Nature Search

Cortical thinning and hippocampal expansion as brain signatures of attention deficit hyperactivity disorder symptom trajectories

This study utilized a longitudinal cohort of adolescents to identify distinct brain signatures linked to ADHD symptom trajectories, revealing that specific cortical and subcortical changes correlate with symptom persistence, remission and emergence, enhancing predictive capabilities for ADHD outcomes.

Wenjie Hou
Daqian Zhu
Qiang Luo
Research10 Feb 2026
Nature Mental Health

Volume: 4, P: 263-278
Hierarchical neurocognitive model of externalizing and internalizing comorbidity

This research identifies two neural factors linked to externalizing and internalizing symptoms through a longitudinal imaging-genetic cohort. Distinct neural configurations and cognitive-behavioral relevance highlight the need for tailored therapeutic strategies addressing psychiatric comorbidity across developmental stages.

Chao Xie
Shitong Xiang
Gunter Schumann
ResearchOpen Access13 Feb 2026
Nature Mental Health

P: 1-15
Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis

Here, the authors find that time-varying brain network analysis better captures cognitive processing than static methods and reveals network measurement linked to task performance and psychopathology that offer precise neural markers for mental health risks.

Xiao Chang
Tianye Jia
Gunter Schumann
ResearchOpen Access03 Feb 2026
Nature Communications

Volume: 17, P: 1-16
Investigating grey matter volumetric trajectories through the lifespan at the individual level

Longitudinal analysis of neuroimaging data are useful for analysing heterogeneity in adolescent brain development. Here the authors cluster adolescent participants of the IMAGEN study into groups based on gray matter volume developmental patterns and investigate genome-wide and epigenome-wide associations with these groups.

Runye Shi
Shitong Xiang
Gunter Schumann
ResearchOpen Access15 Jul 2024
Nature Communications

Volume: 15, P: 1-14
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth

Annie Cheng
Sarah Lichenstein
Sarah W. Yip
ResearchOpen Access05 Sept 2025
Molecular Psychiatry

Volume: 31, P: 953-962
Genetic risk-dependent brain markers of resilience to childhood Trauma

This study shows how the same brain networks may support resilience differently in individuals with varying genetic risks, enabling more personalized mental health approaches.

Han Lu
Edmund T. Rolls
Qiang Luo
ResearchOpen Access05 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Genome-wide association study unravels mechanisms of brain glymphatic activity

Here, the authors perform a genome-wide association study of the ALPS-index, identifying 17 unique genome-wide significant loci, unraveling mechanisms of brain glymphatic activity and providing insight for its relation to neuropsychiatric phenotypes.

Shu-Yi Huang
Yi-Jun Ge
Jin-Tai Yu
ResearchOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Mapping the coupling between tract reachability and cortical geometry of the human brain

Li et al. introduced tract-geometry coupling (TGC) to quantify the coupling between white matter tracts and cortical geometry in the human brain, shedding light on how the brain’s wiring and shape evolve together and its support for behavior and growth.

Deying Li
Andrew Zalesky
Lingzhong Fan
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Relationships of eating behaviors with psychopathology, brain maturation and genetic risk for obesity in an adolescent cohort study

This study identifies distinct eating behavior profiles and links them to eating disorder symptoms, genetic predispositions for high body mass index and brain maturation during adolescence.

Xinyang Yu
Zuo Zhang
Juliane H. Fröhner
ResearchOpen Access10 Jan 2025
Nature Mental Health

Volume: 3, P: 58-70
Deep learning models reveal the link between dynamic brain connectivity patterns and states of consciousness

Chloé Gomez
Lynn Uhrig
Antoine Grigis
ResearchOpen Access30 Dec 2024
Scientific Reports

Volume: 14, P: 1-17
Regional patterns of human cortex development correlate with underlying neurobiology

The neurobiology of human brain development and aging is hard to study in vivo. The authors report on distinct spatial associations between brain morphology and cellular as well as molecular brain properties throughout neurodevelopment and aging.

Leon D. Lotter
Amin Saberi
Juergen Dukart
ResearchOpen Access12 Sept 2024
Nature Communications

Volume: 15, P: 1-21
A stable and replicable neural signature of lifespan adversity in the adult brain

In a birth cohort, Holz et al. found widespread structural brain changes at the age of 25 years as a function of adversity. This pattern was replicated at the age of 33 years and in another cohort. Individual-level volume reductions on top of this pattern predicted anxiety.

Nathalie E. Holz
Mariam Zabihi
Andre F. Marquand
ResearchOpen Access21 Aug 2023
Nature Neuroscience

Volume: 26, P: 1603-1612
A shared neural basis underlying psychiatric comorbidity

Evidence from large longitudinal neuroimaging cohorts, which include genetic and behavioral data, suggest a common neural basis for symptoms seen across multiple psychiatric disorders.

Chao Xie
Shitong Xiang
Betteke Maria van Noort
ResearchOpen Access24 Apr 2023
Nature Medicine

Volume: 29, P: 1232-1242
Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning

Max M. Owens
Matthew D. Albaugh
Gunter Schumann
ResearchOpen Access06 May 2022
Translational Psychiatry

Volume: 12, P: 1-9
Genetic variants associated with longitudinal changes in brain structure across the lifespan

Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.

Rachel M. Brouwer
Marieke Klein
Hilleke E. Hulshoff Pol
Research05 Apr 2022
Nature Neuroscience

Volume: 25, P: 421-432
Global urbanicity is associated with brain and behaviour in young people

Xu et al. show that satellite-measured urbanicity (living in a densely populated area) is correlated with brain volume, cortical surface area and brain network connectivity in a sample of 3,867 people from China and Europe.

Jiayuan Xu
Xiaoxuan Liu
Gunter Schumann
Research28 Oct 2021
Nature Human Behaviour

Volume: 6, P: 279-293
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits

A genome-wide association study of cerebral ventricle phenotypes finds 62 unique loci and reveals a genetic overlap between ventricular and neuropsychiatric traits.

Yi-Jun Ge
Bang-Sheng Wu
Jin-Tai Yu
Research19 Oct 2023
Nature Human Behaviour

Volume: 8, P: 164-180
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders

A genome-wide association study of the human hypothalamus discovers 23 unique loci and examines genetic associations with neuropsychiatric behaviours and disorders.

Shi-Dong Chen
Jia You
Jin-Tai Yu
Research05 Jan 2024
Nature Human Behaviour

Volume: 8, P: 779-793
Association between vmPFC gray matter volume and smoking initiation in adolescents

The relationship between brain development and smoking behaviour is not well understood. Here, the authors show an association between volume of the left ventromedial prefrontal cortex and smoking initiation in adolescents.

Shitong Xiang
Tianye Jia
Jianfeng Feng
ResearchOpen Access15 Aug 2023
Nature Communications

Volume: 14, P: 1-13
Author Correction: A shared neural basis underlying psychiatric comorbidity

Chao Xie
Shitong Xiang
Betteke Maria van Noort
Amendments and CorrectionsOpen Access09 Aug 2023
Nature Medicine

Volume: 29, P: 2375
Differential predictors for alcohol use in adolescents as a function of familial risk

Mira Tschorn
Robert C. Lorenz
Amir Tahmasebi
ResearchOpen Access04 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
Neurobehavioural characterisation and stratification of reinforcement-related behaviour

On the basis of the IMAGEN database of 2,000 Caucasian adolescents, Jia et al identify neural patterns of activity during reward anticipation and motor inhibition associated with different externalising symptoms for ADHD and conduct problems.

Tianye Jia
Alex Ing
Gunter Schumann
Research20 Apr 2020
Nature Human Behaviour

Volume: 4, P: 544-558
Interpretable and integrative deep learning for discovering brain-behaviour associations

Corentin Ambroise
Antoine Grigis
Vincent Frouin
ResearchOpen Access17 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence

Qingyang Li
Miao Cao
Qiang Luo
Research01 Feb 2025
Molecular Psychiatry

Volume: 30, P: 3055-3068
Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits

Kaizhong Xue
Bo Gao
Chunshui Yu
Research22 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4853-4866
Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior

Matthew D. Albaugh
Max M. Owens
Hugh Garavan
Research28 Jun 2023
Molecular Psychiatry

Volume: 28, P: 5173-5182
Arc controls alcohol cue relapse by a central amygdala mechanism

Roberto Pagano
Ahmad Salamian
Kasia Radwanska
Research10 Nov 2022
Molecular Psychiatry

Volume: 28, P: 733-745
Anxiety onset in adolescents: a machine-learning prediction

Alice V. Chavanne
Marie Laure Paillère Martinot
Robert Whelan
ResearchOpen Access08 Dec 2022
Molecular Psychiatry

Volume: 28, P: 639-646
A causal association of ANKRD37 with human hippocampal volume

Jiayuan Xu
Xianyou Xia
Gunter Schumann
Research04 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4432-4445
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern

Zhipeng Cao
Renata B. Cupertino
Hugh Garavan
Research15 Nov 2022
Molecular Psychiatry

Volume: 28, P: 698-709
Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis

Matthew Price
Matthew Albaugh
Hugh Garavan
Research26 Feb 2021
Neuropsychopharmacology

Volume: 46, P: 1888-1894
Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents

Simone Kühn
Anna Mascherek
Jürgen Gallinat
ResearchOpen Access27 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

Monique Ernst
Brenda Benson
D Stephens
ResearchOpen Access25 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-14
Cortical signatures in behaviorally clustered autistic traits subgroups: a population-based study

Angeline Mihailov
Cathy Philippe
Vincent Frouin
ResearchOpen Access27 Jun 2020
Translational Psychiatry

Volume: 10, P: 1-12
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence

Weida Meng
Louise K. Sjöholm
Yun Liu
Research19 Nov 2019
Molecular Psychiatry

Volume: 26, P: 4367-4382
Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces

Evangelos Papanastasiou
Elias Mouchlianitis
Sukhwinder S. Shergill
ResearchOpen Access20 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study

Amirhossein Modabbernia
Abraham Reichenberg
Sophia Frangou
ResearchOpen Access22 May 2020
Molecular Psychiatry

Volume: 26, P: 4905-4918
Correction: Arc controls alcohol cue relapse by a central amygdala mechanism

Roberto Pagano
Ahmad Salamian
Kasia Radwanska
Amendments and Corrections05 Dec 2022
Molecular Psychiatry

Volume: 29, P: 5

Search

Filter By:

Search

Quick links