Research articles

The authors examine public, private, and family time investments in children in the United States using ten nationally representative surveys between 2010 and 2023.

Here authors show Trisomy 21 alters fetal brain development by increasing activity of the RNA-editing enzyme ADARB1, leading to premature RNA editing of key genes involved in early synaptic signaling.

A robust method applied to quantify the wide range of condensate permittivities, from oil- to water-like, reveals that their affinity to membranes is governed not by internal permittivity itself, but by the permittivity contrast with the environment.

Climate and land-use change are transforming biodiversity, yet national futures remain uncertain. The study projects growing extinction debts, but suggests that sustainable low-emission pathways can limit the worst impacts on British biodiversity.

Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highlight its role in maintaining proteome stability and enabling dynamic stress responses in plants.

Here, Wulczynski et al. find fewer small-intestinal fiber-degrading bacteria in CeD patients, independent of the gluten-free diet, while inulin-supplemented diet in gluten-sensitized mice facilitates microbial saccharolytic function and SCFAs, accelerating mucosal healing in the small intestine.

NASA’s Perseverance rover detected high nickel abundances in an ancient Martian river channel. Their chemistry resembles nickel enrichments in ancient Earth rocks and may hint at complex redox–organic processes in Mars’ past.

Protein structure modeling can generate hypotheses about sequence-structure-function relationships. Here, the authors used modern computational methods and experimental characterization to explore the constraints on rapidly evolving chaperones and create functional artificial proteins in C. auris.

Du, Miao et al identify that the spatiotemporal recruitment and activation of Rab5 during early endosome formation are collectively determined by Rabex5/hRME6 recruitment and PI(4,5)P2 depletion during uncoated endocytic carrier formation.

Assessing the impact of rising air temperatures on the Antarctic Ice Sheet is hampered by the coarse resolution of climate models. Here, the authors use an observationally constrained statistical method to calculate surface melt at 1 km resolution.

Rare cells in single-cell and spatial omics are often hidden within dominant populations. Here, the authors introduce RareQ, a small-world-inspired graph method that uses neighborhood cliquishness (Q) to detect rare cell types and reveal fine-grained spatial structures.

This study reveals how the Vip1-Vip2 binary toxin assembles and enables protein translocation into target cells, providing structural insights into binary toxin action and suggesting strategies for developing next-generation bioinsecticides.

Mad1 is an essential component of the mitotic spindle assembly checkpoint with emerging roles in interphase. Here, the authors show that Mad1 plays an unexpected role in cytokinesis via its interphase function in facilitating α5 integrin secretion.

Water-floating nanotransfer printing (WF-nTP) is proposed for transferring nanostructures onto three-dimensional substrates. Using WFnTP, an Au SERS nanomesh for pesticide detection on plants and a Pd-based hydrogen gas sensor are demonstrated.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

Maintaining genome integrity during different life stages is critical. Here, the authors reveal an RNA editing mechanism in the fungal pathogen Fusarium graminearum that adjusts Mus81 protein function to balance heat-stress survival and sexual reproduction. This stage-specific editing fine-tunes DNA repair for adaptation and reproduction.

Converting low-grade heat into electricity is promising to power electronic devices, though it is often limited due to weak ion selectivity and insufficient concentration gradients. Here the authors use a calix[4]pyrrole as an ion trap enhancing electronic properties for energy harvesting.

Global analysis finds stalled tropical cyclones are more common in the Southern Hemisphere. Climate warming slightly reduces how often storms stall but increases rainfall from stalled storms, especially over land, heightening flood risk.

Cells respond to cholesterol levels with increased growth. Here, the authors show that HR3/RORα senses cholesterol to regulate TOR signaling, linking cholesterol availability to cell growth, with implications for cholesterol-related diseases and cancer.

Hu et al. report a low-temperature polar-solvent strategy for high-yield (162 mg mL⁻¹) perovskite nanocrystal synthesis with suppressed self-absorption. The scintillator films achieve ~7 ns fast decay, 28,800 photons MeV⁻¹ light yield, and dynamic X-ray imaging at 7,680 frame per second.