Articles

The study introduces manifold topological deep learning (MTDL) that extends topological deep learning to data on differentiable manifolds through de Rham-Hodge theory. MTDL outperforms competing methods on various biomedical imaging benchmarks.

Mutations in the follicle-stimulating hormone receptor (FSHR) cause spontaneous ovarian hyperstimulation syndrome (OHSS). Here, the authors report that estrildid finches naturally carry an analogous pathogenic mutation found in patients but avoid the syndrome by lowering a related receptor’s activity. Blocking this receptor successfully treats OHSS in mice.

Pooled single-cell perturbation screens can dissect genetic networks but face scalability issues in vivo. Here, the authors present MIC-Drop-seq, pairing high-throughput CRISPR in zebrafish with multiplexed scRNA-seq to enable scalable, whole-animal screening at single-cell resolution.

Metabolic reprogramming toward glycolysis is a hallmark of pathological cardiac hypertrophy, but the regulatory mechanisms remain unclear. Here the authors show that the adipokine, asprosin, drives hypertrophic metabolic remodeling by stabilizing PFKP and activating a YY1–asprosin–PFKP–PDK4–PDH axis.

Stabilizing 4d/5d metals as single atoms for catalysis is challenging due to their strong tendency to cluster. Here, the authors develop a hydrogen embrittlement-like assisted thermal activation strategy that prepares Ru-based single-atom catalysts, which achieve high performance in fuel cells.

Here the authors report that the π-basic cavity of pillar[n]arenes can effectively stabilize bromiranium intermediates generated during olefin halogenation, confining them in a controlled microenvironment. This strategy overrides the intrinsic Markovnikov preference, enabling highly selective anti-Markovnikov halogenation.

Pathological mechanisms underlying the onset and progression of PTSD (post-traumatic stress disorder) are not fully understood. Here authors show that stress-induced Sgk1 upregulation in basolateral amygdala neurons projecting to the hippocampus as a key mechanism underlying the delayed PTSD-like avoidance behavior in mice.

Systemic autoinflammatory disorders (SAID) represent a heterogeneous family of immune dysregulation disorders with overlapping clinical characteristics, making a precise and timely diagnosis challenging. Here, the authors collect samples from a group of patients diagnosed with autoinflammation of unknown origin, and by combining immunophenotyping, plasma proteomics, and machine learning, identify key immunological drivers of this condition with a signature that partially overlaps that of Still’s disease.

Bimerons are magnetic solitons that are topologically equivalent to skyrmions in in-plane magnetized systems. This study demonstrates the room-temperature creation of bimerons in Co₈Zn₈Mn₄ via femtosecond laser pulse excitation, revealing dynamic topological control and morphological transitions of these solitons.

How mutations shape signal processing in protein switches is not well defined. Here, the authors use GluePCA to profile thousands of PYL1 variants, uncovering modular control of sensitivity, basal activity and maximal response, novel inverter and band-stop mutations, and identifying stability‑driven mechanisms.

T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is a protein that has been associated with regulatory processes in different immune cells. Here the authors demonstrate that TIM-3 is associated with regulation of type 2 innate lymphoid cells (ILC2) and use two different mouse allergy models to show how signalling through TIM-3 reduces allergic responses and inflammation.

The authors observe re-entrant superconductivity beyond a superconductor-to-insulator transition in a granular aluminum thin-film nanobridge, which they demonstrate functions as naturally occurring Josephson junction array. They argue that the re-entrant behavior is induced by the screening of electron charge, a many-body correlation effect.

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

Habitat transitions can rewire microbial genomes. This study shows how a bacterial lineage crosses ecosystems either by acquiring genes or via hypermutability, where mutation bias—not selection—drives genome reduction and GC decline.

Authors measured eleven key antibiotic resistance genes (ARGs) in U.S. wastewater to gauge population‑level resistance. Results showed regional differences and links between higher ARG levels, social vulnerability indicators and international travel.

Genome annotation typically requires costly experimental assays across diverse cell types, limiting its scalability. Here, authors introduce BioSeq2Seq, a deep learning framework that leverages DNA sequence and run-on sequencing (RO-seq) data to accurately predict histone modifications, functional elements, gene expression, and transcription factor binding sites.

The immune mechanism causing ischemic heart failure pathology in myocardial infarction (MI) requires further exploration. The authors here find NK cells are recruited to ischemic heart after acute myocardial infarction (MI) and induce cardiomyocyte apoptosis. Pharmacological depletion of NK cells reduces the pathology.

TRPM3 mediates pain, and mutations in the TRPM3 gene cause neurodevelopmental delay and epilepsy. Here, the authors use cryo-EM and functional studies to define an S1–S4 pocket that binds diverse ligands with stereoselective and mutation-dependent effects on channel gating.

Analysing 30 cities worldwide, this study identifies bidirectional yet asymmetric causality between urban systems and traffic dynamics, revealing that urban systems more strongly shape mobility patterns than traffic feeds back into cities.

Time-resolved, high-resolution elastic strain mapping using microfocused synchrotron Laue X-ray diffraction paired with infrared spectroscopy reveal the dynamic nature of spontaneous crack healing in a slide of calcite.