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The Armigeres subalbatus sex-determining locus, M, maps to the 3rd chromosome, but its identity was unknown. Here they identify a sex-specific gene, AsuMf, that is essential for male development and show that it is a novel male-determining factor derived from duplication and neofunctionalization of a conserved DBHS family member.

Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.

A nacre-inspired, centimetre-sized bulk material is prepared by assembling graphene oxide and microscale amorphous/crystalline heterophase reinforcing platelets adhered together with polymer-based crosslinkers, which shows high flexural strength and fracture toughness.

Immunoengineering-based cancer therapies have huge potential. Here the authors report on the lipid nanoparticle delivery, to cancer cells, of self-amplifying RNA encoding SARS-CoV-2 spike epitope-loaded MHC I molecules to take advantage of anti-SARS-CoV-2 immunity from a vaccinated population to treat cancer.

A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administration in mice.

The realization and phonon imaging of nanoscale mechanical metamaterials has remained challenging. Here the authors resolve the phonon dynamics and band structures of five different self-assembled nanoparticle lattices, revealing the role of nanoscale colloidal interactions in modulating the lattice properties.

Giant full-alloy QDs flatten the energy disorder between the QD layer and hole transport layer, realizing low voltage-driven bright QLEDs with a T₉₅@1000 cd m^-2 lifetime surpassing 72,000 h.

Different blood-brain barrier permeable systems, such as bacteria loaded with chemotherapy, have been proposed to treat glioblastoma. Here, the authors generate bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles to eliminate bacteria-infected glioblastoma cells and induce an anti-tumour immune response upon photothermal therapy.

The design of high-efficiency solution-processable orange-red thermally activated delayed fluorescence (TADF) emitters remains to be a challenge. Here, the authors synthesize a series of emitters consisting of a trinaphtho[3,3,3]propellane core with highly efficient emission in the orange-red region of the spectrum.

The authors show that ELL3 maintains chromosomal ploidy by promoting spindle assembly and driving chromosome movement in oocytes. Deficiency of ELL3 results in oocyte aneuploidy and may lead to early miscarriage.

The crystallization of nanoparticles is observed with single-particle resolution via electron microscopy. The growth modes are explained via computer simulations, unifying the understanding of crystallization from the atomic to micrometre scale.

Antimicrobial peptides are identified from metagenomics data using deep learning.

The mechanisms involved in the formation of the premetastatic niche in hepatocellular carcinoma (HCC) are not completely elucidated. Here, the authors show that matrix stiffness in HCC induces cancer-exosome release which increases glucose availability in the lung premetastatic niche favouring metastasis formation and growing.

To measure temperatures close to absolute zero, authors developed a kind of composite phase diamond (CPD) that can measure temperature at the millikelvin level, making it a promising candidate for next–generation cryogenic temperature sensors.

Insertion of a bivalent linker between two regions of interest allows chromatin contacts to be probed without proximity ligation.

Signatures of an excitonic insulator have been reported in several two-dimensional materials. Here the authors report electronic properties of monolayer ZrTe₂ from ARPES and STM measurements that are consistent with the preformed exciton gas phase, a precursor for the excitonic insulator.

The haptic interface is an essential part of human–machine interfaces where tactile information is delivered between human and machine. Yao et al. develop a soft, ultrathin, miniaturized and wireless electrotactile system that allows virtual tactile information to be reproduced over the hand.

Deciphering the reaction mechanisms of CO/CO2 electroreduction to methanol remains challenging. Here the authors report the higher electron density of single-Co-atom center, along with a different adsorption configuration of *CO, is crucial for promoting the CO electroreduction to methanol.

The tailoring of reticular materials is key for enhancing the complexity and diversity of their structure and function. Now, a series of isomeric pillar-layered metal–organic frameworks with tunable topologies have been prepared through altering the layer stacking, which enables variability on the backbone structure, pillar spatial arrangements and pore structure.

Nucleotide second messengers are employed by many bacterial species to regulate various cellular processes. Here, the authors demonstrate that 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) controls the important biological functions and virulence in Ralstonia solanacearum by abolishing the interaction between a transcriptional regulator and the promoters of target genes.

Harnessing solar energy to generate electricity and provide water is recognized as a sustainable pathway to addressing water scarcity and electricity shortage. The integration of passive interfacial cooling in a hybrid system boosts the utilization of waste heat and latent heat from the hybrid modules and minimizes the energy loss to air.

The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

Developing electronic skins for sensing the spatial location of objects beyond two-dimensional space is difficult. The authors present a flexible, lightweight, and transparent electronic skin for non-contact accurate 3D motion sensing. This achieves micron-level precision, reducing complexity and power consumption.

Angle-resolved photoemission spectroscopy measurements in CoSi reveal the presence of unconventional chiral fermions near the Fermi level, with giant surface Fermi arcs and one pair of well separated chiral nodes.

Continuous monitoring of arterial blood pressure is limited by bulky connecting systems and poor interfacial contact. Here, Li et al. report a wearable thin, soft, miniaturized system that integrates sensing, active pressure adaptation, and signal processing for improved performance and accuracy.

EGFR amplification can affect temozolomide sensitivity in glioblastomas (GBM). Here the authors show that EGFR signalling mediates lysine methylation of NFAT5 which contributes to reduced efficacy of temozolomide in GBM.

The XPF-ERCC1 heterodimer is an endonuclease involved in nucleotide excision (NER) and interstrand crosslink (ICL) repair in mammalian cells. Here, the authors provide insights into its regulation by revealing that TIP60 regulates XPF-ERCC1 complex assembly and activation.

The lengthy time in establishing patient-derived organoids(PDOs) hampers the implementation of PDO-based drug sensitivity tests in clinics. Here, the authors show a microwell array-based method to predict patient’s responses to anti-cancer therapies in a week using lung cancer organoids.

While water splitting electrolysis offers an appealing means to produce H₂ fuel, catalysts show sluggish reaction rate in neutral media. Here, authors utilize hydrogen spillover from oxygen-deficient tungsten oxides to Ru nanoparticles to boost the neutral-pH H₂ evolution performances.

A well-designed national coal phase-out pathway in China that considers diverse technology portfolios and plant-level sequential decision-making processes can save over 700 billion dollars and elevate mitigation potential.

R-loops are prevalent in mammalian genomes and involved in many fundamental cellular processes. Here, Wang et al. report that ZFP281 cooperates with BRCA2 in preventing R-loop accumulation to facilitate DNA replication in embryonic stem cells.

Growing biomass carbon stock in China between 2001 and 2020 is driven by conservation and anthropogenic expansion of woodland.

Defects are believed to always scatter carriers. Here, the authors find that the quantum gaps in GeTe-based materials do not scatter carriers, which decouple the carriers and phonons transport leading to high thermoelectric performance.

A haptic interface that uses thermal, mechanical and electrotactile modes of stimulation to target different receptors in the skin can provide users with diverse haptic sensations, reproducing the tactile information of fine roughness, macro roughness, slipperiness, force and temperature.