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cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Coherent ferrons (or polarization waves) driven by an ultrafast laser source in ferroelectric van der Waals materials generate narrow-band terahertz radiation and propagate uniaxially with long coherence times.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Controlling the movement of floating objects at small scales is essential for microfluidics, but traditional methods are limited by fluid and object properties. By shaping liquid interfaces with 3D-printed spines, the study enables programmable manipulation of floating particles for applications like sorting and cleaning.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Several recent experimental studies have found disconnected Fermi surface arcs emerging below the Neel temperature in several rare-earth mono-pnictides. While these electronic states have been attributed to a non-collinear antiferromagnetic order, experimental evidence of this has been lacking. Here Huang et al demonstrate the emergence of non-collinear antiferromagnetic order using spin-polarized scanning tunnelling microscopy.

Peters et al. report the results of the phase 3 CheckMate 73L trial, randomizing participants with untreated, unresectable stage III non-small cell lung cancer to nivolumab plus concurrent chemoradiotherapy (CCRT) followed by consolidation with nivolumab plus ipilimumab or nivolumab alone or to standard-of-care CCRT followed by consolidation with durvalumab.

Scholl et al. show that PopZ forms filamentous condensates driven by its helical domain and inhibited by its disordered region. Phase-dependent conformations modulate client interactions and disruption of filamentation or condensation impairs cellular function and growth.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

A method that combines photopatterning with 10-fold shrinkage can fabricate three-dimensional metastructures with nanoscale features for applications with visible light.

How do low-mass binaries age? Astronomers have constrained a tight, circular orbit of a close-in companion around a dying giant star, raising new questions about how tidal forces shape binary orbits in the final phases of stellar evolution.

There is a long-standing trade-off between piezoelectric coefficient and mechanical quality factor for piezoceramics. Here, authors embed local defect dipoles into phase boundary engineering to relieve this relationship in (K, Na) NbO3 piezoceramics.

A complete theoretical understanding of many simple problems in quantum physics is still lacking, especially when entanglement is involved. Now the full set of possible observations has been established for a minimal scenario of shared entanglement.

This work demonstrates a nonlinearity-enhanced combination of dispersive and dissipative coupling in photon-pressure circuits, a circuit-QED analog of optomechanics, and reveals how transparency and backaction are modified by coupling-interference. The results hold relevance for radiation-pressure systems, (quantum) control protocols and Hamiltonian simulation.

MetaSTAAR enables functionally informed rare variant association analysis in biobank-scale cohorts using an efficient, sparse matrix approach for summary statistic storage.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The intriguing physics of correlated flat bands in moiré superlattices can be mimicked, in classical physics, by twisted acoustic plates with periodic holes. Here, the authors derive a combined analytical and numerical approach that provides computational advantage in band engineering of holey bilayer plates.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Measurements of the proton’s generalized spin polarizabilities provide discriminating power between effective descriptions of the strong interaction at low energy.

In most metals the optical Hall effect is very small at visible wavelengths, and usually can only be observed at low frequencies. Here, Am-Shalom et al present a technique involving a large amplitude modulation of the external magnetic field, allowing for the measurement of the optical Hall effect in a range of metals at visible wavelengths.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Confinement effects enable the design of intersubband polaritons (ISPs) in semiconductor quantum wells (QWs), but this type of light-matter excitations has been rarely explored in van der Waals materials. Here, the authors report the observation of hyperbolic ISPs in WO_x/WSe₂ QW heterostructures with electrically tunable dispersions.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

MEMS-based photonic integrated circuits (PICs) are often limited in speed by mechanical resonances. Here the authors report a programmable architecture for PICs which uses mechanical eigenmodes for synchronized, resonantly enhanced optical modulation.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

GlyContact enables systematic analysis of glycan 3D structures, revealing how structural properties like flexibility and surface accessibility determine lectin binding and introducing AI models to predict structural features directly from sequences.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and their temporal effects.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

This work highlights how changes to beaches are related to sand movement and human impacts to the coast and illuminates opportunities for sand management to resolve shoreline erosion and enhance beach sustainability.

A successful silicon spin qubit design should be rapidly scalable by benefiting from industrial transistor technology. This investigation of exchange interactions between two FinFET qubits provides a guide to implementing two-qubit gates for hole spins.

Managing hydrocephalus relies on non-specific symptoms. Here, the authors report a 0.28-gram implant that measures intracranial pressure long term, tested in pediatric and adult patients.

An on-chip tunable laser operates by harnessing nanomechanical resonances at the radio frequency, achieving ultralow tuning power consumption.

Theoretically predicted in 1979, hyper-Raman optical activity is now experimentally observed through chirality conferral from the electromagnetic field of chiral plasmonic gold nanohelices to crystal violet molecules that are achiral, sparking new science at the organic–inorganic interface.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Scientists have demonstrated non-collinear circularly polarized high-harmonic generation and showed that this method generates bright circularly polarized extreme-ultraviolet beams with both left and right helicity simultaneously.

Optical aberrations can hinder fluorescence imaging of thick samples, reducing image signal, contrast, and resolution. Here, the authors introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition or introducing more optics.

Laser-induced conversion electron Mössbauer spectroscopy, which detects electrons emitted by ²²⁹Th nuclei in a thin ThO₂ sample excited by vacuum ultraviolet light, is demonstrated, opening the possibility of a conversion-electron-based nuclear clock.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Spectral phasor analysis allows unmixing fluorescence microscopy images, but it requires user involvement and has a limited number of labels that can be analyzed and displayed. Here the authors present a semi-automated solution to visualise multiple spectral components of hyperspectral fluorescence images, simultaneously.

Human impacts on marine ecosystems are increasing the likelihood of pathogenic outbreaks, harmful algal blooms and coral stress. Here the authors develop a CRISPR biomonitoring tool that can help detect key marine species that are important to public health, the aquaculture sector and marine ecosystems.