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Rice is a staple food for many households; however, its cultivation can expose farming families to parasitic diseases such as schistosomiasis via freshwater snails. The authors examine how integrating native fish into rice fields can suppress snail hosts, boost yields and improve farmer livelihoods.

Tailoring relativistic laser–plasma interactions on femtosecond timescales unlocks a direct route to extreme field generation using a coherent harmonic focus.

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems ranging from cell culture to mice.

At planets that possess strong dipole magnetic fields, charged particles can be squeezed along magnetic fields helping to deflect the solar wind flow about the planet. Here, the authors show this effect occurring in the ionosphere of Mars, a planet without a strong dipole magnetic field.

A randomized trial in Ecuadorian high schools showed youth videos of both STEM and entrepreneurship role models. This caused both girls and boys to be less likely to enrol in STEM college majors, with girls choosing business and boys other fields.

Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by mRNA-based vaccines against SARS-CoV-2 variants in mice and non-human primates.

Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Floquet engineering is often limited by weak light–matter coupling and heating. Now it is shown that exciton-driven fields in monolayer semiconductors produce stronger, longer-lived Floquet effects and reveal hybridization linked to excitonic phases.

Natural silk, mechanically strong and biodegradable, offers great potential for sustainable functional materials. Here the authors present a simple thermomechanical method for fabricating high-performance structural and optically active materials directly from silk fibres.

Endocrine therapies are the main adjuvant therapy for estrogen receptor positive breast cancer, but 30% of patients recur. Here, the authors discover that endocrine therapy upregulates Rac1 signalling component P-Rex1, and inhibition of Rac1 reduces tumour growth in refractory breast cancer models.

Improvements in the Articulate Medical Intelligence Explorer, a large language model designed for diagnostic dialogue, enable the model to request, interpret and reason about multimodal medical data.

Scale-invariant magnetic anisotropy in RuCl₃ has been revealed through measurements of its magnetotropic coefficient, providing evidence for a high degree of exchange frustration that favours the formation of a spin liquid state.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

An absolute photon upconversion efficiency of 8.2% is demonstrated using a liquid triplet fusion medium that behaves as solid on excitonic timescales. The findings may drive higher efficiencies in nanoscale solid-state photochemical upconversion devices.

Biexciton complexes in atomically thin transition metal dichalcogenides have unusually large binding energies. Here, the authors explore biexciton formation dynamics in monolayer MoSe₂ in the presence of magnetic fields up to 25 T.

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Optical initialization and read-out of nuclear spins with a spin coherence time of 2 ms in a Eu³⁺ molecular crystal is demonstrated with radio-frequency control, providing coherent nuclear spin manipulation for quantum information technologies.

The hippocampus can replay long spatial sequences without ripples. When present, ripples cluster in spatially restricted zones as a function of replayed location that remap with barrier changes, implying a tagging role in consolidation.

The authors develop RO-iSCAT, which uses rotational integration of off-axis oblique-illuminated interference scattering signals to remove speckle noise in real time. It enables fast, label-free imaging of axial spatiotemporal dynamics of tubular membrane protrusions.

New predictions for how temporal stability and resilience depend on their resistance and recovery components are explored.

A tunable artificial crystal in a shallow GaAs quantum well is shown to enable interaction-driven insulating behaviour. Electrostatic control tunes the band structure from graphene-like to kagome-like bands.

By tuning graphene’s electronic density of states, the study shows electrode electronic structure—not just the electrolyte—dominates reorganization energy and thus controls outer-sphere electron-transfer rates at solid–liquid interfaces.

In a biomarker-driven trial evaluating radiotherapy with erlotinib, everolimus or dasatinib in patients with newly diagnosed diffuse intrinsic pontine glioma, the primary endpoint of overall survival was not met, but features associated with long-term survival were defined, and everolimus emerged as a potential candidate for further testing.

The mechanisms driving reversible dedifferentiation events towards a drug-tolerant persister (DTP) state remain to be explored. Here, multi-omics, information-theoretic approaches and dynamic systems modelling highlight the role of the oxidative-stress–mediated NF-κB/RelA axis in driving the transition towards DTP across multiple cancer types.

BaTa₂S₅, which consists of alternating layers of TaS₂ and Ba₂TaS₄, is shown to host a triplet superconducting phase at high magnetic field. This triplet phase emerges from another—more conventional—superconducting state.

In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.

DNA hybridisation thermodynamics parameters underlie rational design of oligonucleotides for diagnostics and nanotechnology. Here, the authors present an accurate method to measure the free energy of a given DNA structure at specific temperature and buffer conditions.

This work demonstrates quaternary non-volatile memory in a single-phase antiferromagnet. Polarized neutron scattering reveals that four magnetic domains in LiNi_0.8Fe_0.2PO₄ can be selectively stabilized using combined electric and magnetic fields.

This study reveals that the immune system has a role in driving ALS. These findings link blood immune changes to spinal cord damage and suggest personalized treatments targeting specific immune pathways.

Modular RNA nanostar motifs spontaneously assemble into programmable synthetic condensates in the nucleus and cytoplasm, with RNA design controlling localization, sequence-specific target recruitment and orthogonal assembly.

Insulin controls adipocyte metabolism through changes in protein localisation. Here, the authors use cell-wide subcellular proteomics to uncover extensive insulin-regulated protein redistribution and identify C3ORF18 as a regulator of adipocyte insulin sensitivity.

Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate cancer risk in patients with chronic inflammatory conditions.

About two decades ago, proof-of-principle demonstrations used light to enable heat-assisted magnetic recording (HAMR). Now, with over a million HAMR drives in the market, Nature Photonics spoke to Seagate VP of Research Ed Gage about what is arguably one of the greatest commercial success stories in plasmonics.

The mechanisms controlling activation of the futile creatine cycle are unknown, calling into question its physiological relevance. In work recently published in Nature, Hussain, Krishnan, Carroll et al. identify glycerol as an allosteric activator of tissue-nonspecific alkaline phosphatase (TNAP) and demonstrate that this activates the futile creatine cycle in adipocytes and osteoblast mineralization in bone.

Entanglement between particles offers insights into quantum behaviour, but methods for studying it in free-electron systems are lacking. Now a two-electron quantum walk is used to probe decoherence of free electrons inside an electron microscope.

Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.

Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via liquid biopsy and used to profile individual cancers and target treatments.

Exchange bias, where an adjacent antiferromagnet leads to an offset magnetization loop in a ferromagnet is a critical effect in magnetic memory devices. Here, Pellet-Mary et al introduce a “lateral exchange bias”, allowing control of the Neel vector in bilayer samples of CrSBr via laterally adjacent odd layered segments.

A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.