Nature Search

APOLLO11: a bio-data-driven model for clinical and translational research in lung cancer

Arsela Prelaj
Leonardo Provenzano
Alessandro Leonetti
ResearchOpen Access29 Jan 2026
npj Precision Oncology

P: 1-12
Neoadjuvant PD-1 blockade in surgically resectable desmoplastic melanoma: cohort A of the phase 2 SWOG S1512 trial

Ribas and colleagues report the results of a phase 2 clinical trial of neoadjuvant PD-1 blockade in patients with surgically resectable desmoplastic melanoma.

Kari L. Kendra
Shay L. Bellasea
Antoni Ribas
ResearchOpen Access29 Jan 2026
Nature Cancer

P: 1-11
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activation drive a treatment-refractory tissue phenotype.

Kartik Bhamidipati
Alexa B. R. McIntyre
Kevin Wei
ResearchOpen Access15 Jan 2026
Nature Immunology

P: 1-16
Mutual inhibition between EPFL2 and auxin extends the intervals of periodic leaf morphogenesis

Plant development is characterized by periodic morphogenesis, yet regulatory mechanisms underlying the periodicity remain unknown. Tameshige et al. reveal that bistable cellular status modulates the spatial pattern of periodic leaf morphogenesis.

Toshiaki Tameshige
Takeshi Tsuchida
Momoko Ikeuchi
ResearchOpen Access13 Nov 2025
Nature Communications

Volume: 16, P: 1-15
MI-181 enhances ciliation and cilia length in a cigarette smoke exposed airway epithelial model

Ankur A. Gholkar
Caroline Cherry
Jorge Z. Torres
ResearchOpen Access24 Jan 2026
Scientific Reports

P: 1-11
Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders

Nora Berz Slapø
Kjetil Nordbø Jørgensen
Erik G. Jönsson
ResearchOpen Access17 Jan 2026
Schizophrenia

P: 1-14
Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes

Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

Jun Li
Jie Hu
Qibin Qi
ResearchOpen Access14 Jan 2026
Nature Medicine

P: 1-11
Gaps in tropical science from unrepresentative distribution of sampling and citation across natural terrestrial environments

Research in the tropics is unevenly distributed across regions and biomes. Here, the authors find that moist broadleaf forests account for 73% of all tropical citations but cover 29% of the land area, while drier, climate-vulnerable areas with fewer trees remain under-sampled and under-cited.

Daniel B. Metcalfe
Emily Anders
Anna-Maria Virkkala
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 16, P: 1-10
Direct measurement of the male germline mutation rate in individuals using sequential sperm samples

Mutations accumulate with age in the male germline, and can lead to genetic diseases in offspring. Here, the authors collect from individuals sequential sperm samples separated by long timespans, which they profile by high-fidelity sequencing to study germline mutation processes.

Jonathan E. Shoag
Amoolya Srinivasa
Gilad D. Evrony
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Evidence for low density holes in Jupiter’s ionosphere

Intense electromagnetic impulses induced by Jupiter’s lightning can produce both low-frequency dispersed whistler emissions and non-dispersed radio pulses. Here, the authors show Jupiter dispersed pulses associated with Jovian lightning that are evidence of low density holes in Jupiter’s ionosphere.

Masafumi Imai
Ivana Kolmašová
Steven M. Levin
ResearchOpen Access21 Jun 2019
Nature Communications

Volume: 10, P: 1-6
Psychotherapy for older adults with depression: a narrative review

Amber M. Gum
Nicole O. Crawford
Reviews15 Jan 2026
Neuropsychopharmacology

P: 1-19
Extinction cascades, community collapse, and recovery across a Mesozoic hyperthermal event

Mass extinctions have repeatedly restructured communities through geological time, but biotic interactions are rarely considered in investigations of extinction dynamics and ecosystem recovery. Here the authors present evidence that secondary extinction cascades were important during a Jurassic hyperthermal extinction event and that it took over 7 million years for community structure to fully recover.

Alexander M. Dunhill
Karolina Zarzyczny
Andrew P. Beckerman
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-11
Consent document translation expense hinders inclusive clinical trial enrolment

The availability of translated consent documents improves recruitment of patients with limited English proficiency to clinical trials, indicating a potentially modifiable barrier to the inclusion of patients with limited English proficiency.

Maria A. Velez
Beth A. Glenn
Edward B. Garon
Research02 Aug 2023
Nature

Volume: 620, P: 855-862
Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family

J. H. Elder
F. C. Jensen
R. A. Lerner
Research05 May 1977
Nature

Volume: 267, P: 23-28
Anti-anxiety drug makes river fish more aggressive

Wastewater treatment fails to remove drug from ecosystem.

Heidi Ledford
News14 Feb 2013
Nature
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

In this genomic analysis of peripheral blood samples of the phase 3 CheckMate-067 trial of ipilimumab (IPI) versus nivolumab (NIVO) versus ipilimumab and nivolumab (IPI-NIVO) in melanoma, the status of certain mitochondrial haplogroups in patients was associated therapeutic resistance to NIVO or IPI-NIVO, a finding validated in an independent cohort.

Kelsey R. Monson
Robert Ferguson
Tomas Kirchhoff
ResearchOpen Access05 Jun 2025
Nature Medicine

Volume: 31, P: 2385-2396
Evolution of homeothermy in mammals

A. W. Crompton
C. Richard Taylor
James A. Jagger
Research01 Mar 1978
Nature

Volume: 272, P: 333-336
Demonstration of Antibodies to Thyroxine and Monoiodothyronine by Mixed Haemadsorption

JONAS A. F. JONSSON
Research22 Oct 1966
Nature

Volume: 212, P: 417-418
DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor

Here, the authors investigate the relationship between HUSH-MORC2 and DNA methylation in embryo-derived human neural progenitor cells, enhancing the understanding of the epigenetic control of repeats in somatic cells.

Ninoslav Pandiloski
Vivien Horváth
Christopher H. Douse
ResearchOpen Access30 Aug 2024
Nature Communications

Volume: 15, P: 1-16
Induction of Multiple Brain Tumours (Gliomata and Leptomeningeal Sarcomata) in Dogs by Rous Sarcoma Virus

G. F. RABOTTI
A. S. GROVE jun.
W. R. ANDERSON
Research26 Feb 1966
Nature

Volume: 209, P: 884-886
DNA mismatch and damage patterns revealed by single-molecule sequencing

A DNA sequencing method with single-molecule fidelity detects mismatches and damage present in only one of the two DNA strands with patterns that are both similar and distinct compared to known mutation patterns.

Mei Hong Liu
Benjamin M. Costa
Gilad D. Evrony
Research12 Jun 2024
Nature

Volume: 630, P: 752-761
A magnesium ion core at the heart of a ribozyme domain

Jamie H. Cate
Raven L. Hanna
Jennifer A. Doudna
Research01 Jul 1997
Nature Structural Biology

Volume: 4, P: 553-558
Complexities in the estimation of overdiagnosis in breast cancer screening

S W Duffy
E Lynge
A H Olsen
ResearchOpen Access02 Sept 2008
British Journal of Cancer

Volume: 99, P: 1176-1178
Differences between germline genomes of monozygotic twins

Whole-genome sequencing of monozygotic twins, along with their parents, spouses and children, identifies postzygotic mutations present in the somatic tissue of one twin, but not the other, and characterizes differences in the number and timing of these mutations.

Hakon Jonsson
Erna Magnusdottir
Kari Stefansson
Research07 Jan 2021
Nature Genetics

Volume: 53, P: 27-34
Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture

G. DI CHIARA
M. OLIANAS
A. TAGLIAMONTE
Research25 Aug 1977
Nature

Volume: 268, P: 743-745
Sequence diversity lost in early pregnancy

Around 1 in 136 pregnancies is lost due to a pathogenic small sequence variant genotype in the fetus.

Gudny A. Arnadottir
Hakon Jonsson
Kari Stefansson
ResearchOpen Access21 May 2025
Nature

Volume: 642, P: 672-681
Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. Here the authors efficiently differentiate human pluripotent stem cells through second heart field progenitors to CFs that exhibit features and functional properties similar to native CFs.

Jianhua Zhang
Ran Tao
Timothy J. Kamp
ResearchOpen Access20 May 2019
Nature Communications

Volume: 10, P: 1-15
Direct observation and temperature control of the surface Dirac gap in a topological crystalline insulator

The opening of a Dirac point gap in topologically non-trivial materials is key to potential applications. Here, the authors use photoelectron spectroscopy to study gap formation and carrier mass acquisition in a topological crystalline insulator as a function of composition and temperature.

B. M. Wojek
M. H. Berntsen
O. Tjernberg
ResearchOpen Access13 Oct 2015
Nature Communications

Volume: 6, P: 1-5
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Targeting FSP1 triggers ferroptosis in lung cancer

The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.

Katherine Wu
Alec J. Vaughan
Thales Papagiannakopoulos
ResearchOpen Access05 Nov 2025
Nature

Volume: 649, P: 487-495
The sequences of 150,119 genomes in the UK Biobank

To measure selection on variants, whole-genome sequencing of approximately 150,000 individuals from the UK Biobank is used to rank sequence variants by their level of depletion.

Bjarni V. Halldorsson
Hannes P. Eggertsson
Kari Stefansson
ResearchOpen Access20 Jul 2022
Nature

Volume: 607, P: 732-740
Inheritance of paternal DNA damage by histone-mediated repair restriction

In Caenorhabditis elegans, paternal exposure to ionizing radiation results in HIS-24 and HPL-1-dependent genome instability phenotypes, causing embryonic lethality in the offspring.

Siyao Wang
David H. Meyer
Björn Schumacher
ResearchOpen Access21 Dec 2022
Nature

Volume: 613, P: 365-374
Health economics of prevention of coronary heart disease and vascular events: a cost-effectiveness analysis based on the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)

B Jönsson
M Buxton
N Poulter
Research18 Mar 2002
Journal of Human Hypertension

Volume: 15, P: S53-S56
Detection and characterization of 1B/1R translocations in hexaploid wheat

J S Heslop-Harrison
A R Leitch
K Anamthawat-Jónsson
Research01 Dec 1990
Heredity

Volume: 65, P: 385-392
The Botany of Iceland

A. D. C.
Books & Arts13 Feb 1913
Nature

Volume: 90, P: 645
Morphine Withdrawal Syndrome Responses to Cholinergic Antagonists and to a Partial Cholinergic Agonist

C. PINSKY
R. C. A. FREDERICKSON
A. J. VAZQUEZ
Research02 Mar 1973
Nature

Volume: 242, P: 59-60
Comments on the “Isolation, Identification and Synthesis of a Specific-behaviour-inducing Brain Peptide”

A. GOLDSTEIN
Research02 Mar 1973
Nature

Volume: 242, P: 60-62
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease

Here the authors elucidate how epigenetic regulation influences the regulatory impact of transposable elements in the human genome using cellular models of the neurodegenerative disease XDP, which is caused by an SVA insertion at the TAF1 locus.

Vivien Horváth
Raquel Garza
Johan Jakobsson
ResearchOpen Access04 Jun 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1543-1556
African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk

Whole-genome sequencing identifies a rare missense variant in IKBKB associated with high risk of cutaneous and systemic lupus erythematosus among people with African ancestry.

Gudny Ella Thorlacius
Erna V. Ivarsdottir
Kari Stefansson
ResearchOpen Access17 Nov 2025
Nature Genetics

Volume: 57, P: 2980-2986
Joint neutrino oscillation analysis from the T2K and NOvA experiments

The joint analysis of datasets from NOvA and T2K, the two currently operating long-baseline neutrino oscillation experiments, provides new constraints related to neutrino masses and fundamental symmetries.

S. Abubakar
M. A. Acero
S. Zsoldos
ResearchOpen Access22 Oct 2025
Nature

Volume: 646, P: 818-824
Whole-genome sequencing of 490,640 UK Biobank participants

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Keren Carss
Bjarni V. Halldorsson
Ole Schulz-Trieglaff
ResearchOpen Access06 Aug 2025
Nature

Volume: 645, P: 692-701
Up-regulation of M3-Muscarinic Receptors in Labial Salivary Gland Acini in Primary Sjögren's Syndrome

Dimitra Beroukas
Rhian Goodfellow
Sally A Waterman
Research01 Feb 2002
Laboratory Investigation

Volume: 82, P: 203-210
Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase

Peter M. Andersen
Peter Nilsson
Stefan L. Marklund
Research01 May 1995
Nature Genetics

Volume: 10, P: 61-66
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

Klaus D. Beck
Janet Valverde
Franz Hefti
Research26 Jan 1995
Nature

Volume: 373, P: 339-341
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Stacy Steinberg, Hreinn Stefansson, Thorlakur Jonsson and colleagues found that rare variants predicted to alter the function of ABCA7 are associated with risk of Alzheimer's disease. The association was found in Iceland and replicated in northern Europe and the United States.

Stacy Steinberg
Hreinn Stefansson
Kari Stefansson
Research25 Mar 2015
Nature Genetics

Volume: 47, P: 445-447
Significant role of the North Icelandic Jet in the formation of Denmark Strait overflow water

The largest dense-water plume feeding the lower limb of the Atlantic meridional overturning circulation from the Nordic seas comes from Denmark Strait overflow water. Measurements of hydrography and water velocity north of Iceland and ocean model simulations indicate that a significant part of this water is supplied by the North Icelandic Jet.

Kjetil Våge
Robert S. Pickart
Tor Eldevik
Research21 Aug 2011
Nature Geoscience

Volume: 4, P: 723-727
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer

A multi-modal analysis of pre-metastatic liver biopsies from patients with localized pancreatic cancer with a minimum of 3 years of follow-up shows that immunological, proliferative and metabolomic features distinguish patients who develop metastases from disease-free survivors and can be used to predict outcomes.

Linda Bojmar
Constantinos P. Zambirinis
David Lyden
Research28 Jun 2024
Nature Medicine

Volume: 30, P: 2170-2180
Granzyme K activates the entire complement cascade

A study finds that a protease called granzyme K can activate the entire complement cascade, explaining how it can drive destructive inflammation in inflammatory diseases such as rheumatoid arthritis.

Carlos A. Donado
Erin Theisen
Michael B. Brenner
Research06 Feb 2025
Nature

Volume: 641, P: 211-221
Mechanomedicine

Mechanical forces are crucial regulators of biological functions in health and disease, offering measurable biomarkers and therapeutic targets. This Review introduces the principles of mechanomedicine and highlights its translational potential across scales, from tissue diagnostics to molecular mechanotherapeutics.

Zeyang Liu
Guorui Chen
Song Li
Reviews07 Jan 2026
Nature Reviews Bioengineering

P: 1-20
Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant

R Hwang
C Zai
J L Kennedy
Research22 Dec 2009
The Pharmacogenomics Journal

Volume: 10, P: 200-218

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