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Despite advances in the design of thermally activated delayed fluorescence (TADF) emitters for devices, the effect of spin interactions is not well understood. Here, the authors report the role of spin-vibronic coupling in TADF organic emitters using transient electron spin resonance spectroscopy.

The authors uncovered a pathway from the lateral amygdala to the auditory cortex (ACx) of mice that is essential for auditory fear memory retrieval. Simultaneous imaging of pre- and postsynaptic structures in ACx in vivo revealed an increased rate of synapse formation in this pathway after auditory fear conditioning.

Devices with a wide-temperature range persistent photoconductivity (PPC) and low power consumption is a challenge for optical synaptic devices in neuromorphic computing. Here, the authors develop a carbon nanotube/porphyrin heterojunction on a flexible array, achieving PPC between 77 K to 400 K.

Factors affecting the fate of disseminating tumour cells in the circulation play a critical role in metastasis. Here the authors show that TLR4 on platelets promotes their adhesion to tumour cells and enhances metastasis.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

While acidic water splitting offers a renewable means to obtain renewable hydrogen fuel, the catalysts needed to oxidize water often require expensive noble metals. Here, authors show manganese oxyhalides as acidic oxygen evolution electrocatalysts.

Optical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection.

It is an open question whether choice signals in primary sensory areas have a causal influence on an animal’s perception. Here, the authors show that early sensory representations in the neocortex can be selectively manipulated to bias perception during discrimination behavior.

Precise and scalable patterning is essential for the use of metal-organic frameworks (MOFs) in solid-state electronics and photonics. Here, the authors report on resistance-free, direct photo- and electron-beam lithography of MOF films using crosslinking chemistry.

Certain devices require rapid adhesion and detachment, but achieving both can be challenging. Here, the authors report the development of a supramolecular hydrogel with reversible tough adhesion and triggered photodetachment.

Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wound healing in mouse models of diabetes.

Woo et al. report new autophagy inhibitors identified through a high-throughput chemical screening using a BRET-based assay and an ATG8 synthetic sensor, that function as safe and effective fungicides against broad fungal pathogens.

Hydrogen oxidation in alkaline media is vital for fuel cells and ammonia compressors but typically requires costly platinum catalysts. Here the authors report a Pd-Ru pair decorated on Pt to enhance the mass activity of noble-metal for hydrogen oxidation reactions.

A family of lattice kinetic schemes is introduced for the simulation of relativistic flows. Taking advantage of GPU acceleration, the scheme allows one to efficiently probe both strongly and weakly interacting regimes, for massive and massless particles.

The democratic peace hypothesis suggests that autocracies are more warlike than democracies. Here, the authors use evolutionary game theory to test this hypothesis across taxa, finding that democratic peace can emerge without the need for complex human institutions.

The endometrium is activated by the pregnancy hormones estrogen and progesterone to facilitate embryo implantation, and errors in endometrial responsiveness can lead to reduced fertility or endometriosis. Here they show that GREB1 interacts with hormone receptors in the endometrium, leading to normal or pathological consequences depending on the hormones involved.

The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery.

CRISPR-based genome editing has revolutionized biotechnology, enabling precise DNA modifications for research and therapy. The authors review how artificial intelligence, including deep learning, is advancing genome editing by improving guide RNA design, editor protein engineering, novel effector discovery and predicting editing outcomes.

In the largest study so far of CAR T cells in patients with solid tumors, autologous CLDN18.2-targeting CAR T cell therapy was well tolerated in patients with advanced CLDN18.2-positive gastrointestinal cancers, with an overall response rate of 42.2% and a disease control rate of 91.1%.

Zhu and colleagues show that chronic activation of arcuate nucleus GABA⁺ neurons, agouti-related protein (AgRP) neurons alone or non-AgRP GABA⁺ neurons promotes severe obesity, but only inhibition of all GABA⁺ neurons can reverse the obese phenotype of hyperphagic mice, thus suggesting a redundant role for arcuate GABA⁺ neurons in obesity.

Bang et al. use behavioural data in culturally distinct settings (United Kingdom and Iran) and computational modelling to show that, when making decisions in pairs, people adopt a confidence-matching heuristic to combine their opinions.

RecBCD is a remarkably fast DNA helicase. Using a battery of biophysical methods, Zananiri et. al reveal additional, non-catalytic ATP binding sites that increase the ATP flux to the catalytic sites that allows fast unwinding when ATP is scarce.

Around 31,000 years ago, a young individual from Borneo had part of their left lower leg surgically amputated, probably as a child, and lived for another 6–9 years after amputation.

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

Brain functions require a constant supply of glucose. However, the brain energy stores are unclear. Here, the authors show that oligodendroglial fatty acid metabolism can be an energy reserve for white matter axons, supporting their function.

This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake.

Laramide flat-slab subduction releases fluids into the overlying crust that mediate water-fluxed melting of precursor arc lower crust, ultimately forming porphyry copper deposits, according to a geochronology and thermobarometry study.

Sepsis can result in acute lung injury which may involve cross interaction via the gut-lung axis. Here the authors show γδ T17 cell migration from the gut to the lung in a murine model of sepsis and link IL-17A-mediated lung inflammation regulation by Wnt/β-catenin signaling in alveolar macrophages via CCL1.

NLRP3 inflammasomes trigger release of IL-1 to promote tissue injury. Here, Li et al identify a ZFYVE21-Rubicon-RNF34 (ZRR) signaling complex localizing to endosomes and modulating complement-mediated inflammasome activity in vitro and in vivo.

Agarwal et al. and Wang et al. show that vesicle-associated membrane protein 2 (VAMP2) interacts with and regulates alpha-synuclein biomolecular condensation, affecting α-synuclein function, which may prevent pathological amyloid aggregation.

Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification. Here the authors provide further support for the role of MyoD in 3D genome architecture in muscle stem cells by comparing MyoD knockout and wild-type mice.

Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sensing.

The genomic details of adaptation to extreme environments remain challenging to characterize. Using new methods to analyze flies experimentally evolved to survive extreme O₂ conditions, the authors find a surprising level of synchronicity in selective sweeps, de novo mutations and adaptive recombination events.

Wnt signalling can be transmitted both through a canonical pathway, via the co-receptors LRP5/6, and through Frz in a non-canonical pathway. Here, the authors demonstrate a direct interaction between Frz and LRP5/6, describing a new mechanism for how these receptors are primed to respond to Wnt ligands.

Gridarenes with well-defined edges and vertices represent versatile nanoscale building blocks for installating frameworks but suffer from lack of stereoselective control during their synthesis. Here, the authors report a diastereoselective gridization of superelectrophilic diazafluorene-containing substrates with crescent shapes into Drawing Hands grids (DHGs).

Rosacea is a common chronic inflammatory skin disorder mainly affecting the central face. Here, a single-cell atlas of facial skin from rosacea patients and healthy individuals reveals the molecular and cellular changes in skin-resident cell populations and identifies fibroblasts as a determinant in rosacea development.

In this work, the authors develop a platform called AGILE or AI Guided Ionizable Lipid Engineering, which streamlines ionizable lipid development. Using AGILE, they rapidly design, synthesize, and evaluate ionizable lipids for mRNA delivery.

The upgrade of carbon monoxide to higher alcohols offers a route to renewable fuels. Now, Sinton, Sargent and co-workers report a highly fragmented, copper-based catalyst with engineered interfaces between the (111) and (100) facets that promote the coupling of C₁ and C₂ species, leading to enhanced production of n-propanol.

The functional-metabolic state of macrophages fundamentally influences the tumour microenvironment, making adoptive cell therapy with pro-inflammatory macrophages an attractive anti-tumour approach. Here authors introduce pluripotent stem cell-derived CAR-macrophage that are depleted of ACOD1, an essential gene in itaconate metabolism, which reprograms them to a pro-inflammatory state enabling enhanced anti-tumour function.

Multi-ancestry genome-wide association meta-analysis of major depression identifies new risk loci, assesses the transferability of risk loci across ancestry groups, and improves fine-mapping resolution and prioritization of candidate effector genes.

The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical development.

The mode of action of the biological Dnd antiphage defence system to cleave foreign DNA was not known. Now the activities of Dnd protein complexes are revealed, and a mechanism to discriminate between self-DNA and invading DNA is proposed.

Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 which explains the selectivity of this scaffold for D1R over other aminergic receptors and the mechanism of activating D1R.