Pharmacology and Pharmaceutical Sciences articles for Chinese Academy of Sciences (CAS), China

Time frame: 1 June 2025 - 30 May 2026

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Count: 158

Article ‘Count’ for Pharmacology and Pharmaceutical Sciences.

Journal Count Share
21 7.08
Nose-to-Brain Delivery of mRNA-Loaded Lipid Nanoparticles Bypasses the Blood–Brain Barrier for Effective Brain Disease Therapy 0.53
Endolysosomal-Targeting Nanovaccine Coordinates Antigen-Adjuvant Delivery to Enable Cross-Protective Immunity against Multidrug-Resistant Enterococci 0.21
Zwitterionic Lipid Nanotherapeutics from Mulberry for Oral Treatment of Diabetic Colitis 0.10
Reversing Cuproptosis Tolerance with Twinborn Metallic Polymer Nanoparticles for Enhancing Efficacy of Chemo-Immunotherapy 0.25
In Vivo-Assembled Artificial Base-Albumin Platform for Tumor-Targeted General Drug Delivery 0.06
<atl>Tumor-Selective Autophagy Blockade of Renal-Clearable Bi sub2/sub S sub3/sub Nanoflowers for Precise Photothermal Therapy</atl> 0.89
Coassembled Prodrug Nanoparticles Mitigating the Acquired Resistance to Protein Degradation Therapy 0.36
A Redox-Responsive Selenium-Containing Nanomedicine Enables Dual Antioxidant System Inhibition to Overcome Platinum Resistance and Enhance Immunotherapy in Bladder Cancer 0.03
Intranasal Conformal Patch for Sustained Levodopa Delivery and Reactive Oxygen Species Scavenging in Parkinson’s Disease 0.06
Chiral Polyproline Enables Functional Stealth for Simultaneous Long Circulation and Endoplasmic Reticulum-Targeted Antigen Presentation 0.70
Structure-to-Therapeutic Transformation of Nanohydrogels Triggers Calcium Overload for Potentiated Boron Neutron Capture Therapy 0.81
In Vivo Programmed Assembly of Polymer–Peptide Conjugates to Overcome Multistage Drug Delivery Barriers 0.42
Water Confinement in Hollow Fe-TA Nanoparticles Synergistically Enhances Photothermal-MRI Theranostics 0.29
Holistic and Multivalent Engineering of In Vivo Nanomedicine Reactions for Enhanced Multistage Tumor Delivery 0.07
Tuning the Needling Length of Copper Single-Atom Nanozyme for Enhanced Cellular Uptake and Chemodynamic Therapy 0.45
Piezoelectricity-Potentiated Bioorthogonal Catalysis Disrupts Cholesterol Metabolism for Tumor Immunotherapy 0.33
Engineered Magnetic Resonance Nanoprobes for Visualizing Tumor Programmed Cell Death Ligand 1 Level and Enhancing Synergistic Radio Immunotherapy 0.07
Machine Learning-Driven Optimization of Therapeutic Substance Composition for High-Hardness, Fast-Dissolving Microneedles for Androgenetic Alopecia Treatment 0.65
Glucose-Responsive Polyzwitterionic Nanoparticles with Enhanced and Targeted Intestinal Epithelial Absorption for Oral Insulin Delivery 0.11
Transcytosis-Enabled Paclitaxel Prodrugs for Potentiated Chemotherapy 0.43
Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping 0.24
3 0.64
Chirality of Poly(γ-glutamic acid) Directs Calcium Nanoparticle Assembly and Adjuvant-Like Immune Activation 0.08
Virus-inspired nanocages potentiate glioblastoma sonochemotherapy via structure-function mimicry 0.20
Tuning the polyethylene glycol-lipid anchor length of lipid nanoparticles to enhance brain-targeted siRNA delivery 0.36
6 1.17
Co‐Delivery of Cationic Polymeric Sonosensitizer and Antimicrobial Peptide Mimic by Polymeric Nanoparticle for Enhanced Therapy of Lethal Bacterial Pneumonia 0.10
Hypoxia‐Activated Radical Anions to Trigger Reactive Oxygen Species Burst for Chemoimmunotherapy 0.50
A One‐Two Punch Strategy Against Cancer: Simultaneously Inducing and Eliminating Senescent Tumor Cells 0.13
Intracellular Self‐Assembled Fe(II)‐Aniline Mustard NPs for Self‐Enhanced Anti‐Tumor Chemo‐/Chemodynamic Therapy 0.14
Terminal Group‐Determined and Dendrimer‐Encapsulated Perovskite Probes for High‐Contrast Biomedical Imaging 0.17
Lattice-distortion Induced Niobium-based Perovskite Polarization Cascade Regulates Na+/K+ ATPase to Enhance Pyroptosis for Cancer Treatment 0.13
11 2.60
Dynamically Hydrogen-Bonded Microphase Separation Enabling Phase Transition in the Gel Composites With Tunable UCST 0.25
Conformationally Variable Peptides Trap and Detoxify Ox-LDL in Plaques for Attenuating Atherosclerosis in Multiple Species 0.29
Brush‐on‐Brush Architecture Enables Durable and Reversible Aptamer Therapeutics With Minimal PEG Associated Immunogenicity 0.78
Inhalable Polymeric Nanoparticle Vaccine for Lysosome-Targeting Co-Delivery of Antigen and Adjuvant With Enhanced Immunoprotection 0.11
Cytosol-Targeting Delivery of Non-Nucleotide STING Agonist Achieves Inhalable Nanoparticle-Based Anthrax Vaccine 0.20
Programming Interfacial Polymerization: Machine Learning Unveils Quantitative Rational Design Rules for Microcapsules and Beyond 0.11
Pathology-Driven Design of a Biomimetic Ferromagnetic Nanomedicine for Dual-Mode Treatment of Ulcerative Colitis and Colitis-Associated Colorectal Cancer 0.08
A Hypoxia-Activatable Prodrug for Targeted Combination Therapy of Hepatoma 0.50
Targeted Cascade Therapy with Multifunctional Nanovesicles Engineered from Synergistic Antibacterial Agents for Precision Treatment of Multidrug‐Resistant Infections and Biofilms 0.07
Synthetic High‐Density Lipoprotein Mimicking Nanodiscs with Pt(IV) Prodrug Enable Tumor Targeting and cGAS‐STING Pathway Activation for Chemo‐Immunotherapy 0.13
Bioinspired Heterogeneous Spheres with Tunable Helical Structure for Accurate and Efficient Control of Sugar Blood Level 0.08
3 1.23
Elucidating Molecular Vibrations within the Cocrystal of a Nonsteroidal Anti-Inflammatory Drug and Amino Acid by Temperature-Dependent Terahertz Spectroscopy at 2–17 THz: A Case Study 0.11
A Robust Immobilization Method for Membrane Protein SPR Assays Using SpyCatcher–SpyTag 0.56
Accurate Identification of MDMB-Type Synthetic Cannabinoids through Design of Dual Excited-State Intramolecular Proton Transfer Site Probe and Deep-Learning 0.56
18 4.14
Hierarchically Chiral Silver Nanoclusters Mediated Enantioselective Glutathione Depletion and Intracellular Self-Assembly for Enhanced Anticancer Therapy 0.13
A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders 0.49
Amphiphilic Zwitterionic Polymers Induce Liposome Morphogenesis into Nanodiscs for Deep Glioblastoma Infiltration 0.04
Benzaldehyde‐Tagged Cell‐Penetrating Peptides Enable Efficient Cytosolic Delivery of Bioactive Cargos via Dynamic Covalent Anchoring 0.25
Counterion-Engineered Water-Stable Intravenously Administered Nanoparticles Enable In Vivo Reversal of Ticagrelor 0.56
Kinetically Stereocontrolled Gem-Fluoro(chloro)-Olefination of Carbonyls by an Unprecedented Sulfoximine: Programmable Construction of Challenging Persubstituted Alkenyl Fluorides 0.01
Ionizable Nano-PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression 0.09
PSMA‐Triggered Phase Separation of Peptide‐Drug Conjugates Enables Zinc‐Dependent Tumor Inhibition 0.08
De Novo Design of Hexamer‐Linker Dual‐Action Nano‐PROTAC for Tumor‐Specific Ferroptosis 0.45
Discovery and Total Synthesis of Crossiguanipyrazines with Potent Activity Against Mycobacterium tuberculosis 0.08
Empowering Chemistry Experts with Large Language Models for Literature Interpretation in Single‐Atom Catalysis Toward Advanced Oxidation 0.19
Interfacially Mineralized Magnetic Colloidal Gel with Microenvironment-Triggered Disassembly for Interventional Treatment of Hepatocellular Carcinoma 0.03
Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation 0.25
Visible‐Light‐Mediated Intramolecular Dearomatization of Naphthalene and Anthracene with Bicyclo[1.1.0]butanes Through Energy Transfer Catalysis 0.33
Stereoselective Nucleophilic Di‐ and Monofluoro(sulfoximidoyl)Methylation of C═C Bonds: Remote Neighboring Group Participation Enables Facile Access to Chiral γ‐Fluorinated Amines 0.08
De Novo Design of Structure‐Tunable Multivalent Targeting Chimeras for Tumor‐Targeted PD‐L1 Degradation and Potentiated Cancer Immunotherapy 0.48
ATP‐Assisted Electron and Proton Transfer Boosting Redox Metabolism‐Induced Ferroptosis and Apoptosis for Cancer Therapy 0.27
Spherical Nucleic Acids‐Directed Cryosynthesis of Manganese Nanoagents for Tumor Imaging and Therapy 0.32
1 0.50
Enhancement of transdermal drug delivery by using a Laval nozzle to intensify shock waves generated by pulsed discharge plasma 0.50
2 0.25
Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy 0.00
Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo 0.25
1 0.42
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates 0.42
1 0.16
Vitamin C conveys geroprotection on primate ovaries 0.16
4 1.05
Facile access to difluoromethylene-linked strained aliphatic rings from 2-(difluoromethylene)cyclobutyl sulfonium salts (CB-DFAS) and [1.1.1]propellane 0.05
J-aggregates of ethene-bridged aza-BODIPY dimers for bright NIR-II bioimaging and efficient photothermal therapy 0.24
Programmable PROTAC delivery for precise and spatiotemporal protein degradation 0.19
A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells 0.57
5 0.97
Stearic acid-modified PSMA-targeting peptide–drug conjugate for long-acting prostate cancer therapy 0.09
Difluoromethylene cyclobutyl sulfonium salts: versatile reagents for chemodivergent synthesis of difluoroalkylated cyclobutenes and cyclobutanes 0.11
Special solvation effects of mixed water and alcohols revealed by molecular aggregation 0.50
Intermediate knowledge enhanced the performance of the amide coupling yield prediction model 0.08
A BODIPY-tagged trivalent glycocluster for receptor-targeting fluorescence imaging of live cells 0.19
3 0.39
Neglected Plastic Waste from Discarded Cigarette Butts: A Case Study on Hazards Identification in typical regions in China 0.03
VOCs emission from landfills co-disposed of rural solid waste and sewage sludge: Identification, diffusion, and impact 0.30
Exposure profile of four classes of emerging pesticides in pet dog and cat serum from Wuhan, China 0.06
9 2.87
Intermolecular Interactions as the Bridge: Establishing Structure–Activity Relationships between Microscopic Features of Organophosphorus Compounds (OPCs) and Their Adsorption Performance 0.71
Molecular Insights into Ocular Exposure Risk of Indoor Smoke Components on the Tear Film 0.13
Dynamic Evolution of Fe3O4 Nanoparticles’ Protein Corona during Extracellular to Intracellular Trafficking: The Interference of Integrin αMβ2 0.42
Leveraging Large Language Models for Contextual Prioritization of Contaminants of Emerging Concern in Chemical Mixtures 0.19
Arsenic Impairs Crab Carapace Sclerotization after Molting by Interfering with Phosphorus Metabolism 0.69
ChemBioHepatox: Multimodal Integrating Chemical Structure and Biological Fingerprint for Robust and Interpretable Hepatotoxicity Prediction 0.03
Ferroptosis Induced by Pb Exposure Causes Parkinson’s Disease-Related Dopaminergic Neuronal Death 0.07
Event-Driven Taxonomy (EDT) Screening: Leveraging Effect-Based Spectral Libraries to Accelerate Semiquantitative Nontarget Analysis of AhR Agonists in Sediment in the Era of Big Data 0.13
Single-Nucleus Transcriptomics Reveals Prenatal and Postnatal Pb Exposure-Induced Cell-Specific Neurotoxicity and Dysregulated Microglia-Neuron Communication in Mice Brain 0.50
1 0.03
GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization 0.03
2 0.49
Selenoprotein P deficiency drives hepatocellular carcinoma progression via induction of neutrophil senescence and immunosuppressive microenvironment 0.44
Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer 0.05
1 0.56
Multiscale Modeling and Experimental Validation of Solvent-Mediated Crystal Morphology Control in Sr(OH)2·8H2O for Industrial Crystallization Processes 0.56
1 0.79
Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis 0.79
15 5.72
Hydrogen–Deuterium Exchange Mass Spectrometry Reveals an Antibody-Induced Allosteric Pathway Driving SARS-CoV-2 Spike Trimer Disassembly 0.29
Micron-Scale 2D Antibody Arrays for HER2 Signaling Blockade and Cancer Therapy 0.84
In Situ Transformable Photothermal Targeting Chimeras for Spatiotemporally Controllable Protein Degradation and Combination Immunotherapy for Cancer 0.27
Iridium-Catalyzed Enantioselective C(sp3)–H Borylation of Bicyclo[1.1.0]butanes 0.46
A Versatile Bioorthogonal Theranostic Platform Enables Relay Activation of Tumor Cell Imaging and Targeted Protein Degradation 0.53
Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform 0.35
Poly(bis(guanidinium)-oxazoline)–Insulin Complex Exerting Long-Acting Glucose-Responsive Insulin Release in Mice and Minipigs 0.17
In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy 0.10
A Sodium Iron Phosphate Nanocatalyst-Regulated High-Mobility Ion Reservoir Enables Tumor-Selective Immunotherapy 0.57
Pretargeted Mitochondrial Delivery of Organoarsenicals for Cancer Immunotherapy 0.22
Cell-Selective Targeting Chimeras (SelecTACB) for Membrane Protein Degradation on B Cells 0.14
Magnetic Sorting of Chiral Pharmaceuticals Using Fe3O4–Cellulose Acetate Phthalate Nanosplitters 0.50
Enzymatic Basis of Stereochemical Control in Reserpine Biosynthesis 0.71
Phototriggered LYTAC: Photoactive Bispecific Aptamer Chimera Enhances Targeted Degradation of Membrane Protein through Regulating Cell Autophagy 0.06
Data-Driven Design of Random Heteropolypeptides as Synthetic Polyclonal Antibodies 0.52
3 1.25
Controlled Synthesis of Hydrogen-Bonded Poly[(thio)ester amide]s via Deprotection of Alternating Copolymers from N-tert-Butyloxycarbonyl Aziridine and Cyclic Anhydrides 0.50
Hydrogen Bonding Mechanism in Cononsolvency 0.25
Exploring SMILES and BigSMILES: Toward Efficient and Scalable Polymer Representations for Machine Learning 0.50
1 0.21
Mechanistic insights into cannabidiol-mediated TrkB activation via FRS2 interaction in attenuating Alzheimer’s disease pathology and cognitive impairment 0.21
3 0.37
A Dicer-Activatable Aptamer-Adamantane/siRNA (AptHyT-siRNA) Chimera Enables Synergistic Targeted Protein Degradation and mRNA Silencing 0.08
s-Block Atomic Calcium Sites Boost Biomimetic Hydrolysis for Personal Protection 0.08
Hydrophobically Modified Paclitaxel Prodrug Enables Ultrahigh Drug Loading Driven by Polarity Redistribution 0.20
1 0.05
Crystal structures of agonist-bound human cannabinoid receptor CB1 0.05
2 0.84
Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles 0.43
A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2 0.41
2 0.04
Navigating condensate micropolarity to enhance small-molecule drug targeting 0.02
Molecular recording of cellular protein kinase activity with chemical labeling 0.02
21 6.29
Structural characterization of kappa-opioid receptor dimer in complex with two G proteins 0.32
Rational design of a Kappa opioid receptor peptide agonist with attenuated β-arrestin signaling 0.33
Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity 0.08
Structural evolution of carbon frameworks realizes in vitro interfacial transport in metabolically reprogrammed senescent cells for senolysis 0.42
Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy 0.69
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases 0.23
Engineered exosome nanovesicles for delivery of antibodies to treat inflammatory bowel disease 0.03
Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals 0.08
Designing an oxidase toolbox for site-directed oxidation of taxanes 0.17
Alternative antigen retention by a gp96-fusion approach induces long-lasting and broad immunity in mice 0.62
Structural basis for pharmacotherapeutic action of triple reuptake inhibitors 0.19
NIR-IIb fluorescence ratiometric imaging of tumor-associated neutrophils for immunotherapy efficacy monitoring and strategy optimization 0.37
Molecular basis of prostaglandin E reuptake by organic anion transporter PGT 0.09
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs 0.03
Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy 0.52
Crafting defects in two-dimensional organic platelets via seeded coassembly enables emergent molecular recognition 0.38
Modular synthesis of CF-containing compounds with PhSOCFH reagent through difluoromethylene radical anion synthon strategy 0.11
Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates 0.37
Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors 0.55
Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury 0.11
In situ construction of intracellular supramolecular assemblies as an alternative strategy for protein degradation 0.62
1 0.03
Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus 0.03
1 0.14
A genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 dynamics in vivo 0.14
3 0.86
Modular Defluorinative Annulation Enabled by a Dearomative Rearrangement: Diversified Synthesis of Azaheterocycles 0.13
Pyridine-Fused C25 abeo-Steroid Alkaloids from a Fungus: Biomimetic Semisynthesis and Anti-HIV Mechanistic Study 0.67
Difluorocarbene as a Dual C1/CF2 Source for HCF2S Heterocycle Synthesis 0.07
2 0.79
DeepDegradome: A structure-aware deep learning framework for PROTAC and ligand generation against protein targets 0.09
Enhanced screening via a pure DNA-encoded peptide library enabled by an Fmoc modification 0.70
1 0.03
Deep contrastive learning enables genome-wide virtual screening 0.03
6 1.49
Pulmonary neuroendocrine cell–derived exosomes regulate iron homeostasis and oxidative stress in lung neurons 0.01
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia 0.61
Site-specific adaptive nanovesicles for oral insulin delivery 0.42
Construction of a whole-brain panorama for glioma vasculature reveals tumor heterogeneity and blood-brain barrier disruption 0.29
Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy 0.08
Lipid droplet–enriched luminogens enable adoptive macrophage transfer for treatment of bacterial sepsis 0.07
2 0.63
Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs 0.56
S-nitrosoglutathione reductase as a therapeutic target for diabetic vascular complications in rodent models 0.07
1 0.59
Structural insights into selective and dual antagonism of EP2 and EP4 prostaglandin receptors 0.59

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