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Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

Wu et al. show that cooperative coupling at buried and top perovskite interfaces promotes chemically bonded self-assembled monolayers and forms a stable 1D heterojunction, enabling perovskite solar cells with 27.05% efficiency and maintaining over 95% of the efficiency after 2,100-hour continuous operation at 65 °C.

Host factor that restrain viral propagation offer new anti-RNA virus strategies. Here the authors provide evidence that endonuclease G (ENDOG) is a host anti-viral factor and engineer ENDOG expression on the mitochondrial outer membrane to eliminate viral RNA.

AmiAge predicts biological age from plasma amino acids, linking age gaps to frailty, disease risk, and aging markers. An 8-amino acid model offers a scalable tool for personalized health and aging research.

Ferroptosis is an iron-dependent form of cell death with important implications for cancer biology. Here, the authors report that tumor necrosis-induced iron overload in the tumor microenvironment (TME) drives CD8⁺ T cell dysfunction by promoting ferroptosis, proposing the design of CAR-T cells overexpressing SLC40A1 (an iron exporter) to resist ferroptosis in the TME.

Alternative transcription start sites generate transcript diversity but are difficult to detect due to RNA degradation in 5’ scRNA-seq. Here, the authors present scATS, which corrects degradation to quantify TSS usage, improve cell clustering, and identify lung cancer-promoting TSS isoforms.

Soil microbes drive ecosystem functions but are vulnerable to environmental stressors triggered by global change. This study reveals that multiple environmental stressors drive community-level restructuring of soil functional microbiomes globally.

Microsatellite-stable/proficient mismatch repair colorectal cancers are resistant to immune checkpoint blockade immunotherapy due to their immune suppressive tumour microenvironment. Here the authors show in mouse models that the transcription factor Arid3b contributes to the suppression of CD8 + T cell infiltration and activity in these tumours via suppressing Runx3, a known regulator of tissue resident memory phenotype in CD8 + T cells.

Strain-resilient, self-healing conductors are needed for wireless e-skin but usually face a trade-off between conductivity and flexibility. Hou et al. design a polymer-based conductor with ultralow sheet resistance and use it to build a high-performance, self-healing flexible antenna.

Co-deposited perovskite solar cells suffer from self-assemble monolayer (SAM) aggregation that weakens interfacial adhesion and limits performance. Zhuang et al. design an asymmetric SAM and a crosslinking additive to curb aggregation, enabling efficient, stable devices.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Artificial intelligence is increasingly used in medical imaging, but its realworld clinical value for report generation is unclear. Here, the authors show that AI assistance in chest X-ray interpretation reduced reading time while maintaining diagnostic accuracy and agreement in a prospective study.

The authors propose a 3D holographic method that generates physically consistent complex-valued light fields from multi-layer RGB-D data, achieving photorealistic defocus effects in scenes with transparency and reflection.

Poor storage stability and soil survival limits agricultural application of non-spore forming bacteria. Here, the authors develop a hydrogel microcapsule which improves storage and soil survival, demonstrating application in improving plant salt tolerance under field conditions.

Sorbic acid is a widely used food preservative, yet its industrial production lacks a sustainable microbial route. Here the authors identify the biosynthetic pathway of sorbic acid and engineer yeast for its efficient production.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Restricting or permitting H3K27me3 spreading concentrates or dilutes canonical PRC1 (cPRC1), respectively, which affects three-dimensional chromatin interactions. Disruption of cPRC1 compromises repression of Polycomb target genes and induces differentiation and tumor regression in H3K27M-mutant glioma.

Anion-mixing strategy is gaining attention for the development of amorphous halide solid electrolytes. Here, authors investigate the structure evolution of nitrochloride amorphous solid electrolyte, Li_3x ZrCl₄ N_x (0.17 ≤ x ≤ 1), demonstrating ionic conductivities of up to 3.21 mS cm⁻¹ at 30 °C, suggesting that the formation of nitrogen-containing frameworks is crucial for enhancing ionic conductivity.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

This study uses cryo-electron microscopy and tomography to reveal the extracellular filaments of Shewanella oneidensis MR-1 biofilms, identifying flagella and two distinct pili that help organize the biofilm matrix.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

Extracellular vesicles (EVs) mediate intercellular communication by transferring signaling macromolecules. Unexpectedly, the author here identifies that adipocyte-specific loss of SMPD3 triggers neighboring preadipocytes to release EVs containing SMPD3 mRNA, restoring SMPD3 expression in genetically null adipocytes.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

The mechanisms that restrict NK cell activity in tumor microenvironments remain to be explored. The authors here establish genome-wide CRISPR screening in primary NK cells and uncover intracellular checkpoints that limit proliferation, cytotoxicity, and resistance in tumor microenvironments.

Researchers have found that extreme hot-wet weather in 2024 triggered a spike in ecosystem respiration, mainly in tropical non-forests, significantly reducing the year’s land carbon sink and pushing the atmospheric CO2 growth rate to a record high.

RNovA is an open-search de novo peptide sequencing model.

Starting with early settlements, water has long shaped the form, fate and location of cities. This study finds that preurban development in the Yangtze River Basin was tied to rivers even as it remained vulnerable to their fluctuations.

Here the authors reveal a large-scale multi-ancestry genome-wide association study (GWAS) that identifies 11 new risk loci for kidney cancer, including one specific to Chinese populations.

UCl₃-type electrolytes show promise for all-solid-state batteries, yet their structure and Li⁺ transport remain debated. Here, authors reveal foreign cations reside in the amorphous phase, which serve as the dominant Li⁺ pathway yielding enhanced conductivity and low-temperature battery performance.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

The family of oxiranes encompasses a variety of compounds with extensive applications across different fields. Herein, the authors report the photochemical syntheses of a range of highly functionalized strained oxiranes.

Elevated exposure to 4-hydroxyphenanthrene (4-OHPhe) is positively associated with obesity risk. Here, the authors show that exposure to 4-OHPhe downregulates expression of hydroxylamine reductase genes in Bacteroides uniformis, leading to altered gut microbiota-bile acid-FXR axis and suppression of adipose thermogenesis.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.

Interfacial solvation structures are key to stable fast charging in Si anodes. Qiao and colleagues show that S-vacancy-driven anion-reduction catalysis regulates these structures to form a LiF-rich solid electrolyte interphase, enabling ultrafast charging and long cycle life.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

Peritoneal metastasis of ovarian cancer is often accompanied by the accumulation of ascitic fluid. Here, the authors find that ascites protects ovarian cancer cells against ferroptosis, thus enabling their spread in the peritoneum.

The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These spines thus boost neuronal firing and act as a fast track to route circuit information.

A two-dimensional polar hedgehog lattice spontaneously forms in layer-ordered perovskites, showing stable topological ferroelectric states without external constraints and enabling new pathways for functional material design.