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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

A permanently porous organic framework assembled and stabilized solely by non-covalent chalcogen bonding is reported. Empirical and computational studies reveal the characteristic influence of the operative Te···N chalcogen bonds on assembly, electronic structure, framework regeneration and lattice dynamics.

The red body is a characteristic cellular structure of unknown function in eustigmatophyte algae. Using imaging and spectroscopy, the authors investigate the red body and propose a role in delivery of algaenan precursors for cell wall formation.

Community-associated Staphylococcus aureus strains show heightened wall teichoic acid production, which correlates with virulence and abscess formation.

Imaging of ferroelectric domain walls and their polarity is achieved through scanning stress microscopy. Twin boundaries are found to allow nanoscale gating of the two-dimensional electron gas at the LaAlO₃/SrTiO₃ interface.

In ferroelectric thin films, ferroelastic domains affect the features of polarization switching. Gao et al.perform real-time transmission electron microscopy measurements and show that ferroelastic domains can hinder the switching via formation of a transient interface layer with a dipole glass structure.

Ferroelectric materials are characterized by a spontaneous polarization, which in practical applications is manipulated by an electric field. This study examines how defects affect the switching with atomic resolution, by usingin situaberration-corrected transmission electron microscopy.

An electron subject to a periodic potential and a constant electric field exhibit oscillatory dynamics, known as Bloch oscillations. Here, the authors demonstrate a magnetic analogue of Bloch oscillations in a ferromagnetic near-Ising chain, where magnetic excitations oscillate in response to a magnetic field.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

The presence of an accessory genetic element, tarIJLM—which leads to the production of a S. aureus-type wall teichoic acid—alters the lifestyle of S. epidermidis invasive clones, impairing in vivo mouse colonization but increasing endothelial attachment and host mortality.

EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.

Risk factors for hepatosplenic multimorbidity, particularly in chronic infection contexts, remain poorly understood. Here, the authors develop a Bayesian machine learning framework to jointly model 45 hepatosplenic conditions related to schistosomiasis in rural Uganda, identifying shared risk factors and condition dependencies, as well as improving prediction of severe multimorbidity.

Second-generation oxidation boosts the production of anthropogenic organic aerosol, according to an analysis of urban haze in an experimental chamber.

Microbial magnetosymbiosis has rarely been reported and is poorly studied. Here, the authors describe this symbiosis in a ciliate that acquires magnetic navigation through endosymbiotic bacteria with reduced genomes that produce magnetite crystals, allowing the host to move efficiently in stratified waters.

Atomic-resolution microscopy and AI reveal how metallic nanowires grow inside carbon nanotubes through atom-by-atom wetting, advancing understanding of how next-generation materials can be synthesized from the atomic scale up.

A search for transient dark matter in the form of domain walls of axion-like particles finds no statistically significant signal. This places constraints on our theoretical understanding of such scenarios.

An analysis of whole-exome sequencing data linked to longitudinal electronic health records from 44,028 British South Asians finds new gene–phenotype associations and identifies 2,991 genes with rare biallelic predicted loss-of-function genotypes.

This work describes protein-coated clay nanoparticles that are actively taken up by roots to deliver synthetic RNA and DNA-encoded genes into plants. The nanoparticles can also deliver functional nucleic acids directly into other plant tissues.

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Metabolizing lignocellulosic feedstocks to industrial chemicals by microorganisms requires surmounting  the recalcitrance caused by lignin. Here, the authors pair transgenic lignin modified poplar lines with engineered Caldicellusiruptor bescii to achieve biomass solubilization and ethanol conversion without pretreatment.

In a kagome superconductor, sublattice degrees of freedom are shown to govern a distinct density wave phase featuring chiral textures and symmetry properties that align with one of the fundamental frieze symmetry groups.

This study identifies AcuB as a conserved inhibitor of the deacetylase AcuC in bacteria. AcuB directly suppresses AcuC activity, and this inhibition is enhanced the alarmone diadenosine tetraphosphate, linking stress signaling to acetylation control.

Ferroelectric domain wall profiles can be modeled by phenomenological Ginzburg-Landau theory, with different candidate models and parameters. Here, the authors solve the problem of model selection by developing a Bayesian inference framework allowing for uncertainty quantification and apply it to atomically resolved images of walls. This analysis can also predict the level of microscope performance needed to detect specific physical phenomena.

Benoit et al. present nanoMDBG, a scalable metagenome assembler for the latest ONT long reads, developed by adding error correction to metaMDBG. They demonstrate superior performance to the state-of-the-art and equivalent results to PacBio HiFi reads.

The sea floor at the easternmost Southwest Indian mid-ocean ridge is smooth, unlike that at other mid-ocean ridges. Sonar imaging and analysis of rock samples show that the sea floor here is composed almost entirely of sea-water-altered mantle rocks that have been brought to the surface by large faults on both sides of the ridge axis over the past 11 million years.

The domain-wall structure and dynamics are found to enhance, rather than inhibit, the high-frequency performance of an intrinsically tunable material, obtaining ultralow loss and exceptional frequency selectivity.

Using an integrated approach, it is possible to identify the molecular addresses on blood-vessel walls that are read by blood cells — and, at least in rats, to deliver imaging agents and drugs to specific tissues.

Advancements in congenital heart surgery stress the need for durable biomaterials. Here, the authors compare tissue-engineered vascular grafts (TEVGs) with traditional polytetrafluoroethylene grafts, revealing TEVGs’ superior durability and reduced calcification, promising improved long-term success for surgeries.

Bond et al. predict mechanism of action of hit compounds from a pooled screen of Mycobacterium tuberculosis mutants underproducing essential proteins by comparing the strain-specific responses of screening hits to those elicited by known antimicrobials.

A fusion protein designed to comprise IL-2 and a helminth-derived TGFβ mimic activates IL-2 and TGFβ signalling pathways in IL-2 receptor-expressing T cells and induces stable antigen-specific regulatory T cells in peripheral lymphoid organs.

The synthetic biology era has seen a rapidly growing number of engineered DNA sequences. Here, the authors develop a deep learning method to predict the lab-of-origin of a DNA sequence based on hidden design signatures.

Staphylococcus epidermidis induces a potent, durable and specific antibody response that is conserved in humans and non-human primates, and which could be redirected against pathogens as a new form of topical vaccination.

Da Pra, Boriati and colleagues show that physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagonism as a strategy to enhance their protective and regenerative effects.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Quantum simulations of topological insulator phases with single-site control would allow to see richer phenomenology. Using a programmable trapped-ion simulator with site-resolved Floquet control, the authors implement a long-range spin model, revealing protected edge excitations and rich many-body dynamics beyond the single-excitation regime.

Most non-line-of-sight imaging requires scanned illumination, limiting applicability for dynamic scenes. Here the authors exploit occlusion and a sensor array to estimate locations and sizes of moving foreground objects and a static background map.

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.