Promyelocytic leukemia (PML) nuclear bodies (NB) facilitate the proteasomal degradation of protein aggregates through the SUMO-targeted ubiquitin ligase pathway. A study now reveals a non-proteolytic role for PML-NBs in preventing TDP-43 aggregation that still relies on the SUMOylation–ubiquitylation cascade but uses it to direct protein aggregates towards p97 ATPase-mediated disaggregation.
- Xiaoyang Yu
- Huaiying Zhang
