+-Phenolic Nanoparticles for Mild-Temperature Photothermal Eradication of Bacterial Biofilms 1.00
Rational Design of a Multifunctional Copper-Cobalt Sulfide Nanozyme for Cholesterol Depletion and Thermo-Resistant Tumor Ablation 1.00
A Potent Nickel‐Based STING Agonist Nanodrug Against Prostate Cancer Bone Metastasis 1.00
Dual-Scale Targeting of Myofibroblasts and Mitochondria via Oral Cascade Delivery Systems Alleviate Intestinal Fibrosis 1.00
Hypoxia‐Activated Radical Anions to Trigger Reactive Oxygen Species Burst for Chemoimmunotherapy 1.00
5-Aminosalicylic Acid-Derived Carbon Dots Nanozyme for Ulcerative Colitis Treatment via Inhibiting NF-κB/AGE-RAGE Pathway and Modulating Arachidonic Acid Metabolism 1.00
Peptide‐Modified Fluorinated Polymeric Carriers for Targeted Delivery of β‐GP to Enhance Bone Regeneration 1.00
A Natural Self-Assembled Hydrogel Alleviates Inflammatory Bowel Disease by Targeting Mitochondrial Dysfunction and NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis 1.00
A Probiotic-Derived Oral Dual-Triggered Platform for Synergistic Anti-Inflammatory and Microbiota Modulation Therapy of Inflammatory Bowel Disease 1.00
A Multifunctional NIR‐II Rare‐Earth Nanoagent for In Vivo Monitoring Cancer Revascularization and Prognosis 0.78
Oral Dosed Organo-Silica Nanoparticles Restore Glucose Homeostasis and β-Cell Function in Diabetes Rats 0.93
Bioinspired Multi-Gradient Structure Enables Environment-Adaptive Personal Respiratory Protection and Moisture Management for Biodegradable Poly(lactic acid) Meta-Membranes 1.00
Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy 0.33
A One‐Two Punch Strategy Against Cancer: Simultaneously Inducing and Eliminating Senescent Tumor Cells 1.00
An In Situ Self‐Responsive Nano‐Prodrug to Enable Tumor Chemo‐Metalloimmunotherapy 1.00
An Inhalable Spike–Conjugated Gold Nanoparticle for Treating Acute Lung Inflammation 1.00
Reprogramming Tumor Cell Death via Processing Natural Drug to Carbon Dots Overcomes Collagen Barrier and Activates Antitumor Immunity 1.00
Hierarchical Precision Nanoplatform for Synergistic Radio‐Immunotherapy in Glioblastoma via Controllable P‐Selectin Targeting 1.00
Sono-Controllable Janus Microneedle for Postsurgical Tumor Eradication and Scarless Wound Healing in Melanoma 1.00
Dual‐Targeted Metabolic Nanovesicles Reprogram Macrophage‐Cardiomyocyte Crosstalk for Myocardial Ischemia‐Reperfusion Therapy 1.00
Ferulic Acid Integrated Non-Invasive Microneedle Patches for Localized Bruising Treatment 1.00
Mechanistic Insights into a Smart Nanomotor‐Laden Inulin Hydrogel Reprogramming Gut‐Brain Axis for Combinatorial Inflammatory Bowel Disease‐Depression Therapy 1.00
Intracellular Self‐Assembled Fe(II)‐Aniline Mustard NPs for Self‐Enhanced Anti‐Tumor Chemo‐/Chemodynamic Therapy 1.00
CDT Prodrug Therapy With Cascade‐Activated PROTAC Delivery Platform for Mutually Reinforced Ferroptosis and Apoptosis‐Based Therapy 1.00
Overcoming Solubility Limitations in Inverse Temperature Crystallization for Universal Growth of High‐Quality Perovskite Single Crystals for X‐Ray Detection 1.00
Bioengineered Violet Phosphorus Hybrid Nanoassembly for Pathogen-Specific Eradication of Multidrug-Resistant Bacteria 0.87
Sialylated Macrophage Nano-Decoys Mitigate Inflammatory-ROS Microenvironment and Reprogram Endothelial Function in Myocardial Infarction 1.00
Precision Cuproptosis Activation via HER2-Targeted Bimetallic MOF Nanoreactors Breaks Metabolic Adaptation in Aggressive Breast Cancers 1.00
Terminal Group‐Determined and Dendrimer‐Encapsulated Perovskite Probes for High‐Contrast Biomedical Imaging 1.00
Multifunctional Nanotherapy Rescues Fetal Growth Restriction via Alleviating Hypoxic Embryonic Microenvironment 1.00
Friends Fight the Foes: Synergistic Low‐Temperature Photothermal/Chemo/Gas Therapy for Conquering Cancer Cells 1.00
Homologous Membrane‐Camouflaged Pretargeting Synergized with Bioorthogonal Amplification Enables High‐Fidelity Tumor Imaging 1.00
Magnetic Navigation of Spatiotemporally Synergistic Delivery to Potentiate Sonodynamic Therapy of Orthotopic Pancreatic Carcinoma 1.00
Thermal‐Triggered Polymerizable Hydrogels with Localized Hyperthermia for Shrinkage‐Driven Starvation Therapy 1.00
Neutrophil‐Targeting Framework Nucleic Acid Based NETosis‐Inhibiting Nanoplatform Orchestrates Intra‐ and Extra‐tumoral Attack to Suppress Primary Tumor and Liver Metastasis 1.00
Breaking the Depth Barrier: Dual‐Activated Radical Storm from a Natural Product‐Based Nanoplatform for Spatiotemporally Controlled Deep Tumor Sonodynamic Therapy 1.00
ROS‐Activatable Cyclodextrin Nanoparticles Remodel Adenosine‐A2AR Pathway for Augmented Photo‐Immunotherapy 1.00
Hypoxia- and pH-Responsive Metal-Phenolic Network-Engineered Ferroptosis-Immuno Microspheres for Transarterial Chemoembolization in Hepatocellular Carcinoma 1.00
Phospholipid‐Like Prodrug Liposomes with High Drug‐carrier Affinity and High Tumor Selectivity: Strong Competitors of Paclitaxel Nanomedicines 0.97
Lattice-distortion Induced Niobium-based Perovskite Polarization Cascade Regulates Na+/K+ ATPase to Enhance Pyroptosis for Cancer Treatment 0.94
An Intelligent Hyperthermia System with Photothermal Temperature Wall Effect for Programmable Gated Drug Release in Wound Healing 1.00
Near‐Infrared‐II Plasmonic Multi‐Enzyme Nanocapsules for Hyperthermia‐Augmented Cascade Catalytic Oncotherapy 1.00
Melittin‐Loaded Multifunctional Nanozyme for Ulcerative Colitis Treatment via Enzyme‐Immunotherapy and Ferroptosis Inhibition 1.00
Dual‐Driven Janus Nanomotors Combined with a Size‐Shrinkage Strategy for Enhanced Tumor Penetration and Synergistic Chemo/Photothermal/Photodynamic Therapy 1.00
Biomimetic Cascade‐Targeted Nanoplatform for Fluorescent Localization and Eradication of Oral Squamous Cell Carcinoma 1.00
Four‐Pronged Nanomotor Strategy Achieves Efficient TNBC Treatment via Synergistic Chemo‐Photothermal‐Immune Therapy 0.90
Armored Superhydrophobic Dental Devices Regulate Oral Microecology via Long‐Term Antifouling 1.00
Near‐Infrared Photoaccelerated MicroRNA Response for Image‐Guided Photodynamic‐Chemodynamic Synergistic Cancer Therapy via Nanoprobe Programmed Disassembly 1.00
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Self-Assembly of Stimuli-Responsive Peptide Enhances Therapeutics by Specifically Disrupting Hepatocellular Carcinoma Lysosomes In Vivo 0.91
Electrically Modulated Semi-Convertible Hydrogel Microneedles for Programmable Insulin Delivery 1.00
Dynamically Hydrogen-Bonded Microphase Separation Enabling Phase Transition in the Gel Composites With Tunable UCST 1.00
Conformationally Variable Peptides Trap and Detoxify Ox-LDL in Plaques for Attenuating Atherosclerosis in Multiple Species 1.00
Brush‐on‐Brush Architecture Enables Durable and Reversible Aptamer Therapeutics With Minimal PEG Associated Immunogenicity 1.00
A Nano-Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast-Immune Communication via CCL2 Sequestration 1.00
Inhalable Polymeric Nanoparticle Vaccine for Lysosome-Targeting Co-Delivery of Antigen and Adjuvant With Enhanced Immunoprotection 1.00
Cytosol-Targeting Delivery of Non-Nucleotide STING Agonist Achieves Inhalable Nanoparticle-Based Anthrax Vaccine 1.00
Dynamically Crosslinked Carbon Dot/Alginate Hydrogels for On‐Demand Osteomyelitis Therapy 1.00
A Biomimetic Nanomachine Reprograms Transmembrane ATP Flux to Induce Tumor‐Selective Bioenergetic Crisis 1.00
Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy 0.78
Potentiating Antibody-Dependent Cell-Mediated Cytotoxicity via Tumor-Specific Anchoring and Activation of Nano-Haptens 0.80
In Vivo Target Drug Enrichment Based on Spatiotemporal Acoustic Node Modulation (STANM) for Bladder Cancer Treatment 1.00
Inhalable Respiratory Driven Penetration of Porous Microsphere‐Based Mucosal Vaccine for Long‐Term Immune Protection 1.00
Single‐Molecule All‐In‐One (SMALL) Dendritic Dots for Precise Cancer Theranostics 1.00
Microcrystalline-Infused Peptide Hydrogel Enables Sustained Tacrolimus Delivery to Prolong Survival and Prevent Rejection in Kidney Transplantation 1.00
Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue 0.75
STAR Therapy: Spatiotemporal Antitumor Regimen via a Size‐Gated DNA Hydrogel Drug Delivery System 1.00
Epigenetic Metal‐Organic Framework Nanoagonist Overcomes Triple Defenses to Enable Effective Chemo‐Metalloimmunotherapy in Platinum‐Resistant Ovarian Cancer 0.91
Modulation of MOF Energy State to Construct Smart Activated Sensitizers for Membrane Directed C–H Ketene Therapy in Tumor Cells 1.00
Programming Interfacial Polymerization: Machine Learning Unveils Quantitative Rational Design Rules for Microcapsules and Beyond 1.00
Molecular Gardening for Neuroinflammation via Nose-to-Brain Delivery: A Ca2+ Responsive DNA Nanocage-Hydrogel System With Neuron Targeting and STING Inhibiting 1.00
Dismantling the Necroptotic Engine: An Oral Theranostic Nanosponge for Ulcerative Colitis 0.88
Mitochondria-Targeted Nanomotor: H2S-Driven Cascade Therapy for Hepatocellular Carcinoma 0.71
Machine Learning‐Assisted Design and Discovery of High‐Performance Cyanine‐Based Photosensitizers for Integrated Theranostic Applications 1.00
Amorphous A‐BiOI@PEG Nanoenzyme Targets Imaging and Synergistic Phototherapy in Differentiated Thyroid Cancer 1.00
Photo-Controlled MUC1 Ablation via Steric Locking of Turn-On Reactors Enhances Pyroptosis-Immunotherapy of Triple Negative Breast Cancer 0.67
Diatomic Mn/Ca Nanozymes with Jaw Vascular Unit Mimicry for Triple-Enzyme Synergistic Therapy of Osteoradionecrosis 1.00
Tannin-Mediated Ischemia-Homing-Angiogenesis Nanodots (IHAND) for Synergistic Angiogenesis and Heart Failure Prevention Post-Myocardial Infarction 1.00
Pathology-Driven Design of a Biomimetic Ferromagnetic Nanomedicine for Dual-Mode Treatment of Ulcerative Colitis and Colitis-Associated Colorectal Cancer 0.83
Targeted Lipid Transfer Nanoshuttle via Lipid-Specific Transcytosis Induces Atherosclerotic Plaque Regression 1.00
Metal‐Imidazolate Cages as Porous Ionic Liquids: A Nitric Oxide Delivery Therapeutic Platform for Burn Wound Healing 1.00
Heat‐Responsive Phase‐Change Cream Broadly Enhances Transdermal Delivery Through a Mild Photothermal Strategy 1.00
A Hypoxia-Activatable Prodrug for Targeted Combination Therapy of Hepatoma 1.00
All Drug Glassy Microneedle Patches for Instantaneous Transdermal Delivery 1.00
Targeted Cascade Therapy with Multifunctional Nanovesicles Engineered from Synergistic Antibacterial Agents for Precision Treatment of Multidrug‐Resistant Infections and Biofilms 1.00
Engineered Biomimetic Nanovesicles Derived From Bone Marrow Stromal Cells With Innate Homing Capability for Targeted Delivery 1.00
Tumor Microenvironment-Activated Fe3+-Doped Dendritic Mesoporous Organosilica Nanocomposites as Ferroptosis Inducers for Enhanced Immunotherapy 1.00
Lipidic Prodrug Co-Crystals: A Platform for Combination Therapy Targeting Fungal Biofilms 1.00
Synthetic High‐Density Lipoprotein Mimicking Nanodiscs with Pt(IV) Prodrug Enable Tumor Targeting and cGAS‐STING Pathway Activation for Chemo‐Immunotherapy 1.00
Plaque‐Targeted Delivery of Fluoride‐Free MXene Nanozyme for Alleviating Atherosclerosis via Sonocatalytic Therapy 1.00
Activatable Enzymatic Nanoplatform Incorporated into Microneedle Patch for Relieving Tumor Hypoxia Augmented Photodynamic Therapy 0.94
mTORC1 Selective Nano‐Inhibitor by Disrupting the Lysosomal Arginine‐SLC38A9‐ mTORC1‐CDKs Axis for Precision Bladder Cancer Therapy 1.00
Engineered‐Macrophage‐Escorted Rotaxane Nanoscavengers for Precise Diquat Detoxification 1.00
Lesional Macrophage‐Targeted Nanomedicine Regulating Cholesterol Homeostasis for the Treatment of Atherosclerosis 1.00
Injectable Functional Porous Carbon‐Loaded Hydrogel with Long‐Term Retention and Synergistic Anti‐Tumor Properties for Tumor Therapy 1.00
Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer 0.91
Bioinspired Heterogeneous Spheres with Tunable Helical Structure for Accurate and Efficient Control of Sugar Blood Level 1.00
A Metabolism‐Oriented Strategy to Directly Generate Photosensitizer‐Engineered Extracellular Vesicles from Cancer Cells 0.35
1 0.13
Blood micronutrients modified associations between blood heavy metals and cognitive decline in a nationally representative cross-sectional study 0.13
41 39.06
Mimotope-Driven lucCage–lucKey Homogeneous Bioluminescent Immunosensor for the Small Molecule Fumonisin B1 1.00
Discovery of Nanobodies against Tetramethylenedisulfotetramine by Integrating Next-Generation Sequencing and Moderate Random Mutagenesis 1.00
Development of Magnetic Microbeads Equipped with Temperature-Responsive Artificial Antibodies for Efficient Anticancer Drug Administration 0.20
Database of Chemicals for Organophosphorus (DCOP): An Information Application Platform for Organophosphorus Compounds 1.00
Logic-Gated NIR-IIb Theranostic Nanozymes for Longitudinal Quantitative Assessment of In-Situ Cytotoxic T Lymphocytes 1.00
A Multi-Domain Affinity Metal Organic Polymer-MXene Heterostructure for Superior Advanced Antibody Separation 1.00
Efficient Discovery of Immunoglobulin Genes for Detecting Organophosphorus Pesticides Using a Reverse Virtual Screening Pipeline 1.00
Deciphering the In Vivo Metabolism of Polyethylene Glycol by a Polymeromics Approach 1.00
In Vivo Two-Dimensional Correlation Raman Spectroscopy Unveiling the Reversible Microstructural Changes and Spatially Differential Swelling of the Human Stratum Corneum in Response to Glycerin as a Temporary Penetration Enhancer 1.00
Caspase-3-Instructed Nanosonosensitizer Disassembly for Real-Time NIR-II Feedback of Tumor Sonodynamic Therapy 0.88
Endogenous-Activatable Nanotheranostic Platform for Multimodal Bioimaging-Guided Photodynamic and Gas Synergistic Cancer Therapy 1.00
Proximity-Based Phospho-Interactome (Prob-PhI) Characterization Reveals Distinct Signaling Activities of MEK1 and MEK2 1.00
Antibody Affinity Modulation Mechanisms via Benzene Ring Spacer Arm Conjugation Sites (Ortho, Meta, Para) in Coating Hapten Design 1.00
Hemin-DNA Switch-Assisted Microfluidic Chemiluminescence Immunoimaging for Rapid and Quantitative Screening of Specific Hybridomas 1.00
Light-Driven Upconverting Nanoparticles-Based Nanodevice for Accurate Subcellular Dual Molecular Imaging and Combinational Tumor Therapy 1.00
Fe–N3S Single-Atom Nanozyme with Asymmetric Coordination for Ultra-Low-Background Colorimetric Immunoassays 1.00
In Situ Characterization and Deep Profiling of Engineered Multispecific Nanoparticle Metabolite Coronas for Precise Serum Diagnostics 1.00
AnnoTCM: An Annotation Tool for Multimodal Metabolite–Phenotype Integration in Decoding Bioactive Compounds of Traditional Chinese Medicine 1.00
A Novel Ficoll400-Based Signal Amplification Platform for High-Sensitive Cardiac Troponin I Immunoassay 1.00
Precision Strike at Lipid Droplets by Spherical Nano-Browning Agents Promotes Obesity Remission 1.00
Artifactual Sequence Variant Induced by Nonspecific Cleavage-Linked Transpeptidation in Peptide Mapping 1.00
MSformer: A Meta-Structure Based Interpretable Framework for Representation Learning of Natural Products 1.00
Engineered Exosomes Disguised NIR-II Nanoaggregates for High-Resolution Photoacoustic Angiography and Robust Photothermal Therapy of Glioblastoma 1.00
Machine Learning Guided by Physicochemical Principles Enables Generalized Prediction of Small-Molecule Subcellular Localization and Discovery of Targeted Molecules 1.00
Physicochemical Tuning of Bispecific Antibody Fragment Immobilization for Robust Digital SERS Biosensing 0.13
A 19F-Labeled Isothiocyanate Derivatizing Agent for the Chiral Discrimination of Cyclic Secondary Amines 1.00
Advanced Spectroscopic Techniques for Lactose Crystallization Analysis: Investigating Water Participation in Crystal Morphology 1.00
Elucidating Molecular Vibrations within the Cocrystal of a Nonsteroidal Anti-Inflammatory Drug and Amino Acid by Temperature-Dependent Terahertz Spectroscopy at 2–17 THz: A Case Study 1.00
Dual-Functional Microneedles for In Situ Diagnosis and Biofilm-Targeted Therapy of Diabetic Periodontitis via Biomarker-Responsive Probes and Photothermal NO Nanomotors 1.00
Multifunctional Gold Nanoclusters for a Lung Tissue Distribution Study of a Novel Anti-asthma Inhaled Antibody 1.00
A Robust Immobilization Method for Membrane Protein SPR Assays Using SpyCatcher–SpyTag 1.00
Large Language Model-Empowered Compound Collision Cross-Section Prediction 0.86
NMR-Metabologenomics Coupled with Activity-Picking Inspires Discovery of Samsumycins: a Fast-Mining Strategy for Novel Antibiotics 1.00
A Novel Nontargeted Screening Strategy for New Psychoactive Substances: A Case Study of Synthetic Cannabinoids Based on Electron-Activated Dissociation High-Resolution Mass Spectrometry and Intelligent Elucidation 1.00
Homo-Tag-Assembler Assay for Full-Length Antibody Sequencing 1.00
Visualization of Immune Rejection: Noninvasive Imaging/Efficacy Evaluation of Immune Rejection after Liver Transplantation via Stable NIR-II Scaffolds 1.00
Analytical Data Review on an Artificial Intelligence Platform for Doping Control in Horse Racing 1.00
Dual Ratiometric Single-Molecule Theranostic Probes for Photothermal Therapy and Real-Time Quantitative Evaluation of Therapeutic Efficacy iIn Vivo/i 1.00
Reliable Quantification of Conjugated Peptides from T-DM1 In Vivo by Two-Step Enrichment and Internal Standards from Derivatized Analytes 1.00
DNA Hybridization-Accelerated Programmable Immuno-Aggregation of Microbeads Enabling Mix-and-Read Flow Cytometric Protein Analysis 1.00
Accurate Identification of MDMB-Type Synthetic Cannabinoids through Design of Dual Excited-State Intramolecular Proton Transfer Site Probe and Deep-Learning 1.00
2 1.09
A Novel Role of Dexmedetomidine in the Modulation of Morphine Reward Memory via Gamma-Aminobutyric Acid Transporter-1. 1.00
Sensory-selective peripheral and neuraxial nerve blockade with 2',6'-pipecolylxylidine. 0.09
67 63.09
Unveiling Aziridine-Containing Natural Products by Genomic and Spectroscopic Approaches 1.00
Perilipin-2-Anchored Lipid Droplet-Targeting Phototheranostics 0.60
Hierarchically Chiral Silver Nanoclusters Mediated Enantioselective Glutathione Depletion and Intracellular Self-Assembly for Enhanced Anticancer Therapy 0.88
A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders 1.00
Discovery of Perilloxazole Pseudo‐Natural Products Yields a New Sterol Biosynthesis Inhibitor Chemotype 1.00
Catalytic ROS‐Amplifying Self‐Immolative Linkers Enable Carrier‐Free Prodrugs for Refractory Tumors 0.86
Large‐Scale Profiling of Kinase Degradation by Using Norbornene‐Based Hydrophobic Tag (HyT) Strategy 0.68
Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2′,6′-Pipecoloxylidide 0.90
Amphiphilic Zwitterionic Polymers Induce Liposome Morphogenesis into Nanodiscs for Deep Glioblastoma Infiltration 1.00
Benzaldehyde‐Tagged Cell‐Penetrating Peptides Enable Efficient Cytosolic Delivery of Bioactive Cargos via Dynamic Covalent Anchoring 1.00
Genome-Guided Discovery of Antimalarial 4-Amino-2,4-Pentadienoate-Containing Cyclolipodepsipeptides 0.36
Programmable Coacervate–Membrane Interactions Direct Internal and Collective Organization in Membranized Protocells 0.92
Self‐Immolative Nanotheranostics with Albumin‐Guided Tumor Targeting for Oxidative Stress‐Amplified Photodynamic Therapy 1.00
Counterion-Engineered Water-Stable Intravenously Administered Nanoparticles Enable In Vivo Reversal of Ticagrelor 1.00
CD44-Assisted Transcytosable Chimeras for Extracellular Protein Depletion in Deep Tumors 1.00
A Dual-Key Gated Nuclear-DNA-Targeted Photogenerator for Amplified Photodynamic Immunotherapy of Breast Cancer 1.00
Kinetically Stereocontrolled Gem-Fluoro(chloro)-Olefination of Carbonyls by an Unprecedented Sulfoximine: Programmable Construction of Challenging Persubstituted Alkenyl Fluorides 1.00
Lipid Modified with Pyridinium Betaine Manipulates Liposomal Membrane Fusion Behavior for Spatially Confined Cytoplasmic Delivery 1.00
Adhesive Photoinitiator Constructs Polymer Jackets on Enzymes: Direct, Release‐Free Cytosolic Delivery 1.00
Split-Deliver-Click: Tumor-Specific Protein Degradation via “AND” Logic-Gated In-Cell Bioorthogonal Clicking of PROTACs 1.00
Synthetic Applicability Domain (SynAD): Navigating Chemical Space for Reliable AI‐Driven Reaction Prediction 1.00
Amino Acid Platform for Poly(amino ester)s: Controlled Ring‐Opening Polymerization, Complete Recyclability, and Tunable Polymerizability/Depolymerizability 1.00
Apoptosis-Amplified Intracellular Paclitaxel Nanoparticle Formation Enhances Microtubule Aggregation and PANoptosis 1.00
Meltable Polycarbonate Polymersomes as Photoresponsive Micro‐Analgesia Pumps for Concurrent Tumor Therapy and Pain Relief 1.00
Engineering Gas-Releasing Polymersome Nanoreactors for Selective Biocatalytic Activation 0.80
Physicochemically Informed Axial Chirality Descriptors Enable Accurate Prediction of Atropisomeric Stability 1.00
Iodine(I)-Induced Skeletal Rearrangement of α-Bicyclobutanyl Alcohols and Amines: A Universal Approach to 2-Oxabicyclo[2.1.1]hexanes and 2-Azabicyclo[2.1.1]hexanes 1.00
A Unique CYP450 Enzyme Unlocks Antrodia Camphorata Lanostane Triterpenoid Diversity Through Oxidation and Skeletal Rearrangement 1.00
Reverse Lipid Droplet Function for Hepatocellular Carcinoma Immunotherapy 1.00
In Situ Coordination-Assembly Nano-Drugs/Probes for Enhanced Tumor Retention and Responsive Release 1.00
A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood‐Brain Barrier in Aging Brain 1.00
Ionizable Nano-PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression 1.00
PSMA‐Triggered Phase Separation of Peptide‐Drug Conjugates Enables Zinc‐Dependent Tumor Inhibition 1.00
De Novo Design of Hexamer‐Linker Dual‐Action Nano‐PROTAC for Tumor‐Specific Ferroptosis 1.00
Discovery and Total Synthesis of Crossiguanipyrazines with Potent Activity Against Mycobacterium tuberculosis 0.26
Development of Indolo-Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes 1.00
Empowering Chemistry Experts with Large Language Models for Literature Interpretation in Single‐Atom Catalysis Toward Advanced Oxidation 1.00
A Sonosensitive Heterometallic Polyoxometalate for Highly Efficient Chemo‐Sonodynamic Synergistic Cancer Therapy 1.00
Interfacially Mineralized Magnetic Colloidal Gel with Microenvironment-Triggered Disassembly for Interventional Treatment of Hepatocellular Carcinoma 1.00
Brain‐Targeted Near‐Infrared Chiral TeSe Nanodrug Against Orthotopic Drug‐Resistant Glioma 1.00
Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation 0.25
Defluorinative Fluoro-Aza-Nazarov Cyclization 1.00
Skeletal Remodeling of Pyridines Through Nitrogen Atom Transposition 1.00
A Self‐Homing Liposomal Nanobot for Active Therapy of Glioblastoma 1.00
Chemoenzymatic Synthesis and Protein Engineering Enable Efficient, Scalable Production of Teleocidin Derivatives 1.00
Polymerization of L‐Arginine into Nanomicelles for Immunometabolic Engineering of Adoptive Macrophages in Solid Tumor Therapy 1.00
Chemical Proteomics Identifies RBBP7 as a New E3 Ligase Supporting Targeted Protein Degradation 1.00
Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes 1.00
Phospholipid‐Drug Conjugates Self‐Organized into Well‐Defined Supramolecular Nanotubes for Efficient Drug Delivery 1.00
Tandem‐Activatable PROTAC Prodrug for Tumor Biomarker‐Driven Near‐Infrared Opto‐Proteolysis 1.00
Synthesis of a Library of N-monofluoromethyl Compounds from N-monofluoromethyl Carbamoyl/Thiocarbamoyl Fluorides 1.00
Visible‐Light‐Mediated Intramolecular Dearomatization of Naphthalene and Anthracene with Bicyclo[1.1.0]butanes Through Energy Transfer Catalysis 1.00
Stereoselective Nucleophilic Di‐ and Monofluoro(sulfoximidoyl)Methylation of C═C Bonds: Remote Neighboring Group Participation Enables Facile Access to Chiral γ‐Fluorinated Amines 1.00
Dual Enzyme‐Responsive Polymer‐Drug Conjugates Induce Diverse Cells Mutual Transcytosis to Achieve Deep Pancreatic Tumor Penetration 1.00
Solid-Phase Parallel Synthesis of Photocleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery 1.00
A Neutral Single‐Molecule Carrier for Delivery of Phosphonate Drugs 1.00
Ultrasound‐Responsive Lipid Nanosonosensitizers with Size Reduction and NO Release: Synergistic Sonodynamic‐Chemo‐Immunotherapy for Pancreatic Tumors 1.00
Tumor‐Specific On‐Site Activation of Cisplatin via Cascade Catalytic‐Redox Reactions for Highly Efficient Chemo‐Immunotherapy 1.00
De Novo Design of Structure‐Tunable Multivalent Targeting Chimeras for Tumor‐Targeted PD‐L1 Degradation and Potentiated Cancer Immunotherapy 1.00
On‐Membrane Supramolecular Assemblies Serving as Bioorthogonal Gating for Melphalan 1.00
Supramolecular Host–Guest Assemblies for Tunable and Modular Lysosome‐Targeting Protein Degradation 1.00
A Multifunctional Polyester Nanoplatform for the Synergistic Anticancer: Enhanced Photodynamic Therapy and Targeted Gene Silencing 1.00
Direct Conversion of Aromatic Lactones into Bioisosteres by Carbonyl‐to‐Boranol Exchange 1.00
Spherical Nucleic Acids‐Directed Cryosynthesis of Manganese Nanoagents for Tumor Imaging and Therapy 0.73
ATP‐Assisted Electron and Proton Transfer Boosting Redox Metabolism‐Induced Ferroptosis and Apoptosis for Cancer Therapy 1.00
An Activatable Caged Palladium Nanocomposite for Targeted Cancer Therapy 0.86
Membrane‐Bounded Intracellular E3 Ubiquitin Ligase‐Targeting Chimeras (MembTACs) for Targeted Membrane Protein Degradation 1.00
1 0.06
Upadacitinib vs adalimumab in patients with rheumatoid arthritis and a prior inadequate response or intolerance to a tumour necrosis factor inhibitor: 12-week results from the randomised, double-blind, SELECT-SWITCH study 0.06
1 1.00
Enhancement of transdermal drug delivery by using a Laval nozzle to intensify shock waves generated by pulsed discharge plasma 1.00
1 1.00
Distinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia 1.00
1 0.92
Inhibition of mTOR Enhances the Efficacy of Proteasome-Dependent Targeted Protein Degradation Approaches 0.92
6 4.87
Rational design of Gi-biased CB1 agonist with reduced side effects 1.00
Hijacking ERAD for targeted degradation of transmembrane proteins 1.00
Unified modeling of 3D molecular generation via atomic interactions with PocketXMol 0.78
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo 1.00
Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy 1.00
Nutrient competition predicts gut microbiome restructuring under drug perturbations 0.09
2 1.88
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates 0.90
Body-wide multi-omic counteraction of aging with GLP-1R agonism 0.98
1 0.88
Vitamin C conveys geroprotection on primate ovaries 0.88
30 29.44
Construction of gem-difluoroalkenyl indoles via photoinduced Fukuyama-type cyclization of isocyanides 1.00
HFIP-Promoted [18F] trifluoromethylation via iodofluorination of gem-difluoroalkenes 1.00
Facile access to difluoromethylene-linked strained aliphatic rings from 2-(difluoromethylene)cyclobutyl sulfonium salts (CB-DFAS) and [1.1.1]propellane 1.00
A dual-gated polymersome nanoreactor 1.00
Photocatalytic surface grafting of hydrophobic shells onto hydrogels 0.67
DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy 1.00
Enhancing photodynamic therapy effects by a glutathione-responsive SO2 donor as a nanocarrier for cancer therapy 1.00
A pH-responsive iron/manganese bimetallic organic framework nanosystem for synergistic therapy of colon cancer 1.00
A new polar glass–ceramic built from monovalent perrhenate anions and large methyltriphenylphosphonium cations 1.00
Mild nanoencapsulation of single mammalian cells by surface initiated polymerization 1.00
J-aggregates of ethene-bridged aza-BODIPY dimers for bright NIR-II bioimaging and efficient photothermal therapy 1.00
Tumor microenvironment-responsive COF-based core–shell cascade nanoreactor with photocatalytic H2O2 self-supply for improved treatment 1.00
Programmable PROTAC delivery for precise and spatiotemporal protein degradation 1.00
Manipulating RTP properties of the same organic molecule by polymorphic engineering 1.00
Supramolecular macrocyclic-mediated logic-gated antitumor therapy nanoplatform 1.00
Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells 1.00
A GSH-consuming nanoamplifier for synergistic SO2 gas therapy and ferroptosis promotion 1.00
Small is different: N,N-chelated organoboron complexes with seven-membered rings 0.89
Multifaceted reactions of difluorocarbene with amines: synthesis and mechanistic insights 1.00
A pillar[5]arene-based polydopamine–prodrug nanoplatform for targeted and synergistic chemodynamic–photothermal–chemotherapy of cancer 1.00
A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells 1.00
An endoplasmic reticulum-targeted NIR-II type I AIE photosensitiser for triggering pyroptosis 1.00
A trident-like multi-cationic photosensitizer with stabilized membrane camouflage for efficient tumor-targeted photodynamic therapy 1.00
An ultrasonically sensitive small-molecule chimera for sono-controllable proteolysis 1.00
Benzylamine cation-directed introduction of polar structure in stator-rotor crown ether system 1.00
Synergistic isoniazid-Mn(ii) mediated non-Fenton-type hydroxyl radical generation for amplifying tumor chemodynamic therapy 1.00
Cycloaddition of bicyclo[1.1.0]butanes with enamides for the efficient synthesis of 2-amino-bicyclo[2.1.1]hexanes 0.89
Photocatalytic difluoroalkylation/cyclization of N-cinnamyl-N-cyanobenzamides with difluoroalkyl bromides toward C2-difluoroalkylated pyrroloquinazolinones 1.00
Self-immolative PEGylated dendritic drug conjugates for cancer therapy with enhanced cellular uptake 1.00
A self-stabilized amphiphilic fluorescent sensor enables the ratiometric detection of human serum albumin in urine 1.00
23 20.85
Stearic acid-modified PSMA-targeting peptide–drug conjugate for long-acting prostate cancer therapy 0.87
Machine learning-assisted screening of small-molecule drugs for suppressing protein aggregation and ROS generation based on ECL and CV dual-mode signals amplified by DNA 1.00
The underlying synergistic mechanism of co-solvents to fabricate high-quality FAPbI3 perovskite films 1.00
A structural reorganization-based catalytic hairpin assembly enabling small-molecule monitoring in living cells 1.00
DeepMetab: a comprehensive and mechanistically informed graph learning framework for end-to-end drug metabolism prediction 1.00
Molecule generation for target protein binding with hierarchical consistency diffusion model 1.00
Regiodivergent Lewis acid catalysis of bicyclo[1.1.0]butanes with 2-naphthols 1.00
Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly 0.11
GSH-responsive magnetic imaging for iin situ/i monitoring of tumor chemodynamic therapy 1.00
Decoding the limits of deep learning in molecular docking for drug discovery 1.00
Fully dissolved glucose-responsive insulin delivery system based on a self-immolative insulin prodrug and glucose oxidase 0.04
Effective generation of heavy-atom-free triplet photosensitizers containing multiple intersystem crossing mechanisms based on deep learning 1.00
Data-driven discovery of near-infrared type I photosensitizers for RNA-targeted tumor photodynamic therapy 1.00
Difluoromethylene cyclobutyl sulfonium salts: versatile reagents for chemodivergent synthesis of difluoroalkylated cyclobutenes and cyclobutanes 1.00
Understanding polymer encapsulation of enzymes: a dissipative particle dynamics simulation study on the regulation of structural characteristics of polymer nanocapsules 1.00
Special solvation effects of mixed water and alcohols revealed by molecular aggregation 1.00
Cordycepin: a dual-function molecular element for aptamer engineering with enhanced anticancer activity 1.00
Single-carbon-atom transfer to para-quinone methides from TMSCF2Br 1.00
Strain-release driven spirocyclization of bicyclo[1.1.0]butanes: access to 6,7-diazaspiro[3.4]octanes† 1.00
Intermediate knowledge enhanced the performance of the amide coupling yield prediction model 1.00
A BODIPY-tagged trivalent glycocluster for receptor-targeting fluorescence imaging of live cells 0.94
Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade 1.00
Multi-objective drug design with a scaffold-aware variational autoencoder 0.89
3 1.04
Fixed-Dose Rifapentine–Isoniazid (1HP) for Tuberculosis Preventive Treatment in Chinese Adults: A Prospective Real-World Safety and Pharmacokinetic Study 1.00
Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study 0.02
Direct Oral Challenge for Penicillin Allergy: A Hospital Implementation Evaluation Via the International Network of Antibiotic Allergy Nations (iNAAN) Study 0.02
2 1.10
Metabolic Improvement Mediates the Causal Relationship Between GLP-1 Receptor Agonists and Myocardial Infarction: A Mendelian Randomization and Mediation Analysis Study. 1.00
Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. 0.10
33 32.47
Predictors, Sources, and Health Risks of Environmental Antibiotic Exposure in Chinese Pregnant Women 0.89
Intestinal Inflammation Is Associated with Higher Cadmium Burden, Potentially via Compromised Gut Barriers: Evidence from NHANES and Colitic Mouse Model 1.00
Adverse Associations of ambient fine particulate matter amp; components with Semen Quality and the Mitigating Role of Residential Greenness: Evidence from the PREBIC Study in China 1.00
The interaction of toxic metal exposure and oxidative balance score on semen quality: A cross-sectional study based on Shanghai volunteers, China 1.00
Linking environmental concentrations to cytotoxic mechanisms in second-hand vapor exposure of electronic cigarette via an integrated approach for in vitro toxicity assessment 1.00
Improved health risk management of heavy metals in cigarette smoke from middle Chinese best-selling cigarettes using respiratory tract deposition modeling and simulated lung fluid extraction 1.00
Precision occupational lead exposure assessment through medical-informed machine learning 1.00
Neurobehavioral toxicity of paroxetine in Gambusia affinis: Dissociated behavioral syndromes and impaired monoaminergic neurotransmission 1.00
Polycyclic Aromatic Hydrocarbon Exposure and Mitochondrial DNA Copy Number: Opposing Roles of Oxidative Stress and Inflammation 1.00
Association of Microcystin-LR and Metals Co-Exposure with Semen Quality and Sperm Telomere Length in Humans 1.00
Prenatal exposure to multiple insecticides and reduced birth weight: a possible mediating role of plasma metabolomic alterations 1.00
Childhood dyslexia risk elevated by heavy metal mixtures from e-waste: A machine learning–driven mixture modeling study 1.00
DNA methylation-mediated alterations in Copper(I/II) redox equilibrium underlie lead-induced neurotoxicity 1.00
Longitudinal Triglyceride-Glucose Index and Metal Interactions: A Multi-Model Cohort Integrating Synergistic and Antagonistic Indices 1.00
Urinary Zinc-Lead and Strontium-Iron Combinations Affect Renal Function via Serum Uric Acid: A Cross-Sectional Study in Chinese Adults 1.00
Accelerated Biological Aging Underlies the Link Between Heavy Metal Mixture Exposure and Depression: A Multi-Omics Study 1.00
Can urinary OH-PAHs serve as biomarkers for indicating inhalation exposure to PAHs of children: Evidence based on a panel study 1.00
Urinary total arsenic, arsenic species, and arsenic methylation capacity: an integrative profiling analysis of microRNAs in plasma and leukocytes 0.96
Enhancing Identification Confidence in Non-Targeted Screening of Emerging Contaminants via an Ensemble Retention Time Prediction Model: Applications in Screening and Ecological Risk Assessment 1.00
Cigarette butts: A hidden toxic time bomb for aquatic metabolism and behavior 1.00
Human exposure to organophosphate esters (OPEs): A comparison between home and school microenvironments and inter-individual variations 0.75
Hypoxia-Driven Ferroptosis Escape Mediates Lung Injury Induced by Nickel-Refining Fumes via Oxygen-Sensing Signaling PHD1/HIF-1α 1.00
Perfluorooctanesulfonic Acid Facilitates the Migration of Choriocarcinoma Cell Line BeWo: Integrins as Potential Target 1.00
Intestinal barrier disruption by cadmium and microplastics: Mechanistic insights from integrated metabolomic and proteomic analysis in mice 1.00
Residential greenness modifies the association between long-term exposure to PM2.5 components and allergic diseases in schoolchildren: A large-scale study in Southern China 1.00
Investigating the potential molecular mechanisms of dibutyltin dilaurate induced brain injury: a network toxicology and molecular docking approach 1.00
Time-course physiological and transcriptomic study reveals cadmium effects on antioxidant, apoptosis, and immunity in the kidney of the freshwater snail Pomacea canaliculata 1.00
Quercetin alleviated cadmium-induced oxidative stress, endoplasmic reticulum stress, and autophagy in chicken kidneys 1.00
Novel Graph Neural Network Reveals Binding Mechanisms and Environmental Risks of PAHs Interaction with Estrogen Receptor B 0.86
Potential interactive effect of placental heavy metals and gestational diabetes mellitus on neonatal anthropometric measures: a birth cohort study 1.00
Quantification of amino-PAHs in human urine using UHPLC- hybrid quadrupole orbitrap high resolution MS (Q-orbitrap-HRMS): Assessing potential carcinogenic risks of Nitro-PAHs 1.00
Effects of in utero exposure to multiple metal(loid)s on neonatal birth size and hormones in the growth hormone/insulin-like growth factor axis: A mixture analysis 1.00
Lead induced intracellular copper redox imbalance with aggravated cellular dysfunction 1.00
26 23.51
Prenatal exposure to metal(loid)s and hormone profile in umbilical cord serum: Evidence of sex-specific association 1.00
First-Trimester Profiling of Maternal Plasma Metals and Vitamins in Relation to Gestational Hypertension 1.00
Association between toenail scandium concentrations and incidence of hypertension among American young adults: 28 years of follow-up 0.17
Associations of pesticide exposures with lipid profiles and mediation by metabolic pathways in children 1.00
Plasma organophosphate ester exposure-associated microRNA expression profiles and their functional analysis in Chinese healthy adults 0.92
A novel framework integrating a coupled mixing rule with deep learning for toxicity prediction and environmental risk assessment of antibiotic mixtures 1.00
Urinary Cadmium and Growth Faltering in Children Aged 3–6 Years: A Nationwide Cross-sectional Study from China 1.00
Advancing screening of aquatic persistent, mobile, and toxic substances via integration of graph convolutional networks and multitask learning 1.00
Exposure trends of neonicotinoids from 2008 to 2018 and health risk in a longitudinal study in China 1.00
Relationship of serum polycyclic aromatic hydrocarbon (PAHs) and lung function in adults: Evidence from a large community-based population in Guangzhou, China 0.89
Prenatal urinary biomarkers of metal and metalloid exposure and child neurodevelopmental outcomes in Puerto Rico 0.08
Neglected Plastic Waste from Discarded Cigarette Butts: A Case Study on Hazards Identification in typical regions in China 1.00
Association between placental single and mixed metals and offspring weight trajectories: a prospective birth cohort study 1.00
Associations of particulate matter size fractions and chemical composition with conjunctivitis and eczema: epidemiological evidence from the Pearl River Delta, China 0.92
Interpretable machine learning framework for predicting pesticide phytotoxicity in wastewater reuse: Integrating molecular, quantum, and experimental descriptors 1.00
QSAR-based prediction of acute inhalation toxicity and SHAP interpretability analysis of fluorocarbon environmental-friendly insulating gases 1.00
VOCs emission from landfills co-disposed of rural solid waste and sewage sludge: Identification, diffusion, and impact 1.00
Prenatal and postnatal exposure to environmental level arsenic declines male reproductive function by affecting spermatogenesis and maturation in offspring 1.00
Exposure profile of four classes of emerging pesticides in pet dog and cat serum from Wuhan, China 1.00
Prenatal exposure to environmental metal mixtures and social development in early childhood: Evidence from a birth cohort and mechanistic study 0.83
Arsenic exposure, genetic susceptibility, lifestyle, and glucose-insulin homeostasis impairment: Revealing the association and interaction in a repeated-measures prospective study 1.00
Comprehensive analysis of the association between volatile organic compound pollutants and chronic kidney disease in hypertensive populations: insights from multi-omics approaches and identification of potential therapeutic targets 1.00
Associations between PM2.5 components, temperature, and semen quality: Insights from seminal plasma metabolome 1.00
QSAR Model for Pesticide Toxicity in Bioluminescent Vibrio qinghaiensis sp.-Q67 0.80
Volatile organic compounds in various workplaces and during commutes in a Chinese city: occurrence and health risks for different occupations 1.00
Metal exposure and internalizing and externalizing psychobehavioral problems in a Chinese early adolescent cohort 0.91
43 40.81
Suspect Screening of Urinary Neurotoxicants in Children with Autistic Spectrum Disorder 1.00
Rapid and Highly Selective Detection of the Tire Antioxidant 6PPD in Water Samples via Dual-Mode Fluorescent and Photoelectrochemical Sensing Based on Host–Guest Recognition 1.00
AOP-Guided Toxicogenomic Mapping Profiles for Mechanism-Informed Toxicity Pattern Prediction in Zebrafish 1.00
Intermolecular Interactions as the Bridge: Establishing Structure–Activity Relationships between Microscopic Features of Organophosphorus Compounds (OPCs) and Their Adsorption Performance 1.00
Molecular Insights into Ocular Exposure Risk of Indoor Smoke Components on the Tear Film 0.88
BeeEcoTox: A Large Language Model-Empowered Graph-Learning Framework for Predicting Ecotoxicity of Agrochemicals to Bees 1.00
Classification Pretraining Enhances Performance of Target-Based Affinity Prediction for Reproductive Toxicity Assessment 1.00
Dynamic Evolution of Fe3O4 Nanoparticles’ Protein Corona during Extracellular to Intracellular Trafficking: The Interference of Integrin αMβ2 1.00
Solid-Phase Reactivity-Directed Microextraction Analysis for Identifying Unknown Toxic Disinfection Byproducts 1.00
Leveraging Large Language Models for Contextual Prioritization of Contaminants of Emerging Concern in Chemical Mixtures 0.86
Probing the Large Discrepancy of Highly Oxygenated Organic Molecules and Secondary Organic Aerosol Formation from Atmospheric Oxidation of Nerolidol by OH, NO3, and O3 1.00
Structure-Informed Comprehensive Screening and Risk Prioritization of Organophosphorus Compounds in Human Serum: Revealing the Hidden Burden and Emerging Risks 1.00
A Stacking Ensemble Model for KOC Prediction and Environmental Mobility Assessment of Global Neutral Chemicals 1.00
DNAPL-Responsive Hydrogel Nanoreactor Encapsulating nZVI for Enhanced Degradation of Chlorinated Contaminants in Groundwater 1.00
Acrylamide Exposure and Type 2 Diabetes in a Prospective Cohort Study of Chinese Adults: Association, Mediation, and Gene–Environment Interaction 0.88
Molecular Representation and Closed-Loop Validation for Toxicity Assessment of Organic Compounds in Ambient Air PM2.5 1.00
Environmental Dose MEOHP Promotes Bladder Cancer Progress through Hybrid EMT Mechanism: Based on the Adverse Outcome Pathway 1.00
Single-Cell Dissection of Dimethomorph-Induced Neurotoxicity in the Gestational Brain: Metabolic Disruption and Blood–Brain Barrier Dysfunction 1.00
Integrated Biomonitoring of Organophosphate Mixtures Reveals Food-Driven Exposure and Hormetic Oxidative Responses in Urban Adults 1.00
Arsenic Impairs Crab Carapace Sclerotization after Molting by Interfering with Phosphorus Metabolism 1.00
Cadmium Exposure Promotes Atherosclerosis by Disrupting Cholesterol Homeostasis via miR-30d-5p Regulation 1.00
ChemBioHepatox: Multimodal Integrating Chemical Structure and Biological Fingerprint for Robust and Interpretable Hepatotoxicity Prediction 1.00
Microbial Arsenic Methylation and Microbial Reduction of Dimethylarsenate Contribute to the Production of Highly Toxic Dimethylarsenite in Paddy Soil 1.00
A Protein Interactome-Based Framework Reveals the General Toxicity of Chemicals 0.83
Sex-Specific Associations of Early Life Exposure to the Pesticide Mixture with Cardiometabolic Outcomes in CHAMACOS Young Adults 0.06
Ferroptosis Induced by Pb Exposure Causes Parkinson’s Disease-Related Dopaminergic Neuronal Death 1.00
Prenatal Insecticide Exposure and Adverse Birth Outcomes: Evidence for Mediation via Disruptions in Amino Acid and Acylcarnitine Metabolism 0.88
The Mediation Role of the Placental IGF1 Signaling Pathway on Associations between Prenatal PFAS Exposure and Adverse Birth Outcomes: Evidence from Serial Mediation Models 1.00
Multiscale-Information-Embedded Universal Toxicity Prediction Framework 1.00
Prenatal OPEs Trimester- and Sex-Specifically Linked to Trajectories of Preschoolers’ Emotional and Behavioral Problems: Insights from Cord Blood Metabolomics 1.00
Characterization on Respiratory Bioaccessibility of Organophosphate Esters Based on a Mouth–Throat Model, Exhaled Breath Condensate, and Sputum 1.00
Cocrystal Engineering of Low-Melting-Point Pesticides for Replacement of Emulsifiable Concentrates: A Scalable Strategy to Reduce Pesticide-Derived Volatile Organic Compound Emissions 1.00
Environmental Exposure to Melamine Derivatives and Early Kidney Injury: Role of Ferroptosis and Oxidative Stress 0.92
Oral Exposure of Arsenic-Contaminated Soils Triggers Hepatic Ferroptosis via Iron Dysregulation and Glutathione Metabolism Disruption: From Bioavailability to Mechanisms 0.88
m6A-Methylated Taurine Transporter SLC6A6 Promotes Arsenic-Induced Malignant Transformation of Keratinocytes while Enhancing Sensitivity to Cuproptosis 1.00
Event-Driven Taxonomy (EDT) Screening: Leveraging Effect-Based Spectral Libraries to Accelerate Semiquantitative Nontarget Analysis of AhR Agonists in Sediment in the Era of Big Data 1.00
Innovative Benefit–Risk-Value Assessment for Cadmium and Selenium Coexposure in Black Shale Regions 1.00
The Potential Carcinogenicity of Long-Term Polymetallic Exposure on the Development of Primary Liver Cancer: Nested Case-Control Evidence from the Jinchang Cohort Study 1.00
Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut–Brain Axis 1.00
Single-Nucleus Transcriptomics Reveals Prenatal and Postnatal Pb Exposure-Induced Cell-Specific Neurotoxicity and Dysregulated Microglia-Neuron Communication in Mice Brain 1.00
Dimethylmonothioarsenate Is a Key Arsenic Species Driving Rice Straighthead Disease 1.00
Occurrence of Current-Use Pesticides in Paired Indoor Dust, Drinking Water, and Urine Samples from the United States: Risk Prioritization and Health Implications 0.75
Organic Cation Transporter Mediates the Uptake of Quaternary Ammonium Compounds in iArabidopsis/i 0.90
1 0.97
GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization 0.97
2 2.00
Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment 1.00
Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer 1.00
1 0.33
GLP-1 receptor agonist-SGLT-2 inhibitor combination and risk of major adverse liver and cardiovascular outcomes in adults with MASLD and type 2 diabetes. 0.33
9 8.29
Fluorination-Induced Room-Temperature Ferroelectricity in a Quasi-spherical Bismuth(III) Bromide Hybrid 1.00
Half-Sandwich Ir(III) and Ru(II) Complexes Featuring a Coumarin-Based Chelating Core for Mitochondrial-Targeted Anticancer Activity 1.00
Amino-Functionalized Zn(II)-Based Trilinker Metal–Organic Frameworks Conjugated with Folic Acid for Targeted Delivery of Doxorubicin on the MCF‑7 Cell Line of Human Breast Cancer 0.43
Multiscale Modeling and Experimental Validation of Solvent-Mediated Crystal Morphology Control in Sr(OH)2·8H2O for Industrial Crystallization Processes 1.00
Defective Engineered Metal–Organic Frameworks for Tumor Cell-Specific Combined Therapy 1.00
Water-Induced Reversible Structural Transition Enables Dual Cooperative Switching of Second-Harmonic Generation and Proton Conductivity 1.00
A Dual pH-Gated Nanoplatform Enabled by Schiff Base Chemistry on ZIF-90 for a Synergistic Anticancer Effect In Vitro 1.00
Mechanochemical and Solvent-Mediated Approach to Polymorphic Control in a Cu3I3 Luminescent Cluster: Combined Functional Studies and Theoretical Calculation 1.00
Zr-MOF-Derived Zirconium Oxide Nanozyme and Its Hydrogel Composite Membrane for Organophosphate Detoxification 0.86
1 1.00
Threshold and sex-specific associations of prenatal low-level lead exposure with neonatal birth outcomes: a Chinese prospective birth cohort study 1.00
1 1.00
Canagliflozin regulates adipocyte lipolysis in vitro via a SGLT2 independent signaling pathway 1.00
1 0.27
ANK3 as a Novel Genetic Biomarker for Liafensine in Treatment-Resistant Depression 0.27
4 2.37
A tandem recruitment site in the pseudokinase scaffold PEAK3 is subject to phosphorylation-dependent regulation and cancer-associated mutations 0.07
Targeting the Golgi apparatus enhances PD-L1 blockade and synergizes with oxaliplatin to improve immunotherapy efficacy 1.00
Protein tyrosine kinase Src suppresses hepatitis C virus particle release through regulation of Ndrg1 0.30
Selective inhibition of TRPV3 channel by natural rosmarinic acid and its analogs for alleviation of skin lesions through downregulation of NF-κB pathway 1.00
3 3.00
A QSAR-machine learning hybrid model for predicting the ecotoxicity of soil organic compounds and deriving thresholds 1.00
Biomimetic dual-layer fertilizer: Hydrophilic-hydrophobic synergistic system for enhanced water retention and controlled nutrient release 1.00
Novel mechanisms of cadmium detoxification mediated by selenium nanoparticles in selenium hyperaccumulator plants: Discovery of HSP90-1 as a pivotal potential regulatory hub 1.00
1 0.89
Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis 0.89
1 1.00
Multi-omics Analysis Reveals miR-7220-5p Alleviates N2O Addictive Behaviors via NR2B/ERK/CREB Signaling 1.00
49 44.82
Targeted Coacervates Enabled by Polyphenol–Peptide Networks for Therapeutic Delivery 0.58
Protein Post-Translational Modification-Inspired Regulation of Peptide Coacervation in Living Cells for Pro-Necroptotic Kinase Delivery 1.00
Programmable DNA Origami-Based Protease Device for Precise and Direct Proteins Degradation 1.00
Supramolecular Polymorphism of an Ir(III) Complex: Kinetic/Thermodynamic Control and Mechano-Responsiveness 0.71
Hydrogen–Deuterium Exchange Mass Spectrometry Reveals an Antibody-Induced Allosteric Pathway Driving SARS-CoV-2 Spike Trimer Disassembly 1.00
A Spatially Cued, Sequentially Activated DNA Nanodevice for Atherosclerosis Theranostics via Precise Targeting of Lesional Macrophages 1.00
Micron-Scale 2D Antibody Arrays for HER2 Signaling Blockade and Cancer Therapy 1.00
A MOF-Lanthanide Theranostic Agent with Bidirectional Near-Infrared Photon Conversion for Tumor-Responsive Therapy and Real-Time Imaging 0.92
When Reality Defies Prediction: Polymorphism, Twinning, and Accordion Crystals 0.03
Acetylation-Tagging-Assisted Cocrystallization of Stubborn Molecules with Trinuclear Complexes 1.00
An Engineered Nanovesicles-Based Lysosome-Targeting Protein Degradation Platform (NV-TACs) for Cancer Immunotherapy 1.00
Stability and Degradation-based Proteome Profiling Reveals Cannabidiol as a Promising CDC123-eIF2γ Inhibitor for Colorectal Cancer Therapy 0.94
In Situ Transformable Photothermal Targeting Chimeras for Spatiotemporally Controllable Protein Degradation and Combination Immunotherapy for Cancer 0.85
Nonclassical Crystallization of Covalent Organic Frameworks Guided by Exogenous Noncovalent Interactions 1.00
Spatiotemporal Cascade Targeting from the Cell Membrane to the Endoplasmic Reticulum for Chemoimmunotherapy via the Cyclometalated Iridium-Fatty Acid Scaffold 1.00
Iridium-Catalyzed Enantioselective C(sp3)–H Borylation of Bicyclo[1.1.0]butanes 1.00
A Versatile Bioorthogonal Theranostic Platform Enables Relay Activation of Tumor Cell Imaging and Targeted Protein Degradation 1.00
Fluorocarbyne Insertion into Benzene Skeletons 1.00
Oxoaporphine-Metformin Rhodium(III) Mixed Complex Achieving Dual Antidiabetes and Anticancer Effects by Interfering with Glucose Metabolism Reprogramming 0.90
Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform 1.00
Cell Membrane-Anchored Click Reaction Enhances Porphyrin Uptake for Highly Efficient Photodynamic Therapy of Breast Tumors 1.00
Cationic Nano Single Crystals: From In Situ Structural Determination to Synergistic Photoimmunotherapy 1.00
Development of Dual-Receptor Lysosome-Targeting Chimeras for Protein Degradation 1.00
Poly(bis(guanidinium)-oxazoline)–Insulin Complex Exerting Long-Acting Glucose-Responsive Insulin Release in Mice and Minipigs 1.00
A Sodium Iron Phosphate Nanocatalyst-Regulated High-Mobility Ion Reservoir Enables Tumor-Selective Immunotherapy 1.00
In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy 0.90
Pretargeted Mitochondrial Delivery of Organoarsenicals for Cancer Immunotherapy 1.00
Vitrification and Cold Crystallization of a One-Dimensional Perovskite-like Compound Enabled by Reorganizable Coordination Bonds and a Configurationally Restricted Cation 0.82
Cell-Selective Targeting Chimeras (SelecTACB) for Membrane Protein Degradation on B Cells 1.00
Self-Assembly of Artificial Topological Nanostructures for Enhanced Bioorthogonal Activation and Drug Penetration for Cancer Immunotherapy 1.00
Magnetic Sorting of Chiral Pharmaceuticals Using Fe3O4–Cellulose Acetate Phthalate Nanosplitters 1.00
Trotline-Inspired Mesoporous Carriers for Prolonged Gastrointestinal Retention 1.00
Zwitterionic Sulfadiazine-Based Micelle Achieves Effective Drug Delivery to Glioblastoma by Overcoming Multiple Biological Barriers 1.00
Triplet Carbene Insertion Enables Modular Access to C2-Substituted Bicyclo[1.1.1]pentanes 1.00
Elucidating the Biosynthetic Pathway and Mechanisms of Retrochalcones 0.86
Water Dynamics in the Formation of Single-Component-Based Multiphasic Droplets 1.00
Probiotic–Drug Conjugates Achieve Synchronized Site-Specific Probiotic Colonization and On-Demand Drug Release against Ulcerative Colitis and Its Complication 0.92
N-Heterocyclic Selone-Catalyzed [2σ + 2π] Cycloaddition of Bicyclo[1.1.0]butanes via Photoredox Radical Buffer 1.00
Monodisperse Giant Unilamellar Niosomes as Minimal Synthetic Cells 1.00
Concise Synthesis of Fostriecin and Analogs through Late-Stage Chemoenzymatic Installation of Their Key Pharmacophores 0.33
Engineered Nano-Micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization 1.00
Enzymatic Basis of Stereochemical Control in Reserpine Biosynthesis 1.00
Amorphization-Induced Electronic Modulation of Gd(OH)3 Nanocages with Enhanced Enzymatic Activities for Antitumor Therapy 0.92
Precursors of Carboximidates Deriving from Thioamide-Trimethyl-Lock System: A General Method for Designing Stable Cascade Acid-Sensitive Prodrugs 1.00
Covalent Recruitment of NEDD4 for Targeted Protein Degradation: Rational Design of Small Molecular Degraders 1.00
Phototriggered LYTAC: Photoactive Bispecific Aptamer Chimera Enhances Targeted Degradation of Membrane Protein through Regulating Cell Autophagy 1.00
Data-Driven Design of Random Heteropolypeptides as Synthetic Polyclonal Antibodies 1.00
X-ray-Induced Photodegradation of Hydrogels by the Incorporation of X-ray-Activated Long Persistent Luminescent Nanoparticles 0.80
Development of Sclareol- and Sclareolide-Based Chemoenzymatic Approaches to Ring Intact and Seco Limonoids 0.33
1 0.92
Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People 0.92
1 0.44
Association between glucagon-like peptidase 1 receptor agonist and obesity-related cancer in overweight or obese patients with type 2 diabetes: a nationwide cohort study 0.44
11 10.21
Water Content-Dependent Structural and Mechanical Properties of Host–Guest Hydrogels 1.00
Controlled Synthesis of Hydrogen-Bonded Poly[(thio)ester amide]s via Deprotection of Alternating Copolymers from N-tert-Butyloxycarbonyl Aziridine and Cyclic Anhydrides 1.00
Coupled Thermal–Chemical Stimuli in Hydrogel Swelling: A Multifield Kinetic Model for Dual-Responsive Hydrogel 0.67
Mixed “Nonsolvents” Induced Phase Separation of Amphiphilic Long-Chain Polyurethanes 1.00
Hydrogen Bonding Mechanism in Cononsolvency 1.00
Molecular Dynamics Study on the Temperature Response of a Chitosan-Based Graft Polymer with Different Grafting Densities of Oligo(ethylene glycol) Methacrylate Side Chains 0.86
Exploring SMILES and BigSMILES: Toward Efficient and Scalable Polymer Representations for Machine Learning 1.00
Revisiting the Classical Multicomponent Hantzsch Reaction to Form Fluorescent Dextran Hydrogels with Antibacterial Activity 1.00
Dynamic Hydrogels Using Movable Supramolecular Cores to Prepare Multiarm Macromer Analogs 0.83
The Ester/Amide Exchange Reaction in the Melt Polycondensation of Alternating Poly(Ester Amide)s: Mechanism and Evolution 1.00
Constructing Polycarbonate-Based Oxidation-Responsive Polymersome Nanoreactors with Tunable Biocatalysis 0.86
2 2.00
Nitrous oxide controls the DCN to VTA dopamine circuit by enhancing AMPA receptor functions during rewarding behavior 1.00
Mechanistic insights into cannabidiol-mediated TrkB activation via FRS2 interaction in attenuating Alzheimer’s disease pathology and cognitive impairment 1.00
25 24.25
Anionic Nanoparticles Co-Loaded with Regorafenib/Paclitaxel for Macrophage-Mediated Chemoimmunotherapy against Colorectal Peritoneal Metastases 1.00
Synergistic Chemoimmunotherapy of Hepatocellular Carcinoma via ROS-Responsive Carrier-Free Prodrug Nanoparticles 0.93
Protein Corona-Tailored Nanoplatform Boosts Tumor Accumulation and Reprograms Macrophages for Osteosarcoma Therapy 1.00
Thermodynamics and Molecule Landscape of Protein Corona 1.00
“AND” Logic-Gated Biomimetic Nanoparticles to Activate Macrophage Phagocytosis for Cancer Immunotherapy 1.00
A Dicer-Activatable Aptamer-Adamantane/siRNA (AptHyT-siRNA) Chimera Enables Synergistic Targeted Protein Degradation and mRNA Silencing 1.00
Overcoming Chemoresistance via an AIEgen-Based Covalent Organic Framework 1.00
Hydrophobic/Amphiphilic Prodrug Coassembly Strategy: Exploring the Effect of Oligoethylene Glycol Chains on the Antitumor Efficacy of Nanoassemblies 1.00
Label-Free Analysis Reveals In Vivo Premature Drug Release Governed by Diffusion from Polymeric Micelles 1.00
Transformable “Bullet Train”-like Nanomotors for Sequentially Overcoming Tumor Delivery Barriers 1.00
Carbonic Anhydrase Targeting Polymer with Enhanced Intracellular Protein Delivery and Tumor Penetration for Cancer Therapy 1.00
s-Block Atomic Calcium Sites Boost Biomimetic Hydrolysis for Personal Protection 1.00
Mineralized Lipid Nanoparticles Containing Gadolinium Enable Integrated X-ray Fluorescence Computed Tomography Imaging and Radiotherapy 1.00
Spatiotemporally Orchestrated Microneedle Patch Synergizing Photodynamic Therapy, ROS Scavenging, and Photosynthetic Oxygenation for Chronically Infected Wound Healing 1.00
Synergistic Dual-Targeting Bacterial Extracellular Vesicles Delivering Paclitaxel for Precision Glioblastoma Therapy 1.00
Outperforming Biorecognition: Epitope-Imprinted Nanoparticle Enables High-Species-Specificity Purification of Human IgG 1.00
Dual-Targeting Nanoplatform to Regulate Metabolic Disorders: From Obesity to Obesity-Related Metabolic Dysfunction-Associated Steatotic Liver Disease 0.73
Hydrophobically Modified Paclitaxel Prodrug Enables Ultrahigh Drug Loading Driven by Polarity Redistribution 0.90
A Synthetic Liposome Nanoparticle Vaccine Platform for Broad-Spectrum Vaccine Design 1.00
Inhalable Mucus-Penetrating Engineered Hybrid Nanomedicine for Enhanced Treatment of Idiopathic Pulmonary Fibrosis 1.00
Bioinspired Polymeric Nanomedicines with Tumor Extracellular Matrix Anchoring Capability for Prolonged Tumor Retention and Drug Delivery 0.89
Targeted Europium Chelation: A Strategy for Intervening Tumor Extracellular Matrix 0.89
Inhibition of Post-Surgical Tumor Recurrence by 3-Bromopyruvate-Conjugated Gold Nanoclusters via MAPK and PI3K-Akt Pathways 0.91
Impact of Renal-Targeting Ligand Density on Kidney Targeting, Clearance, and Off-Target Effects of Renal-Clearable Nanoparticles 1.00
Light-Controlled Small Extracellular Vesicle-Based Spherical Nucleic Acid Nanomotor for Enhanced Transdermal Delivery against Skin Aging 1.00
7 3.61
Pancreatic-targeted lipid nanoparticles based on organ capsule filtration 1.00
Language model-guided anticipation and discovery of mammalian metabolites 0.03
Mazdutide versus placebo in Chinese adults with type 2 diabetes 1.00
Inhibitors supercharge kinase turnover through native proteolytic circuits 0.07
A skin-permeable polymer for non-invasive transdermal insulin delivery 0.95
Crystal structures of agonist-bound human cannabinoid receptor CB1 0.50
Identification of medication–microbiome interactions that affect gut infection 0.06
2 2.00
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles 1.00
A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2 1.00
3 2.20
Navigating condensate micropolarity to enhance small-molecule drug targeting 1.00
Molecular recording of cellular protein kinase activity with chemical labeling 0.20
Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins 1.00
1 1.00
Collective synthesis of 1,2,4-trisubstituted, meta- and ortho-substituted arene bioisosteres from bicyclobutanes 1.00
78 71.07
Structural characterization of kappa-opioid receptor dimer in complex with two G proteins 0.81
Bridging hydrogen-bond-stabilized polymeric coacervate core micelles for high-efficiency drug encapsulation and delivery 1.00
Probiotics mitigate non-antibiotic drug-induced dysbiosis via protein homology-driven competitive binding 1.00
Janus nanomotors for topical treatment of radiation-induced dermatitis 1.00
Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts 1.00
Rational design of a Kappa opioid receptor peptide agonist with attenuated β-arrestin signaling 1.00
Enzyme-responsive peptide dendron nanoassemblies for targeting and eliminating intracellular drug-resistant bacteria 1.00
LaMGen: LLM-based 3D molecular generation for multi-target drug design 1.00
Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy 1.00
Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity 1.00
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader 0.05
Surface hydrophobicity and rigidity determines protein corona on orally delivered nanoparticles treating colitis 1.00
Structural evolution of carbon frameworks realizes in vitro interfacial transport in metabolically reprogrammed senescent cells for senolysis 1.00
XA-Novo: high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures 1.00
A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis 1.00
A meta learning and task adaptive approach for drug target affinity prediction 1.00
Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy 1.00
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases 0.80
ReactionSeek: LLM-powered literature data mining and knowledge discovery in organic synthesis 1.00
Visualizing molecular diffusion direction and processes in the solid state via dichromatic fluorescent cocrystalization transformation 0.91
Deciphering DEL pocket patterns through contrastive learning 1.00
Drug-caged drugs enable photocatalytic dual decaging of nitric oxide and anesthetics for antibacterial analgesia 1.00
Multi-to-uni modal knowledge transfer pre-training for molecular representation learning 0.90
Engineered exosome nanovesicles for delivery of antibodies to treat inflammatory bowel disease 1.00
Phosphorescent supramolecular systems for medicine anticounterfeiting 0.86
Molecular determinant of low-voltage dependence of human Nav1.7 inactivation revealed by efficacy-based Nav1.7 selective inhibitor 0.89
Assessing conformation validity and rationality of deep learning-generated 3D molecules 1.00
Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals 1.00
Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications 0.89
Iterative discovery of potent polymeric antibiotics via multi-stage and multi-task learning against antimicrobial resistance 1.00
Injectable hydrogels for osteomyelitis treatment induce metabolic reprogramming for protection against reinfection 0.92
Comprehensive evaluation of GLP-1 receptor agonists: an umbrella review of clinical outcomes across multiple diseases 1.00
Engineered vesicles enhance oral antibiotic absorption in proximal small intestine and mitigate gut dysbiosis 0.83
A brain-to-small intestine circuit mediates morphine-induced constipation in male mice 1.00
Neutrophil-mediated delivery of hybrid cross-species nanovesicles for treatment of bacterial infections 1.00
Alternative antigen retention by a gp96-fusion approach induces long-lasting and broad immunity in mice 1.00
Designing an oxidase toolbox for site-directed oxidation of taxanes 1.00
PhenoProfiler: advancing phenotypic learning for image-based drug discovery 0.70
Structural basis for pharmacotherapeutic action of triple reuptake inhibitors 1.00
Semi-inductive dataset construction and framework optimization for practical drug target interaction prediction with ScopeDTI 0.95
A hardware demonstration of a universal programmable RRAM-based probabilistic computer for molecular docking 0.11
De novo design of epitope-specific antibodies via a structure-driven computational workflow 1.00
Periodic asymmetric field enhances electrofusion of nanoscale lipid systems 1.00
NIR-IIb fluorescence ratiometric imaging of tumor-associated neutrophils for immunotherapy efficacy monitoring and strategy optimization 0.80
Enhancing kinase-inhibitor activity and selectivity prediction through contrastive learning 0.88
TAPB: an interventional debiasing framework for alleviating target prior bias in drug-target interaction prediction 0.86
Molecular basis of prostaglandin E reuptake by organic anion transporter PGT 1.00
Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation 0.81
Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion 1.00
Molecular Motif Learning as a pretraining objective for molecular property prediction 1.00
Highly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid 1.00
pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis 1.00
Bench-stable azidodifluoromethyl imidazolium reagents unlock the synthetic potential of carbonimidic difluorides 1.00
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs 0.17
Ring expansion of bicyclo[1.1.0]butyl ketones to bicyclo[2.1.1]hexenes using ketone as both activating and reacting groups 1.00
Molecular mechanisms of SLC30A10-mediated manganese transport 1.00
Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy 1.00
Chemical knowledge-informed framework for privacy-aware retrosynthesis learning 1.00
Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome 0.86
Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA 0.57
Organic-inorganic covalent selenium reversing ischemic reperfusion injury 1.00
Crafting defects in two-dimensional organic platelets via seeded coassembly enables emergent molecular recognition 1.00
Target-aware 3D molecular generation based on guided equivariant diffusion 1.00
Galloylated liposomes enable targeted drug delivery by overcoming protein corona shielding 1.00
Modular synthesis of CF-containing compounds with PhSOCFH reagent through difluoromethylene radical anion synthon strategy 1.00
Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates 1.00
Chemistry-informed recommender system to predict optimal molecular receptors in SERS nanosensors 0.22
Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord 1.00
De novo designed protein guiding targeted protein degradation 1.00
Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors 0.91
Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury 0.95
ColdstartCPI: Induced-fit theory-guided DTI predictive model with improved generalization performance 0.78
Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control 1.00
In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation 1.00
SE(3)-equivariant ternary complex prediction towards target protein degradation 0.63
Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy 1.00
ToxACoL: an endpoint-aware and task-focused compound representation learning paradigm for acute toxicity assessment 1.00
Bacterial membrane nanovesicles encapsulating prodrug assemblies combine chemical and immunological therapies for chronic bacterial infection 1.00
2 0.08
Glucagon-like peptide-1 receptor agonists for major cardiovascular and kidney outcomes in type 1 diabetes 0.06
Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial 0.02
1 0.19
Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus 0.19
1 1.00
A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo 1.00
40 39.28
Diversified Construction of Benzothiophene-Fused Pyridazinone via a Skeletal Editing and Pyridine Migration Domino Process and DFT Studies 1.00
Iodide-Catalyzed Intermolecular Formal (3 + 3) Cycloaddition of Bicyclo[1.1.0]butanes and Amides: Modular Access to Heteroatom-Enriched Bicyclo[3.1.1]heptane Scaffolds 1.00
Visible-Light-Promoted C(sp2)‑Monofluoromethylation and Difunctionalization of Alkenes with Bench-Stable Sulfonyl Monofluoromethyl Iodides 1.00
Palladium-Catalyzed Sequential Intramolecular Annulation/[2σ + 2π] Cycloaddition of 5‑Allenyloxazolidine-2,4-Diones and Bicyclobutanes 1.00
Fluorinative Cyclization of ortho-Diisocyanoarenes: One-Pot Synthesis of N-CF3 and N-CF2H Benzimidazoles 1.00
Exploring the Construction of a Fused-Ring Triazolopyrimidine Energetic Molecule 1.00
Modular Defluorinative Annulation Enabled by a Dearomative Rearrangement: Diversified Synthesis of Azaheterocycles 1.00
Difluorocarbene-Promoted Regioselective Ring-Opening of Benzimidazoles 1.00
Chemistry for the Incorporation of S-Aryl Dithiocarbamates into a DNA-Encoded Library 1.00
Truce–Smiles Rearrangement Cascade Enables Synthesis of Pyrazoline Derivatives 1.00
PPh3-Catalyzed Remote Aminofluorination Reactions: Regioselective Access to γ- and ε-Fluoroamines Containing Oxindole 1.00
One-Pot Synthesis of Isoindolinones Mediated by LiN(SiMe3)2/CsF 1.00
Construction of Heterocyclic-Triazolopyrimidine Framework for Energetic Compounds: High-Energy, Low-Sensitivity Explosives 1.00
Chromone–Thiocoumarin Transmutation Enabled by Lawesson’s Reagent 1.00
Pyridine-Fused C25 abeo-Steroid Alkaloids from a Fungus: Biomimetic Semisynthesis and Anti-HIV Mechanistic Study 1.00
Accessing α-Ketoamides on DNA through a Coupling–Oxidation Strategy 1.00
Base-Promoted [4 + 3] Cycloadditions Enabling the Construction of Polycycle-Fused Uracils from N-Aminoisoquinolinium Derivatives 1.00
Rhodium(III)-Catalyzed Three-Component Diamination of Bicyclo[1.1.0]butanes via Nitrene Transfer 1.00
B(C6F5)3-Catalyzed Dearomative [2π+2σ] Cycloaddition of 1-Naphthols with Bicyclo[1.1.0]butanes 0.83
Synthesis of Fused Azole-Pyridazine/Pyrimidine and Imino-Bridged Pyrazole-Based Energetic Materials via Property Tuning and Skeletal Editing 1.00
Mechanistic Insights into the Regioselective Defluorofunctionalization of Trifluoromethylanilines via Photocatalytic SET: A Combined Experimental and Computational Study 0.57
Construction of Benzothiophene-Fused 1,2,4-Triazocines via a Skeletal Editing Strategy and DFT Study on the Reaction Mechanism 1.00
Modular Synthesis of Diverse gem-Difluoroalkenes from Trifluoroacetic Anhydride via Phosphorus-Assisted Fluoride Elimination 1.00
On-DNA Synthesis of 2-Hydroxy Dithiocarbamates 1.00
Difluorocarbene as a Dual C1/CF2 Source for HCF2S Heterocycle Synthesis 1.00
Metal-Free, Photoinduced On-DNA Synthesis of β-Hydroxy Sulfides 0.88
Visible-Light-Induced Monofluoromethylation of Styrenes 1.00
SN2′-Type Difluoro- and Perfluoroalkylation of gem-Dichlorocyclobutenones Mediated by (DMPU)2Zn(Rf)2 1.00
Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles 1.00
Palladium-Catalyzed Cascade Transformations of 1,4-Diyn-3-yl Carbonates to Construct Cyclobutane-Embedded Frameworks 1.00
Enantioselective Synthesis of α-Aryl-α-fluoroketones by CPA-Catalyzed Desymmetrization of 1,3-Indanediones 1.00
Lanosdracaenin A and (±)-Neodracaflavonoids A, Triterpenoid and Flavonoids with Anti-Inflammatory Activities from Dracaena cochinchinensis 1.00
Light-Induced and Strain-Releasing Reactions of Bicyclo[1.1.0]butanes with Alkenes as a Route to Spirocyclobutanes 1.00
Controllable Defluorinative Cyclization for Divergent Synthesis of Pyrrolo[2,3-d]pyrimidines and Fluorinated Pyrimidines from β-CF3-1,3-Enynes and Amidine Hydrochlorides 1.00
Sappanumols A−C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum 1.00
Precise Modulation of BCB Reactive Sites via Lewis/Brønsted Acid Switching for the Synthesis of Spirocycles and Bridged Frameworks 1.00
One-Pot Three-Component Cascade Strategy for the Site-Selective Synthesis of 5-Sulfenylated/Selenylated 2,4-Disubstituted Pyrimidines 1.00
Visible-Light-Mediated Perfluoroalkylation/Thioetherification of [1.1.1]Propellane under Photocatalyst-Free Conditions 1.00
Copper-Catalyzed Regio- and Enantioselective Hydroamination of igem/i-Difluoroalkenes to Access Chiral Difluoromethyl Amines 1.00
Synthesis of a 2,4,6,8-Tetraoxaadamantane-Based 3D Energetic Biocidal Agent via Stepwise Cyclization Strategy 1.00
5 5.00
Salvia miltiorrhiza-Derived Vesicle-Like Nanoparticles Functionalised Hydrogel With Excellent Ability of Oxidative Stress Modulation and Anti-Cardiomyocyte Apoptosis for Sepsis-Induced Myocardial Injury 1.00
<atl>A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in iArtemisia capillaris/i</atl> 1.00
Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum 1.00
Characterisation of Early Biosynthetic Steps of Atractylon via an Integrative Strategy 1.00
N6-methyladenosine RNA modification regulates light intensity-dependent terpenoid biosynthesis in Schizonepeta tenuifolia 1.00
14 9.45
Mucinase-engineered cell membrane nanovesicles degrade the glycocalyx shield to potentiate antitumor immunity 1.00
A ginsenoside metabolite and its derivative target PRELID3B against lung cancer cells 0.71
The identification of potent nonopioid analgesics and their potential for perioperative use 1.00
Targeted degradation of c-Myc through the midnolin–proteasome pathway 1.00
Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models 0.07
DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets 1.00
Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance 0.13
Enhanced screening via a pure DNA-encoded peptide library enabled by an Fmoc modification 1.00
Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection 0.29
Therapeutic hypothermia reprograms nanocarrier protein corona via apolipoprotein C1 enrichment for precision cardiovascular therapy 1.00
Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy 0.07
Manifold-constrained nucleus-level denoising diffusion model for structure-based drug design 0.17
Ultrasmall inorganic nanoparticles repair damaged meningeal lymphatic vessels to boost Parkinson’s disease therapy 1.00
Sequential drug release system: Targeting the tumor ECM for enhanced chemotherapy efficacy 1.00
1 1.00
Multiparametric MRI Evaluation of Liver Fat and Iron after Glucagon-like Peptide-1 Receptor and Glucagon Receptor Dual-Agonist Treatment in a High-Fat Diet-induced Mouse Model. 1.00
2 2.00
A high-throughput selection system for fast-acting covalent protein drugs 1.00
Deep contrastive learning enables genome-wide virtual screening 1.00
25 22.05
Erythrocyte patch for enhanced B cell depletion therapy 1.00
Glycerol-mediated nose-to-brain codelivery of anti–IL-17 and anti-CD73 antibodies enhances immunotherapy for melanoma brain metastases 1.00
Helper lipid-engineered extracellular vesicles enable PET imaging–guided pulmonary siRNA delivery to treat lung metastasis 0.93
Pulmonary neuroendocrine cell–derived exosomes regulate iron homeostasis and oxidative stress in lung neurons 0.14
Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel 1.00
Preclinical development of a well-defined semisynthetic glycoconjugate vaccine against Haemophilus influenzae type b 0.90
Assessing the health risks of rice cadmium content standards in China 1.00
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia 0.81
Oxidation-activated nanotherapy boosts tumor immunity and disrupts tumor-nerve crosstalk to combat bone metastases and cancer pain 1.00
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers 1.00
A softness zwitterionic micelles efficiently deliver inhaled nintedanib by enhancing airway mucus penetration 1.00
Nickel-catalyzed radical relay enabled chemoselective fluoroalkyl-borylation of [1.1.1]propellane under kinetic control 1.00
Scalable manufacturing of multifunctional insect wing membrane via interfacial lase-and-peel strategy 0.85
Fluidic microgel assemblies with enhanced oral delivery of biologics alleviate colonic inflammation in murine and canine models 1.00
A gastric retentive robotic capsule enables emergency-prepared and responsive oral drug delivery in canine models 0.95
A unique mechanism involving cocatalysis of enzyme and nonenzyme to form β-carboline and spirotryprostatins in Aspergillus fumigatus 1.00
Padlock-designed MOFs triggers an “avalanche effect” to enhance apoptosis and suppress metastasis in central nervous system lymphoma 0.89
Site-specific adaptive nanovesicles for oral insulin delivery 0.93
Insights into angiosperm evolution and lineage-specialized lignan biosynthesis from the early-diverging Schisandra genome 1.00
A closed-loop bioelectronic patch for intelligent blood pressure management 0.92
Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption 1.00
Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy 0.93
Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy 0.16
Precision-controlled sequential drug release via electrochemical corrosion of liquid metal nanoparticles 1.00
Lipid droplet–enriched luminogens enable adoptive macrophage transfer for treatment of bacterial sepsis 0.64
2 1.97
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs 1.00
S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models 0.97
1 0.93
Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial 0.93
1 1.00
Structural insights into selective and dual antagonism of EP2 and EP4 prostaglandin receptors 1.00
9 9.00
Accurate Prediction of ECD Spectra of Silver-Based Chiral Complexes Using Femtosecond-Informed Machine Learning from Static Structures 1.00
META-Tox: Multiview Ensemble with Topological Aggregation for Robust In Vivo Toxicity Prediction 1.00
Molecular Representation Matters: Comparative Evaluation of Fingerprints, RDKit Descriptors, and Hashing Effects 1.00
Dual-Path Global Awareness Transformer for Optical Chemical Structure Recognition 1.00
Machine Learning Accelerates Discovery of High-Performance Corrole Photosensitizers for Optical Imaging Diagnosis and Photodynamic Therapeutics of Nasopharyngeal Carcinoma 1.00
Multimodal Machine Learning for Molecular Identification Based on IR, Raman, and NMR Spectra 1.00
Manipulating the Aggregation of Phenoxazine-Modified Helical Boron-Dipyrromethene to Enhance Singlet Oxygen Generation for Efficient Tumor Therapy 1.00
LumiCharge: Spherical Harmonic Convolutional Networks for Atomic Charge Prediction in Drug Discovery 1.00
Interpretable Multimodal Deep Ensemble Framework Dissecting Bloodbrain Barrier Permeability with Molecular Features 1.00
1 1.00
Efficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): a 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial 1.00
1 0.13
A Placebo-Controlled Trial of the Oral PCSK9 Inhibitor Enlicitide 0.13
4 3.44
Cross-modal attention deep learning reveals how transformation products inherit life-cycle risks from parent antibiotics: Insights for environmental, ecological, health, and AMR risks 1.00
Screening toxic transformation products of emerging pollutants in advanced oxidation processes with 3D deep learning and in vitro assays 1.00
Insights into the effect of sertraline on anaerobic digestion: stimulating CH4 and CO2 production 1.00
Evaluating dextrorphan as a wastewater biomarker for cough suppressant use:A longitudinal study in China 0.44

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